CN111094279A - 一种苯并呋喃衍生物的制备方法 - Google Patents

一种苯并呋喃衍生物的制备方法 Download PDF

Info

Publication number
CN111094279A
CN111094279A CN201880059239.2A CN201880059239A CN111094279A CN 111094279 A CN111094279 A CN 111094279A CN 201880059239 A CN201880059239 A CN 201880059239A CN 111094279 A CN111094279 A CN 111094279A
Authority
CN
China
Prior art keywords
formula
compound
groups
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880059239.2A
Other languages
English (en)
Other versions
CN111094279B (zh
Inventor
陆伟栋
徐超
张浩宇
邵启云
冯君
贺峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN111094279A publication Critical patent/CN111094279A/zh
Application granted granted Critical
Publication of CN111094279B publication Critical patent/CN111094279B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

一种苯并呋喃衍生物的制备方法。具体而言，提供一种苯并呋喃衍生物的制备方法，根据提供的方法，可以有效的缩短现有技术中合成苯并呋喃类物质所需的反应步骤。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201880059239.2A 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法 Active CN111094279B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017111048883 2017-11-10
CN201711104888 2017-11-10
PCT/CN2018/114798 WO2019091450A1 (zh) 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法

Publications (2)

Publication Number Publication Date
CN111094279A true CN111094279A (zh) 2020-05-01
CN111094279B CN111094279B (zh) 2023-06-16

Family

ID=66438760

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880059239.2A Active CN111094279B (zh) 2017-11-10 2018-11-09 一种苯并呋喃衍生物的制备方法

Country Status (8)

Country Link
US (1) US11390614B2 (zh)
EP (1) EP3708567A4 (zh)
JP (2) JP7295105B6 (zh)
CN (1) CN111094279B (zh)
AU (2) AU2018363467B2 (zh)
MX (1) MX2020004869A (zh)
TW (1) TWI717656B (zh)
WO (1) WO2019091450A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456156A (zh) * 2020-11-09 2022-05-10 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的纯化方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202108578A (zh) * 2019-05-10 2021-03-01 大陸商江蘇恒瑞醫藥股份有限公司 6-取代氨基苯并呋喃化合物的製備方法
TW202330509A (zh) * 2021-10-15 2023-08-01 大陸商江蘇恒瑞醫藥股份有限公司 苯並呋喃衍生物的製備方法
CN113861002B (zh) * 2021-11-02 2024-04-26 琼台师范学院 一种无金属催化体系催化氧化芳香醇类制备芳香酮类化合物的方法
WO2023244918A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. Quinolone bcl6 bifunctional degraders
WO2023244917A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236625A (en) * 1963-07-18 1966-02-22 Tenneco Chem Method of inhibiting plant growth
CN1426388A (zh) * 2000-04-28 2003-06-25 日本农药株式会社 生产2－卤代苯甲酸的方法
CN101434582A (zh) * 2008-11-28 2009-05-20 华东理工大学 苯甲酸(苯并三唑基)苯酯类化合物
WO2011140325A1 (en) * 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3233678B2 (ja) * 1991-06-27 2001-11-26 日本化学工業株式会社 ｏ−アルコキシ安息香酸の製造方法
DK0923568T5 (da) 1996-08-19 2003-11-03 Altana Pharma Ag Hidtil ukendte benzofuran-4-carboxamider
GB0003257D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
FR2923826A1 (fr) * 2007-11-21 2009-05-22 Ppg Sipsy Soc Par Actions Simp Procede de synthese de l'acide 4-benzofurane carboxylique
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
EP2755962B1 (en) 2011-09-13 2017-03-01 Glaxosmithkline LLC Azaindazoles
SI3121175T1 (sl) 2014-03-17 2020-07-31 Daiichi Sankyo Company, Limited Derivati 1,3-benzodioksola kot EZH1 in/ali EZH2 inhibitorji

