CN111108216B - 诊断装置和系统 - Google Patents

诊断装置和系统 Download PDF

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Publication number
CN111108216B
CN111108216B CN201880061420.7A CN201880061420A CN111108216B CN 111108216 B CN111108216 B CN 111108216B CN 201880061420 A CN201880061420 A CN 201880061420A CN 111108216 B CN111108216 B CN 111108216B
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China
Prior art keywords
beads
sensor
station
magnetic
assay
Prior art date
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CN201880061420.7A
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Chinese (zh)
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CN111108216A (zh
Inventor
B·欧法雷尔
C·D·欧沙利文
J·奥德里斯科尔
T·卡明斯
P·弗里
M·麦卡锡
J·沃尔什
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Altra Tech Ltd
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Altra Tech Ltd
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Priority claimed from EP17192156.2A external-priority patent/EP3460077B1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2547/00—Reactions characterised by the features used to prevent contamination
    • C12Q2547/10—Reactions characterised by the features used to prevent contamination the purpose being preventing contamination
    • C12Q2547/107—Use of permeable barriers, e.g. waxes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/143—Magnetism, e.g. magnetic label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/149—Particles, e.g. beads

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
CN201880061420.7A 2017-09-20 2018-09-06 诊断装置和系统 Active CN111108216B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17192156.2 2017-09-20
EP17192153.9 2017-09-20
EP17192156.2A EP3460077B1 (en) 2017-09-20 2017-09-20 Diagnostic device and system
EP17192153 2017-09-20
EP17202859.9 2017-11-21
EP17202859 2017-11-21
PCT/EP2018/074058 WO2019057515A1 (en) 2017-09-20 2018-09-06 DIAGNOSTIC SYSTEM AND DEVICE

Publications (2)

Publication Number Publication Date
CN111108216A CN111108216A (zh) 2020-05-05
CN111108216B true CN111108216B (zh) 2024-02-23

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CN201880061420.7A Active CN111108216B (zh) 2017-09-20 2018-09-06 诊断装置和系统

Country Status (5)

Country Link
US (3) US11459601B2 (https=)
EP (2) EP4219751A1 (https=)
JP (1) JP7212678B2 (https=)
CN (1) CN111108216B (https=)
WO (1) WO2019057515A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN105980558B (zh) 2013-12-12 2021-08-24 阿尔查技术有限公司 样品制备方法和设备
US10746683B2 (en) 2013-12-12 2020-08-18 Altratech Limited Capacitive sensor and method of use
CN111108216B (zh) 2017-09-20 2024-02-23 阿尔查技术有限公司 诊断装置和系统
CN120082430A (zh) * 2020-06-19 2025-06-03 中国疾病预防控制中心病毒病预防控制所 一种样品处理及检测装置
KR102682605B1 (ko) * 2021-11-03 2024-07-09 주식회사 위즈바이오솔루션 일체형 분자 진단 장치 및 이를 이용한 분자 진단 방법
EP4453250A1 (en) * 2021-12-21 2024-10-30 Illumina, Inc. Wax-microsphere matrix compositions and methods of making and using the same
CN119213140A (zh) * 2022-01-28 2024-12-27 阿尔查技术有限公司 用于微生物应用的单个珠粒电容检测器
CN115646562B (zh) * 2022-09-27 2023-08-11 郑州大学 基于微磁作用的操控芯片、检测组件和检测系统、方法
US20240256645A1 (en) * 2023-01-27 2024-08-01 International Business Machines Corporation Validation server in tape-based backup and archive environments
WO2025259122A1 (es) * 2024-06-14 2025-12-18 Universidad Nacional Toribio Rodríguez De Mendoza De Amazonas Dispositivo portátil multilectura electroquímico para la identificación y análisis de muestras biológicas y ambientales

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JP7212678B2 (ja) 2023-01-25
EP4219751A1 (en) 2023-08-02
JP2020533993A (ja) 2020-11-26
US20200216884A1 (en) 2020-07-09
CN111108216A (zh) 2020-05-05
EP3684950A1 (en) 2020-07-29
EP3684950B1 (en) 2023-04-26
US20230094539A1 (en) 2023-03-30
WO2019057515A1 (en) 2019-03-28
US11459601B2 (en) 2022-10-04
US12553078B2 (en) 2026-02-17

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