CN107549803A - A kind of effervescent tablet containing α ketone acids and preparation method thereof - Google Patents
A kind of effervescent tablet containing α ketone acids and preparation method thereof Download PDFInfo
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- CN107549803A CN107549803A CN201710854945.3A CN201710854945A CN107549803A CN 107549803 A CN107549803 A CN 107549803A CN 201710854945 A CN201710854945 A CN 201710854945A CN 107549803 A CN107549803 A CN 107549803A
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Abstract
The present invention relates to pharmaceutical technology field, specifically discloses a kind of effervescent tablet containing α ketone acids and preparation method thereof.The effervescent tablet containing α ketone acids, include the component of following parts by weight：60 100 parts of α ketone acids；230 410 parts of α ketonic acid salts；20 100 parts of trehalose；10 60 parts of L glutamine；1 10 parts of amion acetic acid magnesium；1 10 parts of carnosine zinc；1 10 parts of lysine；1 10 parts of arginine；5 60 parts of flavouring agent.Effervescent tablet provided by the invention containing α ketone acids is using specific α ketone acids, specific α ketonic acid salts and specific amino acid as principal component, each component compatibility, effectively improve the supply of energy and amino acid, promote isohydria, the effervescent tablet for containing α ketone acids allow as health products, the psoas for alleviating sub-health population such as is ached, is weak, be dizzy at the symptom, simultaneously, trehalose and flavouring agent are added with the effervescent tablet containing α ketone acids, improve the mouthfeel of effervescent tablet, allow user quickly to break away from the state of inferior health, be advantageous to physical function recovery.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of effervescent tablet containing 2-ketoacid and preparation method thereof.
Background technology
2-ketoacid is the ketone acid of two carboxyl direct neighbors, and pyruvic acid is simplest 2-ketoacid.Pyruvic acid can be with wine
Acetaldehyde and carbon dioxide are decomposed into during essence fermentation.Acetyl coenzyme A and titanium dioxide can also be decomposed into the presence of enzyme
Sulphur.There is a similar reaction in tricarboxylic acid cycle.Another typical reaction is transamination, one in this reaction
2-ketoacid obtains an amino, while Yi Valley propylhomoserin loses an amino, without discharging ammonia.Can by this reaction pyruvic acid
To be converted into alanine, oxaloacetic acid (it is a 2-ketoacid and beta-keto acid simultaneously) is converted into aspartic acid, a-ketoglutaric acid
Zhuanization Wei Valley propylhomoserins.The 2-ketoacid generated after amino acid deamination can be further metabolized, and generated nonessential amino acid through amination, turned
Become glucogenic amino acid or ketogenic amino acid, or direct oxidation is produced by tricarboxylic acid cycle and oxidative phosphorylation exhaustive oxidation
CO2And water, and the needs for vital movement that give off energy.
What ketone acid mainly supplemented is branched-chain amino acid, and compared with simple low protein diet, ketone acid can be supplied to enough required
Amino acid, energy and essential nutrients, have and reduce albuminuria and avoid the bad dual-use function of nutrient, supplemented with simple low egg
The limitation supplemented in vain, in the absence of underfed danger is caused, renal function is at utmost safeguarded, can be obviously improved weary
Power, have a pain in the back, the subhealth symptom such as dizziness, be the powerful health products of the very high kidney tonifying of a applicability.Effervescent tablet health care at present
There is amino acid compatibility and 2-ketoacid compatibility is single, poor taste more in product, for object be patient groups as medicine, can not make
Used for health products for the young and the middle aged of inferior health and mid-aged population.
The content of the invention
For the effervescent tablet containing 2-ketoacid existing for prior art, amino acid compatibility and 2-ketoacid compatibility are single, cause
Poor taste, is applicable the problems such as crowd is single, and the present invention provides a kind of effervescent tablet containing 2-ketoacid and preparation method thereof.
