CN105982821A - Portable solid herbal mouthwash effervescent tablets and preparation method thereof - Google Patents

Portable solid herbal mouthwash effervescent tablets and preparation method thereof Download PDF

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Publication number
CN105982821A
CN105982821A CN201510332565.4A CN201510332565A CN105982821A CN 105982821 A CN105982821 A CN 105982821A CN 201510332565 A CN201510332565 A CN 201510332565A CN 105982821 A CN105982821 A CN 105982821A
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draft
acid
portable
effervescent tablet
tablet
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胡雅群
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Abstract

The invention discloses portable solid herbal mouthwash effervescent tablets and a preparation method thereof. The portable solid herbal mouthwash effervescent tablets are prepared from, by mass, 23-27 parts of herbal powder, 37-43% of an effervescence disintegrating agent, 0.5-1.5 parts of a binding agent, 4-6% of a lubricating agent, 22-25% of a filling agent and 4-6% of health protection ingredients. The effervescence disintegrating agent is prepared from an acid component and an alkali component, wherein citric acid is adopted as the acid component, and sodium bicarbonate is adopted as the alkali component. The portable solid herbal mouthwash effervescent tablets are obtained through the herbal powder preparation process, the granulation process, drying and tabletting. Acid granules and alkali granules are mixed evenly; the acid component and the alkali component are effectively isolated, the stability is improved, and the disintegration time is shortened. By the adoption of herbal plants, the portable solid herbal mouthwash effervescent tablets can effectively remove residues in the mouth, diminish inflammation, stop bleeding and remove ozostomia, and has the good effects of treating tooth sensitivity, clearing way heat and relieving exterior syndromes; the preparation method is simple and easy to implement, conditions are mild, and industrial production is promoted.

