CN110916032A - 茶皂素解酒护肝饮料及其制备方法 - Google Patents
茶皂素解酒护肝饮料及其制备方法 Download PDFInfo
- Publication number
- CN110916032A CN110916032A CN201911066359.8A CN201911066359A CN110916032A CN 110916032 A CN110916032 A CN 110916032A CN 201911066359 A CN201911066359 A CN 201911066359A CN 110916032 A CN110916032 A CN 110916032A
- Authority
- CN
- China
- Prior art keywords
- tea saponin
- beverage
- protecting liver
- preparation
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001397 quillaja saponaria molina bark Substances 0.000 title claims abstract description 43
- 229930182490 saponin Natural products 0.000 title claims abstract description 43
- 150000007949 saponins Chemical class 0.000 title claims abstract description 43
- 235000013361 beverage Nutrition 0.000 title claims abstract description 39
- 210000004185 liver Anatomy 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 208000007848 Alcoholism Diseases 0.000 title claims abstract description 10
- 201000007930 alcohol dependence Diseases 0.000 title claims abstract description 10
- 235000012907 honey Nutrition 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 235000021552 granulated sugar Nutrition 0.000 claims abstract description 12
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 244000010000 Hovenia dulcis Species 0.000 claims abstract description 9
- 235000008584 Hovenia dulcis Nutrition 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 8
- 235000011477 liquorice Nutrition 0.000 claims abstract description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 4
- 241001122767 Theaceae Species 0.000 claims description 37
- 238000001914 filtration Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 13
- 206010019133 Hangover Diseases 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 238000007605 air drying Methods 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000009461 vacuum packaging Methods 0.000 claims description 5
- 238000000643 oven drying Methods 0.000 claims description 4
- 238000000967 suction filtration Methods 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 27
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 230000035622 drinking Effects 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 3
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 206010036067 polydipsia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
- 235000017709 saponins Nutrition 0.000 description 28
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 19
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 17