To achieve the above object of the invention, the embodiment of the present invention employs following technical scheme：
A kind of effervescent tablet containing 2-ketoacid, include the component of following parts by weight：
Wherein, the 2-ketoacid includes α-ketoglutaric acid, Alpha-hydroxy methionine；The 2-ketoacid salt includes α-one valine
Calcium, alpha-keto-leucine-calcium, α -one isoleucines calcium, alpha-calcium picrolonate, α-Ketophenylalanine Calcium.
Relative to prior art, the effervescent tablet provided by the invention containing 2-ketoacid is with specific 2-ketoacid (α -one penta 2
Acid, Alpha-hydroxy methionine), specific 2-ketoacid salt (α-one valine calcium, alpha-keto-leucine-calcium, α -one isoleucines calcium, α -one
Sour calcium, α-Ketophenylalanine Calcium) and specifically amino acid (lysine and arginine) is principal component, each component compatibility, is effectively carried
The supply of high-energy and amino acid, promote isohydria so that the effervescent tablet containing 2-ketoacid can be used as health products, delay
The psoas of solution sub-health population such as is ached, is weak, be dizzy at the symptom, (is no longer limited to suffer from so as to improve the applicable colony of product
Patient group).Meanwhile trehalose and flavouring agent are added with the effervescent tablet containing 2-ketoacid, effervescent tablet can be improved
Mouthfeel so that the effervescent tablet containing 2-ketoacid goes for different crowds, allows user quickly to break away from inferior health
State, be advantageous to physical function recovery.
Further, present invention also offers the preparation method of the effervescent tablet containing 2-ketoacid.The preparation method, extremely
Comprise the following steps less：
(1) trehalose, 2-ketoacid, 2-ketoacid salt, Glu, amion acetic acid, carnosine zinc are carried out at batch mixing
After reason, wet granulation, complex A is obtained；
(2) after lysine, arginine, flavouring agent being carried out into mixing treatment, wet granulation, complex B is obtained；
(3) part complex A, complex B are taken respectively according to identical weight ratio, the aqueous solution is configured to, into the aqueous solution
Alkaline conditioner is added, adjusts pH to 7.35-7.45, record alkaline conditioner and complex A, the proportioning of complex B；
(4) remaining complex A, complex B and alkaline conditioner are subjected to mixing treatment according to the proportioning in step (3),
Obtain mixed material；
(5) adhesive that weight is mixed material gross weight 2-7% is uniformly sprayed onto in mixed material, carried out at tabletting
Reason, obtains the effervescent tablet containing 2-ketoacid.
Relative to prior art, the preparation method of the effervescent tablet provided by the invention containing 2-ketoacid, technique is simple, operation
It is convenient, it is green, make composition more uniform by multiple batch mixing, the effervescent tablet using 2-ketoacid as principal component can quickly be made
Health products.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
The embodiment of the present invention provides a kind of effervescent tablet containing 2-ketoacid.The effervescent tablet, include the group of following parts by weight
Point：
Wherein, the 2-ketoacid includes α-ketoglutaric acid, Alpha-hydroxy methionine；The 2-ketoacid salt includes α-one valine
Calcium, alpha-keto-leucine-calcium, α -one isoleucines calcium, alpha-calcium picrolonate, α-Ketophenylalanine Calcium.
Preferably, 2-ketoacid includes the component of following parts by weight：
α-ketoglutaric acid 20-30 parts；
Alpha-hydroxy methionine 40-70 parts；And/or
The 2-ketoacid salt includes the component of following parts by weight：
A variety of 2-ketoacids, 2-ketoacid salt and amino acid compatibility, form the main component of the effervescent tablet containing 2-ketoacid.
Preferably, the effervescent tablet containing 2-ketoacid also includes alkaline conditioner, adhesive；Wherein, the alkaline conditioner
Dosage determines by pH, the pH to 7.35-7.45 of regulation system；Described adhesive dosage is the 2%-7% of remaining component weight,
Contribute to compressing tablet process, obtain the effervescent tablet containing 2-ketoacid.