Description

A kind of portable draft solid effervescent tablet for rinsing mouth and preparation method thereof
Technical field
The present invention relates to HCT field, specifically a kind of portable draft solid effervescent tablet for rinsing mouth and preparation side thereof Method.
Background technology
At present, it is well known that all mouthwashes are liquid, also exist inconvenient to carry, can not boarding, easy leakage etc. all How inconvenient.And oral health is paid attention to all the more by people in actual life, gargling after meal brushes teeth has become as the custom of a lot of people, Simply suffer from mouthwash not Portable belt, it is difficult to real realization is gargled immediately in three minutes after meal and removed oral bacteria.Chewing gum Sugar and xylitol harmful and without profit, and chew that facial muscles can be caused to become big impact is attractive in appearance for a long time, Hen Duoai Beauty scholar hardly realizes why to play thin face pin, and long-time chew gum is one of major reason.
Content of the invention
It is an object of the invention to provide the portable draft solid effervescent tablet for rinsing mouth that a kind of stability is high, disintegration time is short and Preparation method, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of portable draft solid effervescent tablet for rinsing mouth, is grouped into according to the one-tenth of mass percent by following: draft powder art 23-27%, gas-producing disintegrant 37-43%, adhesive 0.5-1.5%, lubricant 4-6%, filler 22-25%, healthy protection Composition 4-6%;Described gas-producing disintegrant includes acid constituents and alkaline constituents.
As the further scheme of the present invention: described portable draft solid effervescent tablet for rinsing mouth, by following according to mass percent One-tenth be grouped into: draft powder the 25%th, gas-producing disintegrant the 40%th, adhesive the 1%th, lubricant the 5%th, filler is the 24%th, healthy Protective ingredient 5%;Described gas-producing disintegrant includes acid constituents and alkaline constituents.
As the further scheme of the present invention: draft powder packets containing peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, Aloe, witch hazel.
As the further scheme of the present invention: acid constituents uses citric acid, alkaline constituents uses sodium acid carbonate.
As the further scheme of the present invention: adhesive uses PVP ethanol water, for reducing the moisture absorption, moreover it is possible to use poly-second Alkene pyrrolidone and polyvinyl acetate copolymer.Make particle lubrication, reduce the friction with punch die and adhesion profit.
As the further scheme of the present invention: lubricant is made up of Macrogol 6000, sodium chloride, and Macrogol 6000, The mass ratio of sodium chloride is 2: 3.
As the further scheme of the present invention: filler uses glucose.
As the further scheme of the present invention: healthy protective ingredient comprise vitamin e, calcium, phosphate, lactotransferrin, Fluoride and potassium nitrate.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 50-60 DEG C, and extraction time is in extraction 3-5h, the addition of water is 5-8 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 50-60 DEG C, and extraction time is 2-3h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is at 10-15%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby;
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles;
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles;
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 3-4 ten thousand tablets h, adjust hardness, check smooth appearance Degree;Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 18-26 DEG C, checks simultaneously Record indoor relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
As the further scheme of the present invention: compressing tablet speed 3.6 ten thousand tablets h.
Compared with prior art, the invention has the beneficial effects as follows:
Peppermint dispelling wind and heat from the body in the present invention, the clear profit head, profit pharynx promoting eruption, soothing the liver promoting the circulation of qi.
Honeysuckle is cold in nature, and taste is sweet, enters lung, the heart, stomach warp, has effect clearing heat and detoxicating, that anti-inflammatory, qi-restoratives treat wind, cures mainly Disease, warm disease heating under turgor, the heat poison disease such as large carbuncle and tumour.It makees thirsty, hidrosis unhappiness, intestines for dizzy dizziness, dry Inflammation, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer malignant boil The illnesss such as sore, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Tea tree ethereal oil have bactericidal antiphlogistic, convergence pore, treatment cold, cough, rhinitis, asthma, improve dysmenorrhoea, The effect such as irregular menstruation and genital infection.Be applicable to oiliness and acne-prone skin, treatment suppurative wound and burn, tan severely, fragrant Hong Kong-feet and dandruff.Clear the head, rejuvenate, anti-depression.
The effect of chamomile and effect: mildly bitter flavor, Gan Xiang, improving eyesight, move back irascibility, treatment insomnia, reduces blood pressure, can strengthen Vigor, refresh oneself.Strengthen memory, reduce cholesterol.Expelling phlegm and arresting coughing, can effectively alleviate bronchitis and asthma, can relax The courbature that slow headache, antimigraine or flu cause, helpful to neutralization hydrochloric acid in gastric juice, calm nerves.Flu can be eliminated caused Courbature, can calm spirit, slow mood of relaxing, promote sleep quality, also can improve the skin of allergy.Helpful sleep, Moist skin, prolonged constipation can be controlled, anxiety, eye fatigue, moistening lung, health can be eliminated, and anxiety can be treated and anxiety is made The indigestion becoming, and insomnia, neuralgia and cramp, enterogastritis have all been benefited, mitigated headache.
