WO2014207920A1

WO2014207920A1 - Applicator

Info

Publication number: WO2014207920A1
Application number: PCT/JP2013/067882
Authority: WO
Inventors: 研司横山
Original assignee: テルモ株式会社
Priority date: 2013-06-28
Filing date: 2013-06-28
Publication date: 2014-12-31

Abstract

This applicator (100) is provided with a nozzle (3) having a double-tube structure constituted by an outer tube (5) and inner tubes (6a, 6b). The inner tube (6a) functions as a first liquid flow passage (61) through which a first liquid (L1) flows downward, and the inner tube (6b) functions as a second liquid flow passage (62) through which a second liquid (L2) flows downward. In the outer tube (5), a gap between the inner tubes (6a, 6b) functions as a gas flow passage (51) through which a gas (G) flows downward . The inner tubes (6a, 6b) respectively have a readily-deforming portion (641). When an application operation is taking place, the readily-deforming portions (641) are dilated by the first liquid (L1) and the second liquid (L2) respectively, and when the application operation is halted, are pressed shut by the gas (G).

Description

Applicator

The present invention relates to an applicator.

Conventionally, there has been known a method of mixing two or more liquids and spraying them onto an affected part to form an adhesion preventing material or a living tissue adhesive, and an applicator for that purpose has been developed.

Such an applicator has a configuration in which components that coagulate when mixed, for example, a solution containing thrombin and a solution containing fibrinogen are separated from each other, sent to the vicinity of the affected area, and applied while mixing in the affected area. is there.

As a conventional applicator, there is one having two syringes each containing a different type of liquid and a nozzle that mixes and ejects the liquid from each syringe (for example, see Patent Document 1). Moreover, the applicator described in Patent Document 1 is configured such that the nozzle is connected to a gas supply source that supplies aseptic gas, and a liquid is ejected together with the aseptic gas. The specific configuration of this nozzle is that two inner tubes through which the liquid from each syringe passes, and an outer tube through which the two inner tubes are inserted and gas passes between these inner tubes. It has a double tube structure composed of tubes.

Also, the tip of each inner tube is made of a gas permeable membrane that allows gas to permeate but not liquid. Thereby, if the plunger of each syringe is pressed and liquid ejection operation is performed, each liquid can be ejected with the sterilized gas which flowed into the inner tube through the gas permeable membrane.

In the nozzle having such a configuration, when the liquid ejection operation is stopped, depending on the pressure of the gas flowing into each inner pipe, the liquid in the inner pipe is excessively pushed back, i.e., retreated (reverse flow). Let me). In this case, the next time the liquid ejection operation is performed, it is necessary to press the plunger again by the amount of retraction of the liquid, which may make it difficult to perform the rapid liquid ejection operation.

Japanese Patent No. 5147465

An object of the present invention is to provide an applicator that can prevent the backflow of liquid when the application operation is stopped.

Such an object is achieved by the present inventions (1) to (13) below.
(1) It has a double-pipe structure composed of an outer tube and at least one inner tube, functions as a liquid flow path through which the liquid flows down, and the outer tube and the inner tube The gap between them has a nozzle that functions as a gas flow path through which gas flows down,
The inner pipe is provided in the middle of the longitudinal direction, and is provided with a gas permeable membrane through which the gas permeates but does not permeate the liquid, and an upstream side of the gas permeable membrane in the middle of the longitudinal direction. An easily deformable portion that is deformable in the radial direction,
In a state where an application operation for ejecting the liquid from the nozzle tip together with the gas flowing into the liquid channel through the gas permeable membrane is performed, the easily deformable portion is caused by the liquid flowing down the liquid channel. An applicator characterized in that the easily deformable portion is closed by applying an external force from the gas flow path side to the easily deformable portion while being spread and stopped in the application operation.

(2) The applicator according to (1), wherein the easily deformable portion is closed by pressure to prevent or suppress back flow of the liquid in the liquid flow path.

(3) The above (1) or (2), wherein the wall of the inner pipe has a thickness at the easily deformable portion that is thinner than the thickness at either the upstream side or the downstream side of the easily deformable portion. The applicator according to 1.

(4) The applicator according to any one of (1) to (3), wherein in the state where the application operation is stopped, the easily deformable portion is closed by the gas in the gas flow path.

(5) In the state where the coating operation is performed, the pressure of the liquid acting on the easily deformable portion is higher than the pressure of the gas acting on the easily deformable portion, and in the state where the coating operation is stopped, The applicator according to (4), wherein the pressure of the gas acting on the easily deformable portion is higher than the pressure of the liquid acting on the easily deformable portion.

(6) In any of the above (1) to (5), a pressure closing member that closes the easily deformable portion from the gas flow path side in a state where the application operation is stopped is mounted in the vicinity of the easily deformable portion. The applicator according to claim 1.

