JP2008307227A - Applicator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an applicator that efficiently and reliably mixes first and second liquids together. <P>SOLUTION: Applicator 1 is provided with a supply means for the separate supply of first and second liquids L1 and L2 differing in liquid composition from each other, first and second flow passages 44 and 45 through which the first and second liquids L1 and L2 pass after they were supplied from the supply means, a confluent part 43 with a deformable diameter narrowing part 438, where the first and second liquids L1 and L2 meet together after they passed through the first and second flow passages 44 and 45 respectively, a nozzle 4 communicating with the confluent part 43 and provided with a liquid jet port 431 for jetting out a mixture liquid M, and a gas flow channel 46 as a means to deform the diameter narrowing part 438, which deforms by gas pressures in the gas flow channel 46 while the liquid jet port 431 is jetting out the mixture liquid M. This promotes mixing between the first and second liquids L1 and L2 in the confluent part 43. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an applicator.

  Conventionally, a method of mixing two or more kinds of liquids and spraying them onto an affected area to form an adhesion preventing material, a biological tissue adhesive or the like has been known, and an applicator for that purpose has been developed.

  Such an applicator has a configuration in which components that coagulate when mixed, for example, a solution containing thrombin and a solution containing fibrinogen are separated from each other, sent to the vicinity of the affected area, and applied while mixing in the affected area. is there.

  As a conventional applicator, each of two syringes containing different types of liquid is installed in a state where the flow paths are arranged side by side, and the liquid is ejected while spreading from the tips of both flow paths, that is, the respective discharge ports. Some liquids are configured to mix these liquids (see, for example, Patent Document 1).

  In the applicator described in Patent Document 1, two flow paths are arranged side by side, and two discharge ports are also arranged side by side. Further, as described above, the liquid is ejected from each discharge port while spreading. Due to the ejection of the liquid and the arrangement of the two discharge ports, the ejected liquid has a portion where the two kinds of liquid are mixed and a portion where the liquid remains without being mixed. (For example, refer to FIG. 2A in Patent Document 1). For this reason, there has been a problem that the affected part is applied with a non-uniformly mixed liquid, that is, a liquid in which two kinds of liquids are mixed and a liquid that is not mixed (or insufficiently mixed).

JP 2002-282368 A

  The objective of this invention is providing the applicator which can mix a 1st liquid and a 2nd liquid efficiently and reliably.

Such an object is achieved by the present inventions (1) to (15) below.
(1) supply means for separately supplying a first liquid and a second liquid having different liquid compositions;
A first flow path and a second flow path through which the first liquid and the second liquid supplied from the supply means pass, respectively;
The first liquid that has passed through the first flow path and the second liquid that has passed through the second flow path are merged, and a merging portion having a deformable deformable portion, and communicating in the merging portion. And a nozzle having a liquid ejection port from which a mixed liquid in which the first liquid and the second liquid are merged and mixed is ejected;
Deformation means for deforming the deformation portion,
The deforming portion is deformed by the deforming means when the mixed liquid is ejected from the liquid ejection port, and mixing of the first liquid and the second liquid in the confluence portion is promoted. An applicator characterized in that the applicator is configured.

(2) The deformation means is connected to a gas supply means for supplying a gas, and is provided in a gas flow path through which the gas from the gas supply means passes in the connected state, and is connected to the gas flow path. And a gas outlet from which the gas is ejected,
The applicator according to (1), wherein the deforming portion is located in the gas flow channel, is deformed by being compressed when the pressure in the gas flow channel is increased, and is restored when the pressure is released. .

  (3) The applicator according to any one of (1) and (2), wherein the joining portion has a tubular shape, and the deforming portion is a portion that deforms in a radial direction of the joining portion.

  (4) The applicator according to any one of (3), wherein a plurality of slits are arranged along the circumferential direction or the longitudinal direction of at least the inner circumferential portion of the deformable portion of the merging portion.

  (5) The applicator according to (4), wherein the slits are opened when the deforming portion is deformed, and are closed when the deforming portion is not deformed.

  (6) The joining portion is formed in a tubular shape, and the deforming portion includes at least one reduced diameter portion that is deformed so that the inner diameter is reduced. The applicator according to any one of the above.

  (7) The merge portion includes a soft layer made of a soft material, and a plurality of reinforcing layers intermittently disposed along the longitudinal direction of the merge portion on the soft layer, and adjacent to the soft layer. The applicator according to the above (6), wherein the portion between the reinforcing layers to function functions as the reduced diameter portion.

  (8) The applicator according to (6), wherein the reduced diameter portion is disposed in the middle of the merged portion and is made of a softer material than portions before and after the reduced diameter portion of the merged portion.

(9) In the gas flow path, the first flow path and the second flow path are housed,
At least one of the first flow path and the second flow path is provided with a flow path forming member that deforms so as to increase or decrease an internal volume. In the ejection state in which gas is ejected from the gas ejection port, it is compressed by an increase in pressure in the gas flow path, and in the stopped state in which the gas ejection is stopped, the compression is released and the volume is larger than that in the ejection state. The applicator according to any one of (2) to (8) above.

  (10) The applicator according to (9), wherein when the volume of the flow path forming member becomes large, most of the mixed liquid is drawn to the rear end side with respect to the joining portion.

  (11) The applicator according to (10), wherein when the volume of the flow path forming member becomes large, most of the mixed liquid is drawn into the flow path forming member.

(12) The liquid jet port is disposed inside the gas jet port,
When the nozzle is viewed from the tip side thereof, the outer shape of the liquid jet port is circular, the inner peripheral shape of the gas jet port is a polygon or each corner is rounded, The outer circumference of the liquid jet and the inner circumference of the gas jet are in point contact at a plurality of locations, and the liquid jet is fixed with respect to the gas jet. The applicator according to any one of the above.

  (13) The supply means moves along the longitudinal direction of the syringe outer cylinder, a syringe outer cylinder having a mouth portion protruding from the tip, a gasket inserted into the syringe outer cylinder, and the gasket. The applicator according to any one of (1) to (12), further comprising a syringe having a pusher to be operated.

  (14) The applicator according to any one of (1) to (13), wherein the first liquid and the second liquid are altered by contact with each other.

  (15) The applicator according to (14), wherein the mixed solution serves as an adhesion preventing material for living tissue.

  According to the present invention, the mixed liquid that has entered the deformed portion deformed by the deforming means is squeezed by the deformed portion, and the flow velocity increases. With the flow rate increased, the mixed liquid diffuses when it exits the deformed portion. Due to this diffusion, the mixing of the first liquid and the second liquid constituting the mixed liquid is promoted, so that these liquids can be mixed efficiently and reliably.

  In addition, when the deformed portion is constituted by a reduced diameter portion, the diameter of the flow path cross section is reduced because the reduced diameter portion is surely reduced in diameter by the deformation means. As a result, the flow rate of the mixed liquid can be increased easily and reliably, so that the liquids can be mixed more efficiently as described above.

