CN110974749B

CN110974749B - Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof

Info

Publication number: CN110974749B
Application number: CN201911378658.5A
Authority: CN
Inventors: 张金金; 杨登亮; 林娜妹; 李传茂; 张楚标; 曾伟丹; 张伟杰
Original assignee: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT; Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Current assignee: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT; Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Priority date: 2019-12-27
Filing date: 2019-12-27
Publication date: 2022-05-10
Anticipated expiration: 2039-12-27
Also published as: CN110974749A

Abstract

The invention provides a soothing and repairing composition, a soothing and repairing solid preparation and a preparation method thereof. The soothing and repairing composition comprises a loosening agent, a soothing and repairing component and an auxiliary material; wherein the soothing and repairing ingredients comprise madecassoside, witch hazel extract and carnosine; based on the total mass of the soothing and repairing composition, the addition amount of the loosening agent is 0.2-16%; the addition amount of the madecassoside is 0.5-5%, the addition amount of the Hamamelis virginiana extract is 5-10%, and the addition amount of the carnosine is 20-40%; the addition amount of the auxiliary materials is 40-65%. The soothing and repairing composition has a soothing and repairing effect, can be prepared into a solid preparation according to needs, has long shelf life and high stability, and is particularly suitable for people with allergic skin.

Description

Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof

Technical Field

The invention provides a soothing and repairing composition, a soothing and repairing solid preparation and a preparation method thereof, and belongs to the field of cosmetics.

Background

With the increasing frequency of cosmetic use, the consumer population has become more and more concerned with skin inflammation and allergy in recent years. The product which can effectively relieve the skin discomfort and the cosmetics which can effectively improve and promote the skin resistance after being used are sought, and are deeply pursued by consumers.

The existing cosmetics for sensitive muscles are mainly realized by reducing common allergens, simplifying the formula, selecting mild raw materials, carrying out aseptic packaging and the like, and if essence and spice are not added and preservatives are added as low as possible, amino acid surfactants, vacuum aseptic packaging and disposable packaging are adopted. However, the cosmetic obtained in the above manner has a short shelf life and is inconvenient to carry because of the addition of a small amount of preservative.

In addition, there is an increasing number of new products on the market in the prior art that simultaneously add effective concentrations of anti-allergy and soothing ingredients. But still has the problems that the skin cannot be relieved instantly, the shelf life is short, and the carrying is inconvenient.

Therefore, the research on a high-efficiency anti-allergy and instant soothing and repairing product to solve the main puzzles of the skin of the consumer becomes a technical problem to be solved urgently.

Disclosure of Invention

Problems to be solved by the invention

In order to relieve the trouble faced by sensitive skin consumers, the invention firstly provides a soothing and repairing composition, and the soothing and repairing composition has a soothing and repairing effect, can be prepared into different shapes such as a sheet shape and the like according to requirements, has long shelf life and high stability, and is particularly suitable for people with allergic skin.

Furthermore, the invention also provides a soothing and repairing solid preparation which breaks through the preparation method and the use mode of the traditional cosmetics, has good solubility and stability, long shelf life and is light and easy to carry.

Furthermore, the invention also provides a preparation method of the soothing and repairing solid preparation, and the preparation method is simple and feasible, and raw materials are easy to obtain.

Means for solving the problems

The invention provides a soothing and repairing composition which comprises a loosening agent, a soothing and repairing component and auxiliary materials; wherein the soothing and repairing ingredients comprise madecassoside, witch hazel extract and carnosine; based on the total mass of the soothing repair composition,

the addition amount of the loosening agent is 0.2-16%;

the addition amount of the madecassoside is 0.5-5%, the addition amount of the Hamamelis virginiana extract is 5-10%, and the addition amount of the carnosine is 20-40%;

the addition amount of the auxiliary materials is 40-65%.

The soothing servicing composition according to the present invention, wherein, based on the total mass of the soothing servicing composition,

the addition amount of the loosening agent is 0.5-16%;

the addition amount of the madecassoside is 1-5%, the addition amount of the Hamamelis virginiana extract is 5-9.5%, and the addition amount of the carnosine is 25-40%;

the addition amount of the auxiliary materials is 45-65%.

