CN110997724A - 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 - Google Patents

使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 Download PDF

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Publication number
CN110997724A
CN110997724A CN201880051242.XA CN201880051242A CN110997724A CN 110997724 A CN110997724 A CN 110997724A CN 201880051242 A CN201880051242 A CN 201880051242A CN 110997724 A CN110997724 A CN 110997724A
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btn1a1
molecule
gal
less
antibody
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Chinese (zh)
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斯蒂芬·成汉·柳
以斯拉·明·哲·钟
奉永植
金龙洙
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Stcube & Co Inc
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Stcube & Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201880051242.XA 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 Pending CN110997724A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762516071P 2017-06-06 2017-06-06
US62/516,071 2017-06-06
PCT/US2018/036026 WO2018226671A1 (en) 2017-06-06 2018-06-05 Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands

Related Child Applications (1)

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CN202511334876.4A Division CN121248782A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

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CN110997724A true CN110997724A (zh) 2020-04-10

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CN201880051242.XA Pending CN110997724A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

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US (2) US11542331B2 (enExample)
EP (1) EP3635007A1 (enExample)
JP (2) JP2020522562A (enExample)
KR (2) KR20250097991A (enExample)
CN (1) CN110997724A (enExample)
WO (1) WO2018226671A1 (enExample)

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EP3630834A1 (en) 2017-05-31 2020-04-08 STCube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
US11173325B2 (en) 2017-07-21 2021-11-16 Varian Medical Systems, Inc. Methods of use of ultra-high dose rate radiation and therapeutic agent
US11098093B2 (en) 2019-01-07 2021-08-24 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta T cells
CN113329759A (zh) 2019-01-07 2021-08-31 沙塔克实验室有限公司 用于调节γδT细胞的异二聚体蛋白
KR102162363B1 (ko) 2020-03-02 2020-10-06 현대건설기계 주식회사 카운터 웨이트 장착 장치 및 이를 포함하는 작업기계
WO2022093841A1 (en) * 2020-10-26 2022-05-05 Puretech Lyt, Inc. Anti-galectin-9 antibodies and uses thereof in the treatment of ocular melanoma
WO2023164689A2 (en) * 2022-02-28 2023-08-31 University Of Massachusetts Targeting neuropilin 2 (nrp2) in lethal prostate cancer

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WO2015013389A2 (en) * 2013-07-24 2015-01-29 Dana-Farber Cancer Institute, Inc. Anti-galectin-1 (gal1) monoclonal antibodies and fragments thereof for neutralizing gal1
CN101754771B (zh) * 2007-05-17 2015-03-04 健泰科生物技术公司 抗神经毡蛋白2抗体对肿瘤转移的抑制
WO2015185875A2 (fr) * 2014-06-06 2015-12-10 Universite Sciences Technologies Lille Anticorps dirigé contre la galectine 9 et inhibiteur de l'activité suppressive des lymphocytes t régulateurs
WO2017172517A1 (en) * 2016-03-29 2017-10-05 Stcube & Co., Inc. Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins
CN108025025A (zh) * 2015-05-22 2018-05-11 斯特库伯株式会社 癌症治疗靶点的筛选方法
WO2018222689A1 (en) * 2017-05-31 2018-12-06 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
CN109415437A (zh) * 2015-12-02 2019-03-01 斯特库伯株式会社 与btn1a1免疫特异性结合的抗体和分子及其治疗用途
CN111051346A (zh) * 2017-05-31 2020-04-21 斯特库伯株式会社 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
US20210032334A1 (en) * 2018-02-28 2021-02-04 Dana-Farber Cancer Institute, Inc. Methods for treating cancer using combinations of anti-btnl2 and immune checkpoint blockade agents
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