Hereinafter, the applicator of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.
<First Embodiment>
1 and 2 are perspective views showing a first embodiment of the applicator of the present invention, respectively. FIGS. 3 and 4 are cross-sectional views taken along line AA of the opening / closing means in the applicator shown in FIG. 3 shows a state in which the gas flow path is blocked, FIG. 4 shows a state in which the gas flow path is opened), and FIG. 5 is a detailed longitudinal sectional view of the joining portion in the applicator shown in FIG. 1 is a view (front view) of the nozzle in the applicator shown in FIG. 1 as viewed from the tip side (from the direction of arrow B in FIG. 1), and FIGS. 13 to 17 show the nozzle of the applicator shown in FIG. FIG. 18 is a partial vertical cross-sectional view of a first syringe (also the second syringe) loaded in the applicator shown in FIG. 1. For convenience of explanation, the left side in FIGS. 1, 2, 5 and 13 to 17 (also in FIG. 6) is referred to as “front end”, and the right side is referred to as “rear end (base end)”. The lower side in the middle is called “front end”, and the upper side is called “rear end”. 1 to 4, the upper side is referred to as “upper” and the lower side is referred to as “lower”.

  The applicator 1 of the present invention mixes a first liquid L1 and a second liquid L2 having different liquid compositions and applies the mixed liquid M (see FIG. 15). As shown in FIGS. 1 and 2, the applicator 1 includes a first syringe (supply unit) 2 that stores the first liquid L1 and a second syringe (supply unit) that stores the second liquid L2. 3) and 3 are used.

  First, before describing the configuration of the applicator 1, the configurations of the first syringe 2 and the second syringe 3 will be described. Since the 1st syringe 2 and the 2nd syringe 3 are the substantially the same structures, the 1st syringe 2 is demonstrated typically.

  As shown in FIG. 18, the first syringe 2 in the present embodiment includes an outer cylinder (syringe outer cylinder) 21, a gasket 24 that can slide in the outer cylinder 21, and the gasket 24 in the longitudinal direction of the outer cylinder 21. And a pusher (plunger rod) 26 that is moved along the (axial direction). The gasket 24 is connected to the tip of the pusher 26.

  The outer cylinder 21 is composed of a bottomed cylindrical member, and a mouth portion (reduced diameter portion) 22 that is reduced in diameter relative to the body portion of the outer cylinder 21 is integrally formed at the center of the bottom portion on the front end side. ing.

A flange 23 is integrally formed on the outer periphery of the rear end of the outer cylinder 21.
A scale indicating the amount of liquid is attached to the outer peripheral surface of the outer cylinder 21.

  As a constituent material of the outer cylinder 21, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, Various resins such as polyesters such as polyethylene terephthalate and polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. Resins such as polypropylene, cyclic polyolefin, and polyester are preferred because they are easy to mold and have low water vapor permeability. In addition, it is preferable that the constituent material of the outer cylinder 21 is substantially transparent in order to ensure internal visibility.

  In such an outer cylinder 21, a gasket 24 made of an elastic material is accommodated (inserted). A plurality (two) of ring-shaped protrusions are formed on the entire outer periphery of the gasket 24, and these protrusions slide while being in close contact with the inner peripheral surface of the outer cylinder 21. While maintaining liquid-tightness more reliably, slidability can be improved.

  Further, the gasket 24 is formed with a hollow portion 25 that opens to the rear end face thereof. In this hollow portion 25, a head portion 28 of a pusher 26 described later is screwed (inserted). A female screw is formed on the inner surface of the hollow portion 25.

  The constituent material of the gasket 24 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

The pusher 26 has a rod-like main body 27 whose cross section is a cross shape.
A head portion (connecting portion) 28 that is inserted into the hollow portion 25 of the gasket 24 and connected to the gasket 24 is formed on the distal end side of the main body portion 27. On the outer periphery of the head portion 28, a male screw that can be screwed with a female screw on the inner surface of the hollow portion 25 is formed. The gasket 24 and the pusher 26 are connected by screwing the male screw with the female screw. The gasket 24 and the pusher 26 are not limited to the connection by screwing, but may be, for example, a structure connected by uneven fitting, a structure fixed by adhesion, fusion, or the like, or an integrally molded structure. .

A disc-shaped flange 29 is formed on the rear end side of the main body 27.
Further, as the constituent material of the pusher 26, the same materials as those exemplified as the constituent material of the outer cylinder 21 described above can be used.

  Before the first syringe 2 is loaded into the applicator 1, a space (liquid storage space) 20 surrounded by the outer cylinder 21 and the gasket 24 is filled with the first liquid L1.

  Similarly to the first syringe 2, the second syringe 3 includes an outer cylinder 21, a gasket 24 that can slide in the outer cylinder 21, and a pusher 26 that moves and operates the gasket 24. Is filled with the second liquid L2. Since the structure of each part is the same, the description is abbreviate | omitted.

  The first liquid L1 filled in the first syringe 2 and the second liquid L2 filled in the second syringe 3 have different compositions (components).

  In the present invention, the first liquid L1 and the second liquid L2 are appropriately selected according to the application, purpose of use, case, and the like of the applicator 1. For example, when used for administration of a biological tissue adhesive, one of the first liquid L1 and the second liquid L2 is a liquid containing thrombin (solution or the like), and the other is a liquid containing fibrinogen (solution or the like). ).

  In addition, when used for administration of an adhesion preventing material for living tissue, one of the first liquid L1 and the second liquid L2 is a liquid (solution or the like) containing carboxymethyldextrin modified with a succinimidyl group, and the other Can be a liquid (solution or the like) containing disodium hydrogen phosphate.

  The first liquid L1 and the second liquid L2 in such a combination are altered, that is, gelled (solidified) when they are mixed. By the gelation of the mixed solution M, for example, the mixed solution M can reliably remain in the applied biological tissue (target site). Moreover, since the liquid mixture M reliably stays at the target site, the function as a biological tissue adhesive or an adhesion preventing material can be reliably exhibited at the target site.

  Needless to say, the types and combinations of the first liquid L1 and the second liquid L2 are not limited to those described above.

  By pressing each pusher 26 of the first syringe 2 and the second syringe 3 having such a configuration, the first liquid L1 is supplied to the first flow path 44 of the nozzle 4 to be described later, and the second The second liquid L2 can be easily and reliably supplied to the flow path 45 individually. Moreover, the pressing operation of each pusher 26 is manually performed by an operator (user) of the applicator 1. For this reason, the operator can apply the mixed liquid M at his / her arbitrary timing.

  The applicator 1 loaded with the first syringe 2 filled with the first liquid L1 and the second syringe 3 filled with the second liquid L2 includes an applicator main body 7, a nozzle 4, and A first flow path (liquid transfer path) 44 that connects the nozzle 4 and the first syringe 2; a second flow path (liquid transfer path) 45 that connects the nozzle 4 and the second syringe 3; It has the operation part 8, the opening / closing means (valve mechanism) 9, and the tube (gas flow path) 10 connected to the cylinder (gas supply means) 300 (refer FIG. 1).

