JP7744621B2 - 切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法 - Google Patents

切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法

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Publication number
JP7744621B2
JP7744621B2 JP2020507589A JP2020507589A JP7744621B2 JP 7744621 B2 JP7744621 B2 JP 7744621B2 JP 2020507589 A JP2020507589 A JP 2020507589A JP 2020507589 A JP2020507589 A JP 2020507589A JP 7744621 B2 JP7744621 B2 JP 7744621B2
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Japan
Prior art keywords
gpa
seq
truncated
variant
asparaginase
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JP2020507589A
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English (en)
Japanese (ja)
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JP2020530300A (ja
JP2020530300A5 (enExample
Inventor
ラヴィ，アルモン
グエン，ヒエン－アン
シャルク，アマンダ
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University of Illinois System
Government of the United States of America
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University of Illinois System
Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2020507589A 2017-08-11 2018-08-10 切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法 Active JP7744621B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762544396P 2017-08-11 2017-08-11
US201762544411P 2017-08-11 2017-08-11
US62/544,396 2017-08-11
US62/544,411 2017-08-11
PCT/US2018/046196 WO2019032952A1 (en) 2017-08-11 2018-08-10 TRUNCATED VARIANTS OF INDIA PIG ASPARAGINASE AND METHODS OF USE

Publications (3)

Publication Number Publication Date
JP2020530300A JP2020530300A (ja) 2020-10-22
JP2020530300A5 JP2020530300A5 (enExample) 2021-09-24
JP7744621B2 true JP7744621B2 (ja) 2025-09-26

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JP2020507589A Active JP7744621B2 (ja) 2017-08-11 2018-08-10 切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法

Country Status (8)

Country Link
US (1) US11578315B2 (enExample)
EP (1) EP3664832B1 (enExample)
JP (1) JP7744621B2 (enExample)
CN (1) CN111050784B (enExample)
AU (1) AU2018313253B2 (enExample)
CA (1) CA3106549A1 (enExample)
ES (1) ES2965372T3 (enExample)
WO (1) WO2019032952A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114292853A (zh) * 2021-11-29 2022-04-08 国药集团动物保健股份有限公司 Sumo促溶表达标签及其应用、sumo促溶表达蛋白、重组菌株及蛋白的制备方法
CN114369173B (zh) * 2022-03-22 2022-07-08 中国农业科学院北京畜牧兽医研究所 一种利用融合蛋白标签促进人颗粒溶素及动物NK lysin在毕赤酵母中表达的方法
CN116459344B (zh) * 2023-04-28 2025-03-18 上海市生物医药技术研究院 一种MNSFβ/RC3H1 PPI干扰多肽的抗炎治疗应用
WO2025026424A1 (en) * 2023-08-02 2025-02-06 The Hong Kong Polytechnic University Bioengineered asparaginase fusion proteins
WO2025210068A1 (en) 2024-04-03 2025-10-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Activity-improved variants of human asparaginase 1

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501191A (ja) 2006-08-28 2010-01-21 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｎｆスーパーファミリー融合タンパク質
JP2015503333A (ja) 2011-12-27 2015-02-02 バイオ−キャンサー トリートメント インターナショナル リミテッド（シャンハイ）Ｂｉｏ−Ｃａｎｃｅｒ Ｔｒｅａｔｍｅｎｔ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ． （Ｓｈａｎｇｈａｉ） ヒトアルギナーゼおよび部位特異的ｐｅｇ化ヒトアルギナーゼとその使用方法
JP2016117718A (ja) 2009-08-15 2016-06-30 ジェネンテック， インコーポレイテッド 以前に治療された乳癌の治療のための抗血管新生療法
JP2017513503A (ja) 2014-04-23 2017-06-01 アッヴィ・インコーポレイテッド 単鎖ｔｒａｉｌ受容体アゴニストタンパク質

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
SE9002213D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Albumin binding proteins
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
JP3721210B2 (ja) 1995-02-08 2005-11-30 株式会社林原生物化学研究所 哺乳類のｌ−アスパラギナーゼをコードするｄｎａ
JP3819540B2 (ja) 1996-06-07 2006-09-13 株式会社林原生物化学研究所 Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
US6537547B1 (en) 1996-06-07 2003-03-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having L-asparaginase activity
WO2001045746A2 (en) 1999-12-24 2001-06-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20040001827A1 (en) 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
US20020065397A1 (en) 2000-10-12 2002-05-30 Joseph Roberts Protecting therapeutic compositions from host-mediated inactivation
WO2004112717A2 (en) * 2003-06-17 2004-12-29 Harrison Roger G Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof
JP2007529191A (ja) 2003-06-26 2007-10-25 ライフセンサーズ、インク． タンパク質発現を増強し、精製する方法及び組成物
WO2005097202A2 (en) 2004-04-06 2005-10-20 Affibody Ab Use of serum albumin binding peptides conjugates for the preparation of a medicament
US7985548B2 (en) 2006-03-03 2011-07-26 The United States Of America As Represented By The Department Of Health And Human Services Materials and methods directed to asparagine synthetase and asparaginase therapies
WO2009002947A2 (en) 2007-06-22 2008-12-31 Affymax, Inc. Compounds and peptides that bind the trail receptor
WO2012075173A2 (en) * 2010-12-01 2012-06-07 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
WO2012170640A1 (en) * 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy
US20150044208A1 (en) 2011-09-23 2015-02-12 Technophage, Investigaçäo E Desenvolvimento Em Biotecnologia, Sa Modified Albumin-Binding Domains and Uses Thereof to Improve Pharmacokinetics
WO2013177398A2 (en) 2012-05-25 2013-11-28 Janssen Biotech, Inc. Non-natural consensus albumin binding domains

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501191A (ja) 2006-08-28 2010-01-21 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｎｆスーパーファミリー融合タンパク質
JP2016117718A (ja) 2009-08-15 2016-06-30 ジェネンテック， インコーポレイテッド 以前に治療された乳癌の治療のための抗血管新生療法
JP2015503333A (ja) 2011-12-27 2015-02-02 バイオ−キャンサー トリートメント インターナショナル リミテッド（シャンハイ）Ｂｉｏ−Ｃａｎｃｅｒ Ｔｒｅａｔｍｅｎｔ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ． （Ｓｈａｎｇｈａｉ） ヒトアルギナーゼおよび部位特異的ｐｅｇ化ヒトアルギナーゼとその使用方法
JP2017513503A (ja) 2014-04-23 2017-06-01 アッヴィ・インコーポレイテッド 単鎖ｔｒａｉｌ受容体アゴニストタンパク質

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Drug Delivery System (2003) vol.18, no.6, p.536-544
The Journal of Biological Chemistry (2014) vol289, no.48, p.33175-33186
河野 通良、非病原性天疱瘡抗体を用いた表皮特異的ドラッグデリバリーシステムの開発、科学研究費助成事業 研究成果報告書、2016年5月24日、課題番号：２５４６１７１３

Also Published As

Publication number Publication date
AU2018313253A1 (en) 2020-02-27
CA3106549A1 (en) 2019-02-14
JP2020530300A (ja) 2020-10-22
WO2019032952A1 (en) 2019-02-14
ES2965372T3 (es) 2024-04-15
AU2018313253B2 (en) 2024-09-26
EP3664832A1 (en) 2020-06-17
CN111050784A (zh) 2020-04-21
EP3664832B1 (en) 2023-10-18
CN111050784B (zh) 2024-03-19
WO2019032952A8 (en) 2019-07-25
US11578315B2 (en) 2023-02-14
EP3664832C0 (en) 2023-10-18
US20200239867A1 (en) 2020-07-30

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