CN110709016B - Biological tissue adhesive application tool and biological drug solution injection tool - Google Patents

Abstract

The invention aims to prevent the blockage of the liquid medicine at the front end part of a liquid medicine flow passage by a simple structure at low cost, and inhibit the gap of the pushing-in amount of a plunger when restarting the liquid medicine discharge after stopping the liquid medicine discharge so as to ensure the good operability. A biological tissue adhesive application tool is provided with: a nozzle body (2) having a space (2 s) therein; and a plurality of chemical solution flow tubes (3, 4) which pass through the space (2 s) of the nozzle body (2) and flow the chemical solution. The nozzle body (2) is provided with: a gas spraying part (2 h) for spraying and mixing the liquid medicine sprayed from the liquid medicine spraying part (2 e) in a mist shape by spraying gas. The chemical solution flow tubes (3, 4) connect the chemical solution injection part (2 d) and the chemical solution discharge part (2 e). The chemical liquid flow pipe (3) is provided with: the balloon (3 c) is contracted by external pressure generated by the introduction of the supply gas from the gas injection part into the space (2 s), and is restored when the external pressure is reduced.

Description

Biological tissue adhesive application tool and biological drug solution injection tool

Technical Field

The present invention relates to a biological tissue adhesive application tool that mixes a plurality of chemical solutions functioning as biological tissue adhesives and sprays the mixed solution onto a diseased part of a living body to apply the applied solution. The present invention also relates to a biological chemical solution injector for spraying a chemical solution to an affected part of a living body, and more particularly to a biological chemical solution injector for spraying a chemical solution obliquely with respect to the axial direction of a nozzle.

The present application claims priority from japanese patent application No. 2017-108785 and japanese patent application No. 2017-108786, which were filed in japan on 31/5/2017, and the contents thereof are incorporated herein by reference.

Background

In the past, a biological tissue adhesive application tool in which two kinds of medicinal liquids are mixed and sprayed has been circulated. When a liquid medicine containing fibrinogen or the like and having a high viscosity and being easily coagulated is used as a liquid medicine for a biological tissue adhesive application tool, the liquid medicine may be dried and coagulated in the vicinity of the distal end of a nozzle that discharges the liquid medicine. Further, the coagulation may occur due to contact and mixing with another chemical liquid passing through another chemical liquid flow tube, and discharge of the chemical liquid may be hindered.

Patent document 1 discloses a biological tissue adhesive application tool having a communicating port as a slit in a drug solution flowing tube through which a drug solution passes, and configured such that a high-pressure gas enters from the communicating port when discharge of the drug solution is stopped. The living tissue adhesive application tool has a structure in which the residual medical fluid on the distal end side is discharged from the medical fluid flow tube by the action of the high-pressure gas.

Specifically, when the plunger for introducing the chemical liquid into the chemical liquid flow tube is stopped from being pushed in the syringe, the chemical liquid positioned on the tip side of the communication port is discharged from the chemical liquid flow tube by the high-pressure gas entering the chemical liquid flow tube. Therefore, the chemical liquid remaining in the chemical liquid flow tube can be prevented from being mixed with the chemical liquid in the other chemical liquid flow tube.

The applicator for biological tissue adhesive is provided with a check valve which can prevent the upstream side backflow of bubbles generated by gas in the solution mixed in the chemical solution flow tube. The use of the check valve can prevent the reverse flow of the bubbles toward the upstream side of the chemical solution flow tube. The check valve is configured to appropriately prevent: bubbles of gas mixed into the chemical liquid on the upstream side of the chemical liquid flow tube expand, and the chemical liquid pressed to the distal end side of the chemical liquid flow tube comes into contact with another chemical liquid and is mixed with the other chemical liquid, and is solidified.

In general, the following operations are performed in vivo treatment or therapy: the trocar is passed through a hole formed in the abdomen or the like, and the nozzle is passed through the interior of the trocar to introduce the drug solution into the body cavity.

Patent document 2 discloses the following technique: even in a state where the nozzle is restricted in placement by the trocar, the liquid medicine can be ejected in a wide range by the nozzle.

The biological medical fluid injection device described in patent document 2 (in this document, a biological tissue adhesive application device) can spray a plurality of types of medical fluids and a gas for mixing the medical fluids obliquely with respect to the axial direction of the nozzle. In this manner, if the chemical solution is sprayed obliquely with respect to the axial center direction of the nozzle, the chemical solution can be sprayed over a wide range by rotating the nozzle about the axial center.

Documents of the prior art

Patent literature

Patent document 1: japanese patent laid-open publication No. 2012-100851

Patent document 2: japanese patent laid-open publication No. 2013-74988

Disclosure of Invention

Technical problem to be solved by the invention

However, in the biological tissue adhesive application tool of patent document 1, since the high-pressure gas is introduced from the communication port of the chemical solution flow tube and the chemical solution on the tip side of the communication port is discharged, a gap may be generated in the pushing-in of the plunger to restart the spraying of the chemical solution.

Specifically, when the pushing-in of the plunger is stopped, the chemical liquid on the distal end side of the chemical liquid flow tube is discharged by the high-pressure gas. Therefore, a space, i.e., a gap, in which the chemical solution does not exist is formed between the chemical solution and the distal end portion of the chemical solution flow tube. Therefore, when the plunger is further pushed in to re-spray the drug solution, the plunger needs to be additionally pushed in until the drug solution reaches the distal end portion of the drug solution flow tube.

In addition, since the biological tissue adhesive application tool of patent document 1 has a structure in which gas is mixed into the liquid medicine flow tube, it is necessary to provide a check valve as described above, and it takes labor, time, and cost for its installation. Therefore, it is desired to prevent the coagulation of the chemical solution in a different manner to prevent the clogging of the chemical solution flow passage.

In the biological chemical solution injector disclosed in patent document 2, the distal end portions of both the gas ejection passage and the chemical solution flow passage are formed obliquely with respect to the axial direction of the nozzle, whereby the chemical solution and the gas are sprayed. In particular, since the gas ejection passage has a complicated structure surrounding the chemical liquid flow passage and both of them are inclined with respect to the axial direction of the nozzle, it is difficult to manufacture the gas ejection passage.

Therefore, as in the structure of the biological chemical solution injector described in patent document 2, a new structure capable of spraying a chemical solution obliquely with respect to the axial center direction of the nozzle is desired.

The present invention has been made in view of the above problems. That is, the present invention has an object to prevent clogging of a chemical solution at a distal end portion of a chemical solution flow passage with a simple structure at low cost, and to suppress a gap in a plunger push-in amount when restarting the chemical solution discharge after stopping the chemical solution discharge, thereby improving operability.

Another object of the present invention is to provide a liquid chemical injection device for living body which can spray a liquid chemical obliquely by ejecting a gas and can be easily manufactured.

Means for solving the technical problem

Namely, the present invention is as follows.

(1) A biological tissue adhesive application tool comprising: a nozzle body having a space therein; and a plurality of chemical liquid flow passages passing through the space inside the nozzle body, and communicating a chemical liquid injection portion provided in the nozzle body and a chemical liquid discharge portion provided at a distal end of the nozzle body to allow the chemical liquid to flow therethrough. The nozzle body is provided with: a gas injection unit for filling the space with a gas; and a gas ejection portion located in the vicinity of the chemical liquid discharge portion, ejecting gas filled in the space from the gas injection portion, and spraying and mixing the chemical liquid discharged from the chemical liquid discharge portion of the plurality of chemical liquid flow passages in a mist form, wherein at least one of the chemical liquid flow passages is provided with: and an expansion/contraction unit which is contracted by an external pressure generated by the gas introduced into the space from the gas injection unit and which is restored when the external pressure is reduced.

(2) The biological tissue adhesive application tool according to (1), wherein a plurality of the liquid medicine flow passages are disposed in the space, and the expansion/contraction portion is provided only in a part of the plurality of liquid medicine flow passages disposed in the space.

(3) The tool for applying an adhesive to biological tissue according to (1) or (2), wherein the stretchable part has a recovery promoting part for promoting recovery, and the recovery promoting part is a convex part formed on an outer surface of the stretchable part.

(4) The biological tissue adhesive application tool according to any one of (1) to (3), wherein the stretchable portion has a recovery promoting portion that promotes recovery, and the recovery promoting portion is formed over the entire circumference of the stretchable portion.

(5) The tool for applying a biological tissue adhesive according to any one of (1) to (4), wherein the stretchable portion has a contraction promoting portion that promotes contraction, and the contraction promoting portion is a recessed portion formed on an outer surface of the stretchable portion.

(6) The biological tissue adhesive agent application tool according to any one of (1) to (5), wherein the stretchable portion has a contraction promoting portion that promotes contraction, and the contraction promoting portion has a waveform that is formed by being bent so as to repeatedly approach and separate from the medical fluid injection portion and the medical fluid discharge portion.

(7) The tool for applying an adhesive to biological tissue according to (5) or (6), wherein the contraction promoting portion is formed in a non-circumferential shape.

(8) The tool for applying an adhesive to biological tissue according to any one of (1) to (7), wherein a cross-sectional area of a flow path of a portion adjacent to a distal end side of the stretchable part in the medical-fluid flow path is smaller than a cross-sectional area of a flow path of a portion adjacent to a proximal end side of the stretchable part.

(9) The tool for applying an adhesive to biological tissue according to any one of (1) to (8), wherein a resisting member that inhibits the flow of the medical liquid to the stretchable portion is provided on a position closer to the end side than the stretchable portion in the medical-liquid flow path.

