JP2008295834A - Nozzle and applicator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a nozzle and an applicator that securely mix the two kinds of liquids differing in liquid composition tegether. <P>SOLUTION: An applicator 1, used after a first and a second syringes are fitted with it, is provided with an applicator body, an operation part, an opening and closing means, a tube connected with a tank and a nozzle 4. The nozzle 4 is provided with a first inner tube 44a, a second inner tube 44b and the outer tube 43 where the first and second inner tubes 44a and 44b have been inserted. Gas jet ports 42 are unevenly located closer to a region 52 from the central axis 440a to a first remote part 447a and from the central axis 440b to a second remote part 447b, in comparison with a region 51 between central axes 440a and 440b, respectively. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a nozzle and an applicator.

  Conventionally, a method of mixing two or more kinds of liquids and spraying them onto an affected area to form an adhesion preventing material, a biological tissue adhesive or the like has been known, and an applicator for that purpose has been developed.

  Such an applicator has a configuration in which components that coagulate when mixed, for example, a solution containing thrombin and a solution containing fibrinogen are separated from each other, sent to the vicinity of the affected area, and applied while mixing in the affected area. is there.

  Conventional applicators are installed in a state where the flow paths are lined up from two syringes each containing different types of liquid, and the liquid is ejected and mixed from the ends of both flow paths, that is, from the respective discharge ports. (For example, refer to Patent Document 1). In order to eject the liquid, the pusher (plunger) of each syringe is pressed. Thereby, two types of liquids are ejected from the respective discharge ports, and are mixed and applied by the ejected gas.

  However, the conventional applicator has a drawback that a part (a considerable amount) of the two types of ejected liquid is applied as it is without being mixed (insufficient mixing).

JP 2002-282368 A

  An object of the present invention is to provide a nozzle and an applicator that can reliably mix two liquids having different liquid compositions.

Such an object is achieved by the present inventions (1) to (18) below.
(1) liquids having different liquid compositions pass through the inside, and a first inner pipe and a second inner pipe whose central axes are parallel to each other;
A nozzle having the first inner pipe and the second inner pipe inserted therein, and an outer pipe through which gas passes between the first inner pipe and the second inner pipe,
The first inner tube and the second inner tube each have a first liquid discharge port and a second liquid discharge port that are open at the tip and discharge the liquid,
The outer tube has a gas outlet opening at the tip, arranged around the first liquid outlet and the second liquid outlet, and from which the gas is jetted.
The first liquid discharge port and the second liquid discharge port are respectively opposite to each other via a first adjacent portion and a second adjacent portion that are adjacent to each other, and the first adjacent portion and the central axis of the first inner tube. The first distal portion and the second adjacent portion, and a second distal portion opposite to the central axis of the second inner tube,
The nozzle, wherein the first adjacent portion and the second adjacent portion are located on the proximal side with respect to the first distal portion and the second distal portion, respectively.

  (2) The nozzle according to (1), wherein the first adjacent portion and the second adjacent portion are located on a proximal end side with respect to a distal end surface of the outer tube.

  (3) In the above (1) or (2), the positions of the first distal portion, the second distal portion, and the distal end surface of the outer tube in the longitudinal direction of the outer tube substantially coincide with each other. The nozzle described.

  (4) The front end surface of the first liquid discharge port and the front end surface of the second liquid discharge port are inclined with respect to the central axis of the first inner tube and the central axis of the second inner tube, respectively. The first adjacent portion is located on the proximal side with respect to the first distal portion, and the second adjacent portion is located on the proximal side with respect to the second distal portion by the respective inclinations. (1) The nozzle in any one of (3).

  (5) Each of the first liquid discharge port and the second liquid discharge port has a step, and the first adjacent portion is located on the proximal side with respect to the first distal portion by the step. And the said 2nd adjacent part is a nozzle in any one of said (1) thru | or (3) located in a base end side with respect to the said 2nd distal part.

  (6) The gas jet port may be configured such that the first distal portion is located on the center axis of the first inner pipe as compared with a region between the center axis of the first inner pipe and the center axis of the second inner pipe. The nozzle in any one of said (1) thru | or (5) which is unevenly distributed toward the area | region of the said 2nd distal part side from the side and the central axis of the said 2nd inner pipe | tube.