(7) It has a double tube structure composed of an outer tube and at least one inner tube, and the inner tube functions as a liquid flow path through which liquid flows, and the outer tube and the inner tube The gap between them has a nozzle that functions as a gas flow path through which gas flows down,
The inner pipe is provided in the middle of the longitudinal direction, and has a gas permeable membrane that allows the gas to pass therethrough but does not allow the liquid to pass through. The portion upstream of the gas permeable membrane has flexibility, and the portion Is equipped with a pressure-closure member that can be
In a state where an application operation of ejecting the liquid from the nozzle tip together with the gas flowing into the liquid flow path through the gas permeable membrane is performed, the inner tube is not closed by the pressure closing member, In the state where the application operation is stopped, the inner tube is pressure-closed by the pressure-closing member.

(8) The applicator according to (7), wherein the inner pipe is closed to prevent or suppress back flow of the liquid in the liquid channel.

(9) The applicator according to any one of (6) to (8), wherein the pressure closing member includes a clamping portion that is clamped from both side portions via the central axis of the inner tube.

(10) The clamp part includes a fixed piece fixed to the outer peripheral surface of the inner tube, and an elastic piece having elasticity and approaching and separating from the fixed piece. Applicator.

(11) The applicator according to any one of (1) to (10), wherein a plurality of the inner pipes are installed, and liquids having different liquid compositions flow through the inner pipes.

(12) The applicator according to (11), wherein the plurality of inner pipes merge with each other at an upstream portion to form a merge portion, and an inner diameter of the upstream portion of the merge portion is reduced. .
(13) The applicator according to (12), wherein the gas permeable membrane is disposed in the joining portion.
In the applicator of the present invention, it is preferable that the distance between the easily deformable portion and the gas permeable membrane is shorter than the length of the gas permeable membrane in the longitudinal direction.

In a state where the coating operation is stopped, the liquid in the liquid channel is likely to be pushed back to the upstream side by the gas flowing into the liquid channel through the gas permeable membrane.

However, according to the present invention, since the easily deformable portion is closed in a state where the coating operation is stopped, the backflow of the liquid in the liquid flow path is prevented. Thus, when the application operation is resumed, it is possible to omit re-pressing the liquid by the amount of the reverse flow of the liquid, and thus the application operation can be resumed quickly.

FIG. 1 is a perspective view showing a first embodiment of the applicator of the present invention. FIG. 2 is a longitudinal sectional view of a nozzle provided in the applicator shown in FIG. FIG. 3 is an enlarged detail view of the tip of the nozzle shown in FIG. FIG. 4 is an enlarged detail view of the tip of the nozzle shown in FIG. FIG. 5 is an enlarged detailed view of the nozzle tip shown in FIG. FIG. 6 is a longitudinal sectional view (a diagram showing a change in application state with time) of a nozzle provided in the applicator (second embodiment) of the present invention. FIG. 7 is a vertical cross-sectional view (a diagram showing a change in application state over time) of a nozzle provided in the applicator (second embodiment) of the present invention. FIG. 8 is a perspective view of the pressure closing member. FIG. 9 is a perspective view of the pressure closing member. FIG. 10 is a longitudinal sectional view (a diagram showing a change in application state with time) of a nozzle provided in the applicator (third embodiment) of the present invention. FIG. 11 is a longitudinal sectional view (a diagram showing a change in application state with time) of a nozzle provided in the applicator (third embodiment) of the present invention.

Hereinafter, the applicator of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

<First Embodiment>
1 is a perspective view showing a first embodiment of the applicator of the present invention, FIG. 2 is a longitudinal sectional view of a nozzle provided in the applicator shown in FIG. 1, and FIGS. 3 to 5 are respectively shown in FIG. It is an enlarged detailed view (a figure showing change with time of an application state) of a tip part of a nozzle. In the following, for convenience of explanation, the right side of FIGS. 1 to 5 (same as in FIGS. 6 to 11) is “base (back)” or “upstream”, and the left is “tip (front)” or Say “downstream”. 3 to 5 (the same applies to FIGS. 6, 7, 10 and 11), the length direction of the nozzle is shortened and the thickness direction of the nozzle is exaggerated for easy understanding. It is schematically shown, and the ratio between the length direction and the thickness direction is different from the actual ratio.

The applicator 100 shown in FIG. 1 includes a syringe connector 10 and a nozzle 3. As shown in FIG. 4, the applicator 100 is an application operation for applying the mixed liquid L3 together with the gas G while mixing two kinds of liquids (first liquid L1 and second liquid L2) having different liquid compositions. Is done. Hereinafter, the configuration of each unit will be described.

As shown in FIG. 1, the syringe assembly 10 is a liquid supply unit that collectively supplies the first liquid L1 and the second liquid L2 to the nozzle 3, and includes a syringe 1a and a syringe 1b that are connected to each other side by side. have.

The syringe 1a is prefilled with the first liquid L1, and the syringe 1b is prefilled with the second liquid L2.

Then, when the liquid mixture L3 is prepared by mixing the first liquid L1 and the second liquid L2 at a predetermined mixing ratio, and the liquid mixture L3 is used as the living tissue adhesive, the first liquid L1 and the second liquid L2 One of the two liquids L2 can be thrombin and the other drug can be fibrinogen. Moreover, when using the said liquid mixture L3 as an adhesion preventing material, one side can be made into the carboxymethyl dextrin modified with the succinimidyl group, and the other can be made into the mixture of sodium hydrogencarbonate and sodium carbonate.

