CN110638849A - Compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol and preparation method thereof - Google Patents
Compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol and preparation method thereof Download PDFInfo
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- CN110638849A CN110638849A CN201910992561.7A CN201910992561A CN110638849A CN 110638849 A CN110638849 A CN 110638849A CN 201910992561 A CN201910992561 A CN 201910992561A CN 110638849 A CN110638849 A CN 110638849A
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- polysaccharide
- polyphenol
- kiwi fruit
- effervescent tablet
- fruit peel
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Abstract
The invention discloses a compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol, which comprises the following components: 12-24% of pueraria polysaccharide, 12-24% of kiwi fruit peel polyphenol, 26% of sodium bicarbonate, 2-5% of PEG6000, 8-16% of citric acid, 8-16% of tartaric acid, 2-4% of mannitol, 2-4% of aspartame and 2-4% of PVP ethanol solution; the invention also provides a corresponding preparation method, which comprises the steps of extracting the kiwi fruit peel polyphenol, extracting the kudzu root polysaccharide, sieving, preparing the soft material, preparing the premixed dry granules, mixing the powder, sterilizing and tabletting. According to the invention, the kiwi fruit peel waste residue and the kudzu root dregs are used as compound raw materials and are used as effective components for resisting oxidation and eliminating free radicals of a human body to prepare the unique polyphenol polysaccharide compound effervescent tablet, so that the health-care effect of the effervescent tablet is greatly improved on the premise of ensuring the absorption efficiency of the human body on polyphenol polysaccharide; and the raw materials are cheap, the process is simple, and the environment-friendly standard is met.
Description
Technical Field
The invention relates to the technical field of effervescent tablet compounding, in particular to a compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol and a preparation method thereof.
Background
The effervescent tablet is a novel tablet which can rapidly complete disintegration in water and release a large amount of gas in the dissolving process, and is divided into an external type and an oral type; the shape is usually circular, and the diameter can be adjusted according to the needs. The effervescent tablet has the advantages of convenient carrying, good taste and good patient compliance, and simultaneously, the direct contact area between the medicine and the pathological change part can be increased due to a large amount of foams generated during the disintegration of the effervescent tablet, so that the medicine effect can be better exerted, and the effervescent tablet has better market application prospect.
Polyphenols are a generic term for substances having a chemical structure containing a benzene ring and a plurality of hydroxyl groups, and include flavonoids, tannins, phenolic acids, anthocyanins, and the like. Researches find that the polyphenol substances have various pharmacological and biological activities, such as stronger astringency, hemostasis and antibiosis effects; resisting oxidation, reducing lipid peroxidation, and protecting cell membrane lipid layer structure; preventing cancer, arteriosclerosis, myocardial infarction, cerebral embolism, resisting aging, enhancing immunity and the like, and has wide application prospect in the fields of medicines, foods, cosmetics and the like.
The polysaccharide is formed by condensing and dehydrating a plurality of monosaccharide molecules, the molecular weight can be from tens of thousands to tens of millions, and the polysaccharide is a general name for a class of carbohydrate substances with complex and huge molecular structures. The polysaccharide is one of four basic substances forming a living body, participates in multiple physiological processes, and has multiple biological activities of resisting aging, resisting tumors, enhancing immunity, reducing blood sugar, resisting viruses and the like.
The compounding mechanism and action of the phenol sugar are as follows: the compounding mechanism of polyphenol and polysaccharide comprises two interaction modes of non-covalent and covalent: when polyphenol and polysaccharide are physically mixed, the system mainly takes non-covalent interactions such as hydrogen bond, hydrophobic interaction, ionic interaction and the like as driving forces to induce the polyphenol and the polysaccharide to form reversible or irreversible polyphenol-polysaccharide complexes; whereas covalent interactions are initiated mainly by the o-quinone mechanism of enzymatic or non-enzymatic oxidation.
The compounded phenolic sugar can generate the following three effects: (a) after the polysaccharide chain is introduced, the hydrophilic characteristic of the polyhydroxy group can obviously improve the solubility of the whole molecule; (b) after compounding, the capability of eliminating ABTS free radicals is obviously enhanced due to the synergistic interaction between the polyphenol and the polysaccharide; (c) the reduction performance of the polyphenol and the polysaccharide is also improved.
At present, the production of polyphenol polysaccharide compound products in China is still in the initial stage, and if the advantages and the characteristics of the effervescent tablets formed after the polyphenol polysaccharide is compounded can be well exerted, the prospect is great.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol comprises the following components in percentage by weight:
12-24% of pueraria polysaccharide;
kiwi peel polyphenol, 12-24%;
sodium bicarbonate, 26%;
PEG6000,2-5%;
8-16% of citric acid;
tartaric acid, 8-16%;
2-4% of mannitol;
aspartame, 2-4%;
PVP ethanol solution with concentration of 6 percent and 2 to 4 percent.
