CN110732038A - 一种丝素蛋白纤维中空神经导管及其制备方法和应用 - Google Patents
一种丝素蛋白纤维中空神经导管及其制备方法和应用 Download PDFInfo
- Publication number
- CN110732038A CN110732038A CN201911066992.7A CN201911066992A CN110732038A CN 110732038 A CN110732038 A CN 110732038A CN 201911066992 A CN201911066992 A CN 201911066992A CN 110732038 A CN110732038 A CN 110732038A
- Authority
- CN
- China
- Prior art keywords
- silk fibroin
- fibroin fiber
- nerve conduit
- parts
- fiber hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000835 fiber Substances 0.000 title claims abstract description 148
- 108010022355 Fibroins Proteins 0.000 title claims abstract description 139
- 210000005036 nerve Anatomy 0.000 title claims abstract description 85
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- 241000255789 Bombyx mori Species 0.000 claims description 40
- 238000003756 stirring Methods 0.000 claims description 40
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 33
- 239000000622 polydioxanone Substances 0.000 claims description 33
- 239000008367 deionised water Substances 0.000 claims description 28
- 229910021641 deionized water Inorganic materials 0.000 claims description 28
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 24
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 22
- 235000019253 formic acid Nutrition 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 22
- 230000008961 swelling Effects 0.000 claims description 19
- 238000005406 washing Methods 0.000 claims description 16
- 238000005303 weighing Methods 0.000 claims description 16
- 238000009835 boiling Methods 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 12
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 12
- 238000007710 freezing Methods 0.000 claims description 11
- 230000008014 freezing Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 230000006835 compression Effects 0.000 claims description 7
- 238000007906 compression Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000008055 phosphate buffer solution Substances 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 2
- 230000007480 spreading Effects 0.000 claims description 2
- 238000003892 spreading Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 33
- 239000011521 glass Substances 0.000 description 15
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 229910001220 stainless steel Inorganic materials 0.000 description 12
- 239000010935 stainless steel Substances 0.000 description 12
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 10
- 229910052782 aluminium Inorganic materials 0.000 description 10
- 239000011888 foil Substances 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 8
- 230000012010 growth Effects 0.000 description 8
- 229910052742 iron Inorganic materials 0.000 description 7
- 210000002569 neuron Anatomy 0.000 description 7
- 210000004116 schwann cell Anatomy 0.000 description 6
- 208000028389 Nerve injury Diseases 0.000 description 5
- 108010013296 Sericins Proteins 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000003517 fume Substances 0.000 description 5
- 230000008764 nerve damage Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 238000004382 potting Methods 0.000 description 5
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000010886 Peripheral nerve injury Diseases 0.000 description 1
- 238000011316 allogeneic transplantation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Artificial Filaments (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911066992.7A CN110732038B (zh) | 2019-11-04 | 2019-11-04 | 一种丝素蛋白纤维中空神经导管及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911066992.7A CN110732038B (zh) | 2019-11-04 | 2019-11-04 | 一种丝素蛋白纤维中空神经导管及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110732038A true CN110732038A (zh) | 2020-01-31 |
CN110732038B CN110732038B (zh) | 2022-03-11 |