Before describing each part constituting the applicator 1, the cylinder 300 will be described.
The cylinder 300 is filled with a high-pressure (compressed) sterile gas G (hereinafter simply referred to as “gas G”) in its internal space, and supplies the gas G to the applicator 1 (nozzle 4). Can do. The cylinder 300 is provided with an openable / closable valve (cock) 301 for controlling supply / stop of supply of the gas G to the applicator 1. When the applicator 1 is used, the valve 301 is opened. The gas G is not particularly limited, and examples thereof include carbon dioxide.

  As shown in FIGS. 1 and 2, the applicator body 7 fixes the first syringe 2 and the second syringe 3 side by side (in parallel). The applicator body 7 includes a base 71, a front plate (first engagement portion) 72 provided at the tip of the base 71, and a rear plate (second engagement portion) provided at the rear end of the base 71. ) 73 and finger hooks 751 and 752 provided near the rear plate 73 of the base 71.

  The base 71 is provided with recesses 711 and 712 in parallel at the top thereof, the cross section of which is substantially semicircular. The outer cylinder 21 of the first syringe 2 is accommodated in the recess 711, and the outer cylinder 21 of the second syringe 3 is accommodated in the recess 712.

  A front plate 72 is provided at the tip of the base 71. Grooves 721 and 722 are formed in the front plate 72 at positions corresponding to the recesses 711 and 712, respectively. When loading the first syringe 2 and the second syringe 3, the opening 22 of the first syringe 2 is inserted into the groove 721, and the opening 22 of the second syringe 3 is inserted into the groove 722. Is done.

  A rear plate 73 is provided at the rear end of the base 71. In the rear plate 73, recesses 731 and 732 are formed at positions corresponding to the recesses 711 and 712, respectively. When loading the first syringe 2 and the second syringe 3, the flange 23 (base end portion) of the first syringe 2 is engaged (inserted) in the recess 731, and the recess 732 is in the second The flange 23 (base end portion) of the syringe 3 is engaged.

  As described above, in the applicator main body 7, each mouth portion 22 is engaged with the front plate 72 and each flange 23 is engaged with the rear plate 73, whereby the first syringe 2, the second syringe 3, and the like. Can be reliably fixed in parallel.

  Finger hooks 751 and 752 are provided near the rear plate 73 of the base 71. Each of the finger hooks 751 and 752 can be hooked by the user's finger when using the applicator 1. The finger hanging portion 751 is constituted by a plate piece protruding upward, and the finger hanging portion 752 is constituted by a plate piece protruding downward. In addition, each of the finger-hanging portions 751 and 752 has an arcuate shape (curved concave shape) facing the tip direction.

  The applicator main body 7 may be one in which the respective parts constituting the applicator main body 7 are integrally formed, or each part may be configured separately and joined together.

  The constituent material of the applicator body 7 is not particularly limited, and various metal materials such as aluminum and stainless steel, various plastics, and the like can be used alone or in combination. When such a material is used, the applicator main body 7 can be easily manufactured, for example, by die molding.

  On the rear end side of the applicator main body 7, an operation unit 8 is installed so as to be movable in the longitudinal direction with respect to the applicator main body 7. This operation part 8 pushes the pusher 26 of the first syringe 2 and the pusher 26 of the second syringe 3 together in the distal direction (the direction of arrow C in FIGS. 1, 2 and 4). It is a part to do. The operation unit 8 includes a connecting part 81 that connects the flanges 29 of the pushers 26 of the first syringe 2 and the second syringe 3, a pressing part 82 that is located on the rear end side of the connecting part 81, and a connecting part 81. And a rail portion 83 extending in the distal direction.

  The connecting portion 81 is provided with recesses 811 and 812 that open upward. The concave portion 811 has a shape corresponding to the flange 29 of the pusher 26 of the first syringe 2, and the flange 29 engages (see FIG. 2). Moreover, the recessed part 812 has comprised the shape corresponding to the flange 29 of the pusher 26 of the 2nd syringe 3, and the said flange 29 engages (refer FIG. 2).

  With the connecting portion 81 having such a configuration, the flanges 29 of the pushers 26 of the first syringe 2 and the second syringe 3 can be reliably connected and fixed. Can be moved in the direction of arrow C.

  Further, the connecting portion 81 is provided with a cylindrical portion 813 having a cylindrical shape between the concave portion 811 and the concave portion 812. The cylindrical portion 813 is provided so that its axis is parallel to the vertical direction in FIG. 1 (also in FIG. 2). Further, most of the opening / closing means 9 is accommodated in the cylindrical portion 813.

  A long rail portion 83 is formed on the outer peripheral portion of the tubular portion 813 of the connecting portion 81 so as to protrude in the distal direction. The rail portion 83 is provided in the base portion 71 of the applicator main body 7 and is inserted into a long guide 713. The rail portion 83 is guided by the guide 713 by the pressing operation of the operation unit 8 in the arrow C direction, and thus the pressing operation can be performed smoothly.

  On the rear end side of the tubular portion 813 of the connecting portion 81, a plate-like pressing portion 82 is installed so as to be movable in the longitudinal direction of the applicator main body 7 with respect to the tubular portion 813.

  The pressing part 82 is a part that is pressed by the user when the applicator 1 is used, that is, when the mixed liquid M is applied to an affected part or the like. When the applicator 1 is used, for example, an index finger can be hung on the finger hanging portion 751, a middle finger can be hung on the finger hanging portion 752, and a thumb can be hung on the pressing portion 82. Thereby, the applicator 1 can be grasped stably and reliably. Moreover, the pressing operation of the operation part 8 (pressing part 82) can be performed smoothly and reliably, so that the operability of the applicator 1 is improved.

The pressing portion 82 is coupled to a second connection portion 92 of the opening / closing means 9 described later.
The constituent material of the operation unit 8 is not particularly limited, and for example, the materials described in the explanation of the applicator main body 7 can be used. When such a material is used, the operation unit 8 can be easily manufactured by, for example, mold molding.

  As described above, the opening / closing means 9 is installed in the cylindrical portion 813 of the operation portion 8. The opening / closing means 9 is for blocking / opening the flow of the gas G from the cylinder 300 to the nozzle 4. The first tube 101 and the second tube 102 are blocked (see FIG. 3) / communication (see FIG. 4) through the opening / closing means 9, that is, by the operation of the opening / closing means 9.

  As shown in FIGS. 3 and 4, the opening / closing means 9 includes a first connecting portion 91 connected to the first tube 101, a second connecting portion 92 connected to the second tube 102, 1 and has a valve part 93 that can be freely opened and closed.

  The first connecting portion 91 has a tubular shape. A storage portion 912 that is located on the downstream side and that stores the valve portion 93 is provided in the lumen portion of the first connection portion 91. Further, a reduced diameter portion 913 having a diameter reduced from the inner diameter on the upstream side of the storage portion 912 is provided in the lumen portion of the first connection portion 91, and at the boundary between the reduced diameter portion 913 and the storage portion 912. A stepped portion 911 having a sharply changed inner diameter is formed.

