CN110029026A

CN110029026A - A kind of sterilizing and itch-relieving medicated soap and preparation method thereof

Info

Publication number: CN110029026A
Application number: CN201910450929.7A
Authority: CN
Inventors: 张慧君; 张凯; 张翔
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-05-28
Filing date: 2019-05-28
Publication date: 2019-07-19

Abstract

The invention discloses a kind of sterilizing and itch-relieving medicated soaps and preparation method thereof, ozone by being fixed in ozone salt and reaching bactericidal and bacteriostatic effect using the effect of the efficient sterilizing of ozone by medicated soap of the present invention, the Chinese herbal medicine and essential oil using a variety of with antipruritic effect reduce itch caused by skin allergy simultaneously, and with giant salamander mucus protein extract, house oil, badger fat and ambergris mutual cooperation nourishes rough skin, itch caused by preventing because of drying and dry and cracked.The present invention is using neutral soap formula and is aided with foaming agent, when use smooth exquisiteness, non-stimulated to skin, skin-friendly is good, and the addition of bulky grain sea salt can make medicated soap hardness and plasticity more preferable, more conducively industrialized production.Protease hydrolyzed and using for natural plant raw material make safety coefficient of the invention higher in preparation process of the present invention, eliminate the risk of allergy.

Description

A kind of sterilizing and itch-relieving medicated soap and preparation method thereof

Technical field

The present invention relates to medicated soap manufacture field, in particular to a kind of sterilizing and itch-relieving medicated soap and preparation method thereof.

Background technique

The crystal phase structure of conventional solid soap is one of basic theory of soap.This also embodies the microcosmic knot of substance Structure determines the viewpoint of its macroscopic property.At abroad, modern framing of soap technique, whether soap preparing process process, or behaviour Make condition, will be selected meticulously according to the determination data of bar soap crystal phase structure, to change soap as far as possible At best crystal phase, guarantee that soap has excellent physical and chemical performance and quality index appearance.Therefore, understand and grasp solid fertilizer The knowledge of soap crystal phase structure to design, selection and is grasped framing of soap technique and operating condition, is had a very important significance.

When a small amount of surfactant is added in soap as modifying agent, these surfactants are referred to as calcium soap dispersion Agent.And when the content of the sodium soap in solid soap gradually decreases, other can be used for the anionic surfactant concentration washed Gradually increase in solid soap, eventually become bulk composition, material is thus formed synthesis of detergent soap blanks.Synthesis of detergent soap blank is also One kind in compound soap.The surfactant for having some compound soaps to use belongs to mild, and the synthetic surfactant used Content is greater than 50%, pH is adjusted by adding some inorganic salts or weak acid and weak base class formula in process, to reach most Whole compound soap when in use system pH close to 7 or the pH close to skin purpose, this soap to skin as mild as a dove, will not Cause to generate very strong irritation to skin due to degreasing power is strong because soap body alkalinity is too strong, usually we claim this mild compound soap For neutral soap.

Currently, the surfactant of most common manufacture neutral soap is fatty phthalidyl sodium isethionate, trade name Yi Jiebang A or Igepon A.The tissue of solid soap is made of the crystallinity fiber containing water.Therefore, add in soap Enter compound soap made of lime soap dispersant and builder, not only overcome the native defect of soap, so that it is had both synthesis and wash Wash agent and soap it is common a little.The biggest advantage is to mildly non-stimulated to skin, detergency is moderate, and it is preferable to wash rear skin sense.

Ozone (O₃) it is oxygen (O₂) allotrope, it is a kind of light blue gas with special odor.Its density It is 1.5 times of oxygen, solubility in water is 10 times of oxygen.Ozone is a kind of strong oxidizer, its oxidation in water is also Former current potential is 2.07eV, is only second to fluorine (2.5eV), and oxidability is higher than chlorine (1.36eV) and chlorine dioxide (1.5eV), can be broken The cell wall of bad decomposing bacteria, soon diffusion penetrates into intracellular, Portugal necessary to oxygenolysis bacterium internal oxidation glucose Grape carbohydrate oxidase etc. can also directly have an effect with bacterium, virus, destroy cell, ribonucleic acid (RNA), decompose deoxidation core The macromolecule polyalcohols such as ribosomal ribonucleic acid (DNA), RNA, protein, lipid and polysaccharide, make bacterium metabolism and reproductive process by It destroys.Bacterium is caused by the fracture of cell membrane by ozone kill, this process is referred to as cell lysis, is since cytoplasm exists Caused by being crushed in water, cell can not regenerate under conditions of dissipation.It should be pointed out that it is different from hypochlorous acid class disinfectant, The sterilizing ability of ozone is not influenced by pH value variation and ammonia, and sterilizing ability is 600-3000 times bigger than chlorine, its sterilizing, disinfection What effect almost instantaneously occurred, it, can lethal bacterium in 0.5~1min in water when 0.3~2mg/L of ozone concentration.It reaches It is only the 0.0048% of chlorine to Ozone Water pharmaceutical quantities needed for identical sterilization effect (as made Escherichia coli killing rate up to 99%).

When common fats acid soda soap is used for Irrigation, irritation is generated to eyes, and the natural pH of skin is caused to become after using Obtain meta-alkalescence.It is mildly non-stimulated when neutral soap cleaning skin, it is also non-stimulated to eyes, also have simultaneously without alkaline moisturizer excellent Elegant clean-up performance adds synthetic detergent into soap, service performance of the soap in hard water and cold water can be improved, but It is then unsatisfactory on foaming properties.Currently, the use of the surfactant of non-soap being the soap bar of main composition, contain in high moisture content Unsatisfactory in the case of amount, solubility property is also not so good, and degreasing power is too strong on the skin, lack common soap have that Kind of lubrication sense, it is difficult to be processed with standard soapmaking machine, the disadvantages of frangible while adhesiveness is poor or soap bar itself is excessively soft. When as use main composition of the surfactant of non-soap as soap bar, the range of pH selects extremely important usually 4.5 to 9.5 Between, soap bar foaming properties can be reduced rapidly when pH is more than 9.5.It is most when selecting the main composition of soap bar internal surfactants Require pH 7 or so, otherwise surfactant be easy hydrolysis perhaps decompose and this pH be 7 or close to 7 soap bar be Neutral soap described in us.Ideal neutral soap needs to have some characteristics, for example, neutral soap should use skin other When surface, the detergency that no matter has been all had in hard water, soft water, seawater, hot water or cold water.It is equal in all types of water Outstanding foaming properties are shown, it is mildly non-stimulated to skin.It should also have the appearance of a pleasant, be easy to after use Rinsing, possesses comfortable feeling after.Neutral soap itself should show to be not easy to soften, mashed, crystallization, fragmentation, drying or Decomposition is generated under condition of storage.In addition, it can should be produced with the soapmaking equipment of standard.

Summary of the invention

The technical problems to be solved by the invention: for various problems present in current perfumed soap production process and product and Defect, the present invention provide a kind of sterilizing and itch-relieving medicated soap extremely preparation method.