(7) a first inner pipe and a second inner pipe through which liquids having different liquid compositions pass;
A nozzle having the first inner pipe and the second inner pipe inserted therein, and an outer pipe through which gas passes between the first inner pipe and the second inner pipe,
The first inner tube and the second inner tube each have a first liquid discharge port and a second liquid discharge port that are open at the tip and discharge the liquid,
The outer tube has a gas outlet opening at the tip, arranged around the first liquid outlet and the second liquid outlet, and from which the gas is jetted.
The first liquid discharge port and the second liquid discharge port are respectively opposite to each other via a first adjacent portion and a second adjacent portion that are adjacent to each other, and the first adjacent portion and the central axis of the first inner tube. The first distal portion and the second adjacent portion, and a second distal portion opposite to the central axis of the second inner tube,
The gas ejection port has a side closer to the first distal portion than the central axis of the first inner tube and the region between the central axis of the first inner tube and the central axis of the second inner tube. A nozzle characterized by being unevenly distributed toward the region on the second distal portion side with respect to the central axis of the second inner tube.

  (8) The nozzle according to (7), wherein a central axis of the first inner pipe and a central axis of the second inner pipe are parallel to each other.

  (9) The outer tube has a first lumen and a second lumen that open at a distal end, and the first liquid discharge port is inserted into the first lumen, and the first lumen is inserted into the second lumen. The nozzle according to (7) or (8), wherein two liquid discharge ports are inserted and arranged.

(10) When the nozzle is viewed from the tip side, the outer shapes of the first liquid discharge port and the second liquid discharge port are each circular,
The shape of the inner periphery of the first lumen is circular, and the radius thereof is larger than the radius of the outer periphery of the first liquid discharge port, and the first liquid discharge port is the first with respect to the first lumen. 1 Eccentric to adjacent side,
The shape of the inner periphery of the second lumen is circular, and the radius thereof is larger than the radius of the outer periphery of the second liquid discharge port, and the second liquid discharge port is 2. The nozzle according to (9), which is eccentric to the adjacent portion side.

  (11) The nozzle according to (10), wherein the first adjacent portion and the second adjacent portion are fixed to each other.

(12) When the nozzle is viewed from the tip side, the outer shapes of the first liquid discharge port and the second liquid discharge port are each circular,
The shape of the inner periphery of the portion of the first lumen on the side of the first adjacent portion from the central axis of the first inner tube and the side of the second adjacent portion of the second lumen from the central axis of the second inner tube The shape of the inner circumference of each part is arcuate,
The shape of the inner circumference of the first distal portion side portion of the first lumen from the central axis of the first inner tube and the second distal end of the second lumen from the central axis of the second inner tube The nozzle according to (9), wherein the inner peripheral shape of the portion side portion is a part of a polygon or each corner is rounded.

  (13) When the nozzle is viewed from the tip side, the radius of the arc-shaped portion of the first lumen is substantially equal to the radius of the outer periphery of the first liquid discharge port, and the second lumen The nozzle according to (12), wherein a radius of the arc-shaped portion and a radius of an outer periphery of the second liquid discharge port are substantially equal.

(14) The outer tube has a communication portion that connects the first lumen and the second lumen in the vicinity of the first adjacent portion and the second adjacent portion,
The nozzle according to any one of (9) to (13), wherein the first adjacent portion and the second adjacent portion are in contact with each other through the communication portion.

(15) The outer tube has one lumen opened at a tip, and the first liquid discharge port and the second liquid discharge port are collectively inserted and disposed in the lumen.
The nozzle according to (7) or (8), further including an opening closing portion that closes at least a part of a distal end opening of the outer tube in the vicinity of the first adjacent portion and the second adjacent portion.

  (16) The nozzle according to any one of (1) to (15), wherein the first adjacent portion and the second adjacent portion are in contact with each other.

  (17) An applicator comprising the nozzle according to any one of (1) to (16).

(18) a first liquid supply means that is filled with a liquid and supplies the liquid to the first inner pipe;
A second liquid supply means that is filled with a liquid having a liquid composition different from that of the liquid and supplies the liquid to the second inner tube;
The applicator according to (17), further comprising gas supply means that is filled with a gas and supplies the gas to the outer tube.

According to the present invention, the two liquids can be reliably mixed.
That is, the first adjacent portion of the first liquid discharge port and the second adjacent portion of the second liquid discharge port are located on the proximal side with respect to the first distal portion and the second distal portion, respectively. Overall, the liquid ejected from the first liquid ejection port and the liquid ejected from the second liquid ejection port are ejected in directions approaching each other, so that the two liquids are reliably mixed. In particular, the two kinds of liquids can be mixed more reliably because they are entrained in the gas ejected from the gas ejection port after some of them are mixed.