(10) A liquid medicine injection tool for living body, comprising: a nozzle having a space therein; and a chemical liquid flow passage which passes through the space inside the nozzle, and which has a chemical liquid injection portion for injecting a chemical liquid and a chemical liquid discharge portion for discharging the chemical liquid to allow the chemical liquid to flow therethrough. The nozzle is provided with: a gas injection unit for injecting a gas into the space; and a gas ejection portion which is located in the vicinity of the chemical liquid ejection portion, ejects the gas filled in the space from the gas injection portion, and sprays the chemical liquid ejected from the chemical liquid ejection portion of the chemical liquid flow passage in a mist form. An angle formed by the discharge direction of the gas discharge portion and the axial direction of the nozzle is larger than an angle formed by the discharge direction of the chemical liquid discharge portion and the axial direction of the nozzle, and the discharge direction of the gas from the gas discharge portion and the discharge direction of the chemical liquid from the chemical liquid discharge portion intersect obliquely at a position where the chemical liquid is discharged from the chemical liquid discharge portion.

(11) The liquid medicine injection device for living body according to (10), wherein a plurality of the liquid medicine flow passages are provided, the gas ejecting portion ejects the gas in a direction intersecting with an arrangement direction of the plurality of liquid medicine flow passages when a distal end opening of the liquid medicine ejecting portion is viewed from the front, and the gas sprays and mixes the liquid medicines ejected from the respective liquid medicine ejecting portions among the plurality of liquid medicine flow passages in a mist form.

(12) The liquid medicine injection device for living body according to (10) or (11), wherein the liquid medicine discharge portion extends along a discharge direction of the liquid medicine, and the gas ejection portion extends so as to face a discharge position of the liquid medicine discharged by the liquid medicine discharge portion.

(13) The liquid medicine injection device for living body according to any one of (10) to (12), wherein the gas ejection portion is formed at a position separated from the liquid medicine ejection portion when a distal end opening of the gas ejection portion is viewed from the front.

(14) The liquid medicine injection device for living body according to any one of (10) to (13), wherein the liquid medicine flow path includes a1 st liquid medicine flow path and a2 nd liquid medicine flow path, and when the distal end opening of the gas discharge portion is viewed from the front, at least a part of the gas discharge portion is formed so as to be located more inward than both ends on a line segment connecting a center of the liquid medicine discharge portion of the 1 st liquid medicine flow path and a center of the liquid medicine discharge portion of the 2 nd liquid medicine flow path.

(15) The liquid medicine injection device for living organisms according to any one of (10) to (14), wherein the gas ejection portion is formed in a non-circumferential shape in a part of a circumferential direction around the liquid medicine ejection portion when a distal end opening of the gas ejection portion is viewed from the front, and the nozzle comprises a1 st member provided with the liquid medicine injection portion and a2 nd member in which the liquid medicine ejection portion and the gas ejection portion are integrally molded.

(16) The liquid medicine injection device for living body according to any one of (10) to (15), further comprising: and a brim provided at a position opposite to a position where the chemical liquid discharge portion is provided, with the gas discharge portion interposed therebetween, wherein the brim is formed to protrude further toward a distal end side than a distal end of the chemical liquid discharge portion with reference to a discharge direction of the chemical liquid.

(17) The liquid medicine injection instrument for living body according to any one of (10) to (16), wherein the distal end opening of the gas ejection portion is formed in an arc shape and is formed along the liquid medicine ejection portion.

(18) The liquid medicine injection device for living body according to (17), wherein the distal end opening of the gas ejection portion is formed in an arc shape having a central angle of 20 ° to 50 ° concentric with the center of the liquid medicine ejection portion.

(19) The liquid medicine injection instrument for living body according to any one of (10) to (18), wherein a distal end surface of the liquid medicine discharge portion is formed along a discharge direction of the gas from the gas discharge portion.

ADVANTAGEOUS EFFECTS OF INVENTION

The invention provides a biological tissue adhesive applicator capable of preventing clogging of a chemical solution at the tip of a chemical solution flow passage with a simple structure and at low cost.

Further, the position of the chemical solution in the chemical solution flow passage can be adjusted by the contraction and expansion of the expansion/contraction portion caused by adjusting the supply amount of the gas supplied to the internal space of the nozzle body, and therefore, it is not necessary to mix the gas into the chemical solution flow passage in order to adjust the position of the chemical solution. Therefore, when gas is supplied to the space inside the nozzle body from a state in which the chemical liquid is sucked from the distal end of the chemical liquid flow passage, that is, from a state in which the expanding portion is expanded, the expanding portion contracts and the chemical liquid is pushed out from the expanding portion to the distal end side of the chemical liquid flow passage. Therefore, the gap between the distal end of the chemical liquid flow passage and the chemical liquid can be reduced. Therefore, when the spraying of the chemical liquid is resumed, the chemical liquid can be smoothly discharged and the operability can be improved.

Further, the liquid medicine injection device for living body of the present invention can spray the liquid medicine obliquely, and according to the present invention, a liquid medicine injection device for living body which can be easily manufactured can be provided.

Drawings

Fig. 1 is a perspective view showing a biological tissue adhesive application tool according to the present embodiment.

Fig. 2 is a view showing a section I-I of fig. 1, and is a sectional view of the nozzle body.

Fig. 3 is an enlarged view showing the balloon.

Fig. 4A is a cross-sectional view of the balloon in a deflated state, showing section II-II of fig. 3.

Fig. 4B is a cross-sectional view of the balloon showing the expanded state of section II-II of fig. 3.

Fig. 5 is a schematic explanatory view showing the vicinity of the balloon of the drug solution distribution tube according to modification 1.

Fig. 6 is a schematic explanatory view showing the vicinity of the balloon of the drug solution distribution tube according to modification 2.

Fig. 7 is a view showing a balloon according to modification 3, and is a view showing a cross section of a portion corresponding to fig. 4B.

Fig. 8 is a diagram showing a balloon according to a modification example of fig. 4, and is a diagram showing a portion corresponding to fig. 3.

Fig. 9 is a perspective view showing a biological tissue adhesive application tool according to the present embodiment.

Fig. 10 is an enlarged perspective view showing the head portion located at the portion III of fig. 9.

Fig. 11 is a front view of the head.

Fig. 12 is a sectional view showing the section IV-IV of fig. 11.

Fig. 13 is a sectional view showing the V-V section of fig. 11.

Fig. 14 is a front view of a head part according to a modification example 5.

Fig. 15 is a front view of the head according to the modification 6.

Fig. 16 is a front view of the head according to the modification 7.

Detailed Description

Hereinafter, embodiments of the biological tissue adhesive application tool or the biological drug solution injection tool according to the present invention will be described with reference to the drawings.

The embodiments described below are merely examples for facilitating understanding of the present invention, and do not limit the present invention. That is, the shapes, sizes, arrangements, and the like of the components described below can be modified or improved without departing from the gist of the present invention, and equivalent means thereof are included in the present invention.

In all the drawings, the same constituent elements are denoted by the same reference numerals, and redundant description thereof is appropriately omitted. Hereinafter, the side of the biological tissue adhesive application tool or the biological medical fluid injection tool from which the medical fluid is discharged is referred to as the distal side or the distal end side, and the opposite side is referred to as the rear side or the proximal end side, and these sides are also referred to as the distal end side and the proximal end side, respectively.

[ biological tissue adhesive coating implement ]

< with respect to the overall Structure >

The overall configuration of the biological tissue adhesive application tool 1 according to the present embodiment will be described mainly with reference to fig. 1 and 2. Fig. 1 is a perspective view showing a biological tissue adhesive application tool 1, and fig. 2 is a view showing a cross section I-I of fig. 1, and is a cross sectional view of a nozzle body 2.

The biological tissue adhesive application tool 1 has a function of spraying and mixing a plurality of kinds of medical solutions described below at a discharge position and applying the medical solutions as an adhesive to organs in a living body. The biological tissue adhesive application tool 1 includes: a nozzle body 2 having a chemical liquid discharge portion 2e for discharging a chemical liquid; and a plurality of chemical liquid flow passages for allowing the chemical liquid to flow through the space 2s inside the nozzle body 2. The chemical liquid flow path communicates a syringe attachment port 2d, which is a chemical liquid injection portion provided in the nozzle body 2, with a chemical liquid discharge portion 2e provided at the distal end of the nozzle body 2.

Two plungers 7 and two syringes 17 are attached to the nozzle body 2 to introduce different chemical solutions into the nozzle body 2. The biological tissue adhesive application tool 1 further includes a plunger holder 8 for simultaneously pushing the two plungers 7 toward the syringe 17. The plunger holder 8 is formed in a size capable of abutting the base end sides of the two plungers 7.

An air supply hose 31 for introducing an air supply gas for spraying a chemical solution into the nozzle body 2 is connected to the biological tissue adhesive application tool 1. The air supply hose 31 is connected to a regulator 30 that adjusts the amount of air supply gas, and is connected to the nozzle main body 2 via the air filter 9. Specifically, the air supply hose 31 is connected to the regulator 30 by a connector 31a provided on the proximal end side, and is connected to the connection port 9a of the air filter 9 by a connector 31b provided on the distal end side. The dust and bacteria are removed from the supplied gas by passing the gas supplied from the regulator 30 to the air filter 9. Therefore, the gas to be blown into the living body is preferred in terms of hygiene.

The air filter 9 may be disposed in the vicinity of the regulator 30 instead of the nozzle body 2. With this arrangement, the number of parts around the biological tissue adhesive application tool 1 is reduced, and therefore the operability of the biological tissue adhesive application tool 1 can be improved.

< Structure about periphery of nozzle body >

Next, the structure around the nozzle body 2 will be described mainly with reference to fig. 1 and 2. The nozzle body 2 is mainly composed of a tip-side member 2a formed to have a tapered tip, a plate-like base-side member 2b attached to the base end of the tip-side member 2a, and a discharge member 2c attached to the tip of the tip-side member 2a from the inside.