It is further preferred that alkaline conditioner is the mixture of sodium acid carbonate and sodium carbonate, wherein, sodium acid carbonate and carbonic acid
Sodium mass ratio is (0.3~0.5):1, the pH of regulation system, pH is controlled in 7.35-7.45, the pH phases with human internal environment
Match somebody with somebody.
Preferably, the specification of the effervescent tablet containing 2-ketoacid is 2g/ pieces and 4g/ pieces, to facilitate different crowd to use.
Effervescent tablet provided in an embodiment of the present invention containing 2-ketoacid is based on a variety of 2-ketoacids, 2-ketoacid salt and amino acid
The addition of composition, trehalose and flavouring agent improves the mouthfeel of effervescent tablet, for different crowds, is mended in energy and amino acid
Fill, isohydria, it is stronger to alleviate the psoas specific aim in symptom such as ache, be weak, be dizzy of sub-health population, makes user quick
The state of inferior health is broken away from, is advantageous to physical function recovery.
The present invention still further provides this and contain 2-ketoacid on the premise of providing this and containing the effervescent tablet of 2-ketoacid
The preparation method of effervescent tablet.
In one embodiment, the preparation method comprises at least following steps：
(1) trehalose, 2-ketoacid, 2-ketoacid salt, Glu, amion acetic acid, carnosine zinc are carried out at batch mixing
After reason, wet granulation, complex A is obtained；
(2) after lysine, arginine, flavouring agent being carried out into mixing treatment, wet granulation, complex B is obtained；
(3) part complex A, complex B are taken respectively according to identical weight ratio, the aqueous solution is configured to, into the aqueous solution
Alkaline conditioner is added, adjusts pH to 7.35-7.45, record alkaline conditioner and complex A, the proportioning of complex B；
(4) remaining complex A, complex B and alkaline conditioner are subjected to mixing treatment according to the proportioning in step (3),
Obtain mixed material；
(5) adhesive that weight is mixed material gross weight 2-7% is uniformly sprayed onto in mixed material, carried out at tabletting
Reason, obtains the effervescent tablet containing 2-ketoacid.
Explanation is further explained to above-mentioned preparation method below：
Preferably, in step (1), (2), the mixing treatment is realized using blender；The blender is bipyramid or V
Type bores blender, and material is sufficiently mixed.
Preferably, wet granulation is realized by pelletizing machine, and particle diameter is sieved by screen cloth, obtains desirable particle size
Complex A and complex B.
It is further preferred that wet granulation is purified water or deionized water with water, water temperature is 15-25 DEG C.
Preferably, complex A particle diameter≤120 μm；Particle diameter≤120 μm of complex B, contribute to mixing and the pressure in later stage
Piece processing, obtains the uniform effervescent tablet of composition.
Preferably, the mass fraction of the aqueous solution is 4%.
Preferably, in the mixed material in step (4), counted using the gross weight of the mixed material as 100%, the α -one
The gross weight percentage composition of acid and 2-ketoacid salt is 40-70%.
This method preparation technology is simple, easy to operate, green, makes composition more uniform by multiple batch mixing, can
The quick effervesce tablet health product being made using 2-ketoacid as principal component.
In order to better illustrate effervescent tablet provided in an embodiment of the present invention containing 2-ketoacid and preparation method thereof, lead to below
Cross that embodiment is further to be illustrated.
