CN110944989A - 作为egfr激酶抑制剂的芳基磷氧化合物 - Google Patents

作为egfr激酶抑制剂的芳基磷氧化合物 Download PDF

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CN110944989A
CN110944989A CN201880047086.XA CN201880047086A CN110944989A CN 110944989 A CN110944989 A CN 110944989A CN 201880047086 A CN201880047086 A CN 201880047086A CN 110944989 A CN110944989 A CN 110944989A
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pharmaceutically acceptable
optionally substituted
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CN110944989B (zh
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吴凌云
刘希乐
丁照中
陈曙辉
胡利红
赵乐乐
潘威
胡国平
黎健
赵宁
赵钧
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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Abstract

一类新的作为EGFR激酶抑制剂的芳基磷氧化合物，其为式(I)所示化合物及其药学上可接受的盐。(I)

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN201880047086.XA 2017-07-19 2018-07-19 作为egfr激酶抑制剂的芳基磷氧化合物 Active CN110944989B (zh)

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CN202110675950.4A CN113354685B (zh) 2017-07-19 2018-07-19 作为egfr激酶抑制剂的芳基磷氧化合物
CN202110675806.0A CN113480575A (zh) 2017-07-19 2018-07-19 作为egfr激酶抑制剂的芳基磷氧化合物

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CN201710592778 2017-07-19
CN201710592778X 2017-07-19
CN201711277584 2017-12-06
CN2017112775847 2017-12-06
CN201810130633 2018-02-08
CN2018101306332 2018-02-08
CN201810355614X 2018-04-19
CN201810355614 2018-04-19
PCT/CN2018/096344 WO2019015655A1 (zh) 2017-07-19 2018-07-19 作为egfr激酶抑制剂的芳基磷氧化合物

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CN114181159A (zh) * 2021-12-28 2022-03-15 南通大学 含2,4,5-三取代嘧啶酰肼衍生物及其制备方法与应用

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KR20220136931A (ko) 2021-04-01 2022-10-11 주식회사 테라펙스 단백질 키나아제 저해 활성을 갖는 피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물
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