  The second connection portion 92 has a tubular shape. As described above, the second connection portion 92 is coupled to the pressing portion 82 of the operation portion 8. The second connection portion 92 has a lower end portion 921 supported by the seal member 94 of the valve portion 93 and is disposed on the downstream side of the first connection portion 91 via the seal member 94. The second connecting portion 92 has a first posture (in the state shown in FIG. 3) in which the axes coincide with each other with respect to the first connecting portion 91, and the axis is a pressing portion 82 (operating operation with the lower end 921 as a fulcrum. And the second posture (state shown in FIG. 4) tilting in the direction of arrow C (operation direction) of the portion 8).

  The valve portion 93 includes a seal member 94 made of an elastic material, a flange portion 95 located on the upstream side of the seal member 94, and a biasing portion 96 that biases the flange portion 95 toward the seal member 94. ing.

  The seal member 94 has a link shape. The seal member 94 has an inner peripheral portion 941 that is in close contact with the outer peripheral portion 922 of the lower end portion 921 of the second connection portion 92. Further, the outer peripheral portion 942 of the seal member 94 is in close contact with the inner peripheral portion 914 of the storage portion 912 of the first connection portion 91. With such a seal member 94, the first connection portion 91 and the second connection portion 92 are airtightly connected through the seal member 94.

  The flange portion 95 has an outer diameter larger than the outer diameter of the second connection portion 92. The flange portion 95 is disposed to face the lower end surface of the second connection portion 92 with a gap 97 therebetween.

  In the present embodiment, the urging portion 96 is constituted by a compression coil spring. In the compressed state, the upper end portion 961 abuts on the flange portion 95 and the lower end portion 962 is the first connection portion 91. It abuts on the stepped portion 911. Thereby, the flange part 95 can be reliably urged | biased to the seal member 94 side.

  In the valve portion 93 having such a configuration, the flange portion 95 includes the biasing portion 96 when the second connecting portion 92 is in the first posture, that is, when no external force is applied to the second connecting portion 92. Urged to airtightly adhere to the seal member 94 (see FIG. 3). Thereby, the valve part 93 will be in a closed state.

  Further, when a pressing force in the direction of arrow C by the pressing portion 82 of the operation portion 8 acts on the second connection portion 92, the second connection portion 92 is displaced from the first posture to the second posture. At this time, the flange portion 95 is displaced against the urging force of the urging portion 96, whereby a part (or all) of the peripheral edge portion 951 of the flange portion 95 is separated from the seal member 94, A gap 98 is formed between the seal member 94 (see FIG. 4). As a result, the gas G flows from the first connecting portion 91 into the second connecting portion 92 through the gap 98, that is, the valve portion 93 is opened.

  In the opening / closing means 9 configured as described above, the valve portion 93 can be reliably opened / closed in conjunction with the pressing operation by the operation portion 8. Thereby, when the valve part 93 is in the closed state, the flow of the gas G from the cylinder 300 to the nozzle 4 can be reliably interrupted, and when the valve part 93 is in the open state, the flow of the gas G is reliably released. can do.

  In addition, although it does not specifically limit as a constituent material of the 1st connection part 91, the 2nd connection part 92, the flange part 95, and the biasing part 96, For example, various metal materials and various plastics, such as aluminum and stainless steel Etc. can be used alone or in combination.

  The constituent material of the seal member 94 is not particularly limited, and various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber can be used.

  A nozzle 4 is disposed on the distal end side of the applicator main body 7, and this nozzle 4 is connected to the first syringe 2 via a first flow path 44 and via a second flow path 45. It is connected to the second syringe 3 and connected to the second tube 102 via a gas flow path (third flow path) 46.

  Thereby, the 1st liquid L1 supplied from the 1st syringe 2 can pass the 1st flow path 44, and the 2nd liquid L2 supplied from the 2nd syringe 3 is 2nd. It is possible to pass through the flow path 45. The gas G supplied from the cylinder 300 reaches the nozzle 4 through the first tube 101, the opening / closing means 9, the second tube 102, and the gas flow path 46 in order.

  Each of the first flow path 44 to the third flow path 46 is composed of a tube made of a hard material. Although it does not specifically limit as a hard material, For example, the material which was mentioned by description of the applicator main body 7 can be used.

  As shown in FIGS. 13 to 17, the first flow path 44 and the second flow path 45 are accommodated (inserted) in the gas flow path 46.

  These first flow path 44 to third flow path 46 are fixed to the applicator main body 7 via a fixing member 41 (see FIGS. 1 and 2). The fixing member 41 has a cylindrical shape having both ends opened and a distal end opening 411 and a proximal end opening 412.

  The proximal end opening 412 is fitted (engaged) with the front plate 72 of the applicator main body 7. The distal end opening 411 has a size smaller than that of the proximal end opening 412, specifically, is set to be approximately equal to or slightly smaller than the outer diameter of the third flow path 46. The middle of the flow path 46 is supported.

  As shown in FIGS. 13 to 17, the nozzle 4 includes a cylindrical nozzle tip 42 having both ends open, and a confluence portion 43 that is concentrically disposed in the nozzle tip 42 and has a tubular shape. have.

  The nozzle tip 42 has a base end portion 426 that is airtightly fitted to a distal end portion of the third flow path 46 and communicates with the third flow path 46. In addition, the tip portion 427 of the nozzle tip 42 has a tapered shape whose outer diameter gradually decreases in the tip direction.

  Although it does not specifically limit as a constituent material of the nozzle tip 42, For example, the material which was mentioned by description of the applicator main body 7 can be used.

  The merge part 43 is a part where the first liquid L1 that has passed through the first flow path 44 and the second liquid L2 that has passed through the second flow path 45 merge. The merging portion 43 has a base end connected to the first flow path 44 and the second flow path 45 and communicates with these flow paths.

  The merge portion 43 has a tapered portion 432 whose inner diameter gradually decreases in the distal direction in the middle of the merge portion 43. As a result, the merge portion 43 is passed through the tapered portion 432 into a large diameter portion 433 having a larger inner diameter on the distal end side than the tapered portion 432 and a small diameter portion 434 having a smaller inner diameter on the proximal end side than the tapered portion 432. Can be divided. By forming the small diameter portion 434, the flow rate of the mixed liquid M is accelerated (promoted) at the small diameter portion.

  Moreover, the front-end | tip opening part of the confluence | merging part 43 functions as the liquid jet nozzle 431 from which the liquid mixture M ejects (refer FIG. 15).

  In the nozzle 4, the joining portion 43 is inserted through the nozzle tip 42, and a gap formed between the tip opening portion of the nozzle tip 42 and the tip opening portion (liquid jet port 431) of the joining portion 43. It functions as a gas outlet 423 from which the gas G is ejected (see FIGS. 14 to 16).

  As shown in FIG. 5, the large-diameter portion 433 of the merging portion 43 includes an elastic layer (soft layer) 435 made of an elastic material (soft material), and an adhesive layer 436 on the outer peripheral side of the elastic layer 435. A plurality (three in the illustrated configuration) of reinforcing layers 437 bonded (bonded) are formed. These reinforcing layers 437 are intermittently disposed along the longitudinal direction of the merging portion 43 (large diameter portion 433).