Embodiment 1
The preparation method of effervescent tablet containing 2-ketoacid, comprises the following steps：
(1) in C levels area of toilet, humidity≤45% is controlled, temperature control is at 23-25 DEG C, by weight, weighs trehalose
4.0kg, α-ketoglutaric acid 2.0kg, α-one valine calcium 7.5kg, Alpha-hydroxy methionine 4.5kg, alpha-keto-leucine-calcium 7.5kg,
α -one isoleucine calcium 4.0kg, alpha-calcium picrolonate 3.0kg, α-Ketophenylalanine Calcium 3.0kg, Glu 1.0kg, amino second
Sour magnesium 0.5kg, carnosine zinc 0.5kg amount to 11 kinds of materials and are well mixed in double cone mixer, water-filling phase wet granulation of going forward side by side, mistake
Pelletizing machine, sieved from 120 μm of screen clothes, it is standby to be prepared into 2-ketoacid complex A, gross weight 38.7kg；
(2) by lysine 1.0kg, arginine 1.0kg, flavoring pineapple essence flavouring agent 1.5kg while in another blender
Wet granulation is carried out, crosses pelletizing machine and by 120 μm of screen clothes, is prepared into that 2-ketoacid complex B is standby, and weigh 3.7kg；
(3) 2-ketoacid complex A38.7g and complex B 3.7g are taken, the aqueous solution for being configured to 4% or so amounts to 1L, Xiang Shui
Alkaline conditioner is added in solution, and detects aqueous solution pH, pH to 7.35 is adjusted with alkaline conditioner sodium acid carbonate/sodium carbonate,
Alkaline conditioner weight 4.9g is recorded, determines alkaline conditioner and complex A, the proportioning of complex B；
(4) by alkaline conditioner and complex A, the proportioning of complex B, by 2-ketoacid complex A, complex B and alkalescence
Conditioning agent is added in blender and mixed, and well mixed feed powder is weighed 47.3kg, 2-ketoacid is detected according to the methods of sampling
Total content and pH two indices, content is 60.33%, pH=7.39 to detection 2-ketoacid at long last, meets internal control index, then to feed powder
In the adhesive of uniform sprinkling feed powder gross weight 2% carry out tabletting, obtain the effervescent tablet containing 2-ketoacid that specification is 4g/ pieces,
Packaging 20/pipe, it is a box that pipe, which is filled effervescent tablet to set the pipe of counting 10 automatically, and 56 boxes are dressed up in subpackage, dispense yield 94.7%.
Embodiment 2
The preparation method of effervescent tablet containing 2-ketoacid, comprises the following steps：
(1) in C levels area of toilet, humidity≤45% is controlled, temperature control is at 23-25 DEG C, by weight, weighs trehalose
8.0kg, α-ketoglutaric acid 2.0kg, α-one valine calcium 8.0kg, Alpha-hydroxy methionine 5.5kg, alpha-keto-leucine-calcium 6.5kg,
α -one isoleucine calcium 5.5kg, alpha-calcium picrolonate 3.0kg, α-Ketophenylalanine Calcium 3.0kg, Glu 1.0kg, amino second
Sour magnesium 1.0kg, carnosine zinc 0.5kg are well mixed in double cone mixer, water-filling phase wet granulation of going forward side by side, and cross pelletizing machine, are selected
120 μm of screen clothes are sieved, and it is standby to be prepared into 2-ketoacid complex A, gross weight 45.0kg；
(2) while in another blender by lysine 1.0kg, arginine 1.0kg, strawberry essence 3.5kg carry out wet
Method is granulated, and crosses pelletizing machine and by 120 μm of screen clothes, is prepared into that complex B is standby, and weigh 6.9kg；
(3) 2-ketoacid complex A35g and complex B 4.9g are taken, the aqueous solution for being configured to 4% or so amounts to 1.0L, Xiang Shui
Alkaline conditioner is added in solution, and detects aqueous solution pH, pH to 7.45 is adjusted with alkaline conditioner sodium acid carbonate/sodium carbonate,
Record alkalescence adjustment agent weight 7.6g, determines alkaline conditioner and complex A, the proportioning of complex B；
(4) by alkaline conditioner and complex A, the proportioning of complex B, by 2-ketoacid A complexs, α-B complexs and alkali
Property conditioning agent 45.0kg, 6.9kg, 7.6kg add in blender and mixed, well mixed feed powder is weighed 59.4kg, pressed
2-ketoacid total content and pH two indices are detected according to the methods of sampling, content is 49.1%, pH=7.45 to detection 2-ketoacid at long last, is accorded with
Internal control index is closed, then uniformly the adhesive of sprinkling feed powder gross weight 2% carries out tabletting into feed powder, obtains specification as 4g/ pieces
Effervescent tablet, packaging 20/pipe.It is a box that pipe dress effervescent tablet is set into the pipe of counting 10 automatically, and 72 boxes are dressed up in subpackage, dispense yield
96.9%.
