CN111094285A - 新型咪唑喹啉化合物及其制备方法和用途 - Google Patents

新型咪唑喹啉化合物及其制备方法和用途 Download PDF

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Publication number
CN111094285A
CN111094285A CN201880053123.8A CN201880053123A CN111094285A CN 111094285 A CN111094285 A CN 111094285A CN 201880053123 A CN201880053123 A CN 201880053123A CN 111094285 A CN111094285 A CN 111094285A
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China
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amino
cancer
ethyl
compound
butyl
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CN111094285B (zh
Inventor
赵旭阳
白骅
徐肖杰
刘礼飞
冯仁田
王海彬
林赟
汪建洁
董文献
张文彪
程英雀
李译
王二文
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Zhejiang Hisun Pharmaceutical Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

一类新的咪唑喹啉化合物以及这类化合物的制备方法。这类由式(I)所表示的化合物或其药学上可接受的盐具有TLR7和TLR8激动活性，可以用于治疗癌症以及预防和治疗病毒感染。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN201880053123.8A 2017-09-05 2018-09-04 新型咪唑喹啉化合物及其制备方法和用途 Active CN111094285B (zh)

Applications Claiming Priority (3)

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CN2017107921025 2017-09-05
CN201710792102 2017-09-05
PCT/CN2018/103963 WO2019047824A1 (zh) 2017-09-05 2018-09-04 新型咪唑喹啉化合物及其制备方法和用途

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CN111094285B CN111094285B (zh) 2022-05-10

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TW (1) TWI693223B (zh)
WO (1) WO2019047824A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114585621A (zh) * 2019-02-01 2022-06-03 康威(广州)生物科技有限公司 咪唑并喹啉胺衍生物、及其药物组合物和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022037631A1 (zh) * 2020-08-21 2022-02-24 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100634A2 (en) * 2006-02-22 2007-09-07 3M Innovative Properties Company Immune response modifier conjugates
CN103582640A (zh) * 2011-06-03 2014-02-12 3M创新有限公司 肼基1h-咪唑并喹啉-4-胺以及由其制成的缀合物
CN106535938A (zh) * 2014-07-09 2017-03-22 上海博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100634A2 (en) * 2006-02-22 2007-09-07 3M Innovative Properties Company Immune response modifier conjugates
CN103582640A (zh) * 2011-06-03 2014-02-12 3M创新有限公司 肼基1h-咪唑并喹啉-4-胺以及由其制成的缀合物
CN106535938A (zh) * 2014-07-09 2017-03-22 上海博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114585621A (zh) * 2019-02-01 2022-06-03 康威(广州)生物科技有限公司 咪唑并喹啉胺衍生物、及其药物组合物和应用
CN114585621B (zh) * 2019-02-01 2023-11-14 康威(广州)生物科技有限公司 咪唑并喹啉胺衍生物、及其药物组合物和应用

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TWI693223B (zh) 2020-05-11
WO2019047824A1 (zh) 2019-03-14
CN111094285B (zh) 2022-05-10
TW201912644A (zh) 2019-04-01

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