  As shown in FIG. 15, in the applicator 1, the gas G is ejected from the gas ejection port 423 when the mixed liquid M is ejected from the liquid ejection port 431. At this time, the gas channel 46 and the inside of the nozzle tip 42 communicating with the gas channel 46 are filled with the gas G, and the pressure in the gas channel 46 (the same applies to the inside of the nozzle tip 42) increases. Due to the increase in internal pressure, in the large-diameter portion 433, a portion between the adjacent reinforcing layers 437 of the elastic layer 435, that is, two portions where the reinforcing layer 437 of the elastic layer 435 is not bonded (hereinafter, each of the portions). Are referred to as “reduced diameter portions (deformed portions) 438”) in the direction of the arrow in FIG. 5B (compressed). As a result, each reduced diameter portion 438 has its inner flow path deformed in the radial direction, that is, the inner diameter is reduced. As described above, the gas flow path 46 functions as a deforming unit that deforms the joining portion 43, that is, reduces the diameter of each reduced diameter portion 438.

  As shown in FIG. 5B, in the applicator 1 (nozzle 4), the mixed liquid M that has entered the reduced diameter portion 438 is throttled by the reduced diameter portion 438, and the flow velocity increases. With the flow rate increased, the liquid mixture M diffuses when it exits the reduced diameter portion 438. Due to this diffusion, mixing of the first liquid L1 and the second liquid L2 constituting the mixed liquid M is promoted, so that these liquids can be mixed efficiently and reliably. Further, in the present embodiment, the mixed liquid M can be diffused at two locations (see FIG. 5B and FIG. 15), so that the first liquid L1 and the second liquid L2 are further mixed. Promoted. Thereby, mixing with the 1st liquid L1 and the 2nd liquid L2 is performed more efficiently.

  Further, as shown in FIG. 17, when the ejection of the gas G is stopped, the pressure on each reduced diameter portion 438 is released. Thereby, each reduced diameter portion 438 is restored to the state shown in FIG. 5A, that is, the inner diameter thereof is the same as the inner diameter of the elastic layer 435 where the reinforcing layer 437 is bonded. The diameter is expanded.

  The constituent material of the elastic layer 435 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber, polyurethane, polyester, and polyamide And elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

  Further, the constituent material of the reinforcing layer 437 is not particularly limited, but for example, a hard material as mentioned in the explanation of the applicator main body 7 can be used.

  Further, each reinforcing layer 437 is not limited to being disposed on the outer peripheral side of the elastic layer 435, and may be disposed on the inner peripheral side of the elastic layer 435, for example, or in the elastic layer 435. You may embed and arrange.

  The constituent material of the small diameter portion 434 is not particularly limited, but for example, the same material as that of the reinforcing layer 437 can be used.

  As shown in FIG. 12, when the nozzle 4 is viewed from the tip side, the outer periphery 431 a of the liquid ejection port 431 has a circular shape, and the inner periphery 423 a of the gas ejection port 423 has a square shape with rounded corners. It has a tinged shape.

  The distance (length) H from the center 423b of the gas jet port 423 having such a shape to each side is set to be approximately equal to or slightly smaller than the radius R of the outer periphery 431a of the liquid jet port 431. Thereby, the inner periphery 423a of the gas ejection port 423 and the outer periphery 431a of the liquid ejection port 431 are in point contact at four locations. Further, these four contacts 424 are arranged at equiangular intervals around the center 423b.

  Due to such a positional relationship, when the gas G is ejected from the gas ejection port 423 and the liquid mixture M is ejected from the liquid ejection port 431, the liquid ejection port 431 is shaken in the radial direction by the pressure of the gas G, for example (eccentricity). The liquid ejection port 431 is fixed to the gas ejection port 423. As a result, the four gaps (clearances) between the inner circumference 423a of the gas jet 423 and the inner circumference 423a of the gas jet 423 are maintained constant, and thus the gas G is passed through the gaps (gas jet 423). Can be surely ejected uniformly. Thereby, the liquid mixture M is surely atomized and ejected.

  Further, as shown in FIGS. 13 to 17, in the middle of the first flow path 44, a volume increasing / decreasing section (balloon (flow path forming member)) that deforms in the vicinity of the merging section 43 so that the internal volume increases or decreases. ) 441 is provided. The volume increasing / decreasing unit 441 is made of an elastic material (for example, the same material as the elastic layer 435).

  As shown in FIGS. 13 and 17, the volume increasing / decreasing unit 441 has a maximum volume when it is in a natural state. The “natural state” refers to a state where no external force is applied, that is, a state where the gas G is not supplied to the gas flow path 46.

  Further, as shown in FIGS. 14 to 16, when the gas G is ejected from the gas ejection port 423, that is, when the gas is supplied to the gas channel 46, the pressure in the gas channel 46 is increased. The volume increase / decrease part 441 is compressed (pressed) by the increased internal pressure. As a result, the volume of the volume increasing / decreasing unit 441 decreases.

  Further, in the stopped state in which the ejection of the gas G is stopped, the volume increasing / decreasing unit 441 is released from the compression, becomes a natural state, and is restored by its own elasticity, that is, has a larger volume than the ejection state (see FIG. 17).

  Next, the first syringe 2 filled with the first liquid L1 and the second syringe 3 filled with the second liquid L2 are loaded, and the cylinder 300 is ready for use. The operating state of the applicator 1 in a state of being connected to will be described.

  The first syringe 2 and the second syringe 3 are respectively filled with the first liquid L1 and the second liquid L2 having a sufficient amount of liquid necessary for applying to the affected area. Further, the cylinder 300 has the valve 301 in an open state, so that the gas G can be supplied to the applicator 1.

  Further, in the applicator 1, a force that creates a gap 98 between the seal member 94 and the flange portion 95 against the force (biasing force) of the urging portion 96 that presses the flange portion 95 against the seal member 94, that is, a force. The pressing force in the direction of the arrow C that tilts the second connecting portion 92 from the first posture to the second posture causes the pusher 26 of the first syringe 2 and the pusher 26 of the second syringe 3 to move. It is set to be larger than the force to move in the distal direction. As a method for performing such setting, for example, various conditions such as the spring constant of the urging portion 96, the viscosity of each liquid, and the inner diameter of each outer cylinder 21 can be set as appropriate.

  For such an applicator 1, first, for example, an index finger is hung on the finger hanging portion 751 of the applicator main body 7, a middle finger is hung on the finger hanging portion 752, and a thumb is hung on the pressing portion 82 of the operation portion 8. At this time, the first liquid L <b> 1 is not supplied to the first flow path 44, the second liquid L <b> 2 is not supplied to the second flow path 45, and gas is also supplied to the gas flow path 46. G is not supplied (see FIG. 13). For this reason, the gas G and the liquid mixture M are not ejected from the nozzle 4. Further, since the gas G is not supplied to the gas flow path 46, the volume increasing / decreasing portion 441 is not compressed by the pressure in the gas flow path 46.

  Next, when the pressing portion 82 is pressed with the thumb in this state, first, the second connecting portion 92 is tilted, and a gap 98 is formed between the seal member 94 and the flange portion 95. Gas G circulates through (see FIG. 4). Thereby, the gas G is supplied to the gas flow path 46 through the 2nd tube 102, and, thereby, the gas G is ejected from the gas ejection port 423 of the nozzle 4 (refer FIG. 14). Further, at this time, since the internal pressure in the gas flow path 46 increases, each reduced diameter portion 438 and the volume increasing / decreasing portion 441 of the merging portion 46 are compressed. This compression is maintained until the supply of the gas G into the gas flow path 46 is stopped.