Embodiment 3
The preparation method of effervescent tablet containing 2-ketoacid, comprises the following steps：
(1) in C levels area of toilet, humidity≤45% is controlled, temperature control is at 23-25 DEG C, by weight, weighs trehalose
4.0kg, α-ketoglutaric acid 2.0kg, α-one valine calcium 7.5kg, Alpha-hydroxy methionine 4.5kg, alpha-keto-leucine-calcium 7.5kg,
α -one isoleucine calcium 4.0kg, alpha-calcium picrolonate 3.0kg, α-Ketophenylalanine Calcium 3.0kg, Glu 1.0kg, amino second
Sour magnesium 0.5kg, carnosine zinc 0.5kg amount to 11 kinds of materials and are well mixed in double cone mixer, water-filling phase wet granulation of going forward side by side, mistake
Pelletizing machine, sieved from 120 μm of screen clothes, it is standby to be prepared into 2-ketoacid complex A, gross weight 38.7kg；
(2) by lysine 1.0kg, arginine 1.0kg, flavoring pineapple essence flavouring agent 1.5kg while in another blender
Wet granulation is carried out, crosses pelletizing machine and by 120 μm of screen clothes, is prepared into that 2-ketoacid complex B is standby, and weigh 3.7kg；
(3) 2-ketoacid complex A38.7g and complex B 3.7g are taken, the aqueous solution for being configured to 4% or so amounts to 1L, Xiang Shui
Alkaline conditioner is added in solution, and detects aqueous solution pH, pH to 7.35 is adjusted with alkaline conditioner sodium acid carbonate/sodium carbonate,
Alkaline conditioner weight 4.9g is recorded, determines alkaline conditioner and complex A, the proportioning of complex B；
(4) by alkaline conditioner and complex A, the proportioning of complex B, by 2-ketoacid complex A, complex B and alkalescence
Conditioning agent is added in blender and mixed, and well mixed feed powder is weighed 30kg, it is total to detect 2-ketoacid according to the methods of sampling
Content and pH two indices, content is 60.33%, pH=7.39 to detection 2-ketoacid at long last, meets internal control index, then into feed powder
Uniformly the adhesive of sprinkling feed powder gross weight 2% carries out tabletting, obtains the effervescent tablet containing 2-ketoacid that specification is 2g/ pieces, bag
10/pipe is filled, it is a box that pipe, which is filled effervescent tablet to set the pipe of counting 10 automatically, and 143 boxes are dressed up in subpackage, dispense yield 95.3%.
It can be obtained by data above, the preparation method of the effervescent tablet containing 2-ketoacid provided in the embodiment of the present invention, technique
Simply, it is easy to operate, it is green, the effervesce tablet health product using 2-ketoacid as principal component can quickly be made.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modification, equivalent substitution or improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
- A kind of 1. effervescent tablet containing 2-ketoacid, it is characterised in that：Include the component of following parts by weight：Wherein, the 2-ketoacid includes α-ketoglutaric acid, Alpha-hydroxy methionine；The 2-ketoacid salt include α-one valine calcium, Alpha-keto-leucine-calcium, α -one isoleucines calcium, alpha-calcium picrolonate, α-Ketophenylalanine Calcium.
- 2. the effervescent tablet containing 2-ketoacid as claimed in claim 1, it is characterised in that：The 2-ketoacid includes following parts by weight Several components：α-ketoglutaric acid 20-30 parts；Alpha-hydroxy methionine 40-70 parts；And/orThe 2-ketoacid salt includes the component of following parts by weight：
- 3. the effervescent tablet containing 2-ketoacid as claimed in claim 1 or 2, it is characterised in that：Also include alkaline conditioner, bonding Agent；Wherein, described adhesive dosage is the 2%-7% of remaining component weight.