In order to solve the above technical problems, the present invention provides technical solution below:

A kind of sterilizing and itch-relieving medicated soap, the raw material comprising ozone salt, Igepon A and following parts by weight: 5 ~10 parts of Groomwell root oils, 2~6 parts of evening primrose oil, 3~8 parts of rose ethereal oils, 4~8 parts of root of kirilow rhodiola essential oils, 5~8 parts of wormwood essential oils, 0.5~10 part of giant salamander pituitary extract, 1~5 part of tremella polysaccharides, 20~35 parts of antipruritic water extract of TCM, 20~30 parts of cocounut oil acyls Amine propyl betaine, 25~40 parts of foaming agents, 150~250 parts of cocoyl isethionates, 50~75 parts of neat soaps；It is described smelly Oxonium salt is prepared by 20~30 parts by weight sea salt and 2~15 parts by weight honey load ozone；The fatty acyl hydroxyethyl sulphur Sour sodium is reacted through 20~40 wt parts of olive oil, 25~45 parts by weight animal fats and 35~80 parts by weight sodium isethionates to be made It is standby to form；

The antipruritic water extract of TCM extracts processing by the Chinese herbal medicine of following parts by weight and obtains: 15~25 parts of dents Amaranth, 10~20 parts of semen coicis, 15~25 portions of smilaxs, 10~30 portions of elscholtizas, 30~40 portions of wrinkled giant hyssops, 20~37 portions of oriental wormwoods, 15~ 35 parts of rheum officinales, 5~15 portions of lopseeds, 15~25 portions of dark plums, 25~45 parts of cortex moutans, 15~20 portions of Cortex Phellodendris, 20~30 parts of kuh-sengs, 10~20 portions of schizonepeta, 20~35 portions of tribulus terrestris, 15~20 parts of Stephania tetrandra, 20~35 portions of dandelions, 10~33 parts of Radix Glycyrrhizaes, 8~22 Part kiss-me, 13~27 portions of coptiss, 12~25 parts of radix rehmanniae recens, 22~33 portions of cicada sloughs, 15~23 parts of fruit of summer cypress, 13~33 parts it is complete Scorpion, 10~18 portions of zaocys dhumnades, 15~20 portions of Asiatic plantains, 10~30 portions of mother-of-pearls, 12~25 portions of radix gentianaes.

Preferably, 2~3mm of the sea salt partial size；The cocoyl isethionate purity is 98~99%, wherein hydroxyl Mass fraction≤1% of ethylsulfonic acid sodium, mass fraction≤3.32%, pH of sodium isethionate in the sterilizing and itch-relieving medicated soap It is 6.5~7.8.

Preferably, the antipruritic Chinese medical extract the preparation method is as follows:

Oriental wormwood, rheum officinale, dandelion, wrinkled giant hyssop, elscholtiza, lopseed are weighed, adds the water of 10 times of weight, using steam distillation It extracts, volatilization oil volume is read when extraction time is 2~5h, until volatile oil is not further added by, the dregs of a decoction and remaining medicinal material are added 10 times Volume of water decocts jointly, filters and takes filtrate, and the 25~35% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and filtered with concentration 4 DEG C of preservations after liquid is sufficiently mixed.

Preferably, the giant salamander pituitary extract the preparation method is as follows:

(1) artificially-cultured giant salamander mucus is collected, -40 degrees Celsius are freezed 12h, and -70 DEG C of vacuum freeze-dryings obtain freeze-dried powder for 24 hours；

(2) giant salamander mucus freeze-dried powder is redissolved using 30 DEG C of warm water of 10 times of weight, is redissolved liquid and is carried out 75~90 DEG C of high-temperature water 1~3h of bath extraction；

(3) 90% ethyl alcohol of 5 times of volumes is added after concentration in the sample after water mentions, and stand at low temperature generates white afterwards for 24 hours Precipitating, the precipitating after centrifugation are dissolved again with distilled water, are repeated twice above-mentioned ethanol precipitation process, finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 4:1 in sediment, and the volume ratio of this mixed liquor and sediment is 1:3, uses magnetic Power blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, repeat above step, number of processes be 1~3 time to get giant salamander mucus crude extract；

(4) be added in giant salamander mucus crude extract using 90% ethyl alcohol of 5 times of volumes, be placed in 4 DEG C of low temperature refrigerators 24h；After generating a large amount of precipitatings, 30min is centrifuged with 5000rpm, removes supernatant, collects precipitating, it is multiple that 2 times of volume distilled water are added It is molten；

(5) upper step is redissolved liquid to be packed into bag filter, the 48h that dialyses is placed in the distilled water of flowing, to the liquid in bag filter Body is collected, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Preferably, giant salamander mucus freeze-dried powder is redissolved to the mixing of addition papain and trypsase before liquid water-bath extraction The enzyme activity unit ratio of enzyme solution 30~90min of enzymatic hydrolysis, papain and trypsase is 1:2, total zymoprotein in mixed enzyme solution Content is 0.5~1 μ g/mL.

Preferably, the molecular cut off of the bag filter is 500~7000Da.

Preferably, the animal fat is made of house oil, badger fat, ambergris, weight ratio 1:3:2；The olive oil Acidity is 0.8~2%；The foaming agent is made of lauric acid, myristic acid and stearic acid, and weight ratio is 1:3~5:2~3.

A kind of preparation method of above-mentioned sterilizing and itch-relieving medicated soap includes following specific steps:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure of 5~25wt% of mixture is added after mixing Water, is sufficiently mixed to be placed in closed reactor and is heated to 120~150 DEG C, and constant temperature is evacuated 5~25min, after moisture evaporating completely It vacuumizes, is cooled to 30~50 DEG C, being filled with ozone to air pressure is 100~150MPa, maintains 30~120min of high pressure, pumping decompression It to normal pressure, keeps the temperature 20~30min, takes out solid, roll crushing, be sieved, guarantee partial size for 0.5~1.5mm to obtain the final product；

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, is heated to 150~200 DEG C, ethoxy sulphur is added after melting completely Sour sodium, 2~4h of magnetic agitation temperature programming stop heating；To which after reaction, cooled to room temperature will be a certain amount of anhydrous Ethyl alcohol is added in three-necked flask and is uniformly mixed, and stops stirring after system is in milky suspension, is then taken out using decompression Filter carries out separating-purifying, is so repeated twice, dehydrated alcohol removes excessive raw material to obtain the final product；

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, after completely dissolution be made 35~ 50% Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine Mixture side stirring, mixing be placed on three-roll grinder grinding, grind 3~5 times, control grinding material temperature at 30~34 DEG C, Groomwell root oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils is added to continue to grind, temperature is after grinding 33~37 DEG C, material is thick at this time；

(5) giant salamander pituitary extract, tremella polysaccharides, the light ethylsulfonic acid sodium of fatty acyl group is added immediately while hot, it is high-pressure homogeneous And 28~30 DEG C are cooled to, ozone salt is added, mold, natural cooling are injected after being sufficiently stirred；

It is cold under (6) 5~15 DEG C of air-proof conditions to make 7~21 days, it demoulds to obtain the final product.

Preferably, the molar ratio of the olive oil, animal fat, isethionic acid and sodium isethionate is 6:6:3:7.

It is that the present invention obtains the utility model has the advantages that

(1) it uses sea salt and honey mesohigh to be pressed into ozone and prepares ozone salt to fix ozone, the ozone when medicated soap uses Salt dissolution slow release ozone has the function that sterilizing and itch-relieving, while the partial size of ozone salt is larger, and when use plays appropriate friction The effect of skin has the function that further antipruritic；The addition of salt grain can also increase the hardness and wearability of medicated soap, make plasticity The factorial production more preferably can be conducive to；

(2) a variety of Chinese herbal medicine extracts and essential oil are added in medicated soap, includes a variety of volatile oil and water extract, moisturizes the skin, And conditioning skin quality, effective anti-skin oxidative and aging, skin lesion is repaired, skin revitalization is promoted, use for a long time can eradicate eczema, mite Sepage or fuel-displaced equal skin problems are had dry skin caused by worm；

(3) medicated soap be neutral soap, main component be cocoyl isethionate and Igepon A, and Foaming agent is added, stimulation and excessive deoil the drawbacks of of the strong basicity of conventional soap to skin are effectively improved, in fatty acyl group The animals such as hand-to-hand house oil, badger fat, ambergris are formed with human skin using a variety of in the preparation process of sodium isethionate Grease can promote skin repair, prevent dry and cracked, have effects that moisturizing；

(4) collagen being wherein rich in, glycoprotein are made full use of as additive using giant salamander pituitary extract, it is small The multiple beneficials ingredient such as molecular polypeptide and free amino acid supplements the protein in skin, reduces skin because keratin loss is led The chapped skin of cause and cracking.