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 17
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 17
- 230000004913 activation Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 7
- 108010009513 Mitochondrial Aldehyde Dehydrogenase Proteins 0.000 description 6
- 102000009645 Mitochondrial Aldehyde Dehydrogenase Human genes 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 101710088194 Dehydrogenase Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- 229950006238 nadide Drugs 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 3
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 3
- 238000009928 pasteurization Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000002075 anti-alcohol Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 1
- VCNKUCWWHVTTBY-UHFFFAOYSA-N 18alpha-Oleanane Natural products C1CCC(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4CCC3C21C VCNKUCWWHVTTBY-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 241000825107 Hierochloe Species 0.000 description 1
- 235000015466 Hierochloe odorata Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 description 1
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 description 1
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000219100 Rhamnaceae Species 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- SIOMFBXUIJKTMF-UHFFFAOYSA-N hypoglauterpenic acid Natural products C1CC(O)C(C)(C)C2=CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C SIOMFBXUIJKTMF-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 description 1
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- BPAWXSVOAOLSRP-UHFFFAOYSA-N oleanane Natural products CCCCCCCCCCCCCCCC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5CC(C)(C)CCC5(C)C(O)CC34C)C1(C)C BPAWXSVOAOLSRP-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明公开了茶皂素解酒护肝饮料及其制备方法，用来缓解饮酒过量引起的不适感以及长期饮酒对胃、肝脏等造成的损伤。主要由茶皂素、枳椇子、甘草、蜂蜜、白砂糖和碳酸氢钠为原料按一定重量配比而成，同时调pH为7.5‑8.0以形成弱碱性环境。本发明原料来源方便安全，制备工艺简单，成本低廉；能用于大规模生产，具有广阔的市场前景。弱碱性环境不仅能增强茶皂素及各组分的解酒活性，还能促进人体对营养物质的吸收，同时，本产品对机体清除自由基，胃和肝脏具有良好的预防保护作用。
Description
技术领域
本发明涉及解酒饮料技术领域，尤其涉及茶皂素解酒护肝饮料及其制备方法。
背景技术
降低饮酒过度对人体带来的危害，关键在于提高乙醇脱氢酶和乙醛脱氢酶的酶活力，加速其对乙醇和乙醛的分解，从而降低乙醇和乙醛对脑、肝脏的危害，减轻酒精对肠胃的刺激，降低乙醛对细胞的氧化能力，促进新陈代谢。但是，现有的解酒类产品存在成分复杂效果欠佳等问题。
发明内容
基于背景技术存在的技术问题，本发明提出了茶皂素解酒护肝饮料及其制备方法，能够提高乙醇脱氢酶和乙醛脱氢酶的活性，从而达到很好的解酒效果。
本发明提出的一种茶皂素解酒护肝饮料的制备方法步骤如下：
S1：将枳椇子和甘草依次洗净、晾干，烘干后一起粉碎，晾干的条件为25-35℃下晾干4-8h；
S2：将S1中粉碎后的原料加水浸泡，然后进行煮制，结束后抽滤，得药液A；
S3：将S2抽滤后的滤渣加水煮制，结束后抽滤，得药液B；
S4：重复S3步骤1-3次，并将每次得到的药液B与药液A合并，合并后的药液搅拌均匀后用硅藻土过滤备用；