- 4. the effervescent tablet containing 2-ketoacid as claimed in claim 3, it is characterised in that：The alkaline conditioner is sodium acid carbonate With the mixture of sodium carbonate, and the sodium acid carbonate and the sodium carbonate mass ratio are (0.3~0.5):1.
- 5. the preparation method of the effervescent tablet containing 2-ketoacid as described in claim any one of 1-4, it is characterised in that：At least wrap Include following steps：(1) after the trehalose, 2-ketoacid, 2-ketoacid salt, Glu, amion acetic acid, carnosine zinc being carried out into mixing treatment, Wet granulation, obtain complex A；(2) after lysine, arginine, flavouring agent being carried out into mixing treatment, wet granulation, complex B is obtained；(3) part complex A, complex B are taken respectively according to identical weight ratio, be configured to the aqueous solution, added into the aqueous solution Alkaline conditioner, adjust pH to 7.35-7.45, record alkaline conditioner and complex A, the proportioning of complex B；(4) remaining complex A, complex B and alkaline conditioner are subjected to mixing treatment according to the proportioning in step (3), obtained Mixed material；(5) adhesive that weight is mixed material gross weight 2-7% is uniformly sprayed onto in mixed material, carries out compressing tablet process, Obtain the effervescent tablet containing 2-ketoacid.
- 6. the preparation method of the effervescent tablet containing 2-ketoacid as claimed in claim 5, it is characterised in that：It is mixed in step (4) In compound material, counted using the gross weight of the mixed material as 100%, the gross weight percentage composition of 2-ketoacid and the 2-ketoacid salt For 40-70%.
- 7. the preparation method of the effervescent tablet containing 2-ketoacid as claimed in claim 5, it is characterised in that：In step (1), (2), The mixing treatment is realized using blender；The blender is that bipyramid or V-type bore blender.
- 8. the preparation method of the effervescent tablet containing 2-ketoacid as described in claim 5-7 is any, it is characterised in that：The wet method It is granulated and is realized by pelletizing machine, wet granulation is purified water or deionized water with water, and water temperature is 15-25 DEG C.
- 9. the preparation method of the effervescent tablet containing 2-ketoacid as described in claim 5-7 is any, it is characterised in that：The cooperation Thing A particle diameter≤120 μm；Particle diameter≤120 μm of complex B.
- 10. the preparation method of the effervescent tablet containing 2-ketoacid as described in claim 5-7 is any, it is characterised in that：The water The mass fraction of solution is 4%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110974749A (en) * | 2019-12-27 | 2020-04-10 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof |
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| CN102448452A (en) * | 2009-04-03 | 2012-05-09 | 赢创德固赛有限公司 | Dietary supplement comprising alpha keto acids for supporting diabetes therapy |
| CN102488686A (en) * | 2011-12-23 | 2012-06-13 | 武汉同源药业有限公司 | Compound a-keto acid tablet and preparation processes thereof |
| CN104146271A (en) * | 2014-08-27 | 2014-11-19 | 何瑞红 | Metabolism regulating and liver protecting nutritional supplement, preparation method and applications thereof |
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| CN102448452A (en) * | 2009-04-03 | 2012-05-09 | 赢创德固赛有限公司 | Dietary supplement comprising alpha keto acids for supporting diabetes therapy |
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| CN102018704A (en) * | 2009-09-23 | 2011-04-20 | 北京万生药业有限责任公司 | Compound preparation used for treating chronic kidney diseases and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110974749A (en) * | 2019-12-27 | 2020-04-10 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof |
| CN110974749B (en) * | 2019-12-27 | 2022-05-10 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof |
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| CN107549803B (en) | 2021-06-01 |
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