A soothing rejuvenating composition according to the invention, wherein the bulking agent comprises citric acid and/or sodium bicarbonate.

The soothing and repairing composition of the present invention, wherein the citric acid is added in an amount of 0.1-8%, preferably 0.5-8%, based on the total mass of the soothing and repairing composition; the addition amount of the sodium bicarbonate is 0.1-8%, preferably 0.2-8%.

A soothing rejuvenating composition according to the invention, wherein the adjuvant comprises maltitol.

The invention also provides a soothing and repairing solid preparation which comprises the soothing and repairing composition.

The soothing and repairing solid preparation provided by the invention is a soothing and repairing sheet, preferably the thickness of the soothing and repairing sheet is 1-4mm, preferably 1-3 mm; the weight of the soothing and nursing sheet is 1-500mg, preferably 30-300 mg.

The soothing and repairing solid preparation according to the present invention, wherein the hardness of the soothing and repairing sheet is more than 24 newtons, preferably 24.5 to 50 newtons.

The soothing and repairing solid preparation provided by the invention is placed in water or a water-based cosmetic, and the disintegration time of the soothing and repairing solid preparation is less than 5min, preferably less than 4.5 min.

The invention also provides a preparation method of the slow-release and repair solid preparation, which comprises the step of mixing the components of the slow-release and repair composition and then pressing and molding the mixture.

ADVANTAGEOUS EFFECTS OF INVENTION

In view of the problem of the existing sensitive skin consumers, the invention firstly provides a soothing and repairing composition which has the soothing and repairing effect, long shelf life and high stability and is particularly suitable for people with allergic skin.

Furthermore, the invention also provides a soothing and repairing solid preparation, which breaks through the preparation method and the use mode of the traditional cosmetics, has more diversified packaging forms, is light and easy to open, can reduce the product packaging cost, and can be used according to the individual requirements of consumers.

Furthermore, the invention also provides a preparation method of the soothing and repairing solid preparation, and the preparation method is simple and feasible, has easily obtained raw materials, and is suitable for mass production.

Detailed Description

Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps that are well known to those skilled in the art have not been described in detail so as not to obscure the invention.

All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.

First embodiment

A first embodiment of the present invention provides a soothing and repairing composition comprising a bulking agent, a soothing and repairing ingredient, and an adjuvant; wherein the soothing and repairing ingredients comprise madecassoside, witch hazel extract and carnosine; based on the total mass of the soothing and repairing composition, the addition amount of the loosening agent is 0.2-16%; the addition amount of the madecassoside is 0.5-5%, the addition amount of the Hamamelis virginiana extract is 5-10%, and the addition amount of the carnosine is 20-40%; the addition amount of the auxiliary materials is 40-65%. The soothing and repairing composition has a soothing and repairing effect, can be prepared into a solid preparation according to needs, has long shelf life and high stability, and is particularly suitable for people with allergic skin. Specifically, the method comprises the following steps:

< bulking agent >

The loosening agent is very easy to dissolve in water, can be quickly dissolved when meeting water or water-based cosmetics, releases heat and generates bubbles, and can accelerate the dissolving speed of the soothing and repairing components and auxiliary materials. In the invention, the bulking agent is added in an amount of 0.2-16%, preferably 0.5-16%, based on the total mass of the soothing and repairing composition; specifically, the bulking agent may be added in an amount of 0.5%, 1%, 4%, 8%, 12%, 15%, etc. If the content of the loosening agent is less than 0.2%, the composition for soothing repair of the present invention needs an auxiliary external force such as stirring or shaking to accelerate dissolution and release thereof when it is used after being prepared into a solid preparation, and if the content of the loosening agent is more than 16%, the soothing repair effect of the soothing repair of the present invention is affected.

In particular, the bulking agent of the present invention may be citric acid and/or sodium bicarbonate. The citric acid is added in an amount of 0.1-8%, preferably 0.5-8%, based on the total mass of the soothing repair composition, for example: may be 0.2%, 0.8%, 2%, 4%, 6%, 7%, etc. The sodium bicarbonate is added in an amount of 0.1 to 8%, preferably 0.2 to 8%, for example: may be 0.5%, 0.8%, 2%, 4%, 6%, 7%, etc. When the addition amount of the citric acid is 0.1-8% and/or the addition amount of the sodium bicarbonate is 0.1-8%, and the soothing and repairing composition is prepared into a solid preparation for use, the citric acid and/or the sodium bicarbonate is used as a bulking agent, so that the dissolving speed of the soothing and repairing component and the auxiliary material in the water or water-type cosmetic can be effectively accelerated.