Since the syringe 1a and the syringe 1b have substantially the same configuration except that the sizes, that is, the maximum volumes are different, the syringe 1a will be described below representatively.

The syringe 1a includes a syringe outer cylinder 2 and a gasket 12.

The syringe outer cylinder 2 has a barrel portion 21 having a bottomed cylindrical shape, and a mouth portion (syringe side mouth portion) 22 that is formed to protrude from the bottom portion that becomes the distal end wall portion 211 of the barrel portion 21.

The inner diameter and the outer diameter of the barrel 21 are constant along the central axis direction of the barrel 21. In addition, the internal diameter of the trunk | drum 21 of the syringe 1a is larger than the internal diameter of the trunk | drum 21 of the syringe 1b. Similarly, the outer diameter of the barrel portion 21 of the syringe 1a is larger than the outer diameter of the barrel portion 21 of the syringe 1b.

Further, the barrel 21 of the syringe 1a and the barrel 21 of the syringe 1b are connected to each other via a plate-like flange 23 in the middle of the central axis direction. Thereby, the positional relationship between the syringe 1a and the syringe 1b is regulated, that is, the state in which the syringe 1a and the syringe 1b are connected side by side is maintained.

The mouth portion 22 is a portion that is thinner than the trunk portion 21 and communicates with the trunk portion 21. The first liquid L1 is discharged through the mouth portion 22. The mouth portion 22 is disposed at a position eccentric from the center of the distal end wall portion 211 of the trunk portion 21. In the present embodiment, the outer diameter of the mouth portion 22 of the syringe 1a and the outer diameter of the mouth portion 22 of the syringe 1b are the same.

The constituent material of the syringe outer cylinder 2 is not particularly limited. For example, a resin material such as polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) is preferable because it is easy to mold. . In addition, it is preferable that the constituent material of the syringe outer cylinder 2 is substantially transparent in order to ensure the internal visibility.

The gasket 12 is made of an elastic body having a columnar shape or a disk shape. The gasket 12 is housed in the barrel 21 (syringe outer cylinder 2) and can slide within the barrel 21. In addition, the first liquid L1 can be filled in the space surrounded by the gasket 12 and the body portion 21. The first liquid L1 can be discharged through the mouth portion 22 by moving the gasket 12 from the filled state toward the distal direction.

The constituent material of the gasket 12 is not particularly limited, and examples thereof include various rubber materials such as silicone rubber, various thermoplastic elastomers such as polyurethane, and elastic materials such as a mixture thereof.

The syringe connector 10 further includes a plunger 11.

The plunger 11 is a member that operates the gaskets 12 at once. This plunger 11 has a plunger part 111 connected to the gasket 12 of the syringe 1a, a plunger part 112 connected to the gasket 12 of the syringe 1b, and a flange part 113 as an operation part.

The plunger portion 111 has a long shape, and the tip thereof is connected to the gasket 12 of the syringe 1a. The plunger portion 112 is also elongated, and its distal end is connected to the gasket 12 of the syringe 1b. The connection method is not particularly limited, and examples thereof include a screwing method and a fitting method. Note that the plunger portion 111 is thicker than the plunger portion 112.

The flange portion 113 has a plate shape, and the

plunger portions

111 and 112 extend from the front end surface thereof toward the front end direction, respectively. When operating the applicator 100, for example, the thumb of one hand can be hung on the flange portion 113 of the plunger 11, and the index finger and the middle finger can be hung on the flange portion 23 of the syringe outer tube 2.

As shown in FIG. 2, the nozzle 3 has a base 4, a structure 7 having a double tube structure constituted by an outer tube 5 and

inner tubes

6 a and 6 b, and a sheath 8.

The base 4 is configured by a member whose outer shape is a flat shape. It does not specifically limit as a constituent material of the base 4, For example, the same thing as the constituent material of the syringe outer cylinder 2 can be used.

At the base end portion of the base portion 4,

connection portions

41 a and 41 b are provided. The connection part 41a is comprised by the recessed part which makes a column shape, and the opening | mouth part 22 of the syringe 1a is liquid-tightly connected to the inner side. Moreover, the connection part 41b is also comprised by the recessed part which makes a column shape, and the opening | mouth part 22 of the syringe 1b is liquid-tightly connected to the inner side.

Further, a connection portion 42 is provided on one surface of the base portion 4, that is, a surface that becomes a lower surface in the usage state of the applicator 100. The connection part 42 is comprised by the recessed part which makes a column shape, and the one end part of the tube 13 which has flexibility is connected fluid-tightly. A cylinder 14 is connected to the other end of the tube 13.

The cylinder 14 has an internal space filled with a high-pressure (compressed) gas G, and can supply the gas G to the applicator 100 (nozzle 3). The cylinder 14 is provided with an openable / closable valve (cock) 141 for controlling supply / stop of supply of the gas G to the applicator 100. When the applicator 100 is used, the valve 141 is opened. The gas G is not particularly limited, and examples thereof include carbon dioxide. Moreover, although it is preferable that the gas G is aseptic, it may be either as to whether it is aseptic. Further, the internal pressure (gas pressure) in the cylinder 14 is preferably 0.05 MPa or more, and more preferably 0.09 to 0.11 MPa.

In the middle of the tube 13, a filter 16 housed in the housing 15 is installed. The filter 16 can capture impurities mixed in the gas G before the gas G is supplied to the applicator 100.

As shown in FIGS. 1 and 2, the structure 7 has an elongated shape and extends from the base 4 toward the distal end. As described above, the structure 7 is composed of the outer tube 5 and the

inner tubes

6a and 6b.

As shown in FIG. 2, the inner tube 6a is thicker than the inner tube 6b, that is, a tube having a larger inner diameter and outer diameter.

The inner end of the inner tube 6 a is connected to the mouth portion 22 of the syringe 1 a via the connection portion 41 a of the base portion 4. Thereby, the 1st liquid L1 can flow down inside the inner pipe 6a. Thus, the inner side of the inner pipe 6a functions as the first liquid channel 61 through which the first liquid L1 flows down. In addition, the inner pipe 6 b has a base end portion connected to the mouth portion 22 of the syringe 1 b via the connection portion 41 b of the base portion 4. Thereby, the 2nd liquid L2 can flow down inside the inner pipe 6b. Thus, the inner side of the inner tube 6b functions as a second liquid channel 62 through which the second liquid L2 flows down.

Further, the tip portions (upstream portions) of the

inner pipes

6a and 6b are joined together to form a joining portion 63. As shown in FIG. 4, the liquid mixture L3 is prepared by the first liquid L1 and the second liquid L2 flowing into the junction 63.

In the applicator 100, the inner tube 6 a and the inner tube 6 b include a flexible portion 64 that defines a first liquid channel 61 and a second liquid channel 62 that are independent of each other, and the flexible portion 64. Also, it can be divided into a gas permeable membrane 65 that defines the merging portion 63 on the tip side.

Each of the flexible portions 64 of the

inner pipes

6a and 6b has flexibility, and the material thereof is not particularly limited. For example, various thermoplastic elastomers such as polyvinyl chloride and polyurethane are used. Can do.

The gas permeable membrane 65 has a tubular shape, and a base end portion of the gas permeable membrane 65 is fitted together with a distal end portion of each flexible portion 64 in a liquid-tight manner. Further, the opening at the tip of the gas permeable membrane 65 serving as the tip of the nozzle 3 serves as a jet outlet 651 for jetting the mixed liquid L3.

The ventilation film 65 has a large number of pores (not shown). Each pore penetrates the gas permeable membrane 65 in the thickness direction. The average pore diameter of these pores is not particularly limited, but is preferably 2 μm or less, for example. The gas permeable membrane 65 is impermeable (water repellency) to the first liquid L1 and the second liquid L2, that is, has hydrophobicity.

With such a configuration, the gas permeable membrane 65 transmits the gas G but does not transmit the first liquid L1 and the second liquid L2. As a result, the gas G can flow into the merging portion 63 via the gas permeable membrane 65, and thus the gas G that has flowed in is ejected from the ejection port 651 together with the liquid mixture L3. At this time, the liquid mixture L3 becomes mist and is applied to the affected area.

The structure for supporting hydrophobicity is not particularly limited. For example, a material having hydrophobicity (for example, polytetrafluoroethylene) is used as the constituent material of the gas permeable membrane 65, or the surface of the gas permeable membrane 65 is made hydrophobic. It is possible to perform treatment (for example, plasma treatment).

Further, since the gas permeable membrane 65 has a tubular shape as a whole, the gas G can flow into the merging portion 63 from any portion in the circumferential direction via the gas permeable membrane 65. As a result, the gas G can be supplied into the merging portion 63 without excess or deficiency, so that the jetted liquid mixture L3 is surely mist-like. As shown in FIG. 5, when the ejection of the mixed liquid L3 stops, the gas G that has flowed in through the gas permeable membrane 65 surely pushes out (blowns out) the mixed liquid L3 in the merging portion 63. ). Thereby, it is prevented that the liquid mixture L3 remains in the junction 63. Therefore, it is possible to prevent the liquid mixture L3 from solidifying and causing clogging at the ejection port 651. In addition, it is possible to reliably prevent the residual liquid of the mixed liquid L3 from leaking from the ejection port 651.

Further, a tip 66 for narrowing the ejection port 651 is fitted into the ventilation film 65. As a result, the opening diameter of the ejection port 651 can be reduced, and thus the liquid mixture L3 ejects vigorously and reliably reaches the target site.

Such

inner pipes

6a and 6b are inserted through the outer pipe 5. The outer tube 5 has a base end supported by the base 4 and communicates with a tube 13 connected to the base 4. Thereby, the gas G can be supplied to the outer tube 5. In addition, a gap is formed between the outer pipe 5 and the

inner pipes

6a and 6b, and the gas G can flow down through the gap. Thus, the outer tube 5 functions as a gas flow path 51 through which the gas G flows down. As described above, the gas G flows into the merging portion 63 through the gas permeable membrane 65.

Further, in the applicator 100, the outer tube 5 can be divided into a hard portion 52 and a flexible portion 53 on the tip side of the hard portion 52.

The hard portion 52 occupies 60% or more of the outer tube 5 and is a portion made of various metal materials such as stainless steel, aluminum, copper, or a copper alloy. Thereby, the attitude | position as the whole nozzle 3 can be maintained, ie, it can prevent that the whole nozzle 3 bends. The sheath 8 is preferably made of the same material as that of the hard portion 52.

The flexible portion 53 is, for example, a portion made of various thermoplastic elastomers such as polyvinyl chloride and polyurethane similar to the flexible portion 64 of the inner tube 6a. The flexible portion 53 is bent so as to bend in a natural state where no external force is applied. Then, if the sheath 8 that forms a tube covering the outer tube 5 is advanced in the direction of arrow A in FIG. 2, the flexible portion 53 can be straightened, and the jet outlet 651 faces forward. Also, if the sheath 8 is retracted in the direction of arrow B in FIG. 2, the flexible portion 53 is released from the correction and curved, and as shown by the two-dot chain line in FIG. Turn diagonally forward or sideways. Thus, in the applicator 100, the direction of the jet port 651 can be changed according to the position of the target site by moving the sheath 8.

As shown in FIGS. 3 to 5, in the

inner pipes

6a and 6b, a part of the flexible part 64, that is, the middle of the flexible part 64 in the longitudinal direction is an easily deformable part 641. The easily deformable portion 641 is a portion that is particularly easily deformed in the flexible portion 64. The easily deformable portion 641 of the inner tube 6a and the easily deformable portion 641 of the inner tube 6b have substantially the same configuration except that they are different in size. Therefore, hereinafter, the easily deformable portion 641 of the inner tube 6a is representative. I will explain it.

The tube wall of the flexible portion 64 of the inner tube 6a is thinnest at the easily deformable portion 641. In other words, the easily deformable portion 641 has a thickness t ₁ is constituted by a thin walled portion than the thickness t ₀ of any portion of the upstream and downstream of the easily deformable portion 641 of the flexible portion 64 (See FIG. 3). Thereby, the easily deformable part 641 can be preferentially deformed with priority.

Then, the deformable portion 641, the magnitude of the first pressure of the liquid flow path 61 (hydraulic) P _L and the pressure in the gas flow path 51 (the gas pressure) P _G acting on the deformable section 641 The inner tube 6a can be deformed in the radial direction according to the relationship (difference in height). For example, when “pressure P _L > pressure P _G ”, the easily deformable portion 641 is expanded by the first liquid L1 (see FIG. 4), and on the contrary, when “pressure P _L <pressure P _G ”, The easily deformable portion 641 is pressure-closed by the gas G (see FIGS. 3 and 5). In the state shown in FIG. 4, the first liquid L 1 can flow down toward the junction 63. Further, in the state shown in FIGS. 3 and 5, an aseptic state upstream from the easily deformable portion 641 of the first liquid channel 61 can be maintained. In particular, in the state shown in FIG. 5, the back flow of the first liquid L1 can be prevented as will be described later.

Further, the easily deformable portion 641 is preferably as close to the gas permeable membrane 65 as possible. As this position, for example, the separation distance S ₀ between the easily deformable portion 641 and the gas permeable membrane 65 is preferably a position shorter than the total length S ₃ (length in the longitudinal direction) of the gas permeable membrane 65 (see FIG. 3). ). Thereby, the back flow of the 1st liquid L1 can be prevented at an early stage.

Also, the total length _{S 1} of the easily deformable portion 641 of the inner tube 6a is longer than the total length _{S 2} of the easily deformable portion 641 of the inner tube 6b (see FIG. 3). Since the easily deformable portion 641 of the inner tube 6a is thicker than the easily deformable portion 641 of the inner tube 6b, if the total length S1 is increased by that amount, the diameter can be increased or decreased more easily. Note that the total length _{S 1} and the total length _{S 2} are both preferably shorter than the full length _{S 3.}

Further, the method of forming such an easily deformable portion 641 is not particularly limited, and examples thereof include a method of plastically deforming a portion of the flexible portion 64 where the easily deformable portion 641 is to be formed by applying heat.

Next, the operation state of the applicator 100 will be described with reference to FIGS.

[1] First, the applicator 100 to which the cylinder 14 is connected is prepared. Prior to the application operation, the gas 141 is supplied to the applicator 100 in advance by opening the valve 141 of the cylinder 14. Thereby, as shown in FIG. 3, the gas G in the nozzle 3 passes through the gas flow path 51 and the merging portion 63 in this order, and is ejected from the ejection port 651.

Further, the first liquid flow path 61 is not yet filled with the first liquid L1, and the second liquid flow path 62 is not yet filled with the second liquid L2. Accordingly, the pressure P _{L <pressure} P _G becomes, therefore, the deformable portion 641, respectively, will be the external force due to the gas G is applied from the gas flow path 51 side, and is pressure closed.

[2] Next, the index finger and middle finger of one hand are hung on the flange portion 23 of the syringe outer cylinder 2, and the thumb is hung on the flange portion 113 of the plunger 11. Thereafter, the jet outlet 651 of the nozzle 3 is directed to the target site. In this state, a force is applied to the thumb, and the application operation is performed by pressing the plunger 11 toward the distal end. As a result, as shown in FIG. 4, the first liquid L 1 is supplied to the first liquid flow path 61, and the second liquid L 2 is supplied to the second liquid flow path 62.