  Further, according to the present invention, the gas ejection port has a first distal portion with respect to the central axis of the first inner pipe, as compared with a region between the central axis of the first inner pipe and the central axis of the second inner pipe. The first distal portion and the second distal portion rather than the first adjacent portion and the second adjacent portion side, because the first and second adjacent portions are unevenly distributed toward the second distal portion side region. The amount of gas ejected from the side increases, whereby the liquid discharged from the first liquid discharge port and the liquid discharged from the second liquid discharge port each flow in directions approaching each other, thereby The two liquids are reliably mixed.

  Hereinafter, the nozzle and applicator of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

<First Embodiment>
1 and 2 are perspective views showing a first embodiment of the applicator of the present invention, respectively. FIGS. 3 and 4 are cross-sectional views taken along line AA of the opening / closing means of the applicator shown in FIG. 3 shows a state in which the gas flow path is blocked, FIG. 4 shows a state in which the gas flow path is opened), and FIGS. 5 to 9 are schematic views of the nozzle and syringe of the applicator shown in FIG. 1, respectively. FIG. 10 is a partial vertical cross-sectional view (a view showing a change over time of the application state), and FIG. 10 is a view (front view) of the nozzle of the applicator shown in FIG. 1 viewed from the tip side (in the direction of arrow B in FIG. 1). 16 is a partial longitudinal cross-sectional view of a first syringe (also the second syringe) loaded in the applicator shown in FIG. For convenience of explanation, the left side in FIGS. 1, 2 and 5 to 9 is referred to as “tip”, the right side is referred to as “rear end (base end)”, and the lower side in FIG. The upper side is called “rear end”. 1 to 4, the upper side is referred to as “upper” or “upper”, and the lower side is referred to as “lower” or “lower”.

  The applicator 1 of the present invention applies (sprays) two types of liquids (first liquid L1 and second liquid L2) having different liquid compositions while mixing (see FIG. 7). As shown in FIGS. 1 and 2, the applicator 1 includes a first syringe (first liquid supply means) 2 that stores the first liquid L1, and a second syringe that stores the second liquid L2. A syringe (second liquid supply means) 3 is loaded and used.

  First, before describing the configuration of the applicator 1, the configurations of the first syringe 2 and the second syringe 3 will be described. Since the 1st syringe 2 and the 2nd syringe 3 are the substantially the same structures, the 1st syringe 2 is demonstrated typically.

  As shown in FIG. 16, the first syringe 2 in this embodiment includes an outer cylinder (syringe outer cylinder) 21, a gasket 24 that can slide in the outer cylinder 21, and a gasket 24 in the longitudinal direction of the outer cylinder 21. And a pusher (plunger rod) 26 that is moved along the (axial direction). The gasket 24 is connected to the tip of the pusher 26.

  The outer cylinder 21 is composed of a bottomed cylindrical member, and a reduced diameter part (mouth part) 22 that is reduced in diameter relative to the body part of the outer cylinder 21 is integrally formed at the center of the bottom part on the front end side. ing.

A flange 23 is integrally formed on the outer periphery of the rear end of the outer cylinder 21.
A scale indicating the amount of liquid is attached to the outer peripheral surface of the outer cylinder 21.

  In such an outer cylinder 21, a gasket 24 made of an elastic material (for example, isoprene rubber) is accommodated (inserted). A plurality (two in this embodiment) of ring-shaped protrusions are formed on the entire outer periphery of the gasket 24, and these protrusions slide while being in close contact with the inner peripheral surface of the outer cylinder 21. By doing so, liquid-tightness can be more reliably maintained and slidability can be improved.

  Further, the gasket 24 is formed with a hollow portion 25 that opens to the rear end face thereof. In this hollow portion 25, a head portion 28 of a pusher 26 described later is screwed (inserted). A female screw is formed on the inner surface of the hollow portion 25.

The pusher 26 has a rod-like main body 27 whose cross section is a cross shape.
A head portion (connecting portion) 28 that is inserted into the hollow portion 25 of the gasket 24 and connected to the gasket 24 is formed on the distal end side of the main body portion 27. On the outer periphery of the head portion 28, a male screw that can be screwed with a female screw on the inner surface of the hollow portion 25 is formed. The gasket 24 and the pusher 26 are connected by screwing the male screw with the female screw.