(5) protease hydrolyzed giant salamander mucus protein is used, that reduces that the high molecular weight protein in mucus causes skin allergy can Can, and digest after micromolecule polypeptide or amino acid be more easily absorbed by the skin, increase the moist maintenance action of medicated soap.

Specific embodiment

Below by the description to embodiment, specific embodiments of the present invention will be described in further detail, with side Those skilled in the art is helped to have more complete, accurate and deep understanding to inventive concept of the invention, technical solution.

Embodiment 1: sterilizing and itch-relieving medicated soap is produced as follows:

One, the preparation of raw material and prefabricated:

Weigh the raw material of following parts by weight: 20 parts of olive oil, 25 portions of animal fats, 35 parts of sodium isethionates, 5 portions of Asian puccoons Oil, 2 parts of evening primrose oil, 3 parts of rose ethereal oils, 4 parts of root of kirilow rhodiola essential oils, 5 parts of wormwood essential oils, the sea salt of 20 parts of partial size 2mm, 0.5 Part giant salamander pituitary extract, 1 part of tremella polysaccharides, 2 parts of honey, 20 parts of antipruritic water extract of TCM, 20 portions of cocamidopropyl propyl amide beets Alkali, 25 parts of foaming agents, 150 parts of cocoyl isethionates, 50 parts of neat soaps；

The cocoyl isethionate purity is 98%, and wherein the mass fraction of sodium isethionate is 1%.

The animal fat is made of house oil, badger fat, ambergris, weight ratio 1:3:2；The acidity of the olive oil is 0.8%；

The foaming agent is made of lauric acid, myristic acid and stearic acid, weight ratio 1:3:2.

The preparation method of antipruritic Chinese medical extract is following (following number is in parts by weight):

10 portions of elscholtizas, 30 portions of wrinkled giant hyssops, 20 portions of oriental wormwoods, 15 parts of rheum officinales, 5 portions of lopseeds, 20 portions of dandelions are weighed, 10 times of bodies are added Ponding reads volatilization oil volume using extraction by steam distillation, when extraction time is 2h, until volatile oil is not further added by, the dregs of a decoction With 15 portions of purslanes, 10 parts of semen coicis, 15 portions of smilaxs, 15 portions of dark plums, 25 parts of cortex moutans, 15 portions of Cortex Phellodendris, 20 parts of kuh-sengs, 10 parts Schizonepeta, 20 portions of tribulus terrestris, 15 parts of Stephania tetrandra, 10 portions of Radix Glycyrrhizaes, 8 portions of kiss-mes, 13 portions of coptiss, 12 parts of radix rehmanniae recens, 22 parts of cicada sloughs, 15 10 times of bodies are added in part fruit of summer cypress, 13~33 scorpios, 10 portions of zaocys dhumnades, 15 portions of Asiatic plantains, 10 portions of mother-of-pearls, 12 portions of radix gentianaes together Ponding decocts jointly, filters and takes filtrate, and the 25~35% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration filtrate 4 DEG C of preservations after being sufficiently mixed.

Giant salamander pituitary extract the preparation method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 10 times of volumes, 30 DEG C of warm water, is redissolved liquid and is carried out 75 DEG C of high temperature bath extractions 1h；

(3) 90% ethyl alcohol of 5 times of volumes is added after concentration in the sample after water mentions, and stand at low temperature generates white afterwards for 24 hours Precipitating, the precipitating after centrifugation are dissolved again with distilled water, are repeated twice above-mentioned ethanol precipitation process, finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 4:1 in sediment, and the volume ratio of this mixed liquor and sediment is 1:3, uses magnetic Power blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, number of processes be 1 time to get giant salamander mucus crude extract；

(5) upper step is redissolved liquid to be packed into bag filter, is placed in the distilled water of flowing the 48h that dialyses, the bag filter is cut Staying molecular weight is 500~7000Da, is collected to the liquid in bag filter, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Two, the preparation of sterilizing and itch-relieving medicated soap:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of mixture 5wt% is added after mixing, fills Divide mixing to be placed in closed reactor and be heated to 120 DEG C, is vacuumized after constant temperature pumping 5min, be cooled to 30 DEG C, be filled with ozone It is 100MPa to air pressure, maintains high pressure 30min, pumping is decompressed to normal pressure, keeps the temperature 20min, takes out solid, rolls crushing, it is sieved, Guarantee partial size for 0.5mm to obtain the final product；A small amount of moisture wetting is added in honey after mixing with sea salt, increase mobility and be convenient for honey and sea salt Mixing and high pressure gas indentation mixture in, high-pressure ozone can be pressed into sea salt gap and sticky honey, sticky honey packet It is wrapped in outside sea salt and forms sugar-coat, kept the temperature under ozone atmosphere after decompression, honey encapsulating is consolidated in outside ozone salt, forms solid, and will Ozone stable is fixed in solid, forms ozone salt.

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, wherein olive oil, animal fat, isethionic acid and ethoxy The molar ratio of sodium sulfonate is 6:6:3:7, is heated to 150 DEG C, and sodium isethionate, magnetic agitation program liter is added after melting completely Warm 2h stops heating；Dehydrated alcohol can be completely dissolved the complete fatty acid and isethionic acid of unreacted, can dissolve isethionic acid Sodium, and product Igepon A is then insoluble in dehydrated alcohol, selects dehydrated alcohol as extractant to reaction In excessive raw material extract.To which after reaction, a certain amount of dehydrated alcohol is added to three mouthfuls by cooled to room temperature It is uniformly mixed in flask, stops stirring after system is in milky suspension, then filtered using decompression and carry out separating-purifying, It is so repeated twice, dehydrated alcohol removes excessive raw material to obtain the final product；Nitrogen protection device is responsible for whole process in reaction and is passed through nitrogen Gas prevents the generation of oxidation and side reaction as protective gas, improves efficiency of pcr product.

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, 35% is made after completely dissolution Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine The stirring of mixture side, mixing are placed on three-roll grinder grinding, grind 3 times, control grinding material temperature at 30 DEG C, Asian puccoon is added Oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, and temperature is 33 DEG C after grinding, this When material be it is thick；

(5) giant salamander pituitary extract, tremella polysaccharides, the light ethylsulfonic acid sodium of fatty acyl group is added immediately while hot, it is high-pressure homogeneous And 28 DEG C are cooled to, ozone salt is added, mold, natural cooling are injected after being sufficiently stirred；

It is cold under (6) 5 DEG C of air-proof conditions to make 7 days, it demoulds to obtain the final product, after measured, sodium isethionate in sterilizing and itch-relieving medicated soap Mass fraction is 3.32%, pH 6.5.

Embodiment 2: sterilizing and itch-relieving medicated soap is produced as follows:

One, the preparation of raw material and prefabricated:

Weigh the raw material of following parts by weight: 40 parts of olive oil, 45 portions of animal fats, 80 parts of sodium isethionates, 10 parts of purples Careless oil, 6 parts of evening primrose oil, 8 parts of rose ethereal oils, 8 parts of root of kirilow rhodiola essential oils, 8 parts of wormwood essential oils, the sea salt of 30 parts of partial size 3mm, 10 Part giant salamander pituitary extract, 5 parts of tremella polysaccharides, 15 parts of honey, 35 parts of antipruritic water extract of TCM, 30 portions of cocamidopropyl propyl amide beets Alkali, 40 parts of foaming agents, 250 parts of cocoyl isethionates, 75 parts of neat soaps；

The cocoyl isethionate purity 99%, the wherein mass fraction 0.3% of sodium isethionate.

The animal fat is made of house oil, badger fat, ambergris, weight ratio 1:3:2；The acidity of the olive oil is 2%；

The foaming agent is made of lauric acid, myristic acid and stearic acid, weight ratio 1:5:3.

