CN1108824C - 生物活化的诊断成像造影剂 - Google Patents

生物活化的诊断成像造影剂 Download PDF

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Publication number
CN1108824C
CN1108824C CN97193542A CN97193542A CN1108824C CN 1108824 C CN1108824 C CN 1108824C CN 97193542 A CN97193542 A CN 97193542A CN 97193542 A CN97193542 A CN 97193542A CN 1108824 C CN1108824 C CN 1108824C
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China
Prior art keywords
application
prodrug
protein
bioactivation
contrast agent
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Expired - Fee Related
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CN97193542A
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English (en)
Chinese (zh)
Other versions
CN1215341A (zh
Inventor
R·B·拉富尔
T·J·麦克穆里
S·O·杜哈姆
D·M·斯考特
D·J·帕米利
S·杜马斯
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Epix Pharmaceuticals Inc
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Epix Pharmaceuticals Inc
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Publication of CN1215341A publication Critical patent/CN1215341A/zh
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Publication of CN1108824C publication Critical patent/CN1108824C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN97193542A 1996-04-01 1997-03-25 生物活化的诊断成像造影剂 Expired - Fee Related CN1108824C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1444896P 1996-04-01 1996-04-01
US60/014,448 1996-04-01

Publications (2)

Publication Number Publication Date
CN1215341A CN1215341A (zh) 1999-04-28
CN1108824C true CN1108824C (zh) 2003-05-21

Family

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Family Applications (1)

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CN97193542A Expired - Fee Related CN1108824C (zh) 1996-04-01 1997-03-25 生物活化的诊断成像造影剂

Country Status (18)

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US (3) US6709646B2 (cg-RX-API-DMAC7.html)
EP (1) EP0907379B1 (cg-RX-API-DMAC7.html)
JP (2) JP2000507577A (cg-RX-API-DMAC7.html)
KR (1) KR20060025233A (cg-RX-API-DMAC7.html)
CN (1) CN1108824C (cg-RX-API-DMAC7.html)
AT (1) ATE268187T1 (cg-RX-API-DMAC7.html)
AU (1) AU726914B2 (cg-RX-API-DMAC7.html)
BR (1) BR9708470A (cg-RX-API-DMAC7.html)
CA (1) CA2247620A1 (cg-RX-API-DMAC7.html)
DE (1) DE69729380T2 (cg-RX-API-DMAC7.html)
DK (1) DK0907379T3 (cg-RX-API-DMAC7.html)
ES (1) ES2217408T3 (cg-RX-API-DMAC7.html)
IL (1) IL125895A (cg-RX-API-DMAC7.html)
IS (1) IS2059B (cg-RX-API-DMAC7.html)
NO (1) NO319674B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ331629A (cg-RX-API-DMAC7.html)
PT (1) PT907379E (cg-RX-API-DMAC7.html)
WO (1) WO1997036619A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
AU2544897A (en) 1997-10-22
IL125895A0 (en) 1999-04-11
US20040156785A1 (en) 2004-08-12
DE69729380T2 (de) 2005-07-14
PT907379E (pt) 2004-09-30
US20060275216A1 (en) 2006-12-07
US20020034476A1 (en) 2002-03-21
NO984543L (no) 1998-11-26
EP0907379A2 (en) 1999-04-14
BR9708470A (pt) 1999-04-13
DE69729380D1 (de) 2004-07-08
ATE268187T1 (de) 2004-06-15
NO319674B1 (no) 2005-09-05
IL125895A (en) 2001-09-13
KR20060025233A (ko) 2006-03-20
CN1215341A (zh) 1999-04-28
HK1016877A1 (en) 1999-11-12
WO1997036619A3 (en) 1998-01-29
DK0907379T3 (da) 2004-08-16
JP2004210796A (ja) 2004-07-29
EP0907379B1 (en) 2004-06-02
US6709646B2 (en) 2004-03-23
US7147837B2 (en) 2006-12-12
CA2247620A1 (en) 1997-10-09
ES2217408T3 (es) 2004-11-01
NO984543D0 (no) 1998-09-29
WO1997036619A2 (en) 1997-10-09
NZ331629A (en) 2000-04-28
IS2059B (is) 2005-10-14
IS4833A (is) 1998-08-26
JP2000507577A (ja) 2000-06-20
AU726914B2 (en) 2000-11-23

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