A disc-shaped flange 29 is formed on the rear end side of the main body 27.
Before the first syringe 2 is loaded into the applicator 1, a space (liquid storage space) 20 surrounded by the outer cylinder 21 and the gasket 24 is filled with the first liquid L1.

  Similarly to the first syringe 2, the second syringe 3 includes an outer cylinder 21, a gasket 24 that can slide in the outer cylinder 21, and a pusher 26 that moves and operates the gasket 24. Is filled with the second liquid L2. Since the structure of each part is the same, the description is abbreviate | omitted.

  The first liquid L1 filled in the first syringe 2 and the second liquid L2 filled in the second syringe 3 have different compositions (components).

  In the present invention, the first liquid L1 and the second liquid L2 are appropriately selected according to the application, purpose of use, case, and the like of the applicator 1. For example, when used for administration of a biological tissue adhesive, one of the first liquid L1 and the second liquid L2 is a liquid containing thrombin (solution or the like), and the other is a liquid containing fibrinogen (solution or the like). It can be.

  In addition, when used for administration of the adhesion preventing material, one of the first liquid L1 and the second liquid L2 is a liquid (solution or the like) containing carboxymethyldextrin modified with a succinimidyl group, and the other is hydrogen phosphate. It can be a liquid (solution etc.) containing disodium.

  The first liquid L1 and the second liquid L2 in such a combination are altered, that is, gelled (solidified) when they are mixed. By gelling, for example, a mixture of the first liquid L1 and the second liquid L2 (hereinafter referred to as “mixed liquid”) can reliably remain in the applied biological tissue (target site). it can. In addition, since the mixed solution stays at the target site with certainty, the function as a biological tissue adhesive or an adhesion preventing material can be reliably exhibited at the target site.

  Needless to say, the types and combinations of the first liquid L1 and the second liquid L2 are not limited to those described above.

  By pressing each pusher 26 of the first syringe 2 and the second syringe 3 having the above-described configuration, the first liquid L1 is supplied to the first inner tube 44a of the nozzle 4 described later, and the second inner tube. The second liquid L2 can be easily and reliably supplied to 44b. Moreover, the pressing operation of each pusher 26 is manually performed by an operator (user) of the applicator 1. For this reason, the operator can apply the mixed liquid at his / her arbitrary timing.

  The applicator 1 loaded with the first syringe 2 filled with the first liquid L1 and the second syringe 3 filled with the second liquid L2 includes an applicator main body 7, a nozzle 4, and It has the operation part 8, the opening-closing means (valve mechanism) 9, and the tube (gas flow path) 10 connected to the cylinder (gas supply means) 300 (refer FIG. 1).

Before describing each part constituting the applicator 1, the cylinder 300 will be described.
The cylinder 300 is filled with a high-pressure (compressed) sterile gas G (hereinafter simply referred to as “gas G”) in its internal space, and supplies the gas G to the applicator 1 (nozzle 4). Can do. The cylinder 300 is provided with an openable / closable valve (cock) 301 for controlling supply / stop of supply of the gas G to the applicator 1. When the applicator 1 is used, the valve 301 is opened. In addition, it does not specifically limit as gas G, For example, a carbon dioxide is mentioned.

  As shown in FIGS. 1 and 2, the applicator body 7 fixes the first syringe 2 and the second syringe 3 side by side (in parallel). The applicator body 7 includes a base 71, a front plate (first engagement portion) 72 provided at the tip of the base 71, and a rear plate (second engagement portion) provided at the rear end of the base 71. ) 73 and finger hooks 751 and 752 provided near the rear plate 73 of the base 71.

  The base 71 is provided with recesses 711 and 712 that open upward and have a substantially semicircular cross section in parallel. The outer cylinder 21 of the first syringe 2 is accommodated in the recess 711, and the outer cylinder 21 of the second syringe 3 is accommodated in the recess 712.

  A front plate 72 is provided at the tip of the base 71. Grooves 721 and 722 are formed in the front plate 72 at positions corresponding to the recesses 711 and 712, respectively. When the first syringe 2 and the second syringe 3 are loaded, the reduced diameter portion 22 of the first syringe 2 is inserted into the groove 721, and the reduced diameter portion 22 of the second syringe 3 is inserted into the groove 722. Is inserted.