S5：将所述S4过滤后的药液与茶皂素、蜂蜜、白砂糖搅拌均匀，并用pH调节剂调节pH为弱碱性，然后再过滤、杀菌、真空包装得成品。
优选地，所述S1中烘干的条件为温度75-85℃、时间1.5-2.5h。
优选地，所述S2中原料与水的质量比为1:10-20，浸泡的时间为2-3h。
优选地，所述S2中的煮制条件为温度80-100℃、时间0.5-1h。
优选地，所述S3中滤渣与水的质量比为1:4-6，煮制的条件为温度80-100℃、时间20-40min。
优选地，包含如下重量份计的原料：茶皂素0.8-1.2份、枳椇子5-10份、甘草2-6份、蜂蜜6-10份、白砂糖1-3份。
优选地，饮料的pH为7.5-8.0。
优选地，所述pH调节剂为碳酸氢钠。
本发明提出的上述方法制备的茶皂素解酒护肝饮料。
本发明的S4中过滤后的药液需要进行浓缩处理，然后再加入茶皂素、蜂蜜、白砂糖和pH调节剂，保证每100重量份饮料中含有1重量份左右的茶皂素。
本发明的原料中，茶皂素又名皂甙，皂角甙，是山茶科植物中含有的一类天然糖苷，是齐墩果烷型五环三萜皂苷的混合物，基本结构由皂苷元、糖体、有机酸三部分组成。
枳椇子：枳椇子为鼠李科植物枳椇的带有肉质果柄的果实或种子，枳椇子中的黄酮类、三萜皂苷类和生物碱类物质对保护肝脏、抗氧化损伤、降压抗肿瘤具有良好的作用效果。在医书记载中也提起到枳椇子性平味甘、有止渴除烦、利尿解酒等功效。
甘草：甘草又名甜草、乌拉尔甘草是一种补益的中草药。有解毒、祛痰、止痛、解痉以至抗癌等药理作用。甘草中有效成份甘草甜素，对毒物有吸附作用能增强肝脏的解毒能力。甘草素、甘草苷等活性成分能抑制胃液、胃酸分泌，增加胃黏膜细胞的己精胺成份，保护胃黏膜，使之不受损害，促进消化道上皮细胞再生。
蜂蜜：又名蜂糖、石蜜，具有保护心脑血管、保护肝脏，促使肝细胞再生、增强免疫力、杀菌解毒、润肠通便的功效。其中蜂蜜中的果糖、葡萄糖等可促进酒精的分解吸收，加速酒精从血液中清除的速度。
作用机理：本申请的制备的饮料以茶皂素为主体，茶皂素一方面能够抑制血液对酒精的吸收，另一方面进入肝脏后由于其呈弱碱性，能够加快肝脏中乙醇脱氢酶和乙醛脱氢酶的激活，人体中的乙醇脱氢酶以多种二聚体的形式存在，由至少7种不同的基因编码。乙醇脱氢酶一共具有五个类别(Class I-V)，但在人的胃肝脏中存在的主要是Class I。它催化乙醇乙醛氧化作用为：CH3CH2OH+NAD+→CH3CHO+NADH+H+，乙醛脱氢酶是随机组合的四聚体，一个突变型的亚基影响了四聚体的稳定性，进而影响酶的正常表达。研究发现无论携带ALDH2*2的是纯合子(AA)还是杂合子(GA)，四聚的ALDH2均无活性，即ALDH2*2是显性遗传。杂合子GA的ALDH2四个亚基都稳定的概率是(0.5)^4＝6％，因而即使杂合子的野生型与突变等位基因等量表达，其正常的ALDH2的表达量也仅有6％。有ALDH2*2突变表达出的亚基的酶无法正常代谢乙醇的氧化产物乙醛，血液乙醛浓度增高，造成一系列饮酒后的不良反应。
乙醇脱氢酶主要负责将乙醇氧化为乙醛，如果单纯提高乙醇脱氢酶的活性的话则会出现肝脏内乙醛的大量积聚，反而会对人体健康产生更大的影响，而本申请制备的饮料不仅能够提高乙醇脱氢酶的激活率，还能够提高乙醛脱氢酶的激活率，从而提高了乙醛氧化为对人体无害的乙酸的速率，使进入肝脏内的乙醇能够快速分解，本申请制备的饮料中加入的枳椇子和甘草一方面起到护肝的作用，另一方面其还可与茶皂素发生协同作用，提高茶皂素对乙醇脱氢酶和乙醛脱氢酶的激活率，从而进一步提高饮料的解酒性能。
与现有技术相比，本发明的有益技术效果：本发明通过pH调节剂使饮料为弱碱性，提高了饮料对乙醇脱氢酶和乙醛脱氢酶的激活率，乙醇脱氢酶的激活率从弱酸环境下的50％提高到65％左右，乙醛脱氢酶的激活率从弱酸环境下的20％提高到35％左右，而乙醇脱氢酶和乙醛脱氢酶活性的提高能够加快对乙醇及乙醇分解的产物乙醛的分解，从而达到解酒护肝的效果。
具体实施方式
下面结合具体实施例对本发明作进一步解说。
实施例1
本发明的茶皂素解酒饮料的制备方法包括以下步骤：
(1)将枳椇子和甘草洗净、晾干、80℃烘干2h，粉碎，加入10倍的水浸泡3小时，在80℃温度下，煮制0.5h，抽滤，药渣加5倍的水，煮制0.5h，抽滤，合并滤液搅拌均匀后硅藻土过滤备用。
(2)将(1)中的备用液加入原料重量份的茶皂素、蜂蜜和白砂糖合并后搅拌均匀，并用碳酸氢钠调节PH为8.0，过滤膜、巴氏杀菌、真空包装即为成品。
其中：茶皂素0.8份、枳椇子8份、甘草6份、蜂蜜10份、白砂糖1份。
实施例2
本发明的茶皂素解酒饮料的制备方法包括以下步骤：
(1)将枳椇子和甘草洗净、晾干、80℃烘干2h，粉碎，加入15倍的水浸泡2h，在90℃温度下，煮制1h，抽滤，药渣加5倍的水，煮制0.5h，抽滤，合并后搅拌均匀后硅藻土过滤。
(2)将(1)中的备用液加入原料重量份的茶皂素、蜂蜜和白砂糖合并后搅拌均匀，并用碳酸氢钠调节PH为7.5，过滤膜、巴氏杀菌、真空包装即为成品。
其中各原料按重量份计：茶皂素1.2份、枳椇子6份、甘草2份、蜂蜜8份、白砂糖3份。
实施例3
本发明的茶皂素解酒饮料的制备方法包括以下步骤：
(1)将枳椇子和甘草洗净、晾干、80℃烘干2h、粉碎，加入20倍的水浸泡2小时，在100℃温度下，煮制0.5h，抽滤，药渣加5倍的水，煮制0.5h，抽滤，合并后搅拌均匀后硅藻土过滤。
(2)将(1)中的备用液加入原料重量份的茶皂素、蜂蜜和白砂糖合并后搅拌均匀，并用碳酸氢钠调节PH为7.5，过滤膜、巴氏杀菌、真空包装即为成品。
其中各原料按重量份计：茶皂素1份、枳椇子10份、甘草5份、蜂蜜8份、白砂糖2份。
对比例1
该方案与实施例1的区别在于未加入pH调节剂，制备的饮料的pH在6.0左右。
对比例2
该方案与实施例1的区别在于通过碳酸氢钠调节pH为7.0。
分别对实施例1-3和对比例1-2中制备的饮料的解酒性能进行测定，主要测定饮料对乙醇脱氢酶和乙醛脱氢酶的活性促进效果，其中：
乙醇脱氢酶的活力测定采用瓦勒-霍赫法。在试管中分别加入焦磷酸钠缓冲液1.5mL(pH＝8.8)、0.5mL 11.5％(V:V)的乙醇溶液1.0mL 27mmol/L的氧化型辅酶I(NAD+)和一定浓度的茶皂素口服液0.1mL,混合后放入25℃水浴中保温10min。结束后，试管立即加入0.1mL 0.25U/mL的ADH,摇匀后立即在分光光度计340nm波长处测定吸光度值(A340nm),然后每隔10s记数一次,连续测定5min，实验结果作为测定组。以0.5mL蒸馏水作空白调零，以0.1mL蒸馏水代替0.1mL茶皂素饮料作为空白组，测定空白组乙醇脱氢酶的酶活力。
乙醇脱氢酶活性计算法：
以A对时间作图，取反应最初级性部分，计算A340/10s的增加值，根据NADH在340nm处的摩尔消光系数为6.2，计算酶活力。ADH的活性以每分钟NADH生成的纳摩尔数表示。
上述每种实验均重复三次，所测实验数据以
表示，采用配对t检验进行统计学分析，实验结果如表1所示。
表1乙醇脱氢酶活性测定结果
如表1可知，实施例与对比例相比，其乙醇脱氢酶的激活率有显著地提高，从而说明弱碱条件下有利于解酒饮料对乙醇脱氢酶的激活，从而其解酒效果更好。
乙醛脱氢酶活性测定方法：
乙醛脱氢酶活性测定采用Blair&Bodley法。取干燥试管；加入100mmol/L PH为9.5的焦磷酸钠缓冲液1.6mL；加入3.6mmol/L氧化型辅酶I(NAD+)1.0mL；加入100mmol/L乙醛0.1mL；一定浓度的茶皂素饮料0.1mL(空白组加入同体积蒸馏水)0.1mL；混匀，在30℃条件下温育5min；取出立即加入18mmol/L ALDH 0.2mL，摇匀；于340nm波长处测定吸光度，每1min读数1次，直至每分钟吸光度的值达到稳定为止。
上述每种实验均重复三次，所测实验数据以
表示，采用配对t检验进行统计学分析，试验结果如表2所示。
表2乙醛脱氢酶活性测定结果
同样的，从表2可以看出实施例相对于对比例来说，乙醛脱氢酶的激活率的得到显著地提高，从而说明弱碱条件下有利于解酒饮料对乙醛脱氢酶的激活，从而其解酒效果更好。
综上所述，本申请制备的解酒饮料具有很好的激活乙醇脱氢酶和乙醛脱氢酶的效果，具有很好的解酒和护肝的功效。
此外，还对实施例1-3制得的饮料的理化性质进行了测定，其细菌总数(cfu/ml)<70，大肠杆菌(MPN/ml)<1，没有检出致病菌，符合国家标准。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (9)
1.一种茶皂素解酒护肝饮料的制备方法，其特征在于，方法步骤如下：
S1：将枳椇子和甘草依次洗净、晾干，烘干后一起粉碎；
S2：将S1中粉碎后的原料加水浸泡，然后进行煮制，结束后抽滤，得药液A；
S3：将S2抽滤后的滤渣加水煮制，结束后抽滤，得药液B；
S4：重复S3步骤1-3次，并将每次得到的药液B与药液A合并，合并后的药液搅拌均匀后过滤备用；
S5：将所述S4过滤后的药液与茶皂素、蜂蜜、白砂糖搅拌均匀，并用pH调节剂调节pH为弱碱性，然后再过滤、杀菌、真空包装得成品。
2.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，所述S1中烘干的条件为温度75-85℃、时间1.5-2.5h。
3.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，所述S2中原料与水的质量比为1:10-20，浸泡的时间为2-3h。
4.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，所述S2中的煮制条件为温度80-100℃、时间0.5-1h。
5.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，所述S3中滤渣与水的质量比为1:4-6，煮制的条件为温度80-100℃、时间20-40min。
6.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，包含如下重量份计的原料：
茶皂素0.8-1.2份、枳椇子5-10份、甘草2-6份、蜂蜜6-10份、白砂糖1-3份。
7.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，饮料的pH为7.5-8.0。
8.根据权利要求1所述的茶皂素解酒护肝饮料的制备方法，其特征在于，所述pH调节剂为碳酸氢钠。
9.一种如权利要求1-8任一项所述方法制备的茶皂素解酒护肝饮料。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911066359.8A CN110916032A (zh) | 2019-11-04 | 2019-11-04 | 茶皂素解酒护肝饮料及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911066359.8A CN110916032A (zh) | 2019-11-04 | 2019-11-04 | 茶皂素解酒护肝饮料及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110916032A true CN110916032A (zh) | 2020-03-27 |
Family
ID=69852297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911066359.8A Pending CN110916032A (zh) | 2019-11-04 | 2019-11-04 | 茶皂素解酒护肝饮料及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110916032A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518351A (zh) * | 2009-03-27 | 2009-09-02 | 武汉市久共合工贸有限公司 | 一种弱碱性植物解酒饮料及其制备方法 |