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236625A (en) * 1963-07-18 1966-02-22 Tenneco Chem Method of inhibiting plant growth
CN1426388A (zh) * 2000-04-28 2003-06-25 日本农药株式会社 生产2－卤代苯甲酸的方法
CN101434582A (zh) * 2008-11-28 2009-05-20 华东理工大学 苯甲酸(苯并三唑基)苯酯类化合物
WO2011140325A1 (en) * 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HIDETSUGU TABATA 等: ""A complete gear system in n-benzoyl-carbazole derivatives"", 《ORGANIC LETTERS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456156A (zh) * 2020-11-09 2022-05-10 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的纯化方法

Also Published As

Publication number Publication date
EP3708567A4 (en) 2021-07-07
AU2018363467B2 (en) 2023-09-07
AU2018363467A1 (en) 2020-06-04
RU2020118301A3 (zh) 2022-01-27
JP7295105B2 (ja) 2023-06-20
EP3708567A1 (en) 2020-09-16
WO2019091450A1 (zh) 2019-05-16
CN111094279B (zh) 2023-06-16
US20210188822A1 (en) 2021-06-24
JP2021502376A (ja) 2021-01-28
US11390614B2 (en) 2022-07-19
JP2023123543A (ja) 2023-09-05
TWI717656B (zh) 2021-02-01
TW201918469A (zh) 2019-05-16
RU2020118301A (ru) 2021-12-10
JP7295105B6 (ja) 2023-07-24
AU2023278061A1 (en) 2024-01-04
MX2020004869A (es) 2020-08-06

Similar Documents

Publication Publication Date Title
CN111094279B (zh) 一种苯并呋喃衍生物的制备方法
CN113767096B (zh) 一种6-取代氨基苯并呋喃化合物的制备方法
CN109678796B (zh) Pd-1/pd-l1小分子抑制剂及其制备方法和用途
JP7033343B2 (ja) バイアリール誘導体、その製造方法および薬学上の使用
EP3694853A1 (en) Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
WO2014125408A2 (en) Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors
KR20170082563A (ko) 코판리십 및 그의 디히드로클로라이드 염의 합성
JP2017536352A (ja) コパンリシブおよびそれの２塩酸塩の合成
KR20220128428A (ko) 아자비시클릭 치환된 옥사스피로 유도체, 이의 제조 방법 및 의학적 용도
TW201943711A (zh) 一種吡咯並胺基噠嗪酮化合物的製備方法及其中間體
TW202009232A (zh) 一種吡咯并氨基嗒酮化合物的製備方法及其中間體
RU2777624C2 (ru) Способ получения производного бензофурана
KR20200061058A (ko) 비스플루오로술포닐 이미드 알칼리 금속염의 제조방법 및 이에 의해 제조된 비스플루오로술포닐 이미드 알칼리 금속염
CN113166109B (zh) 氨基吡啶类化合物及其制备方法和用途
JP2020537650A (ja) チロシンキナーゼ阻害剤の調製方法およびその中間体
JP2022513215A (ja) Ｃ－ｍｅｔ阻害剤としての有機リン置換化合物およびその治療用途
CN111377873A (zh) 氨基嘧啶化合物及其制备方法和用途
RU2777675C2 (ru) Способ получения ингибитора тирозинкиназы и его промежуточного соединения
WO2023072143A1 (zh) 一种喜树碱类衍生物中间体、其制备方法和用途
CN116514807A (zh) 一种萘啶酮类衍生物及其制备方法
CN116425664A (zh) 一种杂芳环类btk抑制剂中间体的制备方法
JP2024518569A (ja) アルキルフェノール系化合物およびその製造方法
JP2022535228A (ja) チアゾリルピラゾールカルボン酸の製造方法およびそれらのための中間体
KR20170044166A (ko) 3-페닐/헤테로아릴-6-페녹시-8-알킬아미노-이미다조[1,2-ｂ]피리다진 유도체의 제조 방법
KR20070085307A (ko) 벤조[ｃ]페난트리딘 유도체의 제조법

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40027243

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant