CN111087488A - 一种八仙花多糖治疗自身免疫性心肌炎的医药用途 - Google Patents
一种八仙花多糖治疗自身免疫性心肌炎的医药用途 Download PDFInfo
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- CN111087488A CN111087488A CN202010007772.3A CN202010007772A CN111087488A CN 111087488 A CN111087488 A CN 111087488A CN 202010007772 A CN202010007772 A CN 202010007772A CN 111087488 A CN111087488 A CN 111087488A
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- Prior art keywords
- polysaccharide
- hydrangea
- autoimmune myocarditis
- hydrangea macrophylla
- deionized water
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- 235000014486 Hydrangea macrophylla Nutrition 0.000 title claims abstract description 29
- 150000004676 glycans Chemical class 0.000 title claims abstract description 28
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 28
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 28
- 206010064539 Autoimmune myocarditis Diseases 0.000 title claims abstract description 19
- 244000267823 Hydrangea macrophylla Species 0.000 title claims abstract description 16
- 241001092080 Hydrangea Species 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 238000001556 precipitation Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 abstract description 20
- 230000003902 lesion Effects 0.000 abstract description 10
- 230000002757 inflammatory effect Effects 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 5
- 230000008595 infiltration Effects 0.000 abstract description 5
- 238000001764 infiltration Methods 0.000 abstract description 5
- 241000700159 Rattus Species 0.000 description 26
- 102000013691 Interleukin-17 Human genes 0.000 description 12
- 102100037850 Interferon gamma Human genes 0.000 description 9
- 108010074328 Interferon-gamma Proteins 0.000 description 9
- 229940127022 high-dose drug Drugs 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 8
- 229940127021 low-dose drug Drugs 0.000 description 6
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 208000009525 Myocarditis Diseases 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 102000013602 Cardiac Myosins Human genes 0.000 description 1
- 108010051609 Cardiac Myosins Proteins 0.000 description 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 description 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001049988 Mycobacterium tuberculosis H37Ra Species 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202010007772.3A CN111087488B (zh) | 2020-01-05 | 2020-01-05 | 一种八仙花多糖治疗自身免疫性心肌炎的医药用途 |
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CN202010007772.3A CN111087488B (zh) | 2020-01-05 | 2020-01-05 | 一种八仙花多糖治疗自身免疫性心肌炎的医药用途 |
Publications (2)
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CN111087488A true CN111087488A (zh) | 2020-05-01 |
CN111087488B CN111087488B (zh) | 2021-10-08 |
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CN202010007772.3A Expired - Fee Related CN111087488B (zh) | 2020-01-05 | 2020-01-05 | 一种八仙花多糖治疗自身免疫性心肌炎的医药用途 |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60133862A (ja) * | 1984-10-01 | 1985-07-17 | Tamiji Matoba | 保健飲料の製造法 |
JP2003267877A (ja) * | 2002-03-12 | 2003-09-25 | Alpen:Kk | トルマリン入りジェル |
CN102245204A (zh) * | 2008-07-11 | 2011-11-16 | 中央研究院 | α-半乳糖基神经酰胺类似物以及它们作为免疫疗法、佐剂和抗病毒剂、抗细菌剂和抗癌剂的应用 |
CN104258297A (zh) * | 2014-10-15 | 2015-01-07 | 鲁翠花 | 一种治疗气滞血瘀型病毒性心肌炎的中药及其制备方法 |
CN104586906A (zh) * | 2015-03-01 | 2015-05-06 | 陈学红 | 一种防治高尿酸血症的八仙花醇提物及其提取方法和用途 |
CN105592686A (zh) * | 2013-07-08 | 2016-05-18 | 罗地亚经营管理公司 | 植物的生长促进 |
CN107922956A (zh) * | 2015-12-04 | 2018-04-17 | 丸自然美健有限公司 | 衍生自表皮葡萄球菌的甘油产生促进剂、衍生自皮肤表皮角质形成细胞的抗微生物肽产生促进剂以及它们在皮肤保护用外用剂中的应用 |
-
2020
- 2020-01-05 CN CN202010007772.3A patent/CN111087488B/zh not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60133862A (ja) * | 1984-10-01 | 1985-07-17 | Tamiji Matoba | 保健飲料の製造法 |
JP2003267877A (ja) * | 2002-03-12 | 2003-09-25 | Alpen:Kk | トルマリン入りジェル |
CN102245204A (zh) * | 2008-07-11 | 2011-11-16 | 中央研究院 | α-半乳糖基神经酰胺类似物以及它们作为免疫疗法、佐剂和抗病毒剂、抗细菌剂和抗癌剂的应用 |
CN105592686A (zh) * | 2013-07-08 | 2016-05-18 | 罗地亚经营管理公司 | 植物的生长促进 |
CN104258297A (zh) * | 2014-10-15 | 2015-01-07 | 鲁翠花 | 一种治疗气滞血瘀型病毒性心肌炎的中药及其制备方法 |
CN104586906A (zh) * | 2015-03-01 | 2015-05-06 | 陈学红 | 一种防治高尿酸血症的八仙花醇提物及其提取方法和用途 |
CN107922956A (zh) * | 2015-12-04 | 2018-04-17 | 丸自然美健有限公司 | 衍生自表皮葡萄球菌的甘油产生促进剂、衍生自皮肤表皮角质形成细胞的抗微生物肽产生促进剂以及它们在皮肤保护用外用剂中的应用 |
Non-Patent Citations (1)
Title |
---|
王知斌等: ""八仙花叶的化学成分及药理作用研究进展"", 《中医药信息》 * |
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CN111087488B (zh) | 2021-10-08 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20210623 Address after: 211505 D1 building, 9 Chuang Chuang Road, Zhongshan science and Technology Park, Liuhe District, Nanjing, Jiangsu. Applicant after: Zhao Shunying Address before: No. 639 Jiangning longmian Road District of Nanjing City, Jiangsu province 211198 Applicant before: Wu Haijing |
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CB03 | Change of inventor or designer information |
Inventor after: Liang Yang Inventor after: Wu Haijing Inventor after: Other inventor requests not to publish the name Inventor before: Wu Haijing Inventor before: Other inventor requests not to publish the name |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210918 Address after: No. 12b01, gate 2, 33rd floor, Second District, Yuquan Xili, Shijingshan District, Beijing 100043 Applicant after: Liang Yang Address before: 211505 D1 building, 9 Chuang Chuang Road, Zhongshan science and Technology Park, Liuhe District, Nanjing, Jiangsu. Applicant before: Zhao Shunying |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211008 |