| CN102342357A (zh) * | 2010-07-27 | 2012-02-08 | 襄樊隆中药业有限责任公司 | 一种解酒异型糖片的配方及配制方法 |
| CN102696830A (zh) * | 2012-06-15 | 2012-10-03 | 刘富来 | 一种弱碱性解酒护肝枳仙茶及其制备方法 |
| CN105777848A (zh) * | 2016-04-20 | 2016-07-20 | 合肥工业大学 | 一种从油茶饼粕中制备具有解酒功能茶皂素的方法 |
| CN106962934A (zh) * | 2017-04-27 | 2017-07-21 | 合肥工业大学 | 一种以茶皂素为主体的解酒饮料 |
-
2019
- 2019-11-04 CN CN201911066359.8A patent/CN110916032A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518351A (zh) * | 2009-03-27 | 2009-09-02 | 武汉市久共合工贸有限公司 | 一种弱碱性植物解酒饮料及其制备方法 |
| CN102342357A (zh) * | 2010-07-27 | 2012-02-08 | 襄樊隆中药业有限责任公司 | 一种解酒异型糖片的配方及配制方法 |
| CN102696830A (zh) * | 2012-06-15 | 2012-10-03 | 刘富来 | 一种弱碱性解酒护肝枳仙茶及其制备方法 |
| CN105777848A (zh) * | 2016-04-20 | 2016-07-20 | 合肥工业大学 | 一种从油茶饼粕中制备具有解酒功能茶皂素的方法 |
| CN106962934A (zh) * | 2017-04-27 | 2017-07-21 | 合肥工业大学 | 一种以茶皂素为主体的解酒饮料 |
Non-Patent Citations (1)
| Title |
|---|
| 仇凤梅等: "茶皂素解酒饮料的研制", 《农产品加工》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2020048049A1 (zh) | 一种从罗汉果中制备罗汉果甜味组合物的方法及其应用 | |
| KR102062716B1 (ko) | 숙성노니원액이 함유된 숙취해소용 음료조성물 및 그의 제조방법 | |
| KR101301094B1 (ko) | 숙취해소 또는 간 기능 개선용 조성물 | |
| WO1998019687A1 (fr) | Thes naturels destines a combattre les effets de la boisson et procedes de preparation desdits thes | |
| CN106070861A (zh) | 一种复合桦褐孔菌代用茶及其制备方法 | |
| CN105056096B (zh) | 补肾活血通络酒及其制备方法 | |
| KR101461165B1 (ko) | 숙취해소용 식품조성물 | |
| KR100718189B1 (ko) | 숙취해소 및 간기능 회복에 효과가 있는 천연차 및 그제조 방법 | |
| CN110607218B (zh) | 一种醒酒醋及其制备方法与用途 | |
| CN108174945A (zh) | 一种针对吸烟者的清咽润肺食品及其制备方法 | |
| CN112535230A (zh) | 一种草本植物玉米肽维生素糖丸及其制备方法 | |
| CN110916032A (zh) | 茶皂素解酒护肝饮料及其制备方法 | |
| KR102127411B1 (ko) | 복합 천연 추출물을 함유하는 간기능 보호 및 숙취해소용 조성물 | |
| KR20190101063A (ko) | 천연물질 추출물을 함유하는 기관지 질환 예방 및 개선을 위한 조성물 및 그 제조방법 | |
| CN115104730A (zh) | 一种改善睡眠的组合物、线叶金雀花-芦笋睡眠改善液、茶粉的制备方法和应用 | |
| CN101166538A (zh) | 用于预防和治疗酒后病的组合物 | |
| KR101950983B1 (ko) | 엘더베리 조성물 및 이를 이용하는 음료의 제조 방법 | |
| CN107252025A (zh) | 一种预防老年痴呆的固体饮料 | |
| CN113197268A (zh) | 一种醒酒护肝的软饮料及其制备方法 | |
| KR102136053B1 (ko) | 허브추출물을 유효성분으로 하는 숙취해소용 조성물 및 이를 함유하는 음료 | |
| KR101274099B1 (ko) | 유효성분으로 헛개나무줄기새순 및 갈화를 함유하는 숙취해소용 조성물 | |
| CN105380267B (zh) | 一种功能食品及其制备方法 | |
| KR102685420B1 (ko) | 감귤류 가공부산물 효소분해 추출물을 포함하는 숙취해소용 조성물 | |
| KR20050105781A (ko) | 숙취해소용 조성물 및 이를 유효성분으로 함유하는건강보조식품 | |
| KR20140100336A (ko) | 헛개나무 목질부로부터 분리된 추출물을 포함하는 숙취해소 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200327 |