In addition, the invention also provides a compound effervescent tablet of kudzu root polysaccharide and kiwi fruit peel polyphenol with optimized proportion, which comprises the following components in percentage:
18% of pueraria polysaccharide;
kiwi peel polyphenol, 18%;
sodium bicarbonate, 26%;
PEG6000,3%;
12% of citric acid;
12% of tartaric acid;
mannitol, 4%;
aspartame, 4%;
PVP ethanol solution with a concentration of 6%, 3%.
The invention also provides a preparation method of the compound effervescent tablet of the pueraria polysaccharide and the kiwi fruit peel polyphenol, which comprises the following steps:
1) extracting kiwi fruit peel polyphenol: extracting the kiwi fruit peel waste residue with a mixture of acetone and water (molar ratio 1: 1) at 30-50 deg.C for 1-2 h; centrifuging to remove skin residue to obtain supernatant, and boiling at 50-70 deg.C to obtain concentrated solution; sequentially carrying out freeze drying, crushing and sieving to obtain kiwi peel polyphenol powder A for later use;
2) extracting pueraria polysaccharide: placing radix Puerariae residue in Soxhlet extractor, extracting with 80% ethanol at reflux temperature of 80-100 deg.C for 2-4 hr; centrifuging to remove residue, and boiling the supernatant at 60-85 deg.C to obtain concentrated solution; sequentially carrying out freeze drying, crushing and sieving to obtain pueraria polysaccharide powder B for later use;
3) sieving: weighing the powders of the pueraria polysaccharide, the kiwi fruit peel polyphenol, the sodium bicarbonate, the citric acid, the tartaric acid, the mannitol, the aspartame and the PEG6000 in corresponding proportion according to the formula proportion, respectively grinding, and sieving with a 100-mesh sieve to ensure the mixing effect;
4) preparing a soft material: sieving and mixing sodium bicarbonate, citric acid, tartaric acid and mannitol, slowly spraying PVP ethanol solution with mass fraction of 6%, and continuously stirring to obtain soft material C with moderate hardness;
5) preparation of premixed dry granules: sieving the soft material C with 100 mesh sieve to make the soft material A into granules, spreading the prepared mixed wet granules in an enamel tray, drying at 65 ℃ until the water content is below 0.5%, pulverizing, and sieving with 80 mesh sieve to obtain premixed dry granules D;
6) powder mixing: fully mixing the premixed dry particles D with kiwi fruit peel polyphenol powder A, kudzu root polysaccharide powder B, PEG6000 (lubricant), aspartame (flavoring agent) and the like, and placing the mixture in a tabletting groove to obtain powder blank E;
7) tabletting and sterilizing: and (3) carrying out ultraviolet sterilization on the powder blank E by adopting an ultraviolet sterilization machine, and tabletting the powder blank E by adopting a tablet punching machine to obtain a finished product of the composite effervescent tablet F.
Preferably, the powder of the kudzu vine root polysaccharide, the kiwi fruit peel polyphenol, the sodium bicarbonate, the citric acid, the tartaric acid, the mannitol, the aspartame and the PEG6000 obtained in the step 3) is placed in a vacuum drying oven for storage and standby, the temperature of the oven is 30-40 ℃, and the vacuum pressure is 5-10 kPa.
Preferably, the humidity of the environment of the production workshop from the step 2) to the step 7) is 5-10%, and a dehumidifier is provided.
Preferably, the stirring of the soft material C in the step 4) is performed by a colloid mill.
Compared with the prior art, the invention has the beneficial effects that:
the invention relates to a phenol sugar compound effervescent tablet which adopts Chinese gooseberry peel and kudzu root as raw materials, in the conventional industrial processing, most of the Chinese gooseberry peel rich in polyphenol is thrown away as waste residue, and the residual dregs of kudzu root after flavone is extracted contain a large amount of polysaccharide and are generally discarded. The preparation method comprises granulating polysaccharide and polyphenol extract, adding adjuvants such as disintegrant, diluent, binder, lubricant and correctant, sieving, making soft material, drying, pulverizing, mixing, and pressing to obtain the final product.
The phenolic sugar compound effervescent tablet is a scientific composition formula and has the four characteristics of greenness of raw materials, scientific formula, optimized taste and wide applicable population. The formula and the process of the phenolic sugar compound effervescent tablet improve the compound effect of polyphenol polysaccharide, so that the health-care effect of the effervescent tablet is obviously improved. If the product can be quickly brought to the market, the product can be popular with different people, and a choice is added for health care aspects of beautifying, resisting oxidation, enhancing immunity and the like for Chinese people.