< soothing repair ingredient >

Soothing and rejuvenating ingredients of the present invention include madecassoside, hamamelis virginiana extract, and carnosine. When in use, the madecassoside, the hamamelis virginiana extract and the carnosine can generate a synergistic effect, and the soothing and repairing effects are further improved.

Madecassoside

The madecassoside in the soothing and repairing composition is white powder, has the effects of relieving itching, resisting erythema and improving desquamation, effectively prevents the hyperproliferation of keratinocytes, protects the cells from being damaged by active oxygen free radicals, reduces the synthesis of matrix metalloproteinase-1 and promotes the generation of collagen I.

The madecassoside is added in an amount of 0.5 to 5%, preferably 1 to 5%, based on the total mass of the soothing and repairing composition, for example: may be 0.8%, 1.5%, 2%, 3%, 4%, 4.5%, etc. When the addition amount of the madecassoside is 0.5-5%, the madecassoside has a good relieving and repairing effect, and can remarkably improve the capability of skin to respond to external stimulation.

Hamamelis virginiana extract

The witch hazel extract in the soothing and repairing composition is light yellow fine powder, can be obtained by filtering and decoloring after extracting and separating dry barks, has the main component of tannic acid, can adjust sebum secretion, has the effects of calming, soothing and astringing pores, and has the effect of improving cracks, sunburn and acnes.

The hamamelis virginiana extract is added in an amount of 5-10%, preferably 5-9.5%, based on the total mass of the soothing and repairing composition, for example: may be 5.5%, 6%, 7%, 8%, 9%, etc. When the addition amount of the Hamamelis virginiana extract is 5-10%, the Hamamelis virginiana extract has a good soothing and repairing effect, effectively relieves the skin discomfort caused by external stimulation, and improves the barrier capability of the skin.

Carnosine

The carnosine in the soothing and repairing composition is dipeptide consisting of two amino acids of beta-alanine and L-histidine, can prevent active oxygen free radicals generated in the oxidative stress process from damaging cells, can promote the generation of collagen, maintains the activity of human fibroblasts, promotes the healing of wounds and accelerates the metabolism of skin.

The carnosine is added in an amount of 20-40%, preferably 25-40%, based on the total mass of the soothing and rejuvenating composition, for example: can be 28%, 30%, 35%, 38%. When the addition amount of the carnosine is 20-40%, the carnosine has a good cell protection effect, and the resistance of skin to different environments is effectively improved.

< auxiliary materials >

In the soothing and repairing composition, some auxiliary materials can be properly added, so that the texture of the soothing and repairing composition can be improved. In the present invention, the auxiliary material may include maltitol. The addition amount of the auxiliary materials is 40-65%, preferably 45-65% by the total mass of the soothing and repairing composition, for example: may be 42%, 48%, 50%, 55%, 60%, 62%, etc.

Specifically, maltitol in the soothing and repairing composition is sugar alcohol which is prepared by hydrolyzing starch and hydrorefining, has good heat resistance, high acid resistance and good stability, and is used as an auxiliary material of the soothing and repairing composition. Along with the dissolving of the soothing and repairing composition in water, the maltitol can be quickly dissolved to form a liquid product with certain moisturizing effect and moistening feeling and soothing and repairing effects.

In the present invention, when maltitol is used as adjuvant, it is added in an amount of 40-65%, preferably 45-65%, for example: may be 42%, 48%, 50%, 55%, 60%, 62%, etc. When the content of the maltitol is 40-65%, the maltitol can be used as an auxiliary material of the soothing and repairing composition, and provides certain moisturizing effect and moistening feeling for the product.

