CN110713995B - 用于核酸酶介导的基因组工程改造的递送方法和组合物 - Google Patents

用于核酸酶介导的基因组工程改造的递送方法和组合物 Download PDF

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CN110713995B
CN110713995B CN201910993837.3A CN201910993837A CN110713995B CN 110713995 B CN110713995 B CN 110713995B CN 201910993837 A CN201910993837 A CN 201910993837A CN 110713995 B CN110713995 B CN 110713995B
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cells
sequence
cell
nuclease
gene
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CN110713995A (zh
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M·C·霍尔姆斯
汪建斌
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Sangamo Therapeutics Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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CN201910993837.3A 2013-10-17 2014-10-16 用于核酸酶介导的基因组工程改造的递送方法和组合物 Expired - Fee Related CN110713995B (zh)

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US201361892348P 2013-10-17 2013-10-17
US61/892,348 2013-10-17
US201462033424P 2014-08-05 2014-08-05
US62/033,424 2014-08-05
CN201910993837.3A CN110713995B (zh) 2013-10-17 2014-10-16 用于核酸酶介导的基因组工程改造的递送方法和组合物
PCT/US2014/060931 WO2015057980A1 (en) 2013-10-17 2014-10-16 Delivery methods and compositions for nuclease-mediated genome engineering
CN201480055149.8A CN105899665B (zh) 2013-10-17 2014-10-16 用于核酸酶介导的基因组工程改造的递送方法和组合物

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