30 portions of elscholtizas, 40 portions of wrinkled giant hyssops, 37 portions of oriental wormwoods, 35 parts of rheum officinales, 15 portions of lopseeds, 35 portions of dandelions are weighed, add 10 times Volume of water reads volatilization oil volume using extraction by steam distillation, when extraction time is 5h, until volatile oil is not further added by, medicine Slag and 25 portions of purslanes, 20 parts of semen coicis, 25 portions of smilaxs, 25 portions of dark plums, 45 parts of cortex moutans, 20 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 20 Part schizonepeta, 35 portions of tribulus terrestris, 20 parts of Stephania tetrandra, 33 portions of Radix Glycyrrhizaes, 22 portions of kiss-mes, 27 portions of coptiss, 25 parts of radix rehmanniae recens, 33 parts of cicada It sloughs off, 23 parts of fruit of summer cypress, 33 portions of scorpios, 18 portions of zaocys dhumnades, 20 portions of Asiatic plantains, 30 portions of mother-of-pearls, 25 portions of radix gentianaes are added 10 together Times volume of water decocts jointly, and suction filtration takes filtrate, and the 35% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration filtrate 4 DEG C of preservations after being sufficiently mixed.

Giant salamander pituitary extract the preparation method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 10 times of volumes, 30 DEG C of warm water, and giant salamander mucus freeze-dried powder is redissolved liquid water-bath The mixed enzyme solution that papain and trypsase are added before extraction digests 90min, the enzyme activity of papain and trypsase Unit of force ratio is 1:2, and total protein content is 1 μ g/mL in mixed enzyme solution, and total enzyme activity unit of force is 3500U, the redissolution after enzymatic hydrolysis Liquid carries out 90 DEG C of high temperature baths and extracts 3h；

(3) 90% ethyl alcohol of 5 times of volumes is added after concentration in the sample after water mentions, and stand at low temperature generates white afterwards for 24 hours Precipitating, the precipitating after centrifugation are dissolved again with distilled water, are repeated twice above-mentioned ethanol precipitation process, finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 5:2 in sediment, and the volume ratio of this mixed liquor and sediment is 1:3, uses magnetic Power blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, repeat above step, number of processes be 2 times to get giant salamander mucus crude extract；

(4) be added in giant salamander mucus crude extract using the dehydrated alcohol of 5 times of volumes, be placed in 4 DEG C of low temperature refrigerators 24h；After generating a large amount of precipitatings, 30min is centrifuged with 5000rpm, removes supernatant, collects precipitating, it is multiple that 2 times of volume distilled water are added It is molten；

(5) upper step is redissolved liquid to be packed into bag filter, is placed in the distilled water of flowing the 48h that dialyses, the bag filter is cut Staying molecular weight is 7000Da, is collected to the liquid in bag filter, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Two, the preparation of sterilizing and itch-relieving medicated soap:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of mixture 25wt% is added after mixing, It is sufficiently mixed to be placed in closed reactor and is heated to 150 DEG C, constant temperature is evacuated 25min, vacuumizes after moisture evaporating completely, cools down To 50 DEG C, being filled with ozone to air pressure is 150MPa, maintains high pressure 120min, and pumping is decompressed to normal pressure, keeps the temperature 30min, is taken out solid Body rolls crushing, sieving, guarantees partial size for 1.5mm to obtain the final product；

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, wherein olive oil, animal fat, isethionic acid and ethoxy The molar ratio of sodium sulfonate is 6:6:3:7, is heated to 200 DEG C, and sodium isethionate, magnetic agitation program liter is added after melting completely Warm 4h stops heating；Dehydrated alcohol can be completely dissolved the complete fatty acid and isethionic acid of unreacted, can dissolve isethionic acid Sodium, and product Igepon A is then insoluble in dehydrated alcohol, selects dehydrated alcohol as extractant to reaction In excessive raw material extract.To which after reaction, a certain amount of dehydrated alcohol is added to three mouthfuls by cooled to room temperature It is uniformly mixed in flask, stops stirring after system is in milky suspension, then filtered using decompression and carry out separating-purifying, It is so repeated twice, dehydrated alcohol removes excessive raw material to obtain the final product；

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, 50% is made after completely dissolution Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine The stirring of mixture side, mixing are placed on three-roll grinder grinding, grind 3~5 times, control grinding material temperature at 34 DEG C, are added Groomwell root oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, and temperature is 37 after grinding DEG C, material is thick at this time；

(5) giant salamander pituitary extract, tremella polysaccharides, the light ethylsulfonic acid sodium of fatty acyl group is added immediately while hot, it is high-pressure homogeneous And 30 DEG C are cooled to, ozone salt is added, mold, natural cooling are injected after being sufficiently stirred；

It is cold under (6) 15 DEG C of air-proof conditions to make 21 days, it demoulds to obtain the final product, after measured, ethoxy sulphur in the sterilizing and itch-relieving medicated soap The mass fraction 1.77% of sour sodium, pH 7.8.

Embodiment 3: sterilizing and itch-relieving medicated soap is produced as follows:

One, the preparation of raw material and prefabricated:

Weigh the raw material of following parts by weight: 30 parts of olive oil, 35 portions of animal fats, 50 parts of sodium isethionates, 7 portions of Asian puccoons Oil, 4 parts of evening primrose oil, 5 parts of rose ethereal oils, 6 parts of root of kirilow rhodiola essential oils, 6 parts of wormwood essential oils, the sea salt of 25 parts of partial size 2.5mm, 5 Part giant salamander pituitary extract, 3 parts of tremella polysaccharides, 8 parts of honey, 27 parts of antipruritic water extract of TCM, 25 portions of cocamidopropyl propyl amide beets Alkali, 33 parts of foaming agents, 200 parts of cocoyl isethionates, 58 parts of neat soaps；

The cocoyl isethionate purity is 98.5%, and wherein the mass fraction of sodium isethionate is 0.7%.

The animal fat is made of house oil, badger fat, ambergris, weight ratio 1:3:2；The acidity of the olive oil is 1.4%；

The foaming agent is made of lauric acid, myristic acid and stearic acid, weight ratio 1:4:2.5.

20 portions of elscholtizas, 35 portions of wrinkled giant hyssops, 28 portions of oriental wormwoods, 25 parts of rheum officinales, 10 portions of lopseeds, 27 portions of dandelions are weighed, add 10 times Volume of water reads volatilization oil volume using extraction by steam distillation, when extraction time is 3h, until volatile oil is not further added by, medicine Slag and 20 portions of purslanes, 15 parts of semen coicis, 20 portions of smilaxs, 20 portions of dark plums, 35 parts of cortex moutans, 17 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 15 Part schizonepeta, 28 portions of tribulus terrestris, 17 parts of Stephania tetrandra, 20 portions of Radix Glycyrrhizaes, 14 portions of kiss-mes, 20 portions of coptiss, 18 parts of radix rehmanniae recens, 27 parts of cicada It sloughs off, 18 parts of fruit of summer cypress, 23 portions of scorpios, 14 portions of zaocys dhumnades, 17 portions of Asiatic plantains, 20 portions of mother-of-pearls, 18 portions of radix gentianaes are added 10 together Times volume of water decocts jointly, and suction filtration takes filtrate, and the 25~35% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration 4 DEG C of preservations after filtrate is sufficiently mixed.