Second embodiment

A second embodiment of the present invention provides a soothing and repairing solid formulation comprising the soothing and repairing composition of the first embodiment of the present invention. Specifically, the soothing and repairing solid preparation can be obtained by mixing after drying and a compression molding technology; preferably, it can be obtained by vacuum freeze-drying followed by homogeneous mixing and compression molding techniques.

According to the invention, the novel fresh cosmetic which does not contain preservatives and essences is formed by drying, homogenizing and mixing the soothing and repairing composition, and the soothing and repairing solid preparation can be selected to be used in addition according to the skin state of a consumer, and can be used as soothing and repairing essence after being rapidly dissolved in water or water type cosmetics.

Furthermore, the consumption of the composition can be adjusted at any time by consumers according to seasonal climate change and skin states of the consumers, so that the requirements of the consumers are met, and the effect of the soothing and repairing composition is fully exerted.

The application method of the soothing and repairing solid preparation is that the solid preparation is placed in water or water-based cosmetics and dissolved to obtain fresh soothing and repairing liquid which is prepared for use. Specifically, the aqueous cosmetic may be a lotion or essence, preferably a lotion, which is effective in enhancing the soothing and repairing effects of the original product.

Further, the soothing and repairing solid preparation is placed in water or water-based cosmetics, and the disintegration time of the soothing and repairing solid preparation is less than 5min, preferably less than 4.5 min. In addition, the soothing and repairing solid preparation can be completely dissolved within 11 minutes, preferably completely dissolved within 6 minutes to form a fresh soothing and repairing liquid, and the preparation is ready to use.

Specifically, the soothing and repairing solid preparation of the present invention may be a tablet, a spherical preparation, a square preparation, etc. Preferably, the soothing repair solid formulation of the present invention is a tablet.

Soothing and repairing sheet

The soothing and repairing solid preparation can be prepared into soothing and repairing tablets preferably by a tabletting technology. The soothing and repairing sheet disclosed by the invention is mild and safe, has an excellent soothing and repairing effect, can effectively improve the skin barrier function, is fresh, does not contain a preservative and essence, and is especially suitable for people with allergic skin. Meanwhile, the product has good solubility and stability, long shelf life, light weight and easy carrying.

Specifically, the thickness of the soothing and repairing sheet of the present invention is 1 to 4mm, preferably 1 to 3 mm; the weight of the soothing and repairing tablet is 1-500mg, and preferably 30-300 mg. The weight of the soothing and repairing sheet is visual, a consumer can adjust the required dosage at any time according to seasonal climate change and the skin state of the consumer, the soothing and repairing sheet is ready to use, the freshness of a used product is more flexibly ensured, personalized customization is easy to realize, and the attention of the consumer to skin management and the experience of the product in use are improved.

Preferably, the soothing conditioner of the present invention can obtain products of different shapes according to the different tabletting molds, such as: the soothing patch may be made in a circular shape, which may be 1mm to 4mm in diameter. Of course, the soothing repair patch of the present invention may also be quadrilateral, triangular, etc.

Further, in the present invention, the soothing and conditioning sheet has a hardness of more than 24 newtons, preferably 24.5 to 50 newtons. The soothing and repairing sheet has certain hardness, is not easy to break and is convenient to carry.

The soothing and repairing solid preparation is a brand-new preparation, breaks through the preparation method and the use mode of the traditional cosmetics, can be independently dissolved in liquid for use, for example, can be independently dissolved in water for use, and can also be matched with the commercially available water-based cosmetics for use. The soothing and repairing sheet disclosed by the invention is mild and safe, has an excellent soothing and repairing effect, improves the resistance of skin to external stimulation, is fresh, does not contain a preservative and essence, and is especially suitable for people with allergic skin. Meanwhile, the product has good solubility and stability, long shelf life, light weight and easy carrying.

Third embodiment

A third embodiment of the present invention provides a method of preparing a soothing and repairing solid formulation; the preparation method comprises the step of mixing the components of the soothing and repairing composition and then pressing and molding the mixture.

Further, the preparation method comprises the following steps:

drying the soothing and repairing component, the auxiliary material and the loosening agent (such as vacuum freeze drying), and uniformly mixing to obtain a primary mixture;

and (3) performing compression molding on the preliminary mixture to obtain the soothing and repairing solid preparation.

