CN111050784B - 截短的豚鼠l-天冬酰胺酶变体及其使用方法 - Google Patents

截短的豚鼠l-天冬酰胺酶变体及其使用方法 Download PDF

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CN111050784B
CN111050784B CN201880051871.2A CN201880051871A CN111050784B CN 111050784 B CN111050784 B CN 111050784B CN 201880051871 A CN201880051871 A CN 201880051871A CN 111050784 B CN111050784 B CN 111050784B
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CN111050784A (zh
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阿尔农·拉维
海恩-安哈·源
阿曼达·沙尔克
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201880051871.2A 2017-08-11 2018-08-10 截短的豚鼠l-天冬酰胺酶变体及其使用方法 Active CN111050784B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762544396P 2017-08-11 2017-08-11
US201762544411P 2017-08-11 2017-08-11
US62/544,396 2017-08-11
US62/544,411 2017-08-11
PCT/US2018/046196 WO2019032952A1 (en) 2017-08-11 2018-08-10 TRUNCATED VARIANTS OF INDIA PIG ASPARAGINASE AND METHODS OF USE

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CN111050784A CN111050784A (zh) 2020-04-21
CN111050784B true CN111050784B (zh) 2024-03-19

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US (1) US11578315B2 (enExample)
EP (1) EP3664832B1 (enExample)
JP (1) JP7744621B2 (enExample)
CN (1) CN111050784B (enExample)
AU (1) AU2018313253B2 (enExample)
CA (1) CA3106549A1 (enExample)
ES (1) ES2965372T3 (enExample)
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CN114292853A (zh) * 2021-11-29 2022-04-08 国药集团动物保健股份有限公司 Sumo促溶表达标签及其应用、sumo促溶表达蛋白、重组菌株及蛋白的制备方法
CN114369173B (zh) * 2022-03-22 2022-07-08 中国农业科学院北京畜牧兽医研究所 一种利用融合蛋白标签促进人颗粒溶素及动物NK lysin在毕赤酵母中表达的方法
CN116459344B (zh) * 2023-04-28 2025-03-18 上海市生物医药技术研究院 一种MNSFβ/RC3H1 PPI干扰多肽的抗炎治疗应用
WO2025026424A1 (en) * 2023-08-02 2025-02-06 The Hong Kong Polytechnic University Bioengineered asparaginase fusion proteins
WO2025210068A1 (en) 2024-04-03 2025-10-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Activity-improved variants of human asparaginase 1

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JPH1057080A (ja) * 1996-06-07 1998-03-03 Hayashibara Biochem Lab Inc Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
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WO2012075173A2 (en) * 2010-12-01 2012-06-07 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
WO2012170640A1 (en) * 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy
JP2015503333A (ja) * 2011-12-27 2015-02-02 バイオ−キャンサー トリートメント インターナショナル リミテッド（シャンハイ）Ｂｉｏ−Ｃａｎｃｅｒ Ｔｒｅａｔｍｅｎｔ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ． （Ｓｈａｎｇｈａｉ） ヒトアルギナーゼおよび部位特異的ｐｅｇ化ヒトアルギナーゼとその使用方法
WO2015164588A1 (en) * 2014-04-23 2015-10-29 Abbvie, Inc. Single-chain trail-receptor agonist proteins
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EP0811687A2 (en) * 1996-06-07 1997-12-10 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having l-asparaginase activity
JPH1057080A (ja) * 1996-06-07 1998-03-03 Hayashibara Biochem Lab Inc Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
WO2004112717A2 (en) * 2003-06-17 2004-12-29 Harrison Roger G Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof
JP2010501191A (ja) * 2006-08-28 2010-01-21 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｎｆスーパーファミリー融合タンパク質
JP2016117718A (ja) * 2009-08-15 2016-06-30 ジェネンテック， インコーポレイテッド 以前に治療された乳癌の治療のための抗血管新生療法
WO2012075173A2 (en) * 2010-12-01 2012-06-07 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
WO2012170640A1 (en) * 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy
JP2015503333A (ja) * 2011-12-27 2015-02-02 バイオ−キャンサー トリートメント インターナショナル リミテッド（シャンハイ）Ｂｉｏ−Ｃａｎｃｅｒ Ｔｒｅａｔｍｅｎｔ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ． （Ｓｈａｎｇｈａｉ） ヒトアルギナーゼおよび部位特異的ｐｅｇ化ヒトアルギナーゼとその使用方法
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AU2018313253A1 (en) 2020-02-27
CA3106549A1 (en) 2019-02-14
JP2020530300A (ja) 2020-10-22
WO2019032952A1 (en) 2019-02-14
ES2965372T3 (es) 2024-04-15
AU2018313253B2 (en) 2024-09-26
EP3664832A1 (en) 2020-06-17
CN111050784A (zh) 2020-04-21
EP3664832B1 (en) 2023-10-18
WO2019032952A8 (en) 2019-07-25
US11578315B2 (en) 2023-02-14
JP7744621B2 (ja) 2025-09-26
EP3664832C0 (en) 2023-10-18
US20200239867A1 (en) 2020-07-30

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