As shown in fig. 1, the distal end side member 2a has a portion projecting obliquely upward and rearward, and a gas injection portion 2g for filling the space 2s inside the nozzle body 2 with the supplied gas is formed at the distal end thereof. The supply gas is introduced from the regulator 30 through the supply hose 31, the air filter 9, and the gas injection portion 2g, and is filled in the space 2s inside the nozzle body 2. An insertion hole 2aa penetrating in the front-rear direction to communicate the internal space 2s with the outside is formed in the front end of the front end member 2 a. The insertion hole 2aa is a through hole for inserting a discharge pipe 2cb described later. The inner diameter of the insertion hole 2aa is larger than the outer diameter of the discharge pipe 2 cb. The insertion hole 2aa functions as a gas ejection portion 2h that ejects the supply gas filled in the space 2s from the periphery of the discharge pipe 2cb to the outside.

The discharge pipe 2cb according to the present embodiment is separate from the chemical solution flow pipes 3 and 4, but the present invention is not limited to this configuration and may be integrally formed. The chemical solution flow tubes 3 and 4 and the discharge tube 2cb are also collectively referred to as a chemical solution flow path according to the present invention.

Two portions of the base-end member 2b protrude rearward, and a syringe attachment port 2d as a chemical solution injection portion is formed at the rear end of these portions. Syringes 17 are connected to the two syringe attachment ports 2d, respectively. Proximal ends 3a and 4a of chemical solution flow tubes 3 and 4, which will be described later, are connected to distal ends of chemical solution flow passages through the two syringe attachment ports 2d in the proximal end side member 2 b. That is, the chemical solutions filled in the two syringes 17 are pushed into the syringes 17 by the plungers 7, and pass through the chemical solution flow tubes 3 and 4 in the nozzle body 2 via the syringe attachment ports 2d.

The chemical solution flow tubes 3 and 4 are disposed so as to pass through the space 2s inside the nozzle body 2, and flow two kinds of chemical solutions to be mixed. In the present embodiment, the chemical solution flow tube 3 flows a chemical solution 10 (see fig. 4) that contains fibrinogen and the like and has high viscosity and is easily coagulated. The chemical liquid flow tube 4 flows a chemical liquid containing thrombin or the like to act on fibrinogen or the like to function as an adhesive.

Specifically, the chemical solution flow tubes 3 and 4 communicate the two syringe attachment ports 2d provided in the proximal end side member 2b of the nozzle body 2 into which the chemical solution is introduced, with the chemical solution discharge portions 2e of two discharge tubes 2cb provided at the distal end of the nozzle body 2, which will be described later. The chemical solution flow tube 3 is provided with a balloon 3c described later, and the balloon 3c is contracted by external pressure generated by the supply gas introduced from the gas injection portion 2g and filled in the space 2s, and is restored when the external pressure is reduced to a predetermined value.

Hereinafter, a configuration in which the balloon 3c as an expansion/contraction part is provided in a part of the chemical solution flow tube 3 will be described, but the present invention is not limited to a configuration in which an expansion/contraction part is provided only in a part of the chemical solution flow tube 3, and includes a configuration in which the entire chemical solution flow tube 3 is expanded/contracted. For example, the chemical liquid flow tube 3 may be a member entirely made of an elastic material such as an elastomer.

As shown in fig. 2, the medical fluid flow tube 3 having the balloon 3c according to the present embodiment has an inner diameter larger than that of the medical fluid flow tube 4. By forming the chemical solution flow tubes 3 and 4 in this manner, as will be described later, the difference between the discharge amount of the chemical solution 10 (see fig. 4) flowing through the chemical solution flow tube 3 and the discharge amount of the chemical solution flowing through the chemical solution flow tube 4 can be reduced in the state where the balloon 3c is deflated.

Instead of adjusting the inner diameter ratio as described above, the concentration of the chemical solution passing through the chemical solution passing tubes 3 and 4 may be adjusted by making the inner diameters of the chemical solution passing tubes 3 and 4 the same. The inner diameter ratio of the chemical solution flow tubes 3 and 4 may be changed according to a mixing ratio defined to function as a binder.

The discharge member 2c includes two discharge pipes 2cb for discharging the chemical from the chemical flow pipes 3 and 4, and a holding member 2ca for holding the two discharge pipes 2 cb.

The two discharge pipes 2cb are disposed so as to be inserted through insertion holes 2aa formed in the distal end of the distal end side member 2 a.

Distal ends 3b and 4b of the chemical solution flow tubes 3 and 4 are connected to the proximal end of the discharge tube 2 cb. That is, the chemical solution having passed through the two chemical solution flow pipes 3 and 4 is introduced into the two discharge pipes 2 cb.

The distal end of the discharge tube 2cb is a chemical liquid discharge portion 2e for discharging the chemical liquid to the outside. That is, the gas ejection portion 2h positioned around the discharge tube 2cb in the insertion hole 2aa is positioned in the vicinity of the two chemical liquid discharge portions 2e. Therefore, when the supply gas filled in the space 2s from the gas injection portion 2g is ejected to the outside from the gas ejection portion 2h, the chemical solutions ejected from the chemical solution ejection portions 2e of the chemical solution flow tubes 3 and 4 are mixed by mist spraying.

Since the chemical solution flow tubes 3 and 4 are disposed in the space 2s of the nozzle body 2, the chemical solutions discharged from the chemical solution flow tubes 3 and 4 can be sprayed and mixed substantially uniformly by the supply gas discharged from the space 2s through the gas discharge portion 2h.

< about balloon >

Next, the structure and function of the balloon 3c as an expansion/contraction portion provided in the drug solution circulation tube 3 according to the present embodiment will be described mainly with reference to fig. 3 and 4 in addition to fig. 2. Fig. 3 is an enlarged view showing the balloon 3c. Fig. 4A is a sectional view of the balloon 3c showing a contracted state of the section II-II of fig. 3, and fig. 4B is a sectional view of the balloon 3c showing an expanded state of the section II-II of fig. 3.

The balloon 3c has the following functions: the medical fluid 10 can be passed through the balloon in the contracted state shown in fig. 4A, and the medical fluid 10 can be withdrawn from the medical fluid discharge portion 2e to the balloon 3c side by changing the contracted state to the expanded state shown in fig. 4B.

Specifically, the balloon 3c has a structure in which an internal space having a flow path cross-sectional area A1 is secured, so that the medical fluid 10 can pass through even in a state in which it is constricted by the external pressure of the supply gas in the space 2s when the medical fluid 10 is sprayed from the biological tissue adhesive application tool 1. In other words, the balloon 3c is configured such that a part of the inner surface abuts against the balloon in the deflated state and the balloon does not become completely closed. The detailed structure will be described later. The "cross-sectional area of the flow path" refers to the cross-sectional area of a portion of the cross-section perpendicular to the flow direction of the chemical solution 10 through which the chemical solution 10 can flow.

The balloon 3c is expanded to return to a natural cylindrical shape so as to have a flow path cross-sectional area A2 in which the external pressure is reduced by stopping the supply of the gas into the space 2s, and the internal space is increased by the restoration by the elastic force. The balloon 3c has the following functions: the medical fluid 10 is drawn back to the balloon 3c side from the distal end portion of the discharge tube 2cb connected to the medical fluid flow tube 3 by the pressure fluctuation caused by the increase in volume of the internal space due to the expansion.

The balloon 3c is formed so that the cross-sectional area of the flow path in the expanded state is larger than the cross-sectional area of the other portion of the drug solution flow tube 3. By forming the balloon 3c in this manner, the medical fluid 10 can be efficiently sucked from the distal end portion of the discharge tube 2cb to the balloon 3c side, and mixing with the medical fluid flowing through the adjacent medical fluid flow tube 4 and remaining in the medical fluid discharge portion 2e can be suppressed.

Further, as the stretchable portion according to the present invention, a stretchable portion that is more expandable than the surroundings is preferable, like the balloon 3c according to the present embodiment. However, the present invention is not limited to such a configuration, and the entire expansion and contraction portion according to the present invention may be formed flat, and may be contracted by applying external pressure with the supply gas and restored by reducing the external pressure.

The balloon 3c has a waveform concave portion 3ca as a contraction promoting portion on the outer surface and is partially formed thin. The wave-shaped recesses 3ca are arranged in parallel in the axial direction of the chemical solution flow tube 3, and are formed in pairs in a total of eight positions as will be described later. Since the waveform concave portion 3ca is formed and a part of the balloon 3c is thin, the portion is more easily crushed by the external pressure applied by the supplied gas than other portions.

Further, since the wave-shaped concave portion 3ca is formed on the outer surface of the balloon 3c instead of the inner surface, it is possible to suppress the inhibition of the smooth flow of the medical fluid 10 through the inside of the balloon 3c.

In this regard, it is preferable to form the wave-shaped concave portion 3ca on the outer surface of the balloon 3c, but the present invention is not limited to this configuration. That is, the concave portion may be formed on the inner surface thereof as long as the contraction of the balloon 3c can be promoted more than other portions, and the concave portion is not limited to the concave portion as long as it is thin, and may be formed to protrude more than the periphery. Further, only a part of the balloon 3c may be formed of a material having low rigidity.

The contraction promoting portion according to the present invention is not limited to the contraction promoting portion having the concave recess portion, as long as it has a function of easily collapsing the balloon 3c by external pressure from the supplied gas. For example, a notch formed in a part of the surface of the balloon 3c may be used. According to this notch, a reaction force against a bending stress applied to the balloon 3c by the supply gas can be reduced, and therefore, contraction of the balloon 3c can be promoted.

As shown in fig. 2 and 3, the wave-shaped concave portion 3ca is formed in a non-circumferential shape extending in the circumferential direction and is formed so as to be curved so as to repeatedly approach and separate from the syringe attachment port 2d and the drug solution discharge portion 2e.

Specifically, as shown in fig. 4, the waveform concave portions 3ca are formed in pairs at positions of plane symmetry with respect to a plane including the axis of the balloon 3c as the center on the outer surface of the balloon 3c.

The waveform concave portion 3ca extends in the circumferential direction of the balloon 3c so as to repeatedly come closer to and get farther from the syringe attachment port 2d and the medical fluid discharge portion 2e, in other words, so as to be alternately curved and shifted in the axial direction of the balloon 3c.