Lavender has sleeping, antibacterial, effect for reducing fat.
Aloe purging intense heat;Removing toxic substances;Stagnation resolvation;Desinsection.Argument is red;Constipation;Gonorrhoea;Hematuria;Pediatric epilepsy scared;Infantile malnutrition due to digestive disturbances or intestinalparasites;Burn and scald Wound;Women's amenorrhoea;Hemorrhoid;Scabies;Carbuncle furuncle poison;Traumatic injury.Pharmacological action: bactericidal action, antiinflammatory action is wet Profit beautification function, lets out effect under stomach invigorating, the cardiac stimulant effect of invigorating blood circulation, immunity and palingenesis, immunity and antitumor action, removing toxic substances Effect, anti-aging effects, analgesia, sedation, anti-sunlight function.
Witch hazel benefit gas, main internal lesion caused by overexertion is weak.
The present invention uses peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, these herbaceous plant of witch hazel, Not only can effectively remove intraoral residue, also there is to hemodia excellent curative effect, and can anti-inflammation hemostasia, remove halitosis, There is the effect of excellent relieving superficies by cooling;Stable in properties of the present invention, preparation method is simple, mild condition, it is simple to industry Metaplasia is produced.Acid particles and alkali grain are mixed by the present invention.Both it had been effectively isolated acid constituents and alkaline constituents, added stability, Add again the dissolution velocity of sodium acid carbonate, greatly reduce disintegration time.The specification of the product that the present invention obtains is: 1) weight Amount: prepare average tablet weight 0.35g effervescent tablet, difference is less than or equal to 2.5%, averagely every gas production 8ml.2) hardness: Average hardness 5.74KgN, difference is less than or equal to 5.4%.3) disintegration time: 40 seconds average times, difference is less than or equal to 4.7%.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobvious So, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of portable draft solid effervescent tablet for rinsing mouth, by the following one-tenth packet according to mass percent Become: the 23.5%th, the healthy protection of draft powder the 23%th, gas-producing disintegrant the 43%th, adhesive the 0.5%th, lubricant the 4%th, glucose Composition 6%.Gas-producing disintegrant includes acid constituents and alkaline constituents.Acid constituents uses citric acid.Alkaline constituents uses sodium acid carbonate.Viscous Mixture uses PVP ethanol water.Lubricant is made up of Macrogol 6000, sodium chloride, and Macrogol 6000, chlorine The mass ratio changing sodium is 2: 3.Healthy protective ingredient comprises vitamin e, calcium, phosphate, lactotransferrin, fluoride With potassium nitrate.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 50 DEG C, and extraction time is 3h in extraction, The addition of water is 5 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 50 DEG C, and extraction time is 2h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is 10%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby.
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles.
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles.
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 30,000 tablets h, adjust hardness, check aesthetic finish; Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 18 DEG C, checks and in recording room Relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
Embodiment 2
In the embodiment of the present invention, a kind of portable draft solid effervescent tablet for rinsing mouth, by the following one-tenth packet according to mass percent Become: the 24.5%th, the healthy protection of draft powder the 27%th, gas-producing disintegrant the 37%th, adhesive the 1.5%th, lubricant the 6%th, glucose Composition 4%.Gas-producing disintegrant includes acid constituents and alkaline constituents.Acid constituents uses citric acid.Alkaline constituents uses sodium acid carbonate.Viscous Mixture is polyvinylpyrrolidone and polyvinyl acetate copolymer.Lubricant is made up of Macrogol 6000, sodium chloride, and Macrogol 6000, the mass ratio of sodium chloride are 2: 3.Healthy protective ingredient comprises vitamin e, calcium, phosphate, breast iron Transferrin, fluoride and potassium nitrate.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 60 DEG C, and extraction time is 5h in extraction, The addition of water is 8 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor.
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 60 DEG C, and extraction time is 3h, prepares extract.
D. making medicinal extract after concentrating above-mentioned extract, its water content is at 10-15%.
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby.
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles.
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles;
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 40,000 tablets h, adjust hardness, check aesthetic finish; Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 26 DEG C, checks and in recording room Relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
Embodiment 3