  Further, the pressing operation with respect to the pressing portion 82 by the thumb has not reached the entire operation portion 8, that is, the respective pushers 26 are moved in the distal direction. For this reason, the first liquid L1 and the second liquid L2 have not been supplied to the first flow path 44 and the second flow path 45 yet.

  Further, when the pressing portion 82 is pressed, the tilt of the second connecting portion 92 becomes a limit, and the pressing force from the thumb is transmitted to the connecting portion 81 via the pressing portion 82. As a result, the connecting portion 81 (the entire operation portion 8) starts to move, so that the first liquid L1 is pushed out from the first syringe 2 and the second liquid L2 is pushed out from the second syringe 3 as well. . The extruded first liquid L1 flows into the merging portion 43 via the first flow path 44. In addition, the second liquid L2 flows into the merging portion 43 through the second flow path 45 in the same manner as the first liquid. The first liquid L1 and the second liquid L2 that have flowed into the merging portion 43 are merged and mixed to become a mixed liquid M (see FIG. 15). Further, as described above, the first liquid L1 and the second liquid L2 that have flowed into the merging portion 43 are efficiently mixed by the action of the respective reduced diameter portions 438.

  The mixed liquid M thus mixed passes through the small-diameter portion 434 of the merging portion 43, further reaches the tip direction, that is, reaches the liquid ejection port 431, and is ejected therefrom (see FIG. 15).

  The ejected mixed liquid M is caught (mixed) in the gas G ejected from the gas ejection port 423. At this time, the mixed liquid M is sprayed in the form of a mist and applied to the affected area.

  After the application of a predetermined amount to the affected area is completed, when the pressing force applied to the thumb pressing section 82 (operation section 8) is loosened, the movement of the entire operation section 8 is first stopped. Thereby, the movement of each pusher 26 is stopped, and thus the ejection of the first liquid L1 and the second liquid L2 is stopped (see FIG. 16). At this time, since the second posture of the second connecting portion 92 is maintained by the pressing of the pressing portion 82, the gas G is still being ejected (see FIG. 16).

  Furthermore, when the pressing force of the thumb against the pressing portion 82 is loosened, the thumb that has been pressing the pressing portion 82 is finally separated from the pressing portion 82. Thereby, the pressing force with respect to the second connection portion 92 is released, and the second connection portion 92 returns to the first posture. Thereby, the gap 98 between the seal member 94 and the flange portion 95 disappears, that is, the seal member 94 and the entire periphery of the peripheral edge portion 951 of the flange portion 95 are in close contact with each other (see FIG. 3). At this time, the supply of the gas G to the gas flow path 46 is stopped, so that the ejection of the gas G from the gas outlet 423 is also stopped (see FIG. 17).

  Further, when the supply of the gas G to the gas flow path 46 is stopped, the pressure on the reduced diameter portions 438 and the volume increasing / decreasing portion 441 of the merging portion 43 is released. Thereby, the volume of the volume increasing / decreasing unit 441 becomes larger (increased) than that in the state where the mixed liquid M is ejected. As the volume becomes large, most of the mixed liquid M is drawn into the rear end side of the merging portion 43, that is, into the volume increasing / decreasing portion 441 (see FIG. 17). The mixed liquid M drawn into the volume increasing / decreasing unit 441 is sufficiently diluted by the first liquid L1 in the first flow path 44 (volume increasing / decreasing unit 441) so as not to solidify. Thereby, it can prevent reliably that the liquid mixture M which remained in the applicator 1 solidifies, Therefore The applicator 1 can be used for the application to an affected part again. Further, in the second flow path 45, the tip end P <b> 2 of the second liquid L <b> 2 stays in the vicinity of the merge portion 43.

  Further, after the application tool 1 is used, that is, after application, the mixed liquid M is collected in the volume increasing / decreasing unit 441, so that clogging caused by the solidification of the mixed liquid M is ensured near the liquid ejection port 431. Can be prevented. Then, the applicator 1 in a state where the clogging does not occur can be used again for application to the affected area.

  Moreover, in the applicator 1, the timing of supplying / stopping the supply of the gas G to the nozzle 4 when the mixture M is ejected / stopped from the nozzle 4 can be set optimally. In other words, the applicator 1 is configured such that the gas G is ejected from the nozzle 4 in advance of the mixed liquid M more easily and reliably. Thereby, it can prevent that only the liquid mixture M is ejected and applied to an affected part. Further, in the applicator 1, even if the mixed liquid M remains (attaches) to the liquid jet port 431 by stopping the ejection of the mixed liquid M, the gas G can blow off the remaining mixed liquid M. . Therefore, clogging due to the solidification of the mixed liquid M in the vicinity of the liquid ejection port 431 can be more reliably prevented.

  Further, in the applicator 1, in order to draw the mixed liquid M into the volume increasing / decreasing unit 441, by appropriately setting an amount of change (volume) that increases when the volume increasing / decreasing unit 441 is deformed from contraction to expansion, Can be performed reliably.

Second Embodiment
FIG. 6 is a detailed longitudinal sectional view of a merging portion in the applicator of the present invention (second embodiment).

  Hereinafter, the second embodiment of the applicator of the present invention will be described with reference to this drawing. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.

This embodiment is the same as the first embodiment except that the configuration of the merging portion is different.
The large diameter portion 433 of the joining portion 43A of the applicator 1 (nozzle 4) shown in FIG. 6 includes a plurality (three in the illustrated configuration) of hard tubes 47 and a plurality (two in the illustrated configuration) of soft tubes ( (Reduced diameter portion) 48, and these tubes are alternately arranged. The constituent material of each hard tube 47 is not particularly limited, but for example, the same material as the reinforcing layer 437 of the large-diameter portion 433 described in the first embodiment can be used. Each soft tube 48 is made of a material softer than the material forming each hard tube 47, and the material is the same as, for example, the elastic layer 435 of the large-diameter portion 433 described in the first embodiment. Can be used.

  In the applicator 1, when the liquid mixture M is ejected from the liquid jet port 431, the gas channel 46 and the nozzle tip 42 communicating with the gas channel 46 are filled with the gas G, and the gas channel 46 (nozzle tip 42) is filled. The pressure increases in the same way. Due to the increase in the internal pressure, each of the soft tubes 48 is compressed in the direction of the arrow in FIG. As a result, the inner diameter of each soft tube 48 is reduced.

  As shown in FIG. 6B, in the applicator 1 (nozzle 4), the mixed liquid M that has entered each soft tube 48 is squeezed by the soft tube 48 and the flow velocity increases. With the flow rate increased, the mixture M diffuses when it exits the soft tube 48. Due to this diffusion, mixing of the first liquid L1 and the second liquid L2 constituting the mixed liquid M is promoted, so that these liquids can be mixed efficiently and reliably.