On the other hand, there are other portions of the balloon 3c where the wave-shaped concave portions 3ca are not formed, which are continuously formed in the axial direction, so as not to completely block the flow of the medical fluid 10 when the balloon 3c is deflated.

Since the balloon 3c includes the waveform concave portions 3ca, when external pressure from the supplied gas is applied to the balloon 3c, the pair of waveform concave portions 3ca are deformed and the inner surfaces of the balloon 3c corresponding to the positions of the waveform concave portions 3ca abut against each other as shown in fig. 4A.

On the other hand, since the portions other than the waveform concave portion 3ca have higher rigidity than the waveform concave portion 3ca, the inner surfaces of these other portions do not abut against each other, and thus a flow path of the chemical solution 10 can be secured inside.

Since the waveform concave portion 3ca is formed in a non-circumferential shape in this manner, a portion that is easily crushed and a portion that is not easily crushed in the balloon 3c are provided locally in the circumferential direction. Therefore, in a state where the supply gas shown in fig. 4A is filled in the space 2s and the chemical solution 10 is sprayed, the inside of the balloon 3c is not completely closed, and thus the flow of the chemical solution 10 passing through the inside of the balloon 3c can be suppressed from being obstructed.

Further, since the wave-shaped concave portion 3ca is formed by curving, it is possible to suppress the flow of the air supply gas flowing from the gas injection portion 2g toward the gas ejection portion 2h in the direction connecting the syringe attachment port 2d and the chemical solution ejection portion 2e around the wave-shaped concave portion 3ca. Here, a portion of the waveform concave portion 3ca located on a side close to the gas ejection portion 2h and the chemical solution ejection portion 2e is referred to as a top portion 3cb. In the present embodiment, four top portions 3cb are provided.

A part of the supply gas flowing around the balloon 3c is in contact with the wall surface of the wave-shaped concave portion 3ca, and is thereby concentrated on the top portions 3cb and dispersed to the four top portions 3cb to flow. Therefore, the waveform concave portion 3ca can suppress a large interruption of the flow of the supply gas, compared to the case where the concave portion is formed linearly in the circumferential direction of the balloon 3c. Therefore, according to the waveform concave portion 3ca, the rectification property of the supplied gas can be ensured, and the influence on the discharge direction of the supplied gas from the gas discharge portion 2h can be suppressed.

On the other hand, the contraction promoting portion according to the present invention is not limited to a contraction promoting portion having a recess formed in a waveform like the waveform recess 3ca, as long as the flow regulation property of the supply gas is not hindered. For example, the contraction promoting portion formed in the balloon 3c may be a concave portion extending in the axial direction of the medical fluid flow tube 3.

When the medical fluid is intermittently discharged from the biological tissue adhesive application tool 1, the external pressure applied to the balloon 3c is reduced when the supply of the supply gas is stopped and the discharge of the medical fluid is stopped. Therefore, the balloon 3c is restored and expanded to return to the natural state until the flow passage cross-sectional area A1 of the balloon 3c becomes the flow passage cross-sectional area A2, and the inside thereof becomes a negative pressure. Therefore, the residual medical fluid 10 on the distal end side of the discharge tube 2cb and the medical fluid flow tube 3 is returned to the balloon 3c side, and clogging of the medical fluid 10 at the distal end portion of the discharge tube 2cb can be prevented at low cost with a simple structure without using a check valve.

When the supply of the air-supply gas into the space 2s by the regulator 30 is resumed, the balloon 3c is contracted to a predetermined size due to an increase in the external pressure applied to the balloon 3c. The medical fluid 10 is pushed out from the balloon 3c to the position of the distal end of the discharge tube 2cb before the balloon 3c is expanded by the pressure applied to the medical fluid 10 due to the contraction of the balloon 3c, and the gap between the distal end of the discharge tube 2cb and the medical fluid 10 is reduced. Therefore, when the injection of the chemical liquid 10 is restarted by the plunger 7, the chemical liquid 10 is smoothly discharged from the chemical liquid discharge portion 2e, and the operation can be restarted by the low-pressure spraying, so that the operability is improved.

Further, the balloon 3c may be provided in both the chemical solution flowing tubes 3 and 4, but by providing only the balloon 3c in the chemical solution flowing tube 3, mixing with the chemical solution flowing through the other chemical solution flowing tube 4 and remaining in the chemical solution discharge portion 2e can be sufficiently suppressed, and the cost can be reduced.

In particular, it is preferable that the balloon 3c is provided in the drug solution flow tube 3 through which the drug solution 10 containing fibrinogen and the like having high viscosity flows. With such a configuration, the balloon 3c can be prevented from expanding due to the viscosity of the medical fluid 10, and the medical fluid 10 can be sucked toward the balloon 3c and then suddenly returned toward the medical fluid discharge portion 2e due to its own weight. In addition, it is possible to suppress the coagulation of the chemical liquid 10 containing fibrinogen and the like caused by the exposure from the chemical liquid discharge portion 2e to the outside.

The balloon 3c is not limited to the one integrally formed in the drug solution flowing tube 3, and may be a separate structure. In this case, the material of the drug solution circulation tube 3 is preferably made of a material harder than the material of the balloon 3c. With this configuration, the balloon 3c can be appropriately deformed in an expanding and contracting manner while ensuring the flow of the medical fluid 10 in the medical fluid flow tube 3.

(modification 1)

Next, the chemical solution flowing tube 5 according to modification 1 will be described mainly with reference to fig. 5. Fig. 5 is a schematic explanatory view showing the vicinity of the balloon 3c of the drug solution distribution tube 5 according to modification 1.

The chemical liquid flow tube 5 has the following structure: when the balloon 3c is inflated, the medical fluid 10 can be appropriately sucked from the distal end portion of the discharge tube 2cb toward the balloon 3c.

Specifically, the portion of the medical-fluid flow tube 5 adjacent to the distal end side of the balloon 3c has an inner diameter d1 and a flow-path cross-sectional area A3. On the other hand, the portion of the medical-fluid flow tube 5 adjacent to the proximal end side of the balloon 3c has an inner diameter d2 longer than d1 and a flow-path cross-sectional area A4 larger than A3.

According to this configuration, when the balloon 3c is expanded and substantially the same amount of the medical fluid 10 is suctioned from the distal end side and the proximal end side of the balloon 3c, the suction length of the medical fluid 10 from the distal end side of the balloon 3c can be made longer than the suction length of the medical fluid 10 from the proximal end side. Therefore, the leakage of the chemical liquid 10 from the chemical liquid discharge portion 2e of the chemical liquid flow tube 5 can be more appropriately suppressed, and the mixing with the chemical liquid flowing through the other chemical liquid flow tube 4 and remaining in the chemical liquid discharge portion 2e can be suppressed.

(modification 2)

Next, the chemical solution flow tube 6 according to modification 2 will be described mainly with reference to fig. 6. Fig. 6 is a schematic explanatory view showing the vicinity of the balloon 3c of the drug solution distribution tube 6 according to modification 2.

The chemical liquid flow tube 6 has the following structure as in modification 1: when the balloon 3c is inflated, the medical fluid 10 can be appropriately sucked from the distal end of the discharge tube 2cb toward the balloon 3c.

Specifically, the filter 60, which is a resistance member that inhibits the flow of the medical fluid 10 toward the balloon 3c, is provided on the end side of the medical fluid flow tube 6 with respect to the balloon 3c. The filter 60 has a function of removing foreign matters in the chemical solution 10.

According to this configuration, when the balloon 3c is expanded, the medical fluid 10 from the distal end side of the balloon 3c is sucked earlier than the medical fluid 10 from the proximal end side of the balloon 3c, and a relatively larger amount of the medical fluid 10 than the proximal end side is filled from the distal end side with a volume corresponding to the expansion of the balloon 3c. Therefore, the suction length of the medical fluid 10 from the distal end side of the balloon 3c can be made longer than the suction length of the medical fluid 10 from the proximal end side.

Therefore, the leakage of the chemical liquid 10 from the chemical liquid discharge portion 2e of the chemical liquid flow tube 6 can be more appropriately suppressed, and the mixing with the chemical liquid flowing through the other chemical liquid flow tube 4 and remaining in the chemical liquid discharge portion 2e can be suppressed. Further, since the filter 60 is provided on the end side of the balloon 3c, accumulation of foreign matter in the balloon 3c can be suppressed, and thus occurrence of a problem in the expansion and contraction operation of the balloon 3c can be suppressed.

The resistant member according to the present invention is not limited to the filter 60 having the cleaning function as long as it can suppress the flow of the medical fluid 10 on the proximal end side of the balloon 3c. For example, the resist member may be a member in which the inner surface of the proximal end side of the chemical solution flow tube 6 is roughened to provide resistance to the flow of the chemical solution 10 toward the balloon 3c. As the other resisting member, a mesh-like or lattice-like member that generates frictional resistance against the flow of the chemical liquid 10, an orifice that generates a pressure gradient, or the like may be provided.

(modification 3)

In the above embodiment, the balloon 3c is described as an example having the waveform concave portion 3ca for promoting the contraction thereof. However, if the balloon 3c is formed with a sufficiently thin thickness or is formed of a soft material so that the balloon 3c can be contracted by the pressure generated by the supplied gas, the waveform concave portion 3ca is not necessarily required.

As shown in fig. 7, the balloon 13c according to the modification 3 from the other viewpoint includes a wave-shaped convex portion 13ca serving as a restoration promoting portion for promoting restoration. Fig. 7 is a diagram showing a balloon 13c according to modification 3, and is a diagram showing a cross section of a portion corresponding to fig. 4B.

