CN110869029A - 组合癌症治疗 - Google Patents

组合癌症治疗 Download PDF

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Publication number
CN110869029A
CN110869029A CN201880046014.3A CN201880046014A CN110869029A CN 110869029 A CN110869029 A CN 110869029A CN 201880046014 A CN201880046014 A CN 201880046014A CN 110869029 A CN110869029 A CN 110869029A
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pharmaceutical composition
acid
inhibitor
use according
subject
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CN201880046014.3A
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Chinese (zh)
Inventor
鲁思·本亚喀尔
斯泰拉·甘格里诺维奇
所司·特斯勒
利亚特·弗莱肖恩
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Biosight Ltd
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Biosight Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201880046014.3A 2017-07-09 2018-07-09 组合癌症治疗 Pending CN110869029A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762530213P 2017-07-09 2017-07-09
US62/530,213 2017-07-09
PCT/IB2018/000852 WO2019012328A1 (en) 2017-07-09 2018-07-09 ANTICANCER POLY THERAPY

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CN110869029A true CN110869029A (zh) 2020-03-06

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US (1) US20200147117A1 (enExample)
EP (1) EP3651772A4 (enExample)
JP (2) JP7305613B2 (enExample)
KR (1) KR20200027548A (enExample)
CN (1) CN110869029A (enExample)
BR (1) BR112020000492A2 (enExample)
CA (1) CA3069558A1 (enExample)
IL (1) IL271946B (enExample)
WO (1) WO2019012328A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114026121A (zh) * 2019-01-28 2022-02-08 赛诺菲 治疗多发性骨髓瘤的方法
CN115461058A (zh) * 2020-04-23 2022-12-09 拜欧赛特有限公司 用于治疗血液癌的方法和方案
WO2025149017A1 (zh) * 2024-01-11 2025-07-17 四川弘合生物科技有限公司 一种包含榄香烯和激酶抑制剂的药物

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