CN111171047B - 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物 - Google Patents

用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物 Download PDF

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CN111171047B
CN111171047B CN202010051639.8A CN202010051639A CN111171047B CN 111171047 B CN111171047 B CN 111171047B CN 202010051639 A CN202010051639 A CN 202010051639A CN 111171047 B CN111171047 B CN 111171047B
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CN111171047A (zh
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米兰·奇蒂尔
肖恩·恩格尔
泰琳·G·阿纳尼亚
瓦迪姆·亚历山德罗夫
艾默尔·莱希
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Pgi Drug Development Corp
Sunovion Pharmaceuticals Inc
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CN202010051639.8A 2015-02-11 2016-02-11 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物 Active CN111171047B (zh)

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CN202010051639.8A CN111171047B (zh) 2015-02-11 2016-02-11 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物

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US201562115043P 2015-02-11 2015-02-11
US62/115,043 2015-02-11
CN202010051639.8A CN111171047B (zh) 2015-02-11 2016-02-11 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物
PCT/US2016/017527 WO2016130790A1 (en) 2015-02-11 2016-02-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
CN201680018684.5A CN107567454B (zh) 2015-02-11 2016-02-11 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物及其类似物

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CN201680018684.5A Active CN107567454B (zh) 2015-02-11 2016-02-11 用于治疗cns障碍的稠合二氢-4h-吡唑并[5,1-c][1,4]噁嗪基化合物及其类似物

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102623321B1 (ko) * 2015-02-11 2024-01-09 선오비온 파마슈티컬스 인코포레이티드 중추 신경계 질환을 치료하기 위한 융합된 다이하이드로-4h-피라졸로[5,1-c][1,4]옥사진일 화합물 및 유사체
JP7187437B2 (ja) 2016-07-29 2022-12-12 サノビオン ファーマシューティカルズ インク 化合物および組成物ならびにそれらの使用
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
KR101753092B1 (ko) 2016-12-14 2017-07-04 성일하이텍(주) 리튬 함유 폐액으로부터 인산리튬 제조방법
US10850989B2 (en) 2016-12-20 2020-12-01 Sungeel Hitech Co., Ltd. Method for preparing solid lithium salt from lithium solution
EA202090180A1 (ru) * 2017-06-30 2020-05-26 Чейс Терапьютикс Корпорейшн Композиции nk1-антагониста и способы лечения депрессии
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
WO2019236808A1 (en) 2018-06-07 2019-12-12 Sunovion Pharmaceuticals Inc. Salts of a oxazino[4,3-b]indazole derivative and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물
TW202237622A (zh) * 2020-12-04 2022-10-01 美商蘇諾維恩藥業公司 雜環化合物的鹽及其晶型、製備方法、治療用途與醫藥組合物
WO2022217233A1 (en) * 2021-04-08 2022-10-13 Sunovion Pharmaceuticals Inc. Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
US20240417378A1 (en) * 2021-10-11 2024-12-19 Baylor College Of Medicine G-protein-coupled receptor regulators and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101421280A (zh) * 2006-04-12 2009-04-29 惠氏公司 作为5-羟色胺-6配体的经取代二氢[1,4]噁嗪并[2.3.4-hi]吲唑衍生物
WO2013067248A1 (en) * 2011-11-04 2013-05-10 Vertex Pharmaceuticals Incorporated Benzoxazines as modulators of ion channels
WO2013192346A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors
JP2014214130A (ja) * 2013-04-26 2014-11-17 大正製薬株式会社 ジヒドロイミダゾオキサゾール誘導体を含有する医薬

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995052A (en) * 1973-07-09 1976-11-30 Ayerst Mckenna And Harrison Ltd. Indenopyran- and indenothiopyranalkylamines III in the treatment of depression
US4041169A (en) * 1975-03-05 1977-08-09 Ayerst Mckenna And Harrison Ltd. Pharmaceutical method for using pyrano-and thiopyranoindole derivatives
SG173639A1 (en) * 2009-02-11 2011-09-29 Sunovion Pharmaceuticals Inc Histamine h3 inverse agonists and antagonists and methods of use thereof
KR102074089B1 (ko) * 2009-12-04 2020-02-05 선오비온 파마슈티컬스 인코포레이티드 다환형 화합물 및 이의 사용 방법
EP3053925A1 (en) * 2010-12-16 2016-08-10 F. Hoffmann-La Roche AG Tricyclic pi3k inhibitor compounds and methods of use
KR20140082765A (ko) * 2011-10-05 2014-07-02 에프. 호프만-라 로슈 아게 V1a 길항제로서의 사이클로헥실-4H,6H-5-옥사-2,3,10b-트라이아자-벤조[e]아줄렌
JP6112316B2 (ja) * 2011-12-22 2017-04-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung テトラアザ−シクロペンタ[a]インデニル及びポジティブアロステリックモジュレーターとしてのそれらの使用
CN111925360B (zh) * 2015-02-11 2024-03-22 赛诺维信制药公司 用于治疗cns障碍的1-杂环基异苯并二氢吡喃基化合物和类似物
KR102623321B1 (ko) * 2015-02-11 2024-01-09 선오비온 파마슈티컬스 인코포레이티드 중추 신경계 질환을 치료하기 위한 융합된 다이하이드로-4h-피라졸로[5,1-c][1,4]옥사진일 화합물 및 유사체

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101421280A (zh) * 2006-04-12 2009-04-29 惠氏公司 作为5-羟色胺-6配体的经取代二氢[1,4]噁嗪并[2.3.4-hi]吲唑衍生物
WO2013067248A1 (en) * 2011-11-04 2013-05-10 Vertex Pharmaceuticals Incorporated Benzoxazines as modulators of ion channels
WO2013192346A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors
JP2014214130A (ja) * 2013-04-26 2014-11-17 大正製薬株式会社 ジヒドロイミダゾオキサゾール誘導体を含有する医薬

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ZA201706074B (en) 2023-05-31
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