The relieving and repairing solid preparation can be packaged and stored in a sealed plastic bottle or an aluminum-plastic bubble cap packaging box, and can be independently subpackaged or bottled in a plurality of pieces.

Specifically, the invention also provides a preparation method of the soothing and repairing tablet, which specifically comprises the following steps:

freeze-drying the soothing and repairing component, the auxiliary material and the loosening agent in vacuum, and mixing uniformly to obtain a primary mixture;

and tabletting the preliminary mixture by using a tabletting machine to obtain the soothing and repairing tablet.

Preferably, the compression force for the tabletting process may be 3 to 10kN, preferably using a single punch tablet press.

Examples

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.

The parameters are tested according to the method and the instrument required by the pharmacopoeia of the people's republic of China 2015 edition:

disintegration time: ZB-1C type intelligent disintegration tester

And (3) hardness testing: YPD-300CLED type intelligent tablet hardness tester

Weight uniformity: sartorius CP225D quasi microbalance

Placing the soothing repairing tablet in water, and recording the time from the placement to the just disintegration, namely the disintegration time; after the soothing repairing sheet is completely dissolved, the time from the placement to the time when the soothing repairing sheet is just completely dissolved is recorded, namely the dissolving time.

Example 1

Taking 0.1 weight part of citric acid, 6 weight parts of sodium bicarbonate, 1 weight part of madecassoside, 10 weight parts of hamamelis virginiana extract, 30 weight parts of carnosine and 52.9 weight parts of maltitol for standby.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 6kN to form the relieving and repairing tablet I with the diameter of 3mm and the thickness of 1 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 60. + -. 1.05mg, a hardness of 42.22. + -. 1.86N, a disintegration time of 112. + -.8 s and a complete dissolution time in water of 160. + -.5 s, the specific results are shown in Table 1.

Example 2

Taking 2 parts by weight of citric acid, 2 parts by weight of sodium bicarbonate, 3 parts by weight of madecassoside, 8 parts by weight of hamamelis virginiana extract, 20 parts by weight of carnosine and 65 parts by weight of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are pressed into a relieving and repairing tablet II with the diameter of 2mm and the thickness of 2mm under the pressure of 10 kN.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 95. + -. 2.33mg, a hardness of 48.64. + -. 1.32N, a disintegration time of 172. + -.5 s and a complete dissolution time in water of 325. + -.5 s, and the specific results are shown in Table 1.

Example 3

Taking 1 weight part of citric acid, 4 weight parts of sodium bicarbonate, 5 weight parts of madecassoside, 10 weight parts of hamamelis virginiana extract, 40 weight parts of carnosine and 40 weight parts of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 4kN to form the relieving and repairing tablet III with the diameter of 3mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 78. + -. 2.25mg, a hardness of 36.56. + -. 1.58N, a disintegration time of 154. + -.4 s and a complete dissolution time in water of 275. + -.10 s, and the specific results are shown in Table 1.

Example 4

Taking 4 parts by weight of citric acid, 8 parts by weight of sodium bicarbonate, 3 parts by weight of madecassoside, 5 parts by weight of hamamelis virginiana extract, 25 parts by weight of carnosine and 55 parts by weight of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 3kN to form the relieving and repairing tablet IV with the diameter of 4mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 55. + -. 5.46mg, a hardness of 27.35. + -. 2.07N, a disintegration time of 95. + -.3 s and a complete dissolution time in water of 100. + -.15 s, and the specific results are shown in Table 1.

Example 5

Taking 8 parts by weight of citric acid, 0.1 part by weight of sodium bicarbonate, 0.5 part by weight of madecassoside, 5 parts by weight of hamamelis virginiana extract, 40 parts by weight of carnosine and 46.4 parts by weight of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 3kN to form the relieving and repairing tablet V with the diameter of 4mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 53. + -. 3.28mg, a hardness of 25.84. + -. 1.12N, a disintegration time of 236. + -.5 s and a complete dissolution time in water of 625. + -.20 s, and the specific results are shown in Table 1.

Comparative example 1

0.1 part by weight of citric acid, 6 parts by weight of sodium bicarbonate, 1 part by weight of madecassoside, 30 parts by weight of carnosine and 52.9 parts by weight of maltitol are taken for standby.