  A rear plate 73 is provided at the rear end of the base 71. In the rear plate 73, recesses 731 and 732 are formed at positions corresponding to the recesses 711 and 712, respectively. When loading the first syringe 2 and the second syringe 3, the flange 23 (base end portion) of the first syringe 2 is engaged (inserted) in the recess 731, and the recess 732 is in the second The flange 23 (base end portion) of the syringe 3 is engaged.

  As described above, in the applicator main body 7, each reduced diameter portion 22 is engaged with the front plate 72 and each flange 23 is engaged with the rear plate 73, so that the first syringe 2 and the second syringe 3 are engaged. Can be reliably fixed in parallel.

  Finger hooks 751 and 752 are provided near the rear plate 73 of the base 71. Each of the finger hooks 751 and 752 can be hooked by the user's finger when using the applicator 1. The finger hanging portion 751 is constituted by a plate piece protruding upward, and the finger hanging portion 752 is constituted by a plate piece protruding downward. In addition, each of the finger-hanging portions 751 and 752 has an arcuate shape (curved concave shape) facing the tip direction.

  The applicator main body 7 may be one in which the respective parts constituting the applicator main body 7 are integrally formed, or each part may be configured separately and joined together.

  The constituent material of the applicator body 7 is not particularly limited, and various metal materials such as aluminum and stainless steel, various plastics, and the like can be used alone or in combination. When such a material is used, the applicator main body 7 can be easily manufactured, for example, by die molding.

  On the rear end side of the applicator main body 7, an operation unit 8 is installed so as to be movable in the longitudinal direction with respect to the applicator main body 7. The operation unit 8 is a part that presses the pusher 26 of the first syringe 2 and the pusher 26 of the second syringe 3 in the distal direction (direction of arrow C in FIGS. 1, 2, and 4). is there. The operation unit 8 includes a connecting part 81 that connects the flanges 29 of the pushers 26 of the first syringe 2 and the second syringe 3, a pressing part 82 that is located on the rear end side of the connecting part 81, and a connecting part 81. And a rail portion 83 extending in the distal direction.

  The connecting portion 81 is provided with recesses 811 and 812 that open upward. The concave portion 811 has a shape corresponding to the flange 29 of the pusher 26 of the first syringe 2, and the flange 29 engages (see FIG. 2). Moreover, the recessed part 812 has comprised the shape corresponding to the flange 29 of the pusher 26 of the 2nd syringe 3, and the said flange 29 engages (refer FIG. 2).

  With the connecting portion 81 having such a configuration, the flanges 29 of the pushers 26 of the first syringe 2 and the second syringe 3 can be reliably connected and fixed. Can be moved in the direction of arrow C.

  Further, the connecting portion 81 is provided with a cylindrical portion 813 having a cylindrical shape between the concave portion 811 and the concave portion 812. The cylindrical portion 813 is provided so that its axis is parallel to the vertical direction in FIG. 1 (also in FIG. 2). Further, most of the opening / closing means 9 is accommodated in the cylindrical portion 813.

  A long rail portion 83 is formed on the outer peripheral portion of the tubular portion 813 of the connecting portion 81 so as to protrude in the distal direction. The rail portion 83 is provided in the base portion 71 of the applicator main body 7 and is inserted into a long guide 713. The rail portion 83 is guided by the guide 713 by the pressing operation of the operation unit 8 in the arrow C direction, and thus the pressing operation can be performed smoothly.

  On the rear end side of the tubular portion 813 of the connecting portion 81, a plate-like pressing portion 82 is installed so as to be movable in the longitudinal direction of the applicator main body 7 with respect to the tubular portion 813.

The pressing part 82 is a part that is pressed by the user when the applicator 1 is used, that is, when the mixed liquid is applied to the affected part or the like. When the applicator 1 is used, for example, an index finger can be hung on the finger hanging portion 751, a middle finger can be hung on the finger hanging portion 752, and a thumb can be hung on the pressing portion 82. Thereby, the applicator 1 can be grasped stably and reliably. Moreover, the pressing operation of the operation part 8 (pressing part 82) can be performed smoothly and reliably, so that the operability of the applicator 1 is improved.
The pressing portion 82 is coupled to a second connection portion 92 of the opening / closing means 9 described later.

  The constituent material of the operation unit 8 is not particularly limited, and for example, the materials described in the explanation of the applicator main body 7 can be used. When such a material is used, the operation unit 8 can be easily manufactured by, for example, mold molding.