Giant salamander pituitary extract the preparation method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 10 times of volumes, 30 DEG C of warm water, and giant salamander mucus freeze-dried powder is redissolved liquid water-bath The mixed enzyme solution that papain and trypsase are added before extraction digests 30min, the enzyme activity of papain and trypsase Unit of force ratio is 1:5, and total protein content is 0.5 μ g/mL in mixed enzyme solution, and total enzyme activity unit of force is 1500U, answering after enzymatic hydrolysis Solution carries out 75 DEG C of high temperature baths and extracts 1h；

(3) 75% ethyl alcohol of 5 times of volumes is added after concentration in the sample after water mentions, and stand at low temperature generates white afterwards for 24 hours Precipitating, the precipitating after centrifugation are dissolved again with distilled water, repeat 1 above-mentioned ethanol precipitation process, finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 2:1 in sediment, and the volume ratio of this mixed liquor and sediment is 1:3, uses magnetic Power blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, repeat above step, number of processes be 2 times to get giant salamander mucus crude extract；

(4) be added in giant salamander mucus crude extract using 85% ethyl alcohol of 5 times of volumes, be placed in 4 DEG C of low temperature refrigerators 24h；After generating a large amount of precipitatings, 30min is centrifuged with 5000rpm, removes supernatant, collects precipitating, it is multiple that 2 times of volume distilled water are added It is molten；

(5) upper step is redissolved liquid to be packed into bag filter, is placed in the distilled water of flowing the 48h that dialyses, the bag filter is cut Staying molecular weight is 500Da, is collected to the liquid in bag filter, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Two, the preparation of sterilizing and itch-relieving medicated soap:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of mixture 15wt% is added after mixing, It is sufficiently mixed to be placed in closed reactor and is heated to 135 DEG C, constant temperature is evacuated 15min, vacuumizes after moisture evaporating completely, cools down To 40 DEG C, being filled with ozone to air pressure is 125MPa, maintains high pressure 75min, and pumping is decompressed to normal pressure, keeps the temperature 25min, is taken out solid Body rolls crushing, sieving, guarantees partial size for 1mm to obtain the final product；

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, wherein olive oil, animal fat, isethionic acid and ethoxy The molar ratio of sodium sulfonate is 6:6:3:7, is heated to 150~200 DEG C, and sodium isethionate, magnetic agitation is added after melting completely Temperature programming 3h stops heating；To which after reaction, a certain amount of dehydrated alcohol is added to three mouthfuls of burnings by cooled to room temperature It is uniformly mixed in bottle, stops stirring after system is in milky suspension, then filtered using decompression and carry out separating-purifying, such as This is repeated twice, and dehydrated alcohol removes excessive raw material to obtain the final product；

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, 40% is made after completely dissolution Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 70 meshes, side dropwise addition Cocoamidopropyl betaine The stirring of mixture side, mixing are placed on three-roll grinder grinding, grind 4 times, control grinding material temperature at 32 DEG C, Asian puccoon is added Oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, and temperature is 35 DEG C after grinding, this When material be it is thick；

(5) giant salamander pituitary extract, tremella polysaccharides, the light ethylsulfonic acid sodium of fatty acyl group is added immediately while hot, it is high-pressure homogeneous And 29 DEG C are cooled to, ozone salt is added, mold, natural cooling are injected after being sufficiently stirred；

It is cold under (6) 10 DEG C of air-proof conditions to make 14 days, it demoulds to obtain the final product, through detecting, ethoxy sulphur in the sterilizing and itch-relieving medicated soap The mass fraction of sour sodium is 2.64%, pH 7.0.

Embodiment 4: sterilizing and itch-relieving medicated soap is produced as follows:

One, the preparation of raw material and prefabricated:

Weigh the raw material of following parts by weight: 20 parts of olive oil, 45 portions of animal fats, 65 parts of sodium isethionates, 7.5 parts of purples Careless oil, 5 parts of evening primrose oil, 7 parts of rose ethereal oils, 7 parts of root of kirilow rhodiola essential oils, 7 parts of wormwood essential oils, the sea salt of 30 parts of partial size 2mm, 10 Part giant salamander pituitary extract, 3 parts of tremella polysaccharides, 14 parts of honey, 30 parts of antipruritic water extract of TCM, 25 portions of cocamidopropyl propyl amide beets Alkali, 33 parts of foaming agents, 225 parts of cocoyl isethionates, 65 parts of neat soaps；

The cocoyl isethionate purity is 98.7%, and wherein the mass fraction of sodium isethionate is 0.2%.

The animal fat is made of house oil, badger fat, lard, weight ratio 3:1:1；The acidity of the olive oil is 1%；

The foaming agent is made of lauric acid, myristic acid and stearic acid, weight ratio 1:3:3.

15 portions of elscholtizas, 35 portions of wrinkled giant hyssops, 30 portions of oriental wormwoods, 18 parts of rheum officinales, 11 portions of lopseeds, 29 portions of dandelions are weighed, add 10 times Volume of water reads volatilization oil volume using extraction by steam distillation, when extraction time is 4h, until volatile oil is not further added by, medicine Slag and 20 portions of purslanes, 20 parts of semen coicis, 25 portions of smilaxs, 15 portions of dark plums, 45 parts of cortex moutans, 15 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 20 Part schizonepeta, 20 portions of tribulus terrestris, 15 parts of Stephania tetrandra, 10 portions of Radix Glycyrrhizaes, 8 portions of kiss-mes, 27 portions of coptiss, 25 parts of radix rehmanniae recens, 22 portions of cicada sloughs, 10 times of bodies are added in 15 parts of fruit of summer cypress, 13 portions of scorpios, 10 portions of zaocys dhumnades, 15 portions of Asiatic plantains, 10 portions of mother-of-pearls, 12 portions of radix gentianaes together Ponding decocts jointly, filters and takes filtrate, and the 27% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration filtrate be abundant 4 DEG C of preservations after mixing.

Giant salamander pituitary extract the preparation method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 10 times of volumes, 30 DEG C of warm water, and giant salamander mucus freeze-dried powder is redissolved liquid water-bath The mixed enzyme solution that papain and trypsase are added before extraction digests 45min, the enzyme activity of papain and trypsase Unit of force ratio is 1:1, and total protein content is 0.8 μ g/mL in mixed enzyme solution, and total enzyme activity unit of force is 2500U, answering after enzymatic hydrolysis Solution carries out 80 DEG C of high temperature bath extractions, 1.5h；

(5) upper step is redissolved liquid to be packed into bag filter, is placed in the distilled water of flowing the 48h that dialyses, the bag filter is cut Staying molecular weight is 5000Da, is collected to the liquid in bag filter, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Two, the preparation of sterilizing and itch-relieving medicated soap:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of mixture 15wt% is added after mixing, It is sufficiently mixed to be placed in closed reactor and is heated to 130 DEG C, constant temperature is evacuated 18min, vacuumizes after moisture evaporating completely, cools down To 55 DEG C, being filled with ozone to air pressure is 140MPa, maintains high pressure 100min, and pumping is decompressed to normal pressure, keeps the temperature 15min, is taken out solid Body rolls crushing, sieving, guarantees partial size for 1mm to obtain the final product；

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, wherein olive oil, animal fat, isethionic acid and ethoxy The molar ratio of sodium sulfonate is 4:8:5:5, is heated to 170 DEG C, and sodium isethionate, magnetic agitation program liter is added after melting completely Warm 3h stops heating；To which after reaction, a certain amount of dehydrated alcohol is added in three-necked flask and stirs by cooled to room temperature Uniformly mixed, the stopping stirring after system is in milky suspension is mixed, it is subsequent that separating-purifying is carried out using decompression suction filtration, it is such to repeat Twice, dehydrated alcohol removes excessive raw material to obtain the final product；

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, 45% is made after completely dissolution Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine The stirring of mixture side, mixing are placed on three-roll grinder grinding, grind 4 times, control grinding material temperature at 33 DEG C, Asian puccoon is added Oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, and temperature is 36 DEG C after grinding, this When material be it is thick；

It is cold under (6) 8 DEG C of air-proof conditions to make 18 days, it demoulds to obtain the final product, through detecting, isethionic acid in the sterilizing and itch-relieving medicated soap The mass fraction of sodium is 2.98%, pH 7.3.

Embodiment 5: sterilizing and itch-relieving medicated soap is produced as follows:

One, the preparation of raw material and prefabricated:

Weigh the raw material of following parts by weight: 40 parts of olive oil, 35 portions of animal fats, 60 parts of sodium isethionates, 8 portions of Asian puccoons Oil, 3 parts of evening primrose oil, 3 parts of rose ethereal oils, 5 parts of root of kirilow rhodiola essential oils, 7 parts of wormwood essential oils, the sea salt of 28 parts of partial size 3mm, 7 parts Giant salamander pituitary extract, 4 parts of tremella polysaccharides, 13 parts of honey, 35 parts of antipruritic water extract of TCM, 25 portions of cocamidopropyl propyl amide beets Alkali, 30 parts of foaming agents, 250 parts of cocoyl isethionates, 50 parts of neat soaps；

The cocoyl isethionate purity is 99%, and wherein the mass fraction of sodium isethionate is 0.9%.

