CN110876683A - Blue copper polypeptide freeze-dried powder and preparation method thereof - Google Patents
Blue copper polypeptide freeze-dried powder and preparation method thereof Download PDFInfo
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- CN110876683A CN110876683A CN201911255552.6A CN201911255552A CN110876683A CN 110876683 A CN110876683 A CN 110876683A CN 201911255552 A CN201911255552 A CN 201911255552A CN 110876683 A CN110876683 A CN 110876683A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses blue copper polypeptide freeze-dried powder which comprises the following components in percentage by mass: 4.5 to 5.5 percent of mannitol, 2.5 to 3.5 percent of trehalose, 0.5 to 1.5 percent of tripeptide-1 copper, 31 to 2 percent of oligopeptide-1, 0.03 to 0.07 percent of adenosine, 0.5 to 1.5 percent of euglena gracilis polysaccharide, 0.5 to 1.5 percent of hydrolyzed collagen, 1.5 to 2.5 percent of sodium hyaluronate and 85 to 86 percent of water, wherein the preparation method comprises the following steps: s1, weighing sodium hyaluronate, hydrolyzed collagen, mannitol and water, stirring for 12-30 minutes, and heating to obtain a transparent first preparation solution; s2, cooling the transparent first preparation liquid; s3, weighing trehalose, tripeptide-1 copper, oligopeptide-3, adenosine and euglena polysaccharide, adding into the transparent preparation liquid I, and stirring and heating to obtain a transparent preparation liquid II; and S4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying. The invention has the advantages that: can reduce scar generation, effectively fade scar, and has good wrinkle removing effect and convenient use.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to blue copper polypeptide freeze-dried powder and a preparation method thereof.
Background
Nowadays, social substance lives more and more abundantly, people pay more and more attention to the appearance problem of the people, after skin injury, scars left on the skin troubles many beauty-loving people, meanwhile, with the increase of age and the deterioration of living environment, the metabolism of the skin is reduced, the function of absorbing various beneficial elements is reduced, water is easy to lose, various harmful substances are easy to stay on the surface of the skin, the skin gradually loses the original elasticity, so that the skin care product becomes the most popular choice of most people, especially contemporary women, and the good skin care product can play the effects of promoting skin blood circulation, repairing skin injury, keeping skin moisture, increasing skin elasticity and luster, caring skin sensitivity and the like.
However, although skin care products on the market are full of scales and various, most skin care products are fine chemical products, only the surface layer problem of the skin is solved, the skin repair effect cannot be fundamentally achieved, and some cosmetics are added with components such as hormone, so that the beauty effect is not obvious, the negative influence is caused on the human body, and the use safety performance is poor.
Disclosure of Invention
The invention aims to solve the technical problems and provides the blue copper polypeptide freeze-dried powder which can reduce scar generation, effectively fade scars, has good wrinkle removing effect and is convenient to use and the preparation method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: the blue copper polypeptide freeze-dried powder comprises the following components in percentage by mass: 4.5 to 5.5 percent of mannitol, 2.5 to 3.5 percent of trehalose, 0.5 to 1.5 percent of tripeptide-1 copper, 31 to 2 percent of oligopeptide-1, 0.03 to 0.07 percent of adenosine, 0.5 to 1.5 percent of euglena polysaccharide, 0.5 to 1.5 percent of hydrolyzed collagen, 1.5 to 2.5 percent of sodium hyaluronate and 85 to 86 percent of water.
Preferably, the composition comprises the following components in percentage by mass: 4.7 to 5.3 percent of mannitol, 2.7 to 3.3 percent of trehalose, 0.7 to 1.3 percent of tripeptide-1 copper, 31.2 to 1.8 percent of oligopeptide-0.04 to 0.06 percent of adenosine, 0.7 to 1.3 percent of euglena gracilis polysaccharide, 0.7 to 1.3 percent of hydrolyzed collagen, 1.7 to 2.3 percent of sodium hyaluronate and 85.2 to 85.8 percent of water.