The expansion/contraction portion (balloon 13 c) has a restoration promoting portion (wave-shaped protrusion 13 ca) that promotes restoration. The restoration promoting portion (the wavy convex portion 13 ca) is a convex portion formed on the outer surface of the stretchable portion (the balloon 13 c) and having a thickness greater than the surrounding thickness. The wavy convex portion 13ca is the same as the wavy concave portion 3ca in the point of being formed in a wavy shape, but is different in the point of protruding radially outward from the periphery and the point of being formed over the entire periphery of the balloon 13 c. In addition to the wavy convex portion 13ca, the restoration promoting portion may be formed by insert-molding a metal wire into the balloon 13 c.

That is, if the restoration promoting portion is configured to increase the cross-sectional area (to be thick) or increase the young's modulus to increase the cross-sectional secondary torque, restoration of the balloon 13c can be promoted.

For example, the wavy convex portion 13ca may have the same thickness as the surrounding area, that is, the inner surface may have a concave-convex portion along the outer surface of the balloon 13 c. Even with this configuration, in a state where the balloon 13c is deflated by the pressure generated by the supply gas filled in the space 2s, internal stress is generated in each portion of the wave-shaped convex portion 13ca that attempts to return to the natural state, that is, the expanded state. Therefore, the balloon 13c can be promoted to return to the expanded state.

As described above, the balloon 13c is thin and elastic as a whole, and is therefore compressed by the pressure of the supply gas filled in the space 2s. On the other hand, the balloon 13c has the following features: the shape of the corrugated convex portion 13ca serving as the restoration promoting portion is easily restored to the original shape (natural state) when the supply of the supplied gas is stopped by the shape restoring force. Therefore, the balloon 13c facilitates the suction of the medical fluid 10 remaining in the medical fluid discharge portion 2e toward the balloon 13 c.

In particular, since a part of the cross-sectional area of the balloon 13c is continuously increased over the entire circumference of the balloon 13c by the wavy convex portion 13ca, the restoring force of the balloon 13c to the radially outer side can be increased.

The waveform convex portion 13ca is formed into a waveform as in the waveform concave portion 3ca according to the above-described embodiment, and thereby the rectification property of the supplied gas can be secured.

(4 th modification)

The waveform convex portion 13ca of the balloon 13c according to modification 3 is preferably formed in a waveform, in view of ensuring the flow control property of the supplied gas. However, the stretchable portion according to the present invention is not limited to the stretchable portion formed in this manner.

As shown in fig. 8, the expansion/contraction portion (balloon 23 c) according to the second modification example 4 in another point of view has a linear convex portion 23ca formed linearly in a side view as a restoration promoting portion for promoting restoration. Fig. 8 is a diagram showing a balloon 23c according to a modification example of fig. 4, and is a diagram showing a portion corresponding to fig. 3.

The restoration promoting portion (linear convex portion 23 ca) is formed over the entire circumference of the stretchable portion (balloon 23 c). For example, since the height of the linear convex portion 23ca is low or the surface of the linear convex portion 23ca has a chamfered shape, the influence of the balloon 23c on the rectification property of the supplied gas may not be a problem. In this case, the linear convex portion 23ca is effectively in that the manufacturing efficiency can be improved because it can be easily formed in the balloon 23c which is a part of the drug solution flowing tube 3 formed in a tubular shape.

[ liquid medicine injection tool for living body ]

< with respect to the overall Structure >

The overall structure of the biological tissue adhesive application tool 101 as the medical fluid injection tool for living organisms of the present invention will be described mainly with reference to fig. 9 and 10. Fig. 9 is a perspective view showing the biological tissue adhesive application tool 101 according to the present embodiment, and fig. 10 is an enlarged perspective view showing the head 112 positioned in the portion III of fig. 9.

The biological medical solution injection device (biological tissue adhesive application device 101) according to the present invention is a device for injecting (applying or spraying) a medical solution into a body. As will be described later, the drug solution 110 to be injected (see fig. 13) of the drug solution injection device for living body according to the present invention may be one type, or two or more types, such as the drug solution 110 sprayed by the living tissue adhesive application device 101 according to the present embodiment. The biological tissue adhesive application tool 101 has a function of spraying and mixing a plurality of kinds of chemical solutions 110 described later at a discharge position to apply the liquid as an adhesive to organs in a living body or the like.

The biological tissue adhesive application tool 101 includes a nozzle X having a space 102s therein and a liquid medicine flow path Y for allowing a liquid medicine 110 to flow through the space 102s inside the nozzle X. The chemical liquid flow path Y is a flow path through which the chemical liquid 110 flows, and includes a chemical liquid injection portion (syringe attachment port 102 d) into which the chemical liquid 110 is injected, chemical liquid flow tubes 103 and 104 (see fig. 12 and 13) through which the chemical liquid 110 flows, and a chemical liquid discharge portion (discharge tube 112 e) through which the chemical liquid 110 is discharged, as will be described in detail later.

The nozzle X includes a nozzle body 102, an extension portion 111 that communicates with a space 102s inside the nozzle body 102 and extends from the front end side of the nozzle body 102, and a head portion 112, which will be described later, attached to the front end of the extension portion 111.

The nozzle body 102 is a1 st member according to the present invention provided with a chemical solution injection portion (syringe attachment port 102 d) and filled with an air supply gas G (see fig. 13).

The head 112 includes a spray end piece 112d as a2 nd member in which a discharge pipe 112e and a gas ejection portion 112f are integrally formed.

The nozzle X is provided with a gas injection portion 102G for injecting a supply gas G (see fig. 13) into the space 102s therein. As shown in fig. 10, the head 112 of the nozzle X is provided with a gas ejection portion 112f which is located near the chemical liquid ejection portion (ejection pipe 112 e) and which sprays the chemical liquid 110 in the form of a mist.

As shown in fig. 9, a portion projecting upward and rearward obliquely is formed on the nozzle body 102, and a gas injection portion 102g is formed at the projecting end.

As described above, the gas injection portion 102g is preferably provided at a portion of the nozzle body 102 projecting upward, because the work of attaching the air filter 109 to the gas injection portion 102g and the work of connecting the air supply hose 131 via the air filter 109 are easy.

However, the present invention is not limited to this configuration, and the gas injection portion may be formed in the lower portion or the side portion of the nozzle body 102 as long as the supply gas G can be injected into the space 102s inside the nozzle body 102. The structure is not necessarily limited to the end portion formed at the portion formed to protrude.

The gas ejection portion 112f is configured to eject the supply gas G filled in the internal space 102s from the gas injection portion 102G and to spray and mix the chemical solution 110 ejected from the chemical solution ejection portion (ejection tube 112 e) of the chemical solution flow path Y in the form of mist, as will be described later in detail.

A gas supply hose 131 for introducing a gas supply gas G for spraying the chemical solution 110 into the nozzle body 102 is connected to the biological tissue adhesive application tool 101. The gas supply hose 131 is connected to a regulator 130 for adjusting the amount of the gas supply gas G, and is connected to the nozzle body 102 via the air filter 109. Specifically, the air supply hose 131 is connected to the regulator 130 via a connector 131a provided on the proximal end side, and is connected to the connection port 109a of the air filter 109 via a connector 131b provided on the distal end side. The supplied gas G supplied from the regulator 130 is passed through the air filter 109, whereby dust and bacteria are removed from the supplied gas G. Therefore, the feed gas G passed through the air filter 109 is preferable in terms of hygiene as a gas to be ejected into the living body.

The air filter 109 may be disposed near the regulator 130 instead of near the nozzle body 102. With this arrangement, the number of parts around the biological tissue adhesive application tool 101 is reduced, and therefore the operability of the biological tissue adhesive application tool 101 can be improved. Specifically, when the direction of the spray of the chemical solution 110 is changed by the operation of rotating the nozzle X, the air filter 109 can be prevented from interfering with the operation.

The supply gas G is introduced from the regulator 130 through the supply hose 131, the air filter 109, and the gas injection portion 102G, and fills the space 102s inside the nozzle X (the nozzle body 102).

Two plungers 107 and two syringes 117 are attached to the nozzle body 102 to introduce different chemical solutions into the nozzle body 102 through the syringe attachment port 102d. Specifically, two portions project rearward from both side ends of the rear surface of the nozzle body 102, and a syringe attachment port 102d serving as a chemical solution injection portion is formed at the rear end of these portions. The two syringe attachment ports 102d are connected to syringes 117, respectively. The chemical solutions filled in the two syringes 117 are pushed into the syringes 117 by the plungers 107 and pass through chemical solution flow tubes 103 and 104, which will be described later, in the nozzle body 102 via the syringe attachment ports 102d.

The biological tissue adhesive application tool 101 is provided with a plunger holder 108 for simultaneously pushing the two plungers 107 toward the syringe 117. The plunger holder 108 is formed in a size capable of abutting the base end sides of the two plungers 107.

The extension 111 of the nozzle X has a length sufficient to dispose the head 112 attached to the distal end of the extension 111 in the body cavity. For example, the biological tissue adhesive application tool 101 is used for performing a surgical operation using a thoracoscope. For example, when an operation is performed by EAS (endoscopic assisted surgery) by inserting the medical solution into a trocar (not shown), the medical solution 110 needs to be applied to the distal end of the trocar. In this case, since the nozzle X includes the extension portion 111, the nozzle X can be extended in the axial direction to extend the reachable position of the head 112, which is the position where the chemical solution is sprayed, according to the application position of the chemical solution 110.

A line 111c is formed in an upper portion of the extension portion 111, in other words, in a portion on the opposite side of the direction of the jet of the blast gas G (downward direction) in the direction perpendicular to the axial center direction of the nozzle X. The line 111c is formed with a predetermined width and extends in the axial direction of the nozzle X.

For example, when the biological tissue adhesive application tool 101 is used in a surgical operation using a thoracoscope, the line 111c thus formed functions as a marker for confirming the opposite direction of the line 111c, that is, the jet direction of the supply gas G, that is, the spray direction of the chemical solution 110.