Drawings
FIG. 1 shows the extraction process of kiwi fruit peel polyphenol according to the present invention;
FIG. 2 shows the extraction process of pueraria polysaccharide according to the present invention;
FIG. 3 is a main process flow chart for preparing the phenolic sugar composite effervescent tablet provided by the invention;
fig. 4 is a simple mechanism for removing DPPH and GO radicals by polyphenol-polysaccharide complexes proposed by the present invention [ reference 1: interaction of tea polyphenols and polysaccharides: research progress on change of action mechanism and functional characteristics, tourmaline, Wulong, Chenxiaoqiang, Chenschlingling and the like, tea science, 2019, 39 (2): 203-210].
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1, experimental formulation 1:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 2, formulation 2 used for the experiment:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 3, formulation 3 used for the experiment:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 4, experimental formula 4:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 5, formulation 5 used for the experiment:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 6, formulation 6 used for the experiment:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 7, experimental formula 7:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 8, experimental formulation 8:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 9, experimental formulation 9:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
Example 10, experimental formulation 10:
accurately weighing the crushed raw materials according to the prescription proportion, and uniformly mixing the materials; slowly spraying PVP ethanol solution with the mass fraction of 6% to prepare a soft material; drying and tabletting at 65 ℃.
In examples 1-10 above, ABTS: the Chinese name is 2, 2' -biazonitrogen-bis-3-ethylbenzothiazoline-6-sulfonic acid, which is a chemical free radical and is commonly used as a reagent for detecting the total antioxidant capacity; PEG 6000: polyethylene glycol 6000; PVP: polyvinylpyrrolidone.
The invention provides a mechanism for eliminating free radicals in a human body by compounding polysaccharide and polyphenol, and a reference document shows research progress of interaction mechanism of polysaccharide and polyphenol and influence thereof on polyphenol characteristics, Wangliang, Lifuxiang, Yangxuan, Tangyu, Liyao, Shifang, Mingjian, food science 2016-11-08. Researches show that after polyphenol is combined with polysaccharide, the number and the types of groups for providing protons are increased, the free radical reaction is blocked more effectively, and the antioxidation enhancement mechanism is shown in figure 4.
The invention relates to a phenol sugar compound effervescent tablet which adopts Chinese gooseberry peel and kudzu root as raw materials, in the conventional industrial processing, most of the Chinese gooseberry peel rich in polyphenol is thrown away as waste residue, and the residual dregs of kudzu root after flavone is extracted contain a large amount of polysaccharide and are generally discarded. The preparation method comprises granulating polysaccharide and polyphenol extract, adding adjuvants such as disintegrant, diluent, binder, lubricant and correctant, sieving, making soft material, drying, pulverizing, mixing, and pressing to obtain the final product.
The invention provides a phenolic sugar compound effervescent tablet with absorption efficiency by combining the characteristic of easy absorption of the effervescent tablet, extracting the pueraria polysaccharide and the kiwi fruit peel polyphenol from residues in the food extraction industry and compounding the pueraria polysaccharide and the kiwi fruit peel polyphenol as effective components for resisting oxidation and eliminating free radicals of a human body.
The phenolic sugar compound effervescent tablet is a scientific composition formula and has the four characteristics of greenness of raw materials, scientific formula, optimized taste and wide applicable population. The formula and the process of the phenolic sugar compound effervescent tablet improve the compound effect of polyphenol polysaccharide, so that the health-care effect of the effervescent tablet is obviously improved. If the product can be quickly brought to the market, the product can be popular with different people, and a choice is added for health care aspects of beautifying, resisting oxidation, enhancing immunity and the like for Chinese people.
The disintegration test of the phenolic sugar compound effervescent tablet of the invention is as follows: each group of effervescent tablets prepared in the examples 1-10 is respectively and randomly taken out 6 effervescent tablets, and the effervescent tablets are respectively placed in 200mL of 60 ℃ warm water, and can be disintegrated within 4min without residual aggregation granules; and each of the effervescent tablets of examples 1-10 did not exhibit a small range of explosions during dissolution.