<Third Embodiment>
FIG. 7 is a perspective view of a merging portion in the applicator of the present invention (third embodiment), and FIG. 8 is a longitudinal sectional view of the merging portion shown in FIG.

  Hereinafter, the third embodiment of the applicator of the present invention will be described with reference to these drawings. However, the difference from the above-described embodiment will be mainly described, and description of similar matters will be omitted.

This embodiment is the same as the first embodiment except that the configuration of the merging portion is different.
The joining portion 43B of the applicator 1 (nozzle 4) shown in FIGS. 7 and 8 is provided with a deforming portion 49 that is deformed so that the cross section of the flow path becomes smaller when the pressure in the gas flow path 46 rises. It has been. The deformed portion 49 is a hollow disk-shaped portion, and a diaphragm 491 made of an elastic material is provided on both surfaces (or one surface) thereof.

  In the deformed portion 49 having such a configuration, each diaphragm 491 is pressed in the direction of the arrow in FIG. As a result, the size of the cross section of the flow path in the deforming portion 49 is reduced, and thus the liquid mixture M is squeezed by the deforming portion 49 and the flow velocity is increased. In a state where the flow velocity is increased, the mixed liquid M diffuses when it exits from the deforming portion 49. Due to this diffusion, mixing of the first liquid L1 and the second liquid L2 constituting the mixed liquid M is promoted, so that these liquids can be mixed efficiently and reliably.

  The deforming portion 49 is not limited to the one having the diaphragm 491, and may be constituted by a bellows tube, for example.

<Fourth embodiment>
FIG. 9 is a detailed vertical cross-sectional view of a merging portion in the applicator (fourth embodiment) of the present invention.

  Hereinafter, the fourth embodiment of the applicator of the present invention will be described with reference to this drawing. However, the difference from the above-described embodiment will be mainly described, and description of similar matters will be omitted.

  This embodiment is the same as the first embodiment except that a plurality of slits are provided at the junction.

  A plurality of slits 439 are provided over substantially the entire inner peripheral portion of the joining portion 43C (large diameter portion 433) of the applicator 1 (nozzle 4) shown in FIG. Each slit 439 is formed in a single character along the circumferential direction of the inner peripheral portion of the merging portion 43C. The plurality of slits 439 thus formed are arranged along the longitudinal direction of the merge portion 43C. Further, the opposing slits 439 (the slit 439 located on the upper side and the slit 439 located on the lower side in FIG. 9) are displaced at different positions in the longitudinal direction of the joining portion 43C, that is, in the longitudinal direction of the joining portion 43C. Are arranged.

  As shown in FIG. 9A, the slits 439 are closed when the pressure of the gas G does not act (in a natural state) and the reduced diameter portion 438 is not reduced (deformed). It is in the state.

  Further, as shown in FIG. 9B, when the diameter of the reduced diameter portion 438 is reduced by the action of the pressure of the gas G, each slit provided in the reduced diameter portion 438 of the merging portion 43 </ b> C among the plurality of slits 439. Each of 439 is in an open state (opens so that the longitudinal cross-sectional shape is V-shaped). In the vicinity of the edge (edge) of each open slit 439, the flow of the mixed liquid M is disturbed, so that the first liquid L1 and the second liquid L2 constituting the mixed liquid M are further mixed. Promoted.

<Fifth Embodiment>
FIG. 10 is a detailed longitudinal sectional view of a merging portion in the applicator of the present invention (fifth embodiment).

  Hereinafter, the fifth embodiment of the applicator of the present invention will be described with reference to this drawing. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.

This embodiment is the same as the fourth embodiment except that the configuration of the merging portion is different.
The joining portion 43D (large diameter portion 433) of the applicator 1 (nozzle 4) shown in FIG. 10 is made of a relatively hard material. Such a material is not particularly limited, and examples thereof include various resin materials such as polyester such as polyethylene terephthalate, polyimide, polyamide, polymethyl methacrylate, polyacetal, and polyetheretherketone.

  A plurality of slit groups 50 each including a plurality of slits 439 are provided on the inner peripheral portion of the merging portion 43D (see FIG. 10). These slit groups 50 are intermittently arranged along the longitudinal direction of the merging portion 43D. When the pressure of the gas G rises and the pressure acts on the merging portion 43D, each portion of the merging portion 43D provided with the slit group 50 is easily deformed (see FIG. 10B). In the merging portion 43D, each portion functions as a reduced diameter portion 438.

  In the merging portion 43D having such a configuration, when the pressure of the gas G acts, the flow of the mixed liquid M is disturbed near the edge (edge) of each open slit 439, and thus the mixed liquid M is configured. The mixing of the first liquid L1 and the second liquid L2 is further promoted.

<Sixth Embodiment>
FIG. 11: is a cross-sectional perspective view of the junction part in the applicator (6th Embodiment) of this invention.

  Hereinafter, the sixth embodiment of the applicator of the present invention will be described with reference to this drawing. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.

  This embodiment is the same as the fifth embodiment except that the slit forming direction is different.

  In the junction part 43E of the applicator 1 (nozzle 4) shown in FIG. 11, each slit 439 which comprises each slit group 50 is each formed along the longitudinal direction of the junction part 43E. Moreover, in the junction part 43E, each slit group 50 is comprised by the two slits 439, respectively, and these slits 439 are mutually arrange | positioned mutually.

  In the merging portion 43E having such a configuration, similar to the merging portion 43D of the fifth embodiment, when the pressure of the gas G acts, the mixed liquid M is near the edge (edge) of each open slit 439. Therefore, the mixing of the first liquid L1 and the second liquid L2 constituting the mixed liquid M is further promoted.

  As mentioned above, although the applicator of the present invention has been described with respect to the illustrated embodiment, the present invention is not limited to this, and each part constituting the applicator has any configuration that can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.

  Moreover, the applicator of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

  Further, the shape of the inner periphery of the gas outlet is not limited to a shape in which each corner of the square is rounded, for example, a square, other polygons or corners thereof are rounded. The shape may be different.

  Moreover, the flow path forming member is not limited to being provided in only one of the first flow path and the second flow path, and may be provided in both flow paths, for example.