< about the structures around the head >

Next, the head 112 and the structure around the head 112 will be described with reference to fig. 11 to 13 in addition to fig. 9 and 10. Fig. 11 is a front view of the head 112, fig. 12 is a sectional view showing an IV-IV section of fig. 11, and fig. 13 is a sectional view showing a V-V section of fig. 11.

The chemical liquid flow path Y passes through the space 102s inside each of the nozzle body 102, the extension 111, and the head 112, which are a part of the nozzle X, and has a chemical liquid discharge portion (discharge pipe 112 e) that discharges the chemical liquid 110.

The head 112 is provided with a discharge tube 112e having a chemical liquid discharge port 112g and a gas ejection portion 112f.

Specifically, the head 112 is composed of a head main body 112b formed in a cylindrical shape, and a spray end piece 112d having a discharge pipe 112e and a gas discharge portion 112f attached to the distal end side of the head main body 112 b.

A fitting portion 112h to be fitted to the front end of the extension portion 111 is formed at the rear end of the head main body 112 b. The fitting portion 112h has an outer surface having a smaller diameter than the other portion of the head main body 112b, and the outer surface is fitted to the inner surface of the extension portion 111 in a state facing thereto.

As shown in fig. 12 and 13, the inner surface 112c of the head main body 112b on the distal end side is tapered so as to taper toward the proximal end side. By forming in this manner, more supply gas G can be retained on the distal end side than on the proximal end side, so that supply gas G can be continuously discharged from the gas discharge portion 112f described later.

The head 112 includes a brim 112i at its distal end portion via a gas ejection portion 112f, and the brim 112i is provided at a position opposite to the position where the discharge pipe 112e is provided. The details of the brim 112i will be described later.

The atomizing end piece 112d is composed of an end piece body 112j formed in a disk shape and two discharge pipes 112e integrally formed with the end piece body 112j and extending perpendicularly to the end piece body 112 j.

The end piece body 112j is fitted to the inner surface of the head body 112b on the distal end side, and a gas ejection portion 112f as a through hole is formed above each of the two discharge pipes 112 e.

The chemical solution 110 is discharged along the extension of a discharge tube 112e as a chemical solution discharge portion. Conversely, the discharge pipe 112e extends along the discharge direction of the drug solution 110. Hereinafter, the discharge direction is a vector directed toward the distal end side with reference to the discharge pipe 112 e.

The gas ejection portion 112f extends toward the discharge position of the chemical solution 110 discharged from the discharge tube 112 e. Specifically, the gas ejection portion 112f extends obliquely downward toward the distal end side so as to intersect the axial direction of the nozzle X (the thickness direction of the end piece body 112 j) in the end piece body 112j of the atomizing end piece 112d.

Since the discharge pipe 112e and the gas ejection portion 112f extend in such directions, the discharge direction of the chemical solution 110 and the ejection direction of the supplied gas G can be oriented according to the shapes of the discharge pipe 112e and the gas ejection portion 112f. Hereinafter, the discharge direction is a vector toward the distal end side with reference to the gas discharge portion 112f.

The proximal end of the discharge pipe 112e is connected to the distal ends of the chemical solution flow pipes 103 and 104, and the chemical solution 110 that has passed through the two chemical solution flow pipes 103 and 104 is introduced into the two discharge pipes 112 e.

The chemical solution flow tubes 103 and 104 flow two kinds of chemical solutions to be mixed. The chemical solution flow tubes 103 and 104 are members forming the chemical solution flow path Y, and are disposed so as to pass through the nozzle body 102 and a space 102s inside the extension section 111 described later.

The chemical liquid flow path Y includes a plurality of flow paths including a flow path including the chemical liquid flow tube 103 as the 1 st chemical liquid flow path Y1 and a flow path including the chemical liquid flow tube 104 as the 2 nd chemical liquid flow path Y2.

In the present embodiment, one of the chemical solution flow tubes 103 and 104 flows a chemical solution containing fibrinogen or the like. The other of the drug solution flow tubes 103 and 104 flows a drug solution that contains thrombin or the like and acts on fibrinogen or the like to function as a binder. The chemical liquid discharge port 112g is an open end of the discharge tube 112e, and is a portion for discharging the chemical liquid 110 (see fig. 13) which is pushed out of the syringe 117 by the plunger 107, injected from the syringe attachment port 102d, and passed through the chemical liquid flow tubes 103 and 104.

The gas ejection portion 112f is provided in the vicinity of the chemical liquid discharge port 112G, and is a portion for ejecting the supplied gas G filled in the space 102s inside the nozzle X from the gas injection portion 102G at the tip end portion of the head portion 112.

The gas ejection portion 112f is formed at two positions, and the tip openings of the two gas ejection portions 112f are formed along the discharge pipe 112e when viewed from the front. Specifically, the gas ejection portion 112f has an arc-shaped opening at the distal end thereof, and is formed along the discharge pipe 112 e. The gas discharge portion 112f thus formed can suppress the expansion of the discharge area of the supplied gas G, and can efficiently mix the chemical solution 110. Specifically, the supply gas G discharged from the gas discharge portion 112f can wrap the chemical solution 110 discharged from the discharge tube 112e, thereby changing the application direction of the chemical solution 110.

The tip openings of the two gas ejection portions 112f are formed in an arc shape having a central angle of 20 ° to 50 ° concentric with the centers c1 and c2 of the two ejection tubes 112e, respectively, when viewed from the front. When the gas ejection portion 112f is formed in this manner, the range of the gas ejection portion 112f becomes wider with distance from the discharge pipe 112 e. Therefore, the supply gas G discharged from the gas discharge portion 112f can appropriately wrap the chemical solution 110 discharged from the discharge pipe 112e so as not to leak, and can change the application direction of the chemical solution 110.

When the tip of the gas ejection portion 112f is open when viewed from the front, the gas ejection portion 112f is formed in a non-circumferential shape in a part of the circumferential direction around the discharge pipe 112 e. By forming the gas ejection portion 112f in this manner, the supplied gas G is ejected from the gas ejection portion 112f in a partial cylindrical shape.

By forming the gas spouting portion 112f in this manner, the discharge tube 112e and the gas spouting portion 112f can be integrally molded with the atomizing end piece 112d, unlike a conventional gas spouting portion formed in an annular shape. Therefore, the production efficiency of the biological tissue adhesive application tool 101 is improved.

When the front end of the gas ejection portion 112f is open in front view, the gas ejection portion 112f is formed at a position separated from the discharge pipe 112 e. By forming the gas ejection portion 112f in this manner, the supply gas G ejected obliquely downward from the gas ejection portion 112f toward the distal end side can be appropriately ejected to the chemical solution 110 ejected from the ejection tube 112e protruding toward the distal end side from the gas ejection portion 112f.

As shown in fig. 13, the angle formed by the discharge direction of the gas discharge portion 112f and the axial direction of the nozzle X (strictly, the head portion 112) is larger than the angle formed by the discharge direction of the chemical solution 110 of the chemical solution discharge portion (discharge pipe 112 e) and the axial direction. Here, the axial direction serving as a reference of the angle is a vector toward the distal end side. The discharge direction of the chemical solution 110 according to the present embodiment is a direction parallel to the axial direction of the head 112.

The discharge direction of the supply gas G from the gas discharge portion 112f and the discharge direction of the chemical solution 110 from the chemical solution discharge portion (discharge pipe 112 e) obliquely intersect at a position where the chemical solution 110 is discharged from the chemical solution discharge portion (discharge pipe 112 e). The ejection direction here refers to the flow of the supply gas G itself, and the ejection direction refers to the flow of the chemical solution 110 itself. The ejection direction and the ejection direction intersect obliquely with each other, which means that the supply gas G and the chemical solution 110 intersect obliquely with each other. As described later, the "discharge position" is a concept including a position in the very vicinity of the chemical liquid discharge port 112g of the discharge tube 112 e. As shown in fig. 13, the chemical solution 110 obliquely intersects with the supply gas G and is then sprayed along the supply gas G.

The gas jetting section 112f jetting the supply gas G in such a jetting direction can appropriately apply the chemical solution 110 to the affected part by changing the application direction of the chemical solution 110 while atomizing the chemical solution 110. At least a portion (the discharge tube 112e according to the present embodiment) near the chemical liquid discharge port 112g among the portions forming the chemical liquid flow path Y can be configured to be linear, and the chemical liquid flow path Y can be easily formed. Further, the efficiency of manufacturing the biological tissue adhesive application tool 101 can be improved.

The discharge pipe 112e according to the present embodiment is separate from the chemical liquid flow pipes 103 and 104, but the present invention is not limited to this configuration and may be integrally formed. Further, the discharge direction of the chemical solution 110, i.e., the extending direction of the discharge tube 112e, does not necessarily have to be parallel to the axial direction of the nozzle X, as long as the chemical solution 110 can be sprayed in the direction intersecting the axial direction of the nozzle X.

As shown in fig. 10, the discharge pipe 112e has an elliptical distal end surface 112k and is formed along the discharge direction of the supply gas G from the gas discharge portion 112f (parallel to the discharge direction). Specifically, the tip end surface 112k according to the present embodiment is a surface extending in the width direction of the nozzle X including a straight line parallel to the ejection direction of the supply gas G and extending obliquely to the axial center direction of the nozzle X. For example, the distal end surface 112k is formed by obliquely cutting (cutting) the distal end portion of the cylindrical portion that is the discharge pipe 112 e.

The discharge pipe 112e having the distal end surface 112k formed along the discharge direction of the supplied gas G in this manner can linearly guide the chemical solution 110 along the inner surface of the discharge pipe 112e until the chemical solution 110 reaches the supplied gas G.

The chemical solution 110 is sprayed by the supply gas G in the vicinity of the chemical solution discharge port 112G of the discharge pipe 112 e.

Therefore, the discharge pipe 112e can suppress the flow of the supply gas G, which is injected by the own weight of the chemical solution 110 before the chemical solution 110 reaches the chemical solution discharge port 112G, toward a direction away from the chemical solution. Therefore, the chemical solution 110 is uniformly sprayed by the supply gas G.