The animal fat is made of house oil, snake oil, deep sea fish oil, weight ratio 2:3:1；The acidity of the olive oil is 1.6%；

The foaming agent is made of lauric acid, myristic acid and stearic acid, weight ratio 1:5:2.

25 portions of elscholtizas, 31 portions of wrinkled giant hyssops, 25 portions of oriental wormwoods, 18 parts of rheum officinales, 13 portions of lopseeds, 27 portions of dandelions are weighed, add 10 times Volume of water reads volatilization oil volume using extraction by steam distillation, when extraction time is 5h, until volatile oil is not further added by, medicine Slag and 17 portions of purslanes, 17 parts of semen coicis, 17 portions of smilaxs, 17 portions of dark plums, 40 parts of cortex moutans, 19 portions of Cortex Phellodendris, 20~30 parts of hardships Ginseng, 18 portions of schizonepeta, 22 portions of tribulus terrestris, 16 parts of Stephania tetrandra, 26 portions of Radix Glycyrrhizaes, 20 portions of kiss-mes, 20 portions of coptiss, 15 parts of radix rehmanniae recens, 25 Part cicada slough, 20 parts of fruit of summer cypress, 17 portions of scorpios, 13 portions of zaocys dhumnades, 17 portions of Asiatic plantains, 20 portions of mother-of-pearls, 13 portions of radix gentianaes add together Enter 10 times of volume of water to decoct jointly, filters and take filtrate, the 33% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration 4 DEG C of preservations after filtrate is sufficiently mixed.

Giant salamander pituitary extract the preparation method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 10 times of volumes, 30 DEG C of warm water, and giant salamander mucus freeze-dried powder is redissolved liquid water-bath The mixed enzyme solution that papain and trypsase are added before extraction digests 75min, the enzyme activity of papain and trypsase Unit of force ratio is 2:3, and total protein content is 0.5~1 μ g/mL in mixed enzyme solution, and total enzyme activity unit of force is 3000U, after enzymatic hydrolysis Redissolution liquid carry out 88 DEG C of high temperature baths and extract 2h；

(3) 90% ethyl alcohol of 5 times of volumes is added after concentration in the sample after water mentions, and stand at low temperature generates white afterwards for 24 hours Precipitating, the precipitating after centrifugation are dissolved again with distilled water, are repeated twice above-mentioned ethanol precipitation process, finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 1:1 in sediment, and the volume ratio of this mixed liquor and sediment is 1:6, uses magnetic Power blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, repeat above step, number of processes be 3 times to get giant salamander mucus crude extract；

(5) upper step is redissolved liquid to be packed into bag filter, is placed in the distilled water of flowing the 48h that dialyses, the bag filter is cut Staying molecular weight is 3500Da, is collected to the liquid in bag filter, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

Two, the preparation of sterilizing and itch-relieving medicated soap:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of mixture 20wt% is added after mixing, It is sufficiently mixed to be placed in closed reactor and is heated to 140 DEG C, constant temperature is evacuated 22min, vacuumizes after moisture evaporating completely, cools down To 45 DEG C, being filled with ozone to air pressure is 150MPa, maintains high pressure 110min, and pumping is decompressed to normal pressure, keeps the temperature 60min, is taken out solid Body rolls crushing, sieving, guarantees partial size for 0.7mm to obtain the final product；

(2) Igepon A synthesizes: in three mouthfuls equipped with thermometer, nitrogen protection device and condensing unit Olive oil, animal fat and isethionic acid are added in flask, wherein olive oil, animal fat, isethionic acid and ethoxy The molar ratio of sodium sulfonate is 3:9:4:6, is heated to 160 DEG C, and sodium isethionate, magnetic agitation program liter is added after melting completely Warm 2.5h stops heating；To which after reaction, a certain amount of dehydrated alcohol is added in three-necked flask by cooled to room temperature It is uniformly mixed, stops stirring after system is in milky suspension, then filtered using decompression and carry out separating-purifying, so weight Again twice, dehydrated alcohol removes excessive raw material to obtain the final product；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine The stirring of mixture side, mixing are placed on three-roll grinder grinding, grind 5 times, control grinding material temperature at 32 DEG C, Asian puccoon is added Oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, and temperature is 33 DEG C after grinding, this When material be it is thick；

It is cold under (6) 11 DEG C of air-proof conditions to make 20 days, it demoulds to obtain the final product, through detecting, ethoxy sulphur in the sterilizing and itch-relieving medicated soap The mass fraction of sour sodium is 3.18%, pH 6.8.

Comparative examples: 107034048 A of Chinese patent CN discloses a kind of sterilizing and itch-relieving anti-acne medicated soap and its production side Method prepares medicated soap according to method disclosed in wherein embodiment 1, is used for subsequent performance test experiment contrast.

The sterilizing and itch-relieving medicated soap prepared in Examples 1 to 5 and comparative examples is subjected to following test experiments, to detect it Performance:

1, influence of the sterilizing and itch-relieving medicated soap to itch caused by histamine phosphate

Kunming mouse 50,20 ± 2g of weight, half male and half female is randomly divided into 5 groups, respectively model control group, the positive Control group (PINGYANPING RUANGAO), comparative examples emulsifiable paste group, 1 emulsifiable paste group of embodiment, 3 emulsifiable paste group of embodiment, 5 emulsifiable paste of embodiment Group.

With the fine sandpaper polishing right metapedes skin of back of mouse, is spent with rubefaction oozing of blood without bleeding, extract 0.02% Histamine phosphate 0.1mL drop on the skin polished, observe and record immediately mouse in 15min convulsion itch number and it is lasting when Between.Convulsion itch indication be mouse later lick gnaw the right side after skin of dorsum of foot；It is denoted as itch twice within itch duration time interval 3 seconds or more, it is small In itch of 3 seconds notes.It is uniformly applied to the right metapedes skin of back of mouse and soft a moment after medicated soap is dipped in water immediately after modeling, Itch number and the duration for observing and recording mouse in 15min, it the results are shown in Table 1.

Itching-relieving action of the antipruritic emulsifiable paste of table 1 to itch caused by histamine phosphate

The above results show there is significant itching-relieving action, effect when medicated soap is applied on itch model mice skin Close to positive drug control group, antipruritic effect is definite.

2, medicated soap bactericidal effect

The medicated soap 10g prepared in each Example 1~5 and comparative examples, is completely dissolved in conduct in 50mL distilled water Test specimen, and antibacterial and sterilization measurement experiment is carried out immediately, it is surveyed using inhibition zone size measurement method and gradient dilution bactericidal assay Fixed, strain is staphylococcus aureus, and blank control group using physiological saline as test specimen, survey by three repetitions of every group of work Determine antibacterial circle diameter and minimum bactericidal concentration, the results are shown in Table 2:

The fungistatic effect of 2 medicated soap of table

Group	Antibacterial circle diameter (mm)	Minimum bactericidal concentration (mg/L)
			Blank control group	11.3±0.4	Nothing
Embodiment 1	13.2±0.6	578.2±2.6
			Embodiment 2	15.8±0.8	433.4±3.2
Embodiment 3	16.2±1.1	545.2±5.3
			Embodiment 4	14.9±0.7	639.4±4.8
Embodiment 5	15.5±0.6	630.5±3.7
			Comparative examples	11.6±0.7	14032.2±45.2

The above results show that the present invention has outstanding bactericidal ability, and minimum bactericidal concentration is substantially less than to according to the facts Example is applied, there is stronger inhibition and killing effect to pathogenic bacteria.