Furthermore, when the plunger 11 continues to press it, the first liquid flow path 61, and the first liquid L1 is flowing down, the pressure _{P L} <become pressure _{P G} relationship is reversed, the pressure _{P L>} pressure P _G. Thereby, the easily deformable portion 641 on the first liquid channel 61 side is pushed and expanded by the first liquid L 1 flowing down the first liquid channel 61.

Similarly, even the second liquid flow path 62, and flows down the second liquid L2, the pressure _{P L} <pressure _{P G} the relationship is reversed, the pressure _{P L>} a pressure _{P G.} Thereby, the easily deformable portion 641 on the second liquid channel 62 side is pushed and expanded by the second liquid L 2 flowing down the second liquid channel 62.

Moreover, in the junction part 63, the 1st liquid L1 and 2nd liquid L2 which flowed down mix and become the liquid mixture L3. This mixed liquid L3 is jetted from the jet outlet 651 together with the gas G, becomes a mist, and is applied to the target site.

[3] After a predetermined amount of the liquid mixture L3 has been applied to the target site, the pressing force on the plunger 11 is loosened to temporarily stop the application operation. By a coating operation stop state, as shown in FIG. 5, in the first liquid flow path 61, flows down the first liquid L1 is stopped, the re-pressure P _{L <pressure} P _G. As a result, the easily deformable portion 641 on the first liquid channel 61 side is closed by being applied with an external force from the gas G from the gas channel 51 side.

Similarly, even the second liquid flow path 62, flows down the second liquid L2 is stopped, and again the pressure P _{L <pressure} P _G. Thereby, the easily deformable portion 641 on the second liquid channel 62 side is also closed by being applied with an external force from the gas G from the gas channel 51 side.

Incidentally, the gas G continues to flow into the junction 63.

The first liquid L1 in the first liquid channel 61 is likely to be pushed back upstream by the gas G. However, since the easily deformable portion 641 on the first liquid channel 61 side is in the closed state, further backflow of the first liquid L1 in the first liquid channel 61 is prevented or suppressed. Is done.

Also, the second liquid L2 in the second liquid channel 62 is likely to be pushed back upstream by the gas G in the junction 63. However, since the easily deformable portion 641 on the second liquid channel 62 side is in the closed state, further backflow of the second liquid L2 in the second liquid channel 62 is prevented or suppressed. Is done.

Thus, the applicator 100 can prevent the backflow of the first liquid L1 and the second liquid L2 when the application operation is stopped. Thus, when the application operation is resumed, it is possible to omit re-pressing the plunger 11 by the back flow of the first liquid L1 and the second liquid L2, and thus the application operation can be resumed quickly. Can do.

In addition, the liquid level (tip) M1 of the first liquid L1 in the first liquid channel 61 and the liquid level (tip) M2 of the second liquid L2 in the second liquid channel 62 are illustrated in FIG. As indicated by the one-dot chain line in FIG. Thereby, when the coating operation is resumed, the first liquid L1 and the second liquid L2 can flow into the merge portion 63 almost simultaneously. This reliably prevents the mixed liquid L3 from becoming excessive or insufficient in one of the second liquids L2 of the first liquid L1 and the second liquid L2. The mixing ratio with the liquid L2 is constant.

Second Embodiment
6 and 7 are longitudinal sectional views of the nozzles provided in the applicator of the present invention (second embodiment) (showing changes over time in the application state), respectively, and FIGS. 8 and 9 are respectively press-closed. It is a perspective view of a member.

Hereinafter, the second embodiment of the applicator of the present invention will be described with reference to these drawings. However, the difference from the above-described embodiment will be mainly described, and description of similar matters will be omitted.

This embodiment is the same as the first embodiment except that a pressure closing member is provided.

As shown in FIGS. 6 and 7, in the present embodiment, the nozzle 3 includes a pressure-closing member 9 that is mounted in the vicinity of each easily deformable portion 641 of the

inner pipes

6a and 6b. As shown in FIG. 7, the pressure closing member 9 is a member forcibly closing each easily deformable portion 641 from the gas flow path 51 side in a state where the coating operation is stopped.

As shown in FIGS. 8 and 9, the pressure closing member 9 includes a mounting portion 91 that is mounted on the

inner pipes

6 a and 6 b, and a clamping portion 92 that clamps the easily deformable portions 641 together. .

The mounting portion 91 has a cylindrical outer shape and is formed with through

holes

911 and 912 penetrating in the axial direction. The inner diameter of the through hole 911 is substantially the same as the maximum outer diameter of the flexible portion 64 of the inner tube 6a, and the flexible portion 64 can be inserted therethrough. The inner diameter of the through hole 912 is substantially the same as the maximum outer diameter of the flexible portion 64 of the inner tube 6b, and the flexible portion 64 can be inserted therethrough. And the flexible part 64 of the inner tube 6a is fitted into the through hole 911 by inserting the through hole 911, and the flexible part 64 of the inner tube 6b is inserted into the through hole 912 by inserting the through hole 912. Mating. Thereby, the mounting part 91 is mounted on the

inner pipes

6a and 6b.

A clamping portion 92 is provided on the tip side of the mounting portion 91.