Preferably, the composition comprises the following components in percentage by mass: mannitol 5%, trehalose 3%, tripeptide-1 copper 1%, oligopeptide-31.5%, adenosine 0.05%, euglena polysaccharide 1%, hydrolyzed collagen 1%, sodium hyaluronate 2%, and water 85.45%.
Preferably, the water is purified water after secondary filtration.
Preferably, the preparation method of the blue copper polypeptide freeze-dried powder comprises the following steps:
s1, weighing sodium hyaluronate, hydrolyzed collagen, mannitol and water, stirring for 12-30 minutes, and heating at 70-80 ℃ to obtain a first transparent solution;
s2, cooling the transparent first preparation solution to enable the transparent first preparation solution to be cooled to 15-30 ℃ at a constant speed;
s3, weighing trehalose, tripeptide-1 copper, oligopeptide-3, adenosine and euglena polysaccharide, adding the weighed materials into the first transparent preparation solution, stirring for 15-30 minutes, heating to 40-60 ℃ to obtain a second transparent preparation solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into a freeze-drying device, and freeze-drying at the temperature of-15 to-5 ℃.
Compared with the prior art, the invention has the advantages that: according to the blue copper polypeptide freeze-dried powder and the preparation method thereof, trehalose can form a unique protective film on the surface of cells under severe environmental conditions such as high temperature, high cold, high osmotic pressure, drying and dehydration, so that protein molecules can be effectively protected from invariance inactivation, and skin cells can be well protected; oligopeptide-3 is combined with a cell surface specific receptor to regulate and control division, reproduction and growth differentiation of skin epithelium, endothelium and stromal cells, promote cell metabolism, enhance oxidation and have good skin repair effect; the tripeptide-1 copper can promote the regeneration of skin epithelial tissues, restore skin youth, reduce coarse and fine wrinkles and scars, improve skin elasticity, and proliferate keratinocytes and fibroblasts, can thicken subcutaneous tissues, enables the skin to be not fragile and sensitive any more, increases the skin elasticity and toughness, and enables a maintenance product to be absorbed and utilized on the face to the maximum extent; the euglena gracilis polysaccharide can adsorb redundant substances in a human body such as cholesterol, neutral fat, heavy metal, alcohol and the like to be discharged out of the body due to an internal porous structure, so that the euglena gracilis polysaccharide has strong effects of resisting oxidation and viruses and removing free radicals; meanwhile, the freeze-drying synthesis process is adopted to fully extract the effective components in the raw materials, so that the freeze-drying powder is smeared on the face when in use, and the face mask is convenient to use and good in absorptivity.
Detailed Description
Example one
The blue copper polypeptide freeze-dried powder comprises the following components in percentage by mass: 4.8% of mannitol, 3.2% of trehalose, 0.8% of tripeptide-1 copper, 31.7% of oligopeptide, 0.05% of adenosine, 0.8% of euglena polysaccharide, 1.2% of hydrolyzed collagen, 1.8% of sodium hyaluronate and 85.65% of water.
The preparation method comprises the following steps:
s1, weighing sodium hyaluronate, hydrolyzed collagen, mannitol and water, stirring for 30 minutes, and heating at 80 ℃ to obtain a first transparent solution;
s2, cooling the transparent first preparation solution to enable the temperature to be reduced to 15 ℃ at a constant speed;
s3, weighing trehalose, tripeptide-1 copper, oligopeptide-3, adenosine and euglena polysaccharide, adding into the first transparent preparation solution, stirring for 30 minutes, heating to 60 ℃ to obtain a second transparent preparation solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying at the temperature of-5 ℃.
Example two
The blue copper polypeptide freeze-dried powder comprises the following components in percentage by mass: mannitol 5%, trehalose 3%, tripeptide-1 copper 1%, oligopeptide-31.5%, adenosine 0.05%, euglena polysaccharide 1%, hydrolyzed collagen 1%, sodium hyaluronate 2%, and water 85.45%.