Family
ID=69272156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911066992.7A Active CN110732038B (zh) | 2019-11-04 | 2019-11-04 | 一种丝素蛋白纤维中空神经导管及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110732038B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115869466A (zh) * | 2021-09-27 | 2023-03-31 | 中国科学院理化技术研究所 | 神经修复管、其制备、应用和制备该神经修复管的模具 |
CN117018290A (zh) * | 2023-10-10 | 2023-11-10 | 常州丝波敦生物科技有限公司 | 一种具有仿生取向结构的丝蛋白纳米纤维神经导管及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106938057A (zh) * | 2016-12-14 | 2017-07-11 | 南通纺织丝绸产业技术研究院 | 一种丝素蛋白纤维支架及其制备方法 |
CN108114315A (zh) * | 2018-02-22 | 2018-06-05 | 南通大学 | 一种双丝素蛋白神经移植物 |
CN109316633A (zh) * | 2016-08-19 | 2019-02-12 | 苏州大学 | 一种丝素蛋白微纳米纤维多孔支架及其应用 |
-
2019
- 2019-11-04 CN CN201911066992.7A patent/CN110732038B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109316633A (zh) * | 2016-08-19 | 2019-02-12 | 苏州大学 | 一种丝素蛋白微纳米纤维多孔支架及其应用 |
CN106938057A (zh) * | 2016-12-14 | 2017-07-11 | 南通纺织丝绸产业技术研究院 | 一种丝素蛋白纤维支架及其制备方法 |
CN108114315A (zh) * | 2018-02-22 | 2018-06-05 | 南通大学 | 一种双丝素蛋白神经移植物 |
Non-Patent Citations (1)
Title |
---|
贾挺挺等: "聚对二氧环己酮的应用研究进展", 《化学研究与应用》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115869466A (zh) * | 2021-09-27 | 2023-03-31 | 中国科学院理化技术研究所 | 神经修复管、其制备、应用和制备该神经修复管的模具 |
CN117018290A (zh) * | 2023-10-10 | 2023-11-10 | 常州丝波敦生物科技有限公司 | 一种具有仿生取向结构的丝蛋白纳米纤维神经导管及其制备方法 |
CN117018290B (zh) * | 2023-10-10 | 2024-01-05 | 常州丝波敦生物科技有限公司 | 一种具有仿生取向结构的丝蛋白纳米纤维神经导管及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN110732038B (zh) | 2022-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69828050T2 (de) | Ein Verfahren zur Herstellung eines Polyvinylalkohol-Kryogels | |
CN103877617B (zh) | 可注射蚕丝素蛋白-海藻酸盐双交联水凝胶及其制备方法和使用方法 | |
CN109999227B (zh) | 一种基于丝素蛋白和甲壳素混纺纳米纤维嵌入式水凝胶软骨仿生支架的制备方法及应用 | |
CN106730034B (zh) | 基于切片式去细胞支架构建的人工神经移植物及制备方法 | |
CN102218160B (zh) | 神经组织基质源性组织工程支架材料的制备及其应用 | |
CN102671236B (zh) | 纳米纤维增强水凝胶仿生人工半月板复合材料的制备方法 | |
CN103394125A (zh) | 一种组织工程双层管状支架及其制备方法 | |
CN110732038B (zh) | 一种丝素蛋白纤维中空神经导管及其制备方法和应用 | |
CN109851819A (zh) | 一种可注射丝素蛋白多孔水凝胶及其制备方法 | |
CN110038163B (zh) | 一种用于修复腹壁缺损的水凝胶复合生物补片制备方法 | |
CN103263308B (zh) | 多微孔可降解胶原-壳聚糖神经导管及其制备方法 | |
CN108273131A (zh) | 一种复合骨水泥、制备方法及其应用和一种骨修复材料 | |
CN102526809A (zh) | 一种用于骨软骨缺损修复的支架及其制备方法 | |
CN105854077A (zh) | 一种新型神经修复组织工程支架的制备方法 | |
CN114344564B (zh) | 一种仿生多通道电活性神经导管及其制备方法 | |
EP3821919B1 (de) | Verfahren zur herstellung eines bioartifiziellen, primär azellulären konstrukts auf fibrinbasis und dieses konstrukt selbst | |
CN106581776A (zh) | 定向微孔胶原/壳聚糖/丝素蛋白复合支架及其制备方法 | |
CN102552985B (zh) | 一种丝素蛋白/磷酸钙骨水泥基多孔复合材料及其制备方法 | |
CN106581754A (zh) | 一种高仿真组织工程神经修复支架及其制备方法 | |
CN108310461A (zh) | 具有定向释放功能的多孔丝素脊髓支架及其制备方法、制备模具和应用 | |
CN107519535B (zh) | 可降解海藻酸钠/丝素双层皮肤组织工程支架材料及其制备方法 | |
CN114732954A (zh) | 一种载药型人工皮肤及其制备方法 | |
CN107349456B (zh) | 一种具有孔隙大小自适应调节能力的胶原海绵制备方法及胶原海绵 | |
CN112755248A (zh) | 基于卵巢或阴道脱细胞基质的3d打印复合生物墨水的制备方法及应用 | |
CN102038976A (zh) | 负载rhGM-CSF的组织工程皮肤真皮替代物再生材料及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20200131 Assignee: Weinan high tech Zone heshunda electromechanical Co.,Ltd. Assignor: XI'AN POLYTECHNIC University Contract record no.: X2023980034741 Denomination of invention: A silk fibroin fiber hollow neural conduit and its preparation method and application Granted publication date: 20220311 License type: Common License Record date: 20230419 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240428 Address after: Room 702-3, 702-4, Building 1, No. 106-2 Qiuyang Road, Chengyang District, Qingdao City, Shandong Province, 266109 Patentee after: Qingdao Jisheng Technology Co.,Ltd. Country or region after: China Address before: No.58, Shangu Avenue, Lintong District, Xi'an, Shaanxi 710000 Patentee before: XI'AN POLYTECHNIC University Country or region before: China |
|
TR01 | Transfer of patent right |