The clamping portion 92 includes a fixed piece 93 that is fixed to the

inner tubes

6a and 6b, and

elastic pieces

94a and 94b that approach and separate from the fixed piece 93.

The fixing piece 93 is formed so as to protrude from the space between the through hole 911 and the through hole 912 of the mounting portion 91 toward the distal end. As shown in FIGS. 6 and 7, the fixed piece 93 has one surface 931 that contacts the outer peripheral surface of the easily deformable portion 641 of the inner tube 6a and the other surface 932 of the easily deformable portion 641 of the inner tube 6b. Abuts on the outer peripheral surface.

The elastic piece 94 a is formed so as to protrude toward the distal end similarly to the fixed piece 93, and faces one surface 931 of the fixed piece 93. The elastic piece 94a can hold the easily deformable portion 641 of the inner tube 6a from both side portions via the central axis between the elastic piece 94a and the fixed piece 93. Further, a protruding portion 941 protruding toward the fixed piece 93 side is formed at the tip of the elastic piece 94a. Accordingly, the elastic pieces 94a, will be abut concentrated projection 941 on deformable portion 641, thus, it is possible to increase the pressure _{P E} for deformable portion 641 of the elastic piece 94a.

The elastic piece 94 b is formed so as to protrude toward the distal end in the same manner as the fixed piece 93, and faces the other surface 932 of the fixed piece 93. The elastic piece 94b can sandwich the easily deformable portion 641 of the inner tube 6b from both side portions via the central axis between the elastic piece 94b and the fixed piece 93. Further, a protrusion 941 is formed at the tip of the elastic piece 94b so as to protrude toward the fixed piece 93 side. Accordingly, the elastic pieces 94b, it will be abut concentrated projection 941 on deformable portion 641, thus, it is possible to increase the pressure _{P E} for deformable portion 641 of the elastic piece 94b.

It should be noted that the constituent material of the pressure closing member 9 is not particularly limited, and for example, the above-described resin material or metal material can be used.

As shown in FIG. 6, in a state where the coating operation is performed, the pressure P _L > (pressure P _G + pressure P _E ), and the first liquid L1 and the second liquid L2 are each easily deformed. The part 641 is expanded.

Further, as shown in FIG. 7, in a state where the coating operation is stopped, the pressure P _L <(pressure P _G + pressure P _E ), and each easily deformable portion 641 is closed by pressure. Thereby, the backflow of the 1st liquid L1 and the 2nd liquid L2 can be prevented. Incidentally, this pressure closing is a synergistic effect between the pressure P _G and the pressure P _E, it performed more reliably.

<Third Embodiment>
FIG. 10 and FIG. 11 are vertical sectional views of the nozzles provided in the applicator (third embodiment) of the present invention (showing changes over time in the application state), respectively.

Hereinafter, the third embodiment of the applicator of the present invention will be described with reference to these drawings. However, the difference from the above-described embodiment will be mainly described, and description of similar matters will be omitted.

This embodiment is the same as the second embodiment except that the configuration of the inner tube is different.

As shown in FIGS. 10 and 11, in this embodiment, the

inner pipes

6a and 6b have the easily deformable portion 641 omitted, and the pipe wall is constant along the longitudinal direction.

Further, in the present embodiment, the pressure P _E of the

elastic pieces

94a and 94b of the pressure closing member 9 is set to be larger than the pressure P _E in the second embodiment. The setting method is not particularly limited, and examples thereof include a method of appropriately selecting the constituent material of the pressure-closing member 9 and a method of increasing the thickness of the

elastic pieces

94a and 94b.

Then, as shown in FIG. 10, in a state where the coating operation is performed, the pressure P _L > (pressure P _G + pressure P _E ), and the first liquid L1 and the second liquid L2 are joined together, respectively. It can flow down toward the part 63.

As shown in FIG. 11, in a state where the coating operation is stopped, the pressure P _L <(pressure P _G + pressure P _E ), and a part of each flexible portion 64 is closed. Thereby, the backflow of the 1st liquid L1 and the 2nd liquid L2 can be prevented.

As mentioned above, although the applicator of the present invention has been described with respect to the illustrated embodiment, the present invention is not limited to this, and each part constituting the applicator has any configuration that can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.

Further, the applicator of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

Further, the number of inner pipes included in the nozzle is two in each of the embodiments described above, but is not limited to this, and may be one or three or more, for example.

The applicator of the present invention has a double tube structure composed of an outer tube and at least one inner tube, functions as a liquid flow path through which the liquid flows in the inner tube, and the outer tube and the A gap between the inner pipe and the inner pipe is provided with a nozzle functioning as a gas flow path through which gas flows, the inner pipe is provided in the middle of the longitudinal direction, and a gas permeable membrane through which the gas permeates but the liquid does not permeate. And provided on the upstream side of the gas permeable membrane in the middle of the longitudinal direction, and having an easily deformable portion that is deformable in the radial direction of the inner tube, and flows into the liquid flow path through the gas permeable membrane. In a state where the application operation for ejecting the liquid together with the gas from the nozzle tip is performed, the easily deformable portion is pushed and spread by the liquid flowing down the liquid flow path, and the easy operation is performed in a state where the application operation is stopped. External force is applied to the deformed part from the gas flow path side. By Azukasuru, the deformable portion is characterized in that it is pressure closed. Therefore, it is possible to prevent the back flow of the liquid when the application operation is stopped.