The madecassoside, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 6kN to prepare the relieving and protecting tablet VI with the diameter of 3mm and the thickness of 1 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 58. + -. 3.68mg, a hardness of 44.13. + -. 2.26N, a disintegration time of 135. + -.6 s and a complete dissolution time in water of 183. + -.8 s, the specific results are shown in Table 1.

Comparative example 2

Taking 5 weight parts of madecassoside, 10 weight parts of hamamelis virginiana extract, 40 weight parts of carnosine and 40 weight parts of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine and the maltitol are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 4kN to prepare the relieving and protecting tablet VII with the diameter of 3mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 75. + -. 3.64mg, a hardness of 35.98. + -. 2.14N, a disintegration time of 840. + -.25 s and a complete dissolution time of 3360. + -.50 s in water, and the specific results are shown in Table 1.

Comparative example 3

Taking 4 parts by weight of citric acid, 8 parts by weight of sodium bicarbonate, 3 parts by weight of madecassoside, 5 parts by weight of hamamelis virginiana extract and 25 parts by weight of carnosine for later use.

The madecassoside, the witch hazel extract, the carnosine, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and the mixture is tabletted under the pressure of 3kN to prepare the soothing and protecting tablet VIII with the diameter of 4mm and the thickness of 3 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 62. + -. 2.48mg, a hardness of 51.32. + -. 1.52N, a disintegration time of 38. + -.5 s and a complete dissolution time of 25640. + -.240 s in water, and the specific results are shown in Table 1.

Comparative example 4

Taking 1 weight part of citric acid, 4 weight parts of sodium bicarbonate, 5 weight parts of madecassoside, 10 weight parts of hamamelis virginiana extract, 60 weight parts of carnosine and 20 weight parts of maltitol for later use.

The madecassoside, the witch hazel extract, the carnosine, the maltitol, the sodium bicarbonate and the citric acid are uniformly mixed after being frozen and dried in vacuum, and are tabletted under the pressure of 4kN to form the soothing and repairing tablet IX with the diameter of 3mm and the thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 66. + -. 1.56mg, a hardness of 25.24. + -. 3.04N, a disintegration time of 278. + -.6 s and a complete dissolution time of 1275. + -.35 s in water, and the specific results are shown in Table 1.

Comparative example 5

Taking 1 weight part of citric acid, 4 weight parts of sodium bicarbonate, 10 weight parts of hamamelis virginiana extract, 40 weight parts of carnosine and 40 weight parts of maltitol for later use.

Vacuum freeze drying Hamamelis virginiana extract, carnosine, maltitol, sodium bicarbonate and citric acid, mixing, and tabletting under 4kN pressure to obtain soothing and protecting tablet X with diameter of 3mm and thickness of 2 mm.

The resulting tablets were tested for hardness, weight uniformity, disintegration time and dissolution time. The tablets showed an average weight of 79. + -. 1.82mg, a hardness of 39.28. + -. 2.53N, a disintegration time of 168. + -.8 s and a complete dissolution time in water of 292. + -.8 s, and the specific results are shown in Table 1.

TABLE 1

Examples	Uniformity of weight/mg	hardness/Newton	Disintegration time/s	Dissolution time test/s
					Example 1	60±1.05	42.22±1.86	112±8	160±5
Example 2	95±2.33	48.64±1.32	172±5	325±5
					Example 3	78±2.25	36.56±1.58	154±4	275±10
Example 4	55±5.46	27.35±2.07	95±3	100±15
					Example 5	53±3.28	25.84±1.12	236±5	625±20
Comparative example 1	58±3.68	44.13±2.26	135±6	183±8
					Comparative example 2	75±3.64	35.98±2.14	840±25	3360±50
Comparative example 3	62±2.48	51.32±1.52	38±5	25640±240
					Comparative example 4	66±1.56	25.24±3.04	278±6	1275±35
Comparative example 5	79±1.82	39.28±2.53	168±8	292±8

As can be seen from Table 1, in comparison with comparative example 1, in comparative example 1 containing no Hamamelis virginiana extract, the time required for disintegration and dissolution was slightly longer than that of example 1.