It is a perspective view which shows 1st Embodiment of the applicator of this invention. It is a perspective view which shows 1st Embodiment of the applicator of this invention. It is AA sectional view taken on the line of the opening-closing means in the applicator shown in FIG. 1 (The figure which shows the state by which the gas flow path was interrupted | blocked). It is AA sectional view taken on the line of the opening-closing means in the applicator shown in FIG. 1 (The figure which shows the state which the gas flow path was open | released). It is a detailed longitudinal cross-sectional view of the junction part in the applicator shown in FIG. It is a detailed longitudinal cross-sectional view of the junction part in the applicator (2nd Embodiment) of this invention. It is a perspective view of the confluence | merging part in the applicator (3rd Embodiment) of this invention. It is a longitudinal cross-sectional view of the junction part shown in FIG. It is a detailed longitudinal cross-sectional view of the merge part in the applicator (4th Embodiment) of this invention. It is a detailed longitudinal cross-sectional view of the junction part in the applicator (5th Embodiment) of this invention. It is a cross-sectional perspective view of the junction part in the applicator (6th Embodiment) of this invention. It is the figure (front view) which looked at the nozzle in the applicator shown in FIG. 1 from the front end side (from the arrow B direction in FIG. 1). It is a schematic longitudinal cross-sectional view (The figure which shows a time-dependent change of an application state) of the nozzle of the applicator shown in FIG. It is a schematic longitudinal cross-sectional view (The figure which shows a time-dependent change of an application state) of the nozzle of the applicator shown in FIG. It is a schematic longitudinal cross-sectional view (The figure which shows a time-dependent change of an application state) of the nozzle of the applicator shown in FIG. It is a schematic longitudinal cross-sectional view (The figure which shows a time-dependent change of an application state) of the nozzle of the applicator shown in FIG. It is a schematic longitudinal cross-sectional view (The figure which shows a time-dependent change of an application state) of the nozzle of the applicator shown in FIG. It is a fragmentary longitudinal cross-sectional view of the 1st syringe (a 2nd syringe is also the same) with which the applicator shown in FIG. 1 is loaded.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Applicator 2 1st syringe (supply means)
20 space 21 outer cylinder 22 mouth (reduced diameter part)
23 Flange 24 Gasket 25 Hollow portion 26 Pusher 27 Main body portion 28 Head portion 29 Flange 3 Second syringe (supply means)
DESCRIPTION OF SYMBOLS 4 Nozzle 41 Fixing member 411 Front end opening part 412 Base end opening part 42 Nozzle tip 423 Gas jet outlet 423a Inner periphery 423b Center 424 Contact point 426 Base end part 427 Front end part 43, 43A, 43B, 43C, 43D, 43E Merge part 431 Liquid Spout 431a Outer periphery 432 Tapered portion 433 Large diameter portion 434 Small diameter portion 435 Elastic layer (soft layer)
436 Adhesive layer 437 Reinforcing layer 438 Reduced diameter portion (deformed portion)
439 Slit 44 First flow path (liquid transfer path)
441 Volume increase / decrease part (balloon (flow path forming member))
45 Second flow path (liquid transfer path)
46 Gas channel (third channel)
47 Hard tube 48 Soft tube (reduced diameter part)
49 Deformation part 491 Diaphragm 50 Slit group 7 Applicator main body 71 Base part 711, 712 Concave part 713 Guide 72 Front plate (first engaging part)
721, 722 Groove 73 Rear plate (second engaging portion)
731 and 732 Recessed parts 751 and 752 Finger hooking part 8 Operation part 81 Connection part 811 and 812 Recessed part 813 Cylindrical part 82 Press part 83 Rail part 9 Opening and closing means (valve mechanism)
91 First connection portion 911 Step portion 912 Storage portion 913 Reduced diameter portion 914 Inner peripheral portion 92 Second connection portion 921 Lower end portion 922 Outer portion 93 Valve portion 94 Seal member 941 Inner peripheral portion 942 Outer peripheral portion 95 Flange portion 951 Periphery Part 96 Biasing part 961 Upper end part 962 Lower end part 97, 98 Gap 10 Tube (gas flow path)
101 first tube 102 second tube 300 cylinder (gas supply means)
301 Valve G gas (sterile gas)
H Distance (length)
L1 1st liquid L2 2nd liquid M Mixed liquid P2 Tip R Radius

Claims (15)

Supply means for separately supplying a first liquid and a second liquid having different liquid compositions;
A first flow path and a second flow path through which the first liquid and the second liquid supplied from the supply means pass, respectively;
The first liquid that has passed through the first flow path and the second liquid that has passed through the second flow path are merged, and a merging portion having a deformable deformable portion, and communicating in the merging portion. And a nozzle having a liquid ejection port from which a mixed liquid in which the first liquid and the second liquid are merged and mixed is ejected;
Deformation means for deforming the deformation portion,
The deforming portion is deformed by the deforming means when the mixed liquid is ejected from the liquid ejection port, and mixing of the first liquid and the second liquid in the confluence portion is promoted. An applicator characterized in that the applicator is configured. The deformation means is connected to a gas supply means for supplying gas, and a gas flow path through which the gas from the gas supply means passes in the connected state, is provided in the nozzle, communicates with the gas flow path, It consists of a gas outlet from which gas is emitted,
The applicator according to claim 1, wherein the deforming portion is located in the gas flow channel, is deformed by being compressed when the pressure in the gas flow channel is increased, and is restored when the pressure is released.   The applicator according to claim 1 or 2, wherein the merging portion has a tubular shape, and the deforming portion is a portion that deforms in a radial direction of the merging portion.   The applicator according to claim 3, wherein a plurality of slits are arranged along the circumferential direction or the longitudinal direction of at least the inner peripheral portion of the deformable portion of the merging portion.   Each said slit is an applicator of Claim 4 which opens when the said deformation | transformation part is deform | transforming, and closes when not deform | transforming.   The application according to any one of claims 1 to 5, wherein the merging portion has a tubular shape, and the deformation portion is configured by at least one reduced diameter portion that is deformed so that an inner diameter thereof is reduced. Ingredients.   The merging portion includes a soft layer made of a soft material, and a plurality of reinforcing layers intermittently disposed along the longitudinal direction of the merging portion on the soft layer, and the reinforcement adjacent to the soft layer. The applicator according to claim 6, wherein a portion between the layers functions as the reduced diameter portion.   The applicator according to claim 6, wherein the reduced diameter portion is disposed in the middle of the joining portion, and is made of a softer material than portions before and after the reduced diameter portion of the joining portion. The gas flow path contains the first flow path and the second flow path,
At least one of the first flow path and the second flow path is provided with a flow path forming member that deforms so as to increase or decrease an internal volume. In the ejection state in which gas is ejected from the gas ejection port, it is compressed by an increase in pressure in the gas flow path, and in the stopped state in which the gas ejection is stopped, the compression is released and the volume is larger than that in the ejection state. The applicator according to any one of claims 2 to 8.   The applicator according to claim 9, wherein when the volume of the flow path forming member becomes large, most of the mixed liquid is drawn to the rear end side with respect to the joining portion.   The applicator according to claim 10, wherein when the volume of the flow path forming member becomes large, most of the mixed liquid is drawn into the flow path forming member. The liquid spout is disposed inside the gas spout,
When the nozzle is viewed from the tip side thereof, the outer shape of the liquid jet port is circular, the inner peripheral shape of the gas jet port is a polygon or each corner is rounded, The outer periphery of the liquid jet port and the inner circumference of the gas jet port are in point contact at a plurality of locations, and the liquid jet port is fixed to the gas jet port. The applicator described.   The supply means includes a syringe outer cylinder having a mouth portion protruding from a tip, a gasket inserted into the syringe outer cylinder, and a push for moving the gasket along the longitudinal direction of the syringe outer cylinder. The applicator according to any one of claims 1 to 12, further comprising a syringe having a child.   The applicator according to any one of claims 1 to 13, wherein the first liquid and the second liquid are altered by contact with each other.   The applicator according to claim 14, wherein the mixed solution serves as an adhesion preventing material for living tissue.

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