Therefore, the applicator of the present invention has industrial applicability.

DESCRIPTION OF SYMBOLS 100 Applicator 10

Syringe coupling body

1a, 1b Syringe 2 Syringe outer cylinder 21 trunk | drum 211 tip wall part 22 mouth part (syringe side mouth part)
23 flange part 3 nozzle 4

base part

41a, 41b, 42 connection part 5 outer pipe 51 gas flow path 52 hard part 53

flexible part

6a, 6b inner pipe 61 first liquid flow path 62 second liquid flow path 63 merge part 64 Flexible part 641 Easily deformable part 65 Ventilation membrane 651 Spout 66 66 Tip
DESCRIPTION OF SYMBOLS 7 Structure 8 Sheath 9 Clamping member 91 Mounting part 911,912 Through hole 92 Clamping part 93 Fixing piece 931 One surface 932

Other surface

94a, 94b Elastic piece 941 Protrusion part 11

Plunger

111, 112 Plunger part 113 Flange part 12 Gasket 13 Tube 14 Cylinder 141 Valve (cock)
15 Housing 16 Filter G Gas L1 First liquid L2 Second liquid L3 Mixed liquid M1, M2 Liquid level (tip)
P _E Pressure P _G pressure (gas pressure)
P _L pressure (hydraulic)
S ₀ separation distance S ₁ , S ₂ , S ₃ total length t ₀ , t ₁ thickness

Claims

It has a double tube structure composed of an outer tube and at least one inner tube, functions as a liquid flow path in which the liquid flows down in the inner tube, and a gap between the outer tube and the inner tube Has a nozzle that functions as a gas flow path through which the gas flows down,
The inner pipe is provided in the middle of the longitudinal direction, and is provided with a gas permeable membrane through which the gas permeates but does not permeate the liquid, and an upstream side of the gas permeable membrane in the middle of the longitudinal direction. An easily deformable portion that is deformable in the radial direction,
In a state where an application operation for ejecting the liquid from the tip of the nozzle together with the gas flowing into the liquid channel through the gas permeable membrane is performed, the easily deformable portion is caused by the liquid flowing down the liquid channel. An applicator characterized in that the easily deformable portion is closed by applying an external force from the gas flow path side to the easily deformable portion while being spread and stopped in the application operation.
The applicator according to claim 1, wherein the easily deformable portion is closed by pressure to prevent or suppress the backflow of the liquid in the liquid flow path.
The applicator according to claim 1 or 2, wherein the tube wall of the inner tube has a thickness at the easily deformable portion that is thinner than a thickness at any of the upstream side and the downstream side of the easily deformable portion.
The applicator according to any one of claims 1 to 3, wherein in the state where the application operation is stopped, the easily deformable portion is pressure-closed by the gas in the gas flow path.
In the state where the application operation is performed, the pressure of the liquid acting on the easily deformable portion is higher than the pressure of the gas acting on the easily deformable portion, and in the state where the application operation is stopped, the easy deformation is performed. The applicator according to claim 4, wherein the pressure of the gas acting on the part is higher than the pressure of the liquid acting on the easily deformable part.
6. The pressure closing member according to claim 1, wherein a pressure closing member that closes the easily deformable portion from the gas flow path side in a state where the coating operation is stopped is mounted in the vicinity of the easily deformable portion. Applicator.
It has a double tube structure composed of an outer tube and at least one inner tube, functions as a liquid flow path in which the liquid flows down in the inner tube, and a gap between the outer tube and the inner tube Has a nozzle that functions as a gas flow path through which the gas flows down,
The inner pipe is provided in the middle of the longitudinal direction, and has a gas permeable membrane that allows the gas to pass therethrough but does not allow the liquid to pass through. The portion upstream of the gas permeable membrane has flexibility, and the portion Is equipped with a pressure-closure member that can be
In a state where an application operation of ejecting the liquid from the nozzle tip together with the gas flowing into the liquid flow path through the gas permeable membrane is performed, the inner tube is not closed by the pressure closing member, In the state where the application operation is stopped, the inner tube is pressure-closed by the pressure-closing member.
The applicator according to claim 7, wherein the inner tube is closed by pressure to prevent or suppress the backflow of the liquid in the liquid flow path.
The applicator according to any one of claims 6 to 8, wherein the pressure-closing member has a clamping portion that is clamped from both side portions via a central axis of the inner tube.
10. The applicator according to claim 9, wherein the clamping part includes a fixed piece fixed to the outer peripheral surface of the inner tube, and an elastic piece having elasticity and approaching / separating from the fixed piece.
The applicator according to any one of claims 1 to 10, wherein a plurality of the inner pipes are installed, and liquids having different liquid compositions flow through the inner pipes.
The applicator according to claim 11, wherein the plurality of inner pipes merge with each other at an upstream portion to form a merge portion, and an inner diameter of the upstream portion of the merge portion is reduced.
The applicator according to claim 12, wherein the gas permeable membrane is disposed at the junction.