Example 3 compares with comparative example 2, and comparative example 2 does not contain a bulking agent, is difficult to disintegrate, and is very difficult to dissolve.

Example 4 compares with comparative example 3, comparative example 3 does not contain maltitol as an adjuvant, and although it is easily disintegrated, it has a large hardness and requires a long dissolution time.

Example 3 compared to comparative example 4, the carnosine content in comparative example 4 was too high and not within the scope of the present invention, and the maltitol content of the adjuvant was too low and not within the scope of the present invention, the disintegration time was slightly prolonged and the dissolution time was too long.

Example 3 compares with comparative example 5, in comparative example 5, madecassoside is not contained, hardness is slightly increased, and dissolution and disintegration time is slightly prolonged.

Stability test

The soothing repair sheets I to V prepared in examples 1 to 5 and the soothing repair sheets VI to X prepared in comparative examples 1 to 5, each 40 sheets (10 sheets per serving) were packed in an aluminum blister pack and sealed, and stored in the following 4 environments to observe the breakage degree and molding stability of the tablets, respectively, and the results are shown in Table 2 below.

The samples were allowed to stand at 25 ℃ and 60% RH at ambient temperature for comparative testing.

Cold resistance test: the freezer was left for 10 days.

And (3) cold-hot circulation: -18 ℃, 25% RH; 25 ℃ at 60% RH; 40 ℃, 75% RH, 24h each for 5 cycles.

High-temperature acceleration: the test conditions were 50 ℃ plus or minus 1 ℃ and 25% RH plus or minus 5% RH for 1 month.

TABLE 2

As can be seen from Table 2, the soothing repair sheets I to V prepared in examples 1 to 5 and the soothing repair sheets VI, VII, IX and X prepared in comparative examples 1, 2, 4 and 5 were able to maintain their shapes at respective temperatures and were excellent in stability.

However, in comparison with comparative example 3, in comparative example 3, maltitol containing no auxiliary material is inferior in stability at various temperatures, and is liable to be chipped, and thus cannot maintain the molding.

Test of soothing and repairing effects

The trial method for testing the human body skin patch is based on the following steps: technical Specifications for cosmetic safety (2015 edition).

The general test method comprises the following steps: selecting a proper patch test tester, selecting at least 30 qualified volunteers to test by a closed patch test method, and adding a test object, distilled water (deionized water) and a control sample into a square chamber of the patch test tester. The patch test tester added with the test object, the distilled water (deionized water) and the control sample is applied to the inner side of the forearm of the subject, the test object, the distilled water (deionized water) and the control sample are lightly pressed by hands to be uniformly applied on the skin for 24 hours, the skin reaction is observed according to the standard of the table 3 for 30min (after the indentation disappears), 24 hours and 48 hours after the patch test tester added with the test object, the distilled water (deionized water) and the control sample is removed, and the observation result is recorded.

According to the above general method, 33 qualified volunteers were selected to be tested, and the soothing conditioner sheets I to V prepared in examples 1 to 5 and the soothing conditioner sheets VI to X prepared in comparative examples 1 to 5 were completely dissolved in a control sample (aqueous solution containing phenoxyethanol of 1.2% by mass and water-soluble menthol lactate of 0.2% by mass) in an amount of 3% by mass, respectively, to form a corresponding mixed solution, which was the test substance.

The patch test tester with the test substance, deionized water and the control sample was attached to the inner side of the forearm of the subject and removed after 24 hours, and the skin reaction was observed according to the standard of table 3 for 30 minutes, 24 hours and 48 hours after removing the patch test tester and the observation results were recorded.

TABLE 3 skin response grading Standard for skin Enclosed Patch test

TABLE 4 test results of human body patch

As can be seen from the results of the human patch tests in tables 3 and 4, the control sample (aqueous solution containing 1.2% phenoxyethanol and 0.2% water-soluble menthol lactate) was very likely to cause adverse reactions on the skin. However, the soothing repair sheets I-V prepared in examples 1-5 and the soothing repair sheets VI-X prepared in comparative examples 1-5 both have instant soothing repair effects, and can effectively relieve the irritation of the control samples to the skin and reduce the occurrence of adverse reactions to the skin.