3, the ozone release action of medicated soap

The ozone salt and medicated soap prepared in 10g Examples 1 to 5 and comparative examples is taken, in 25~30 DEG C, humidity 40~ 100mL is completely dissolved in respectively after standing 7d under the conditions of 60%, in 25 degrees Celsius of distilled waters, using film-electrode method ozone analyzer The content for measuring ozone in medicated soap solution immediately, the results are shown in Table 3 and table 4:

Ozone content in 3 medicated soap solution of table

Fluid sample	Ozone content (mg/L)
		Distilled water	0.001±0.003
Embodiment 1	3.891±0.045
		Embodiment 2	7.352±0.085
Embodiment 3	6.675±0.077
		Embodiment 4	5.983±0.051
Embodiment 5	4.497±0.039
		Comparative examples	0.001±0.004

Ozone content in 4 ozone salting liquid of table

Include ozone salt in the present invention, fixes ozone when anhydrous in solid form in solid, after meeting water, sea salt collapses Solution, soluble in water together with honey, release ozone is soluble in water, reaches significant sterilizing effect, promotes skin lesion healing, prevent Phenomena such as only infecting and fester.

4, contrast test is had dry skin

Kunming mouse 105,25 ± 2g of weight, half male and half female, lose hair or feathers 3cm × 3cm at back, is equally divided into 7 groups, daily Water is dipped in using sample medicated soap every 6h and smears rubbing 1min, subsequent clear water is cleaned up, dried, and 3 times a day, blank control group is only It is dried with clear water flushing, raises under mouse and tested altogether 7 in dry environment of the ambient humidity lower than 20%, observed after 7 days small The dry and cracked bleeding in mouse back, and the mouse number of elements of dry and cracked bleeding is counted, and calculate dry and cracked rate:

Dry and cracked rate=dry and cracked mouse the number of elements in every group of back/every group of total number of elements

As a result as follows:

5 chapped skin experimental result of table

Group	Dry and cracked rate (%)
		Blank control group	7.2±0.8
Embodiment 1	11.4±1.1
		Embodiment 2	19.6±1.3
Embodiment 3	22.4±0.9
		Embodiment 4	20.9±1.2
Embodiment 5	15.7±0.6
		Comparative examples	89.4±3.2

The present invention uses the damage to skin small in dry environments, and skin-friendly is more preferable, is not easy to make skin dehydration degreasing, lead Chapped skin bleeding is caused, skin can be nourished after cleaning on the contrary, lipid and collagen is supplemented, reduces keratin Excessive loss effectively prevent chapped skin bleeding.

5, medicated soap ozone slow releasing function detects

By the quick stirring and dissolving of 3.5g ozone salt in 500mL distilled water；The medicated soap prepared in embodiment 2 is cut into 3cm³Bulk, separately by 3cm³Medicated soap crush be powder it is spare, medicated soap block is immersed in 500mL distilled water, separately by medicated soap powder Last quickly stirring and dissolving respectively takes the above-mentioned three kinds of solution of 1mL as sample immediately, measures ozone in solution in 500mL distilled water Content, 35 DEG C of constant temperature are kept in dark place and the content of ozone in three kinds of solution are measured by sampling every 12h, and testing result is shown in Table 6:

The content of ozone in table 6 different time, three kinds of solution

Time (h)	Medicated soap block solution (mg/L)	Medicated soap powder solution (mg/L)	Ozone salting liquid (mg/L)
				0	0.001	7.123	8.723
12	2.334	5.134	4.432
				24	4.773	3.023	1.001
36	4.327	1.883	0.034
				48	4.003	0.893	0.022
60	3.986	0.452	0.019
				72	3.017	0.131	0.011
84	3.105	0.104	0.015
				96	3.338	0.065	0.010
108	2.897	0.055	0.008
				120	2.349	0.043	0.011
132	1.886	0.021	0.004
				144	1.434	0.009	0.001

Table 6 the result shows that, the rate of release of medicated soap block ozone in water is more slow, reached ozone at 48 hours or so and contains The peak of amount, subsequent ozone content slowly decline, this is because soap blank surface contacted with water after surface layer ozone salt disintegration dissolution Ozone, and the dissolution of medicated soap is slower, therefore contact of the ozone salt with water inside medicated soap is limited, therefore ozone content growth is slow Slowly, it the ozone rate of release of medicated soap and the evolution of ozone and is reduced to the rate of oxygen after impregnating for a long time and reaches balance, therefore Slowly, the ozone salt in medicated soap is completely dissolved for ozone content decline.As it can be seen that the package of soap-like matter can protect internal ozone The stabilization of salt ensure that the sustained release of ozone salt.

And medicated soap powder and ozone salt, due to being quickly dissolved in the water, a large amount of ozone salt contact disintegration with water, and ozone is rapid Be released into water, be rapidly reached ozone content peak, the content of subsequent ozone declines rapidly, but the decrease speed of medicated soap powder delay in Ozone salt illustrates that the package of soap-like matter has delayed the disintegration of ozone salt to a certain degree, slows down the release of ozone.

The result main analog that this experiment shows successively hydrolyzes the process for melting soap in actual use, because ozone salt exists Being uniformly distributed in soap, therefore with the layer-by-layer dissolution of medicated soap, ozone salt will also contact water and gradually release in internal medicated soap Disintegration release ozone；Therefore the rate of release of ozone salt depends on the contact area of medicated soap and water.Ozone burst size is gradually reduced The reason of mainly due to long-time impregnate after, soap gradually hydrolyze rear surface product becomes smaller, the contact area of soap and water becomes smaller, The exposure of ozone salt and water reduces, and the burst size of ozone is also gradually reduced.

In conclusion using sea salt and honey mesohigh to be pressed into ozone prepares ozone salt to fix ozone, used in medicated soap When ozone salt dissolution slow release ozone have the function that sterilizing and itch-relieving, while the partial size of ozone salt is larger, and when use plays suitable When the effect of chafing against skin, have the function that further antipruritic；The addition of salt grain can also increase the hardness and wearability of medicated soap, make Moulding performance more preferably, is conducive to the factorial production；A variety of Chinese herbal medicine extracts and essential oil are added in medicated soap, includes a variety of volatile oil And water extract, it moisturizes the skin, and conditioning skin quality, effective anti-skin oxidative and aging repair skin lesion, promote skin revitalization, when long Between use can eradicate caused by eczema, acarid dry skin sepage or the skin problems such as fuel-displaced；Medicated soap is neutral soap, main component For cocoyl isethionate and Igepon A, and foaming agent is added, effectively improves conventional soap Stimulation and excessive deoil the drawbacks of of the strong basicity to skin, using a variety of in the preparation process of Igepon A The animal fats such as hand-to-hand house oil, badger fat, ambergris are formed with human skin, can promote skin repair, prevent dry and cracked, are had The effect of moisturizing；Using giant salamander pituitary extract as additive, the collagen being wherein rich in, sugared egg are made full use of White, the multiple beneficials ingredient such as micromolecule polypeptide and free amino acid supplements the protein in skin, reduces skin because of keratin stream Chapped skin caused by losing and cracking.Using protease hydrolyzed giant salamander mucus protein, the high molecular weight protein reduced in mucus causes The possibility of skin allergy, and digest after micromolecule polypeptide or amino acid be more easily absorbed by the skin, increase the moist maintenance of medicated soap Effect.

The above examples only illustrate the technical idea of the present invention, and this does not limit the scope of protection of the present invention, all According to the technical idea provided by the invention, any changes made on the basis of the technical scheme each falls within the scope of the present invention Within；The technology that the present invention is not directed to can be realized by the prior art.

