CN111094279A - 一种苯并呋喃衍生物的制备方法 - Google Patents
一种苯并呋喃衍生物的制备方法 Download PDFInfo
- Publication number
- CN111094279A CN111094279A CN201880059239.2A CN201880059239A CN111094279A CN 111094279 A CN111094279 A CN 111094279A CN 201880059239 A CN201880059239 A CN 201880059239A CN 111094279 A CN111094279 A CN 111094279A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- groups
- alkyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
一种苯并呋喃衍生物的制备方法。具体而言,提供一种苯并呋喃衍生物的制备方法,根据提供的方法,可以有效的缩短现有技术中合成苯并呋喃类物质所需的反应步骤。
Description
PCT国内申请,说明书已公开。
Claims (26)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711104888 | 2017-11-10 | ||
CN2017111048883 | 2017-11-10 | ||
PCT/CN2018/114798 WO2019091450A1 (zh) | 2017-11-10 | 2018-11-09 | 一种苯并呋喃衍生物的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111094279A true CN111094279A (zh) | 2020-05-01 |
CN111094279B CN111094279B (zh) | 2023-06-16 |
Family
ID=66438760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880059239.2A Active CN111094279B (zh) | 2017-11-10 | 2018-11-09 | 一种苯并呋喃衍生物的制备方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US11390614B2 (zh) |
EP (1) | EP3708567A4 (zh) |
JP (2) | JP7295105B6 (zh) |
CN (1) | CN111094279B (zh) |
AU (2) | AU2018363467B2 (zh) |
MX (1) | MX2020004869A (zh) |
TW (1) | TWI717656B (zh) |
WO (1) | WO2019091450A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114456156A (zh) * | 2020-11-09 | 2022-05-10 | 江苏恒瑞医药股份有限公司 | 一种6-取代氨基苯并呋喃化合物的纯化方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113767096B (zh) * | 2019-05-10 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 一种6-取代氨基苯并呋喃化合物的制备方法 |
AU2022365986A1 (en) | 2021-10-15 | 2024-05-09 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Method for preparing benzofuran derivative |
CN113861002B (zh) * | 2021-11-02 | 2024-04-26 | 琼台师范学院 | 一种无金属催化体系催化氧化芳香醇类制备芳香酮类化合物的方法 |
WO2023244918A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Quinolone bcl6 bifunctional degraders |
WO2023244917A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236625A (en) * | 1963-07-18 | 1966-02-22 | Tenneco Chem | Method of inhibiting plant growth |
CN1426388A (zh) * | 2000-04-28 | 2003-06-25 | 日本农药株式会社 | 生产2-卤代苯甲酸的方法 |
CN101434582A (zh) * | 2008-11-28 | 2009-05-20 | 华东理工大学 | 苯甲酸(苯并三唑基)苯酯类化合物 |
WO2011140325A1 (en) * | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
WO2017084494A1 (zh) * | 2015-11-19 | 2017-05-26 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3233678B2 (ja) | 1991-06-27 | 2001-11-26 | 日本化学工業株式会社 | o−アルコキシ安息香酸の製造方法 |
US6211203B1 (en) | 1996-08-19 | 2001-04-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzofuran-4-carboxamides |
GB0003257D0 (en) | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
WO2002010156A1 (en) | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
FR2923826A1 (fr) | 2007-11-21 | 2009-05-22 | Ppg Sipsy Soc Par Actions Simp | Procede de synthese de l'acide 4-benzofurane carboxylique |
TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
WO2013039988A1 (en) | 2011-09-13 | 2013-03-21 | Glax0Smithkline Llc | Azaindazoles |
NZ723312A (en) | 2014-03-17 | 2019-10-25 | Daiichi Sankyo Co Ltd | 1,3-benzodioxole derivative |
-
2018
- 2018-11-09 AU AU2018363467A patent/AU2018363467B2/en active Active
- 2018-11-09 CN CN201880059239.2A patent/CN111094279B/zh active Active
- 2018-11-09 WO PCT/CN2018/114798 patent/WO2019091450A1/zh unknown
- 2018-11-09 US US16/762,795 patent/US11390614B2/en active Active