Examples 1-5 the soothing repair effects of the soothing repair sheets I-V prepared in examples 5, 1, 4, 2 to 3 were enhanced in order.

Example 1 in comparison to comparative example 1, which contained no hamamelis virginiana extract, had a less soothing and repairing effect than example 1, so that the number of adverse reactions observed at 3 different time points was slightly higher than that of example 1.

Example 3 in comparison to comparative example 2, although it did not contain citric acid and sodium bicarbonate, had a soothing and repairing effect comparable to example 3.

Example 4 compares to comparative example 3, comparative example 3 does not contain maltitol adjuvant, the soothing and repairing effect is slightly weaker than example 4 due to insufficient skin moisture retention, and the number of adverse reactions observed at 2 time points, 24h and 48h respectively, is slightly higher than example 4.

Compared with the comparative example 4, the content of carnosine in the comparative example 4 is too high, and although the number of adverse reaction examples observed at the time point of 0.5h is less than that of the example 3, namely, the soothing and repairing effect is stronger, the cost is undoubtedly more than that of the example 3.

Compared with the comparative example 5, in the comparative example 5, the madecassoside is not contained, and the number of adverse reaction examples observed at 3 different time points is higher than that of the example 3, namely, the soothing and repairing effect is much weaker. Meanwhile, in comparative example 5, compared with example 5, although the soothing effect was comparable at 0.5h, the number of adverse reactions observed at 2 time points of 24h and 48h was higher than that of example 5, i.e., the soothing and repairing effect was slightly weaker.

The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A soothing and repairing composition is characterized by comprising a loosening agent, a soothing and repairing component and auxiliary materials; wherein the soothing and repairing ingredients comprise madecassoside, witch hazel extract and carnosine; based on the total mass of the soothing repair composition,

the addition amount of the loosening agent is 0.2-16%;

the addition amount of the auxiliary materials is 40-65%;

the bulking agent comprises citric acid and sodium bicarbonate; the auxiliary material comprises maltitol.

2. A soothing servicing composition according to claim 1, characterized in that, based on the total mass of the soothing servicing composition,

the addition amount of the loosening agent is 0.5-16%;

the addition amount of the auxiliary materials is 45-65%.

3. A soothing servicing composition according to claim 1 or 2, characterized in that the citric acid is added in an amount of 0.1-8% by weight of the total soothing servicing composition; the addition amount of the sodium bicarbonate is 0.1-8%.

4. A soothing servicing composition according to claim 1 or 2, characterized in that the citric acid is added in an amount of 0.5-8% by weight of the total soothing servicing composition; the addition amount of the sodium bicarbonate is 0.2-8%.

5. A soothing and repairing solid formulation comprising the soothing and repairing composition of any one of claims 1 to 4.

6. The soothing and repairing solid preparation according to claim 5, wherein the soothing and repairing solid preparation is a soothing and repairing tablet.

7. A soothing and repairing solid formulation according to claim 6, wherein the thickness of the soothing and repairing sheet is 1-4 mm; the weight of the soothing and repairing sheet is 1-500 mg.

8. A soothing and repairing solid formulation according to claim 7, wherein the thickness of the soothing and repairing sheet is 1-3 mm; the weight of the soothing and repairing tablet is 30-300 mg.

9. A soothing and repairing solid formulation according to any one of claims 6 to 8, wherein the hardness of the soothing and repairing sheet is more than 24N.

10. A soothing and repairing solid formulation according to claim 9, wherein the hardness of the soothing and repairing sheet is 24.5-50 n.

11. A soothing and repairing solid formulation according to any one of claims 5 to 8, wherein the soothing and repairing solid formulation is placed in water or a water-based cosmetic, and the disintegration time of the soothing and repairing solid formulation is less than 5 min.

12. The soothing and repairing solid formulation of claim 11, wherein the soothing and repairing solid formulation is placed in water or a water-based cosmetic, and the disintegration time of the soothing and repairing solid formulation is less than 4.5 min.

13. A method of preparing a soothing and repairing solid formulation as claimed in any one of claims 5 to 12, comprising the step of mixing the components of the soothing and repairing composition and then compression molding the mixture.