Claims

1. a kind of sterilizing and itch-relieving medicated soap, which is characterized in that include ozone salt, Igepon A and following parts by weight Raw material: 5~10 parts of Groomwell root oils, 2~6 parts of evening primrose oil, 3~8 parts of rose ethereal oils, 4~8 parts of root of kirilow rhodiola essential oils, 5~8 parts Wormwood essential oil, 0.5~10 part of giant salamander pituitary extract, 1~5 part of tremella polysaccharides, 20~35 parts of antipruritic water extract of TCM, 20~30 Part Cocoamidopropyl betaine, 25~40 parts of foaming agents, 150~250 parts of cocoyl isethionates, 50~75 parts of soaps Grain；The ozone salt is prepared by 20~30 parts by weight sea salt and 2~15 parts by weight honey load ozone；The fatty acyl group Sodium isethionate is through 20~40 wt parts of olive oil, 25~45 parts by weight animal fats and 35~80 parts by weight isethionic acids Sodium reaction is prepared；

The antipruritic water extract of TCM extracts processing by the Chinese herbal medicine of following parts by weight and obtains: 15~25 parts of purslanes, 10 It is~20 parts of semen coicis, 15~25 portions of smilaxs, 10~30 portions of elscholtizas, 30~40 portions of wrinkled giant hyssops, 20~37 portions of oriental wormwoods, 15~35 parts big Huang, 5~15 portions of lopseeds, 15~25 portions of dark plums, 25~45 parts of cortex moutans, 15~20 portions of Cortex Phellodendris, 20~30 parts of kuh-sengs, 10~20 Part schizonepeta, 20~35 portions of tribulus terrestris, 15~20 parts of Stephania tetrandra, 20~35 portions of dandelions, 10~33 portions of Radix Glycyrrhizaes, 8~22 parts of brave ears Grass, 13~27 portions of coptiss, 12~25 parts of radix rehmanniae recens, 22~33 portions of cicada sloughs, 15~23 parts of fruit of summer cypress, 13~33 portions of scorpios, 10~ 18 portions of zaocys dhumnades, 15~20 portions of Asiatic plantains, 10~30 portions of mother-of-pearls, 12~25 portions of radix gentianaes.

2. a kind of sterilizing and itch-relieving medicated soap according to claim 1, it is characterised in that: 2~3mm of the sea salt partial size；Institute Stating cocoyl isethionate purity is 98~99%, and wherein mass fraction≤1% of sodium isethionate, the sterilization stop Mass fraction≤3.32%, pH of sodium isethionate in medicated soap of itching is 6.5~7.8.

3. a kind of sterilizing and itch-relieving medicated soap according to claim 1, which is characterized in that the system of the antipruritic Chinese medical extract Preparation Method is as follows:

Oriental wormwood, rheum officinale, dandelion, wrinkled giant hyssop, elscholtiza, lopseed are weighed, adds the water of 10 times of weight, is mentioned using steam distillation It takes, volatilization oil volume is read when extraction time is 2~5h, until volatile oil is not further added by, 10 times of bodies are added in the dregs of a decoction and remaining medicinal material Ponding decocts jointly, filters and takes filtrate, and the 25~35% of filtrate decompression distillation and concentration to original volume, it will volatilize oil and concentration filtrate 4 DEG C of preservations after being sufficiently mixed.

4. a kind of sterilizing and itch-relieving medicated soap according to claim 1, it is characterised in that: the system of the giant salamander pituitary extract Preparation Method is as follows:

(2) giant salamander mucus freeze-dried powder is redissolved using 30 DEG C of warm water of 10 times of weight, is redissolved liquid and is carried out 75~90 DEG C of high temperature bath leachings Mention 1~3h；

(3) after concentration 90% ethyl alcohol of 5 times of volumes is added, it is heavy that stand at low temperature generates white afterwards for 24 hours in the sample after water mentions It forms sediment, the precipitating after centrifugation is dissolved again with distilled water, is repeated twice above-mentioned ethanol precipitation process, and it is heavy to finally obtain mucus protein Volume ratio is added as the chloroform and n-butanol mixed liquor of 4:1 in starch, and the volume ratio of this mixed liquor and sediment is 1:3, uses magnetic force Blender stirs 60min, so that floating preteins therein denaturation becomes undissolved substance, after centrifugation, collects upper layer Liquid, repeats above step, and number of processes is 1~3 time to get giant salamander mucus crude extract；

(4) be added in giant salamander mucus crude extract using 90% ethyl alcohol of 5 times of volumes, be placed in 4 DEG C of low temperature refrigerators for 24 hours；It produces After raw a large amount of precipitatings, 30min is centrifuged with 5000rpm, removes supernatant, collects precipitating, 2 times of volume distilled water are added and redissolve；

(5) by upper step redissolve liquid be packed into bag filter in, be placed in the distilled water of flowing the 48h that dialyses, to the liquid in bag filter into Row is collected, and vacuum freeze drying collects solid afterwards for 24 hours to obtain the final product.

5. a kind of sterilizing and itch-relieving medicated soap according to claim 4, which is characterized in that further comprise the steps of: giant salamander mucus Papain is added before redissolving liquid water-bath extraction for freeze-dried powder and the mixed enzyme solution of trypsase digests 30~90min, pawpaw egg The enzyme activity unit of white enzyme and trypsase ratio is 1:2, and total protein content is 0.5~1 μ g/mL in mixed enzyme solution.

6. a kind of sterilizing and itch-relieving medicated soap according to claim 5, it is characterised in that: the molecular cut off of the bag filter For 500~7000Da.

7. a kind of sterilizing and itch-relieving medicated soap according to claim 1, it is characterised in that: the animal fat is by house oil, badger Oil, ambergris composition, weight ratio 1:3:2；The acidity of the olive oil is 0.8~2%；The foaming agent is by lauric acid, meat Myristic acid and stearic acid composition, weight ratio are 1:3~5:2~3.

8. a kind of preparation method of the sterilizing and itch-relieving medicated soap as described in any one of claim 1-7, which is characterized in that comprising as follows Specific steps:

(1) preparation of ozone salt: weighing sea salt and honey by list of ingredients, and the pure water of 5~25wt% of mixture is added after mixing, fills Divide mixing to be placed in closed reactor and be heated to 120~150 DEG C, constant temperature is evacuated 5~25min, takes out after moisture evaporating completely true Sky is cooled to 30~50 DEG C, and being filled with ozone to air pressure is 100~150MPa, maintains 30~120min of high pressure, and pumping is decompressed to often It presses, keeps the temperature 20~30min, take out solid, roll crushing, be sieved, guarantee partial size for 0.5~1.5mm to obtain the final product；

(2) Igepon A synthesizes: in the three-necked flask equipped with thermometer, nitrogen protection device and condensing unit Middle addition olive oil, animal fat and isethionic acid, are heated to 150~200 DEG C, and isethionic acid is added after melting completely Sodium, 2~4h of magnetic agitation temperature programming stop heating；To after reaction, cooled to room temperature, by a certain amount of anhydrous second Alcohol is added in three-necked flask and is uniformly mixed, and stops stirring after system is in milky suspension, is then filtered using decompression It carries out separating-purifying, is so repeated twice, dehydrated alcohol removes excessive raw material to obtain the final product；

(3) antipruritic water extract of TCM, Cocoamidopropyl betaine and foaming agent are weighed, 35~50% are made after completely dissolution Cocoamidopropyl betaine mixture；

(4) cocoyl isethionate is weighed, neat soap smashes it through 80 meshes, side dropwise addition Cocoamidopropyl betaine mixing The stirring of object side, mixing are placed on three-roll grinder grinding, grind 3~5 times, control grinding material temperature at 30~34 DEG C, are added Groomwell root oil, evening primrose oil, rose ethereal oil, root of kirilow rhodiola essential oil, wormwood blend of essential oils continue to grind, after grinding temperature be 33~ 37 DEG C, material is thick at this time；

(5) giant salamander pituitary extract, tremella polysaccharides, the light ethylsulfonic acid sodium of fatty acyl group is added immediately while hot, it is high-pressure homogeneous and cold But to 28~30 DEG C, ozone salt is added, mold, natural cooling are injected after being sufficiently stirred；

9. a kind of sterilizing and itch-relieving medicated soap according to any one of claim 8, it is characterised in that: the olive oil, animal The molar ratio of grease, isethionic acid and sodium isethionate is 6:6:3:7.