In the embodiment of the present invention, a kind of portable draft solid effervescent tablet for rinsing mouth, by the following one-tenth packet according to mass percent Become: the 22%th, the healthy protection of draft powder the 27%th, gas-producing disintegrant the 39.5%th, adhesive the 1.5%th, lubricant the 6%th, glucose Composition 4%.Gas-producing disintegrant includes acid constituents and alkaline constituents.Acid constituents uses citric acid.Alkaline constituents uses sodium acid carbonate.Viscous Mixture uses PVP ethanol water.Lubricant is made up of Macrogol 6000, sodium chloride, and Macrogol 6000, chlorine The mass ratio changing sodium is 2: 3.Healthy protective ingredient comprises vitamin e, calcium, phosphate, lactotransferrin, fluoride With potassium nitrate.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 52 DEG C, and extraction time is 3.5h in extraction, The addition of water is 6 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 52 DEG C, and extraction time is 2.2h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is 11%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby.
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles.
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles.
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 3.2 ten thousand tablets h, adjust hardness, check smooth appearance Degree;Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 20 DEG C, checks and record Indoor relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
Embodiment 4
In the embodiment of the present invention, a kind of portable draft solid effervescent tablet for rinsing mouth, by the following one-tenth packet according to mass percent Become: the 25%th, the healthy protection of draft powder the 23%th, gas-producing disintegrant the 41.5%th, adhesive the 0.5%th, lubricant the 4%th, glucose Composition 6%.Gas-producing disintegrant includes acid constituents and alkaline constituents.Acid constituents uses citric acid.Alkaline constituents uses sodium acid carbonate.Viscous Mixture uses polyvinylpyrrolidone and polyvinyl acetate copolymer.Lubricant is made up of Macrogol 6000, sodium chloride, And the mass ratio of Macrogol 6000, sodium chloride is 2: 3.Healthy protective ingredient comprises vitamin e, calcium, phosphate, breast Siderophillin, fluoride and potassium nitrate.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 58 DEG C, and extraction time is 4.5h in extraction, The addition of water is 7 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 58 DEG C, and extraction time is 2.8h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is 14%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby.
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles.
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles.
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 3.7 ten thousand tablets h, adjust hardness, check smooth appearance Degree;Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 18-26 DEG C, checks simultaneously Record indoor relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
Embodiment 5
In the embodiment of the present invention, a kind of portable draft solid effervescent tablet for rinsing mouth, by the following one-tenth packet according to mass percent Become: draft powder the 25%th, gas-producing disintegrant the 40%th, adhesive the 1%th, lubricant the 5%th, filler the 24%th, healthy protective ingredient 5%.Gas-producing disintegrant includes acid constituents and alkaline constituents.Acid constituents uses citric acid.Alkaline constituents uses sodium acid carbonate.Adhesive Use PVP ethanol water.Lubricant is made up of Macrogol 6000, sodium chloride, and Macrogol 6000, sodium chloride Mass ratio be 2: 3.Healthy protective ingredient comprises vitamin e, calcium, phosphate, lactotransferrin, fluoride and nitre Acid potassium.
The preparation method of described portable draft solid effervescent tablet for rinsing mouth, comprises the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 55 DEG C, and extraction time is 3-5h in extraction, The addition of water is 6.5 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 55 DEG C, and extraction time is 2.5h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is 12%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby.
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles.
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles.
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 3.6 ten thousand tablets h, adjust hardness, check smooth appearance Degree;Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 24 DEG C, checks and record Indoor relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
The specification of the product obtaining in above-described embodiment is: 1) weight: preparing average tablet weight 0.35g effervescent tablet, difference is little In equal to 2.5%, averagely every gas production 8ml.2) hardness: average hardness 5.74KgN, difference is less than or equal to 5.4%.3) Disintegration time: 40 seconds average times, difference is less than or equal to 4.7%.
The mechanism of action of the present invention is that acid-base reaction produces carbon dioxide.During for preventing preparation, the citric acid moisture absorption is easily reacted with alkali, Can soda acid pelletize respectively;Citric acid and filler are sufficiently mixed grinding, use adhesive to pelletize;With lubricator wrap up carbonic acid Hydrogen sodium reduces soda acid contact, and after cooling, drying and crushing is pelletized together with composition again.
The key instrument equipment relating in the present invention is precision acidity meter, freeze drying equipment, vacuum drying chamber, water-bath Pot, evaporimeter, vacuum pump using circulatory water, pulverizer, small-sized seed-coating machine, single-punch tablet press, tablet analyzer.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter from From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but not each embodiment only comprises One independent technical scheme, this narrating mode of specification is only for clarity sake, and those skilled in the art should be by Specification is as an entirety, and the technical scheme in each embodiment also can be through appropriately combined, and forming those skilled in the art can With other embodiments understanding.