Reference specification: the requirement of the effervescent tablet in the 0921 disintegration time limit inspection method of the four ministry of the pharmacopoeia of the people's republic of China is as follows: taking 1 tablet, placing in 250ml beaker (containing 200ml of water at 20 deg.C + -5 deg.C), i.e. many bubbles are released, and when the gas around the tablet or fragment stops escaping, the tablet should be dissolved or dispersed in water without aggregated particles remaining. Unless otherwise specified, 6 tablets were examined in the same way, and each tablet should disintegrate within 5 minutes. If 1 tablet can not be completely disintegrated, 6 tablets should be taken for retesting, and all the results are in accordance with the regulations. "
And (4) supplementary notes: if a small range of explosion phenomena exist in the effervescent tablet dissolution process, the phenomenon indicates that the bubbles generated by the reaction are too much or cannot be rapidly released in a short time, and the specific reasons can be as follows: (1) the effervescent tablet has unreasonable prescription: the acid and alkali content in the formula is too high, so that excessive carbon dioxide is generated in the reaction process, liquid is brought out in the gas rising process, and the phenomenon of 'bumping' is caused; (2) the preparation process of the effervescent tablet is unreasonable, and particularly, the pressure applied during tabletting is overlarge: the hardness of the effervescent tablet is too high, so that excessive gas is generated inside the effervescent tablet when the effervescent tablet is dissolved, and the outer part of the effervescent tablet is not broken and released; when the internal pressure is too high, the constraint outside the tablet is broken, a large amount of gas is released in a short time, and a small-range explosion phenomenon is easily caused. However, this was not observed with effervescent tablets prepared by the formulations described in examples 1-10 of the present application.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. A compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol is characterized by comprising the following components in percentage by weight:
12-24% of pueraria polysaccharide;
kiwi peel polyphenol, 12-24%;
sodium bicarbonate, 26%;
PEG6000,2-5%;
8-16% of citric acid;
tartaric acid, 8-16%;
2-4% of mannitol;
aspartame, 2-4%;
PVP ethanol solution with concentration of 6 percent and 2 to 4 percent.
2. The compound effervescent tablet of kudzu root polysaccharide and kiwi fruit peel polyphenol according to claim 1, is characterized by comprising the following components in percentage:
18% of pueraria polysaccharide;
kiwi peel polyphenol, 18%;
sodium bicarbonate, 26%;
PEG6000,3%;
12% of citric acid;
12% of tartaric acid;
mannitol, 4%;
aspartame, 4%;
PVP ethanol solution with a concentration of 6%, 3%.
3. A preparation method of a compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol is characterized by comprising the following steps:
1) extracting kiwi fruit peel polyphenol: extracting the kiwi fruit peel waste residue with a mixture of acetone and water (molar ratio 1: 1) at 30-50 deg.C for 1-2 h; centrifuging to remove skin residue to obtain supernatant, and boiling at 50-70 deg.C to obtain concentrated solution; sequentially carrying out freeze drying, crushing and sieving to obtain kiwi peel polyphenol powder A for later use;
2) extracting pueraria polysaccharide: placing radix Puerariae residue in Soxhlet extractor, extracting with 80% ethanol at reflux temperature of 80-100 deg.C for 2-4 hr; centrifuging to remove residue, and boiling the supernatant at 60-85 deg.C to obtain concentrated solution; sequentially carrying out freeze drying, crushing and sieving to obtain pueraria polysaccharide powder B for later use;
3) sieving: according to the formula proportion of claim 1 or 2, weighing the powders of pueraria polysaccharide, kiwi fruit peel polyphenol, sodium bicarbonate, citric acid, tartaric acid, mannitol, aspartame and PEG6000 in corresponding proportion, respectively grinding, and sieving with a 100-mesh sieve to ensure the mixing effect;
4) preparing a soft material: sieving and mixing sodium bicarbonate, citric acid, tartaric acid and mannitol, slowly spraying PVP ethanol solution with mass fraction of 6%, and continuously stirring to obtain soft material C with moderate hardness;
5) preparation of premixed dry granules: sieving the soft material C with 100 mesh sieve to make the soft material A into granules, spreading the prepared mixed wet granules in an enamel tray, drying at 65 ℃ until the water content is below 0.5%, pulverizing, and sieving with 80 mesh sieve to obtain premixed dry granules D;
6) powder mixing: fully mixing the premixed dry particles D with kiwi fruit peel polyphenol powder A, kudzu root polysaccharide powder B, PEG6000 (lubricant), aspartame (flavoring agent) and the like, and placing the mixture in a tabletting groove to obtain powder blank E;
7) tabletting and sterilizing: and (3) carrying out ultraviolet sterilization on the powder blank E by adopting an ultraviolet sterilization machine, and tabletting the powder blank E by adopting a tablet punching machine to obtain a finished product of the composite effervescent tablet F.
4. The preparation method of the compound effervescent tablet of pueraria polysaccharide and kiwi fruit peel polyphenol according to claim 3, wherein the powder of pueraria polysaccharide, kiwi fruit peel polyphenol, sodium bicarbonate, citric acid, tartaric acid, mannitol, aspartame and PEG6000 obtained in step 3) is stored in a vacuum drying oven for later use, wherein the temperature of the oven is 30-40 ℃, and the vacuum pressure is 5-10 kPa.
5. The preparation method of the compound effervescent tablet of pueraria polysaccharide and actinidia chinensis polyphenol as claimed in claim 3, wherein in the steps 2) to 7), the humidity of the preparation environment is controlled to be 5-10% by a dehumidifier.
6. The method for preparing the composite effervescent tablet of pueraria polysaccharide and actinidia chinensis polyphenol as claimed in claim 3, wherein the step 4) is performed by stirring the soft material C with a colloid mill.
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