The preparation method comprises the following steps:
s1, weighing sodium hyaluronate, hydrolyzed collagen, mannitol and water, stirring for 25 minutes, and heating at 75 ℃ to obtain a first transparent solution;
s2, cooling the transparent first preparation solution to enable the temperature to be reduced to 20 ℃ at a constant speed;
s3, weighing trehalose, tripeptide-1 copper, oligopeptide-3, adenosine and euglena polysaccharide, adding into the transparent preparation solution I, stirring for 20 minutes, heating to 45 ℃ to obtain a transparent preparation solution II;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying at the temperature of-8 ℃.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (5)
1. The blue copper polypeptide freeze-dried powder is characterized by comprising the following components in percentage by mass: 4.5 to 5.5 percent of mannitol, 2.5 to 3.5 percent of trehalose, 0.5 to 1.5 percent of tripeptide-1 copper, 31 to 2 percent of oligopeptide-1, 0.03 to 0.07 percent of adenosine, 0.5 to 1.5 percent of euglena polysaccharide, 0.5 to 1.5 percent of hydrolyzed collagen, 1.5 to 2.5 percent of sodium hyaluronate and 85 to 86 percent of water.
2. The blue copper polypeptide freeze-dried powder according to claim 1, which is characterized by comprising the following components in percentage by mass: 4.7 to 5.3 percent of mannitol, 2.7 to 3.3 percent of trehalose, 0.7 to 1.3 percent of tripeptide-1 copper, 31.2 to 1.8 percent of oligopeptide-0.04 to 0.06 percent of adenosine, 0.7 to 1.3 percent of euglena gracilis polysaccharide, 0.7 to 1.3 percent of hydrolyzed collagen, 1.7 to 2.3 percent of sodium hyaluronate and 85.2 to 85.8 percent of water.
3. The blue copper polypeptide freeze-dried powder according to claim 1, which is characterized by comprising the following components in percentage by mass: mannitol 5%, trehalose 3%, tripeptide-1 copper 1%, oligopeptide-31.5%, adenosine 0.05%, euglena polysaccharide 1%, hydrolyzed collagen 1%, sodium hyaluronate 2%, and water 85.45%.
4. The blue copper polypeptide freeze-dried powder according to claim 1, which is characterized in that: the water is purified water after secondary filtration.
5. The preparation method of the blue copper polypeptide freeze-dried powder according to claim 1, which is characterized by comprising the following steps:
s1, weighing sodium hyaluronate, hydrolyzed collagen, mannitol and water, stirring for 12-30 minutes, and heating at 70-80 ℃ to obtain a first transparent solution;
s2, cooling the transparent first preparation solution to enable the transparent first preparation solution to be cooled to 15-30 ℃ at a constant speed;
s3, weighing trehalose, tripeptide-1 copper, oligopeptide-3, adenosine and euglena polysaccharide, adding the weighed materials into the first transparent preparation solution, stirring for 15-30 minutes, heating to 40-60 ℃ to obtain a second transparent preparation solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into a freeze-drying device, and freeze-drying at the temperature of-15 to-5 ℃.
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CN201911255552.6A CN110876683A (en) | 2019-12-10 | 2019-12-10 | Blue copper polypeptide freeze-dried powder and preparation method thereof |
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CN201911255552.6A CN110876683A (en) | 2019-12-10 | 2019-12-10 | Blue copper polypeptide freeze-dried powder and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111358732A (en) * | 2020-04-08 | 2020-07-03 | 陈占军 | Rice fermentation product and rice bran extract freeze-dried powder and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111358732A (en) * | 2020-04-08 | 2020-07-03 | 陈占军 | Rice fermentation product and rice bran extract freeze-dried powder and preparation method thereof |
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