Claims (10)

1. a portable draft solid effervescent tablet for rinsing mouth, it is characterised in that be grouped into according to the one-tenth of mass percent by following: Draft powder 23-27%, gas-producing disintegrant 37-43%, adhesive 0.5-1.5%, lubricant 4-6%, filler 22-25%, Healthy protective ingredient 4-6%;Described gas-producing disintegrant includes acid constituents and alkaline constituents.
2. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that draft powder packets contains thin Lotus, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel.
3. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that acid constituents uses lemon Acid, alkaline constituents uses sodium acid carbonate.
4. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that adhesive uses PVP Ethanol water, or use polyvinylpyrrolidone and polyvinyl acetate copolymer.
5. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that lubricant is by poly-second two Alcohol the 6000th, sodium chloride forms, and the mass ratio of Macrogol 6000, sodium chloride is 2: 3.
6. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that filler uses grape Sugar.
7. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that healthy protective ingredient bag Containing vitamin e, calcium, phosphate, lactotransferrin, fluoride and potassium nitrate.
8. portable draft solid effervescent tablet for rinsing mouth according to claim 1, it is characterised in that by following according to quality The one-tenth of percentage is grouped into: draft powder the 25%th, gas-producing disintegrant the 40%th, adhesive the 1%th, lubricant the 5%th, filler is the 24%th, Healthy protective ingredient 5%;Described gas-producing disintegrant includes acid constituents and alkaline constituents.
9. a preparation method for the portable draft solid effervescent tablet for rinsing mouth as described in claim 1-8 is arbitrary, its feature exists In comprising the steps:
1) draft powder preparing processes
A. dry after peppermint, honeysuckle, tea tree ethereal oil, chamomile, lavender, aloe, witch hazel being cleaned, insert powder Broken machine is pulverized, and crosses 100-180 mesh sieve;
B. add water extraction again by the draft of above-mentioned pulverizing, and twice, each extraction temperature is 50-60 DEG C, and extraction time is in extraction 3-5h, the addition of water is 5-8 times of the draft gross mass of above-mentioned pulverizing, merges leaching liquor;
C. extracting above-mentioned leaching liquor ethanol, extraction temperature is 50-60 DEG C, and extraction time is 2-3h, prepares extract;
D. making medicinal extract after concentrating above-mentioned extract, its water content is at 10-15%;
E. medicinal extract is inserted in freeze drying equipment and carry out freeze-drying, be ground into draft powder standby;
2) pelletization
With lubricator wrapping up after pulverizing alkaline constituents, adding the adhesive of half, granulation after mixing prepares alkali grain; Granulation after mixing with the adhesive of other half after pulverizing acid constituents prepares acid particles;
3) it is dried: alkali grain and acid particles are inserted in vacuum drying chamber, heat source temperature 80 DEG C, product maximum temperature 58℃;After startup so that it is vacuum drying during stirring, upset, tilt, vacuum degree control at below 100mbar, Moisture controls below 0.15%, begins to cool down, and is cooled to 30 DEG C, closes vacuum drying chamber, prepares dried alkalescence Grain and acid particles;
4) compressing tablet: draft powder, filler, healthy protective ingredient, dried alkali grain are mixed with acid particles Uniformly, insert and single-punch tablet press carries out compressing tablet, compressing tablet speed 3-4 ten thousand tablets h, adjust hardness, check smooth appearance Degree;Timing sampling checks average tablet weight and hardness, checks and records indoor temperature and controlled at 18-26 DEG C, checks simultaneously Record indoor relative humidity is simultaneously controlled below 20%, obtains portable draft solid effervescent tablet for rinsing mouth.
10. the preparation method of portable draft solid effervescent tablet for rinsing mouth according to claim 9, it is characterised in that pressure Piece speed 3.6 ten thousand tablets h.
CN201510332565.4A 2015-06-14 2015-06-14 Portable solid herbal mouthwash effervescent tablets and preparation method thereof Pending CN105982821A (en)

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CN106619318A (en) * 2017-02-07 2017-05-10 泉州医学高等专科学校 Making method of herbal effervescent tablets for rinsing mouth
CN107510747A (en) * 2017-08-04 2017-12-26 上海中华药业南通有限公司 A kind of effervescent tablet for rinsing mouth and preparation method thereof
CN110302126A (en) * 2019-07-30 2019-10-08 攀枝花学院 Gargle tablet and preparation method thereof containing artificial saliva
CN110522714A (en) * 2019-08-29 2019-12-03 哈尔滨医科大学 A kind of dark plum mouthwash effervescent tablet and preparation method thereof with rush salivary secretion effect
CN110974749A (en) * 2019-12-27 2020-04-10 广州市科能化妆品科研有限公司 Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106619318A (en) * 2017-02-07 2017-05-10 泉州医学高等专科学校 Making method of herbal effervescent tablets for rinsing mouth
CN107510747A (en) * 2017-08-04 2017-12-26 上海中华药业南通有限公司 A kind of effervescent tablet for rinsing mouth and preparation method thereof
CN110302126A (en) * 2019-07-30 2019-10-08 攀枝花学院 Gargle tablet and preparation method thereof containing artificial saliva
CN110522714A (en) * 2019-08-29 2019-12-03 哈尔滨医科大学 A kind of dark plum mouthwash effervescent tablet and preparation method thereof with rush salivary secretion effect
CN110974749A (en) * 2019-12-27 2020-04-10 广州市科能化妆品科研有限公司 Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof
CN110974749B (en) * 2019-12-27 2022-05-10 广州市科能化妆品科研有限公司 Soothing and repairing composition, soothing and repairing solid preparation and preparation method thereof

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Application publication date: 20161005