In this manner, the distal end surface 112k of the discharge pipe 112e is preferably formed parallel to the ejection direction of the supplied gas G, but the same effect can be exhibited as long as the direction is along the ejection direction of the supplied gas G from the gas ejection portion 112f. Therefore, the distal end surface of the chemical liquid discharge portion according to the present invention may be formed to be slightly inclined with respect to the discharge direction of the supply gas G.

Specifically, the discharge direction of the supply gas G is a straight line parallel to the extending direction of the gas discharge portion 112f, and as shown in fig. 13, a virtual straight line connecting the base-end-side upper edge 112fa and the tip-end-side lower edge 112fb of the gas discharge portion 112f, which is a through hole formed in the end piece main body 112 j. In this case, the distal end surface 112k of the discharge pipe 112e is preferably formed with an inclination within a range of an angle R formed by a straight line in the discharge direction of G and an imaginary straight line.

Further, if the chemical solution 110 does not flow down in a direction away from the ejected supply gas G due to the viscosity of the chemical solution 110 and the chemical solution 110 can be uniformly sprayed by the supply gas G, the distal end surface of the chemical solution discharge portion may be a distal end surface perpendicular to the axial direction of the nozzle X. With this configuration, the distal end portion of the chemical solution discharge portion can be easily formed without additional processing.

When the front end of the gas ejection portion 112f is open in front view, the center-side end of the gas ejection portion 112f is formed so as to be closer to the inner side than the both ends of the line segment s 1. Here, the line segment s1 connects the center c1 of the chemical liquid discharge port 112g of the 1 st chemical liquid flow path Y1 and the center c2 of the chemical liquid discharge port 112g of the 2 nd chemical liquid flow path Y2.

As described above, since a part of the gas ejection portion 112f is formed so as to be closer to the inner side than both ends of the line segment s1, the supply gas G is ejected from the gas ejection portion 112f like an air curtain (air current). Therefore, the supply gas G ejected from the gas ejection portion 112f can prevent the chemical solutions 110 ejected from the chemical solution ejection ports 112G of the 1 st and 2 nd chemical solution flow paths Y1 and Y2 from being mixed at an early stage after being ejected from the chemical solution ejection ports 112G. Therefore, when the chemical solution 110 functioning as a binder at the time of mixing is used, the chemical solution 110 discharged from the two chemical solution discharge ports 112g can be prevented from being mixed in the vicinity of the chemical solution discharge ports 112g, from solidifying, and from becoming a cause of clogging.

When the distal end of the discharge pipe 112e is open as viewed from the front, the gas ejection portion 112f ejects the supply gas G in a direction intersecting the arrangement direction of the plurality (two in the present embodiment) of 1 st chemical liquid flow passages Y1 and 2 nd chemical liquid flow passages Y2. The air supply gas G thus injected mixes the chemical solutions 110 discharged from the discharge pipes 112e of the 1 st chemical solution flow path Y1 and the 2 nd chemical solution flow path Y2 in a mist form.

The biological tissue adhesive application tool 101 according to the present embodiment includes two 1 st and 2 nd medical fluid flow paths Y1 and Y2, and the two 1 st and 2 nd medical fluid flow paths Y1 and Y2 are formed by two medical fluid flow tubes 103 and 104 and a discharge tube 112e continuous to each of them. However, the biological chemical solution injector according to the present invention is not limited to this configuration, and may be configured to further include a plurality of chemical solution flow paths Y.

The brim 112i is provided so as to cover the tip of the discharge tube 112e, and is formed to protrude further toward the distal end side than the tip of the discharge tube 112e with reference to the discharge direction of the chemical solution 110. In particular, the eaves 112i are formed in a gently pointed shape. Specifically, the eaves 112i are formed as follows: the central portion in the width direction (in the present embodiment, the direction parallel to the direction in which the chemical liquid discharge ports 112g are arranged) protrudes the most toward the distal end side, and the amount of protrusion from the spraying end piece 112d decreases as it goes toward both sides in the width direction.

The brim 112i thus formed functions as a partition wall for separating the gas ejection portion 112f and the chemical liquid discharge port 112g from the surrounding environment. Therefore, the brim 112i can suppress the influence of the supply gas G discharged from the gas discharge portion 112f from the surrounding environment, and can maintain the rectification property of the spray of the chemical solution 110. Further, the brim portion 112i can prevent the gas ejection portion 112f or the chemical liquid discharge port 112g from being clogged by body fluid or the like adhering to the discharge pipe 112e for discharging the chemical liquid 110 by coming into contact with organs or the like. Further, by forming the brim 112i into a sharp shape, the nozzle X can be easily inserted from the head 112 into a trocar not shown.

In the biological tissue adhesive application tool 101 according to the above embodiment, since the chemical solution 110 can be sprayed obliquely with respect to the axial direction of the nozzle X, the spray area of the chemical solution 110 can be changed by rotating the nozzle X. By adjusting the supply speed of the supply gas G by the regulator 130, the spray angle of the chemical solution 110 sprayed in the spray direction of the supply gas G can be adjusted.

(modification 5)

Next, the head 142 according to the 5 th modification will be described mainly with reference to fig. 14. Fig. 14 is a front view of a head 142 according to a modification example 5.

As shown in fig. 14, two gas ejection portions 142f are formed in the end piece main body 142j of the atomizing end piece 142d provided in the head 142 of the 5 th modification in a shape of a letter v 12467when viewed from the front. The two gas ejection portions 142f are formed so that the open sides thereof face the two discharge pipes 112 e. In other words, both end portions of the gas spouting portion 142f extend downward so as to wrap the chemical solution 110 spouted from the chemical solution spouting port 112g of the spouting tube 112 e.

Even the v-shaped 12467like gas jetting portion 142f included in the head portion 142 according to the present modification can exhibit the same effect as the arc-shaped gas jetting portion 112f included in the head portion 112 according to the above-described embodiment. Specifically, the head 142 can also effectively mix the chemical solution 110 while suppressing the expansion of the discharge area of the supply gas G.

Both ends of the gas ejection portion 142f extend downward and are formed closer to the inner side than both ends of a line segment s1 connecting the center c1 of the chemical liquid discharge port 112g of the 1 st chemical liquid flow path Y1 and the center c2 of the chemical liquid discharge port 112g of the 2 nd chemical liquid flow path Y2.

Therefore, the head 142 having the gas ejection portion 142f can exhibit the same effects as those of the head 112 according to the above-described embodiment.

Specifically, the supply gas G ejected from both ends (near portions) of the gas ejection portion 142f can prevent the chemical liquids 110 ejected from the respective chemical liquid ejection ports 112G of the 1 st chemical liquid flow path Y1 and the 2 nd chemical liquid flow path Y2 from being mixed at an early stage after being ejected from the chemical liquid ejection ports 112G.

(6 th modification)

Next, the head 152 according to the modification 6 will be described mainly with reference to fig. 15. Fig. 15 is a front view of a head portion 152 according to a modification 6.

As shown in fig. 15, one gas ejection portion 152f is formed in an end piece body 152j of a spray end piece 152d provided in the head 152 according to the 6 th modification, and is formed in a T shape when viewed from the front. In other words, the center portion of the gas spouting portion 152f is formed to extend downward and to be closer to the inner side than both ends of a line segment s1 connecting the center c1 of the chemical liquid discharge port 112g of the 1 st chemical liquid flow path Y1 and the center c2 of the chemical liquid discharge port 112g of the 2 nd chemical liquid flow path Y2.

Therefore, the head 152 can exhibit the same effects as the head 112 according to the above-described embodiment and the head 142 according to the 5 th modification. Specifically, the supply gas G ejected from the central portion (near portion) of the gas ejection portion 152f can prevent the chemical liquids 110 ejected from the chemical liquid ejection ports 112G of the 1 st and 2 nd chemical liquid flow passages Y1 and Y2 from being mixed at an early stage after being ejected from the chemical liquid ejection ports 112G.

In particular, since the gas discharge portion 152f is formed at only one position, the head portion 152 can be easily manufactured.

When viewed from the front, both end portions of the gas discharge portion 152f may extend downward in the same manner as the central portion of the gas discharge portion 152 f. With such an arrangement, similarly to the gas ejecting portion 112f or the gas ejecting portion 142f, the chemical solution 110 can be efficiently mixed while suppressing the expansion of the ejection region of the supplied gas G.

(modification 7)

The head 162 according to the modification 7 will be described mainly with reference to fig. 16. Fig. 16 is a front view of a head 162 according to a modification example of fig. 7.

In the biological tissue adhesive application tool 101 according to the above embodiment, in order to spray and mix the two types of chemical solutions 110 that function as adhesives by being mixed, a pair of members such as the plunger 107, the syringe 117, the chemical solution flow tubes 103 and 104, and the discharge tube 112e is provided.

The biological medical fluid injection device provided with the head 162 according to modification 7 is a medical fluid injection device for spraying one medical fluid, and only one of the pair of members of the biological tissue adhesive application device 101 is provided.

Only one arc-shaped gas ejection portion 162f is formed in the end piece main body 162j of the spraying end piece 162d of the head 162. The gas ejection portion 162f is formed along the outer periphery of the single discharge pipe 112e when viewed from the front.

As described above, the present invention is not limited to the biological tissue adhesive application tool of the biological tissue adhesive application tool, and may be a biological medical fluid injection tool that sprays the medical fluid 110 through one discharge pipe 112 e. In the biological medical fluid injection device, the supply gas G from the gas ejection portion 162f can be ejected in a direction inclined with respect to the axial direction of the nozzle X, as in the biological tissue adhesive agent application device 101 according to the above-described embodiment. More specifically, even if the discharge tube 112e is formed along the axial direction of the nozzle X, the chemical solution 110 can be sprayed obliquely with respect to the axial direction of the nozzle X.