- 2018-11-09 MX MX2020004869A patent/MX2020004869A/es unknown
- 2018-11-09 TW TW107139895A patent/TWI717656B/zh not_active IP Right Cessation
- 2018-11-09 JP JP2020525952A patent/JP7295105B6/ja active Active
- 2018-11-09 EP EP18875981.5A patent/EP3708567A4/en active Pending
-
2023
- 2023-06-08 JP JP2023094525A patent/JP2023123543A/ja active Pending
- 2023-12-07 AU AU2023278061A patent/AU2023278061A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236625A (en) * | 1963-07-18 | 1966-02-22 | Tenneco Chem | Method of inhibiting plant growth |
CN1426388A (zh) * | 2000-04-28 | 2003-06-25 | 日本农药株式会社 | 生产2-卤代苯甲酸的方法 |
CN101434582A (zh) * | 2008-11-28 | 2009-05-20 | 华东理工大学 | 苯甲酸(苯并三唑基)苯酯类化合物 |
WO2011140325A1 (en) * | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
WO2017084494A1 (zh) * | 2015-11-19 | 2017-05-26 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
Non-Patent Citations (1)
Title |
---|
HIDETSUGU TABATA 等: ""A complete gear system in n-benzoyl-carbazole derivatives"", 《ORGANIC LETTERS》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114456156A (zh) * | 2020-11-09 | 2022-05-10 | 江苏恒瑞医药股份有限公司 | 一种6-取代氨基苯并呋喃化合物的纯化方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2021502376A (ja) | 2021-01-28 |
EP3708567A4 (en) | 2021-07-07 |
TW201918469A (zh) | 2019-05-16 |
WO2019091450A1 (zh) | 2019-05-16 |
JP7295105B2 (ja) | 2023-06-20 |
RU2020118301A3 (zh) | 2022-01-27 |
AU2023278061A1 (en) | 2024-01-04 |
JP2023123543A (ja) | 2023-09-05 |
RU2020118301A (ru) | 2021-12-10 |
MX2020004869A (es) | 2020-08-06 |
US20210188822A1 (en) | 2021-06-24 |
JP7295105B6 (ja) | 2023-07-24 |
AU2018363467A1 (en) | 2020-06-04 |
AU2018363467B2 (en) | 2023-09-07 |
TWI717656B (zh) | 2021-02-01 |
CN111094279B (zh) | 2023-06-16 |
EP3708567A1 (en) | 2020-09-16 |
US11390614B2 (en) | 2022-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111094279B (zh) | 一种苯并呋喃衍生物的制备方法 | |
CN113767096B (zh) | 一种6-取代氨基苯并呋喃化合物的制备方法 | |
CN109678796B (zh) | Pd-1/pd-l1小分子抑制剂及其制备方法和用途 | |
JP7033343B2 (ja) | バイアリール誘導体、その製造方法および薬学上の使用 | |
CA3079019A1 (en) | Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile | |
KR20180012853A (ko) | 피페리딘 유도체 및 이의 제조 방법 및 약학적 용도 | |
WO2014125408A2 (en) | Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors | |
KR20170082563A (ko) | 코판리십 및 그의 디히드로클로라이드 염의 합성 | |
KR20220128428A (ko) | 아자비시클릭 치환된 옥사스피로 유도체, 이의 제조 방법 및 의학적 용도 | |
TW201943711A (zh) | 一種吡咯並胺基噠嗪酮化合物的製備方法及其中間體 | |
TW202009232A (zh) | 一種吡咯并氨基嗒酮化合物的製備方法及其中間體 | |
RU2777624C2 (ru) | Способ получения производного бензофурана | |
CN113166109B (zh) | 氨基吡啶类化合物及其制备方法和用途 | |
JP2020537650A (ja) | チロシンキナーゼ阻害剤の調製方法およびその中間体 | |
CN111377873A (zh) | 氨基嘧啶化合物及其制备方法和用途 | |
RU2777675C2 (ru) | Способ получения ингибитора тирозинкиназы и его промежуточного соединения | |
WO2023072143A1 (zh) | 一种喜树碱类衍生物中间体、其制备方法和用途 | |
AU2022365986A1 (en) | Method for preparing benzofuran derivative | |
CN116514807A (zh) | 一种萘啶酮类衍生物及其制备方法 | |
CN116425664A (zh) | 一种杂芳环类btk抑制剂中间体的制备方法 | |
JP2024518569A (ja) | アルキルフェノール系化合物およびその製造方法 | |
JP2022535228A (ja) | チアゾリルピラゾールカルボン酸の製造方法およびそれらのための中間体 | |
JP2023505550A (ja) | ビフェニル基フッ素置換二重結合誘導体、その製造方法と薬学的な応用 | |
KR20170044166A (ko) | 3-페닐/헤테로아릴-6-페녹시-8-알킬아미노-이미다조[1,2-b]피리다진 유도체의 제조 방법 | |
KR20070085307A (ko) | 벤조[c]페난트리딘 유도체의 제조법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40027243 Country of ref document: HK |
|
GR01 | Patent grant | ||
GR01 | Patent grant |