Industrial applicability

A biological tissue adhesive application tool which can prevent clogging with a chemical solution with a simple structure and at low cost can be provided. Further, it is possible to provide a liquid medicine injection device for living body which can spray a liquid medicine obliquely by ejecting gas and which can be easily manufactured.

Description of the reference numerals

1-an applicator for biological tissue adhesive,

2-the main body of the nozzle,

2 a-a front end side member,

2 aa-a through-hole for insertion,

2 b-a base-end side member,

2 c-a discharge member for discharging the liquid,

2 ca-the holding means,

2 cb-discharge pipe (liquid medicine flow path),

2 d-syringe mounting port (liquid medicine injection part),

2 e-a liquid medicine discharge portion,

2 g-the gas injection part (c-l),

2 h-the gas-spraying part,

the space of the two-dimensional (2 s-),

3. 4, 5, 6-liquid medicine circulating pipe (liquid medicine circulating pipe),

3a, 4 a-a base end portion,

3b, 4 b-a front end portion,

3 c-balloon (telescoping section),

3 ca-wave-shaped concave portion (contraction promoting portion),

the 3 cb-top portion of the substrate,

7-a plunger piston is arranged at the bottom of the reaction chamber,

8-the plunger holder is held by the plunger holder,

9-the air filter is arranged on the upper surface of the shell,

9 a-a connecting port, wherein,

10-the liquid medicine is prepared by mixing the raw materials,

13 c-balloon (telescoping section),

13 ca-a wave-shaped convex portion (restoration promoting portion),

17-an injector, wherein the injector is arranged on the upper portion of the cylinder,

23 c-balloon (telescoping portion),

23 ca-linear protrusion (restoration promoting portion),

30-the adjustment of the position of the actuator,

31-an air-feeding hose for supplying air,

31a, 31 b-connectors, are provided,

60-a filter (resistant component),

101-a biological tissue adhesive application tool (a biological chemical solution injection tool),

102-nozzle body (part 1),

102 d-syringe attachment port (chemical solution injection part, chemical solution flow path),

102 g-the gas injection portion of the gas injection portion,

102 s-the space of the air conditioner chamber,

103-chemical liquid flow tube (1 st chemical liquid flow path, chemical liquid flow path),

104-chemical solution flowing tube (No. 2 chemical solution flowing path, chemical solution flowing path),

107-a plunger, which is arranged in the cylinder,

108-the plunger holder,

109-the air filter(s) is (are),

109 a-a connecting port, wherein,

110-the liquid medicine is prepared by mixing the components,

111-an extension of the length of the wire,

the line 111 c-is taken as a reference,

112-the head part of the water-treatment tank,

112 b-the body of the head part,

112 c-the inner surface of the tube,

112 d-spray end piece (part 2),

112 e-a discharge pipe (drug solution discharge part, drug solution flow path),

112 f-the gas ejection section,

112 fa-the base end side upper edge,

112 fb-front end side lower edge,

112 g-a liquid medicine discharge port,

112 h-the engaging part of the engaging part,

112 i-the eaves-for example,

112 j-the end-piece body,

112 k-the front end face,

117-a syringe-the liquid is injected into the syringe,

130-the adjustment of the position of the actuator,

131-a flexible air-feeding tube for air,

131a, 131 b-a connector, and,

142-the head part of the water-cooling water tank,

142 d-spraying end piece (part 2),

142 f-the gas-ejecting part,

142 j-the body of the end piece,

152-the head part of the water-treatment tank,

152 d-spraying end piece (part 2),

152 f-the gas-ejecting section,

152 j-the end-piece body,

162-the head part of the patient,

162 d-spray end piece (part 2),

162 f-the gas-ejecting section,

162 j-the end-piece body,

c1, c 2-center of the polymer,

s 1-the line segment-s 1,

g-gas-feeding gas, wherein the gas is,

an X-nozzle, wherein the X-nozzle is arranged on the upper surface of the shell,

a Y-shaped liquid medicine flow passage is arranged on the upper portion of the liquid medicine tank,

y1-the 1 st liquid medicine flow path,

y2-2 nd drug solution flow path.

Claims (8)

1. A biological tissue adhesive application tool comprising:

a nozzle body having a space therein; and

a plurality of chemical liquid flow passages passing through the space inside the nozzle body and communicating a chemical liquid injection portion provided in the nozzle body with a chemical liquid discharge portion provided at a tip end of the nozzle body to circulate a chemical liquid,

the nozzle body is provided with:

a gas injection unit for filling the space with a gas; and

a gas ejection portion located in the vicinity of the chemical liquid discharge portion, ejecting gas filled in the space from the gas injection portion, and spraying and mixing the chemical liquid discharged from the chemical liquid discharge portion of the plurality of chemical liquid flow passages in a mist form,

at least one of the liquid medicine flow passages is provided with: a telescopic part which is contracted by external pressure generated by the gas introduced into the space from the gas injection part and is restored when the external pressure is reduced,

the expansion part is provided with a restoration promoting part for promoting restoration,

the restoration promoting portion is a convex portion formed on an outer surface of the expansion portion.

2. A biological tissue adhesive application tool comprising:

a nozzle body having a space therein; and

a plurality of chemical liquid flow passages passing through the space inside the nozzle body and communicating a chemical liquid injection portion provided in the nozzle body with a chemical liquid discharge portion provided at a tip end of the nozzle body to circulate a chemical liquid,

the nozzle body is provided with:

a gas injection part for filling the space with gas; and

a gas ejection portion located in the vicinity of the chemical liquid discharge portion, ejecting gas filled in the space from the gas injection portion, and spraying and mixing the chemical liquid discharged from the chemical liquid discharge portion of the plurality of chemical liquid flow passages in a mist form,

at least one of the chemical liquid flow passages is provided with: a telescopic part which is contracted by external pressure generated by the gas introduced into the space from the gas injection part and is restored when the external pressure is reduced,

the expansion part is provided with a restoration promoting part for promoting restoration,

the restoration promoting portion is formed over the entire circumference of the expansion portion.

3. The biological tissue adhesive application tool according to claim 1 or 2,

the stretchable portion has a contraction promoting portion promoting contraction,

the contraction promoting portion is a recess formed in an outer surface of the expansion portion.

4. A biological tissue adhesive application tool comprising:

a nozzle body having a space therein; and

a plurality of chemical liquid flow passages passing through the space inside the nozzle body and communicating a chemical liquid injection portion provided in the nozzle body with a chemical liquid discharge portion provided at a tip end of the nozzle body to circulate a chemical liquid,

the nozzle body is provided with:

a gas injection part for filling the space with gas; and

a gas ejection portion located in the vicinity of the chemical liquid ejection portion, ejecting the gas filled in the space from the gas injection portion, and mixing the chemical liquid ejected from the chemical liquid ejection portion of the plurality of chemical liquid flow passages in a mist form,

at least one of the chemical liquid flow passages is provided with: an expansion/contraction section which is contracted by external pressure generated by the gas introduced from the gas injection section into the space and which is restored when the external pressure is reduced,

the stretchable portion has a contraction promoting portion promoting contraction,

the contraction promoting portion has a waveform formed by being curved so as to repeatedly approach and separate from the chemical liquid injection portion and the chemical liquid discharge portion.

5. A biological tissue adhesive application tool comprising:

a nozzle body having a space therein; and

a plurality of chemical liquid flow passages passing through the space inside the nozzle body and communicating a chemical liquid injection portion provided in the nozzle body with a chemical liquid discharge portion provided at a distal end of the nozzle body to allow the chemical liquid to flow therethrough,

the nozzle body is provided with:

a gas injection part for filling the space with gas; and

a gas ejection portion located in the vicinity of the chemical liquid discharge portion, ejecting gas filled in the space from the gas injection portion, and spraying and mixing the chemical liquid discharged from the chemical liquid discharge portion of the plurality of chemical liquid flow passages in a mist form,

at least one of the liquid medicine flow passages is provided with: a telescopic part which is contracted by external pressure generated by the gas introduced into the space from the gas injection part and is restored when the external pressure is reduced,

the stretchable portion has a contraction promoting portion promoting contraction,

the contraction promoting portion is a recess formed in an outer surface of the expansion portion,

the contraction promoting portion is formed in a non-circumferential shape.

6. A biological tissue adhesive application tool comprising:

a nozzle body having a space therein; and

a plurality of chemical liquid flow passages passing through the space inside the nozzle body and communicating a chemical liquid injection portion provided in the nozzle body with a chemical liquid discharge portion provided at a distal end of the nozzle body to allow the chemical liquid to flow therethrough,

the nozzle body is provided with:

a gas injection part for filling the space with gas; and

a gas ejection portion located in the vicinity of the chemical liquid discharge portion, ejecting gas filled in the space from the gas injection portion, and spraying and mixing the chemical liquid discharged from the chemical liquid discharge portion of the plurality of chemical liquid flow passages in a mist form,

at least one of the chemical liquid flow passages is provided with: a telescopic part which is contracted by external pressure generated by the gas introduced into the space from the gas injection part and is restored when the external pressure is reduced,

the cross-sectional area of the flow path in the portion of the medical fluid flow path adjacent to the distal end side of the expansion/contraction section is smaller than the cross-sectional area of the flow path in the portion of the medical fluid flow path adjacent to the proximal end side of the expansion/contraction section.

7. The biological tissue adhesive agent application tool according to any one of claims 1, 2, and 4 to 6,

a plurality of the liquid medicine flow passages are arranged in the space,

the expansion/contraction portion is provided only in a part of the plurality of chemical liquid flow passages disposed in the space.

8. The applicator for a biological tissue adhesive according to any one of claims 1, 2, and 4 to 6, wherein,

a resistance member that suppresses the flow of the chemical liquid to the expansion/contraction portion is provided on the end side of the chemical liquid flow path with respect to the expansion/contraction portion.

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