  As described above, the opening / closing means 9 is installed in the cylindrical portion 813 of the operation portion 8. The opening / closing means 9 is for blocking / opening the flow of the gas G from the cylinder 300 to the nozzle 4. The first tube 101 and the second tube 102 are blocked (see FIG. 3) / communication (see FIG. 4) through the opening / closing means 9, that is, by the operation of the opening / closing means 9.

  As shown in FIGS. 3 and 4, the opening / closing means 9 includes a first connecting portion 91 connected to the first tube 101, a second connecting portion 92 connected to the second tube 102, 1 and has a valve part 93 that can be freely opened and closed.

  The first connecting portion 91 has a tubular shape. A storage portion 912 that is located on the downstream side and that stores the valve portion 93 is provided in the lumen portion of the first connection portion 91. Further, a reduced diameter portion 913 having a diameter reduced from the inner diameter on the upstream side of the storage portion 912 is provided in the lumen portion of the first connection portion 91, and at the boundary between the reduced diameter portion 913 and the storage portion 912. A stepped portion 911 having a sharply changed inner diameter is formed.

  The second connection portion 92 has a tubular shape. As described above, the second connection portion 92 is coupled to the pressing portion 82 of the operation portion 8. The second connection portion 92 has a lower end portion 921 supported by the seal member 94 of the valve portion 93 and is disposed on the downstream side of the first connection portion 91 via the seal member 94. The second connecting portion 92 has a first posture (in the state shown in FIG. 3) in which the axes coincide with each other with respect to the first connecting portion 91, and the axis is a pressing portion 82 (operating operation with the lower end 921 as a fulcrum. And the second posture (state shown in FIG. 4) tilting in the direction of arrow C (operation direction) of the portion 8).

  The valve portion 93 includes a seal member 94 made of an elastic material, a flange portion 95 located on the upstream side of the seal member 94, and a biasing portion 96 that biases the flange portion 95 toward the seal member 94. ing.

  The seal member 94 has a link shape. The seal member 94 has an inner peripheral portion 941 that is in close contact with the outer peripheral portion 922 of the lower end portion 921 of the second connection portion 92. Further, the outer peripheral portion 942 of the seal member 94 is in close contact with the inner peripheral portion 914 of the storage portion 912 of the first connection portion 91. With such a seal member 94, the first connection portion 91 and the second connection portion 92 are airtightly connected through the seal member 94.

  The flange portion 95 has an outer diameter larger than the outer diameter of the second connection portion 92. The flange portion 95 is disposed to face the lower end surface of the second connection portion 92 with a gap 97 therebetween.

  In the present embodiment, the urging portion 96 is constituted by a compression coil spring. In the compressed state, the upper end portion 961 abuts on the flange portion 95 and the lower end portion 962 is the first connection portion 91. It abuts on the stepped portion 911. Thereby, the flange part 95 can be reliably urged | biased to the seal member 94 side.

  In the valve portion 93 having such a configuration, the flange portion 95 includes the biasing portion 96 when the second connecting portion 92 is in the first posture, that is, when no external force is applied to the second connecting portion 92. Urged to airtightly adhere to the seal member 94 (see FIG. 3). Thereby, the valve part 93 will be in a closed state.

  Further, when a pressing force in the direction of arrow C by the pressing portion 82 of the operation portion 8 acts on the second connection portion 92, the second connection portion 92 is displaced from the first posture to the second posture. At this time, the flange portion 95 is displaced against the urging force of the urging portion 96, whereby a part (or all) of the peripheral edge portion 951 of the flange portion 95 is separated from the seal member 94, A gap 98 is formed between the seal member 94 (see FIG. 4). As a result, the gas G flows from the first connecting portion 91 into the second connecting portion 92 through the gap 98, that is, the valve portion 93 is opened.

  In the opening / closing means 9 configured as described above, the valve portion 93 can be reliably opened / closed in conjunction with the pressing operation by the operation portion 8. Thereby, when the valve part 93 is in the closed state, the flow of the gas G from the cylinder 300 to the nozzle 4 can be reliably interrupted, and when the valve part 93 is in the open state, the flow of the gas G is reliably released. can do.

  In addition, although it does not specifically limit as a constituent material of the 1st connection part 91, the 2nd connection part 92, the flange part 95, and the biasing part 96, For example, various metal materials and various plastics, such as aluminum and stainless steel Etc. can be used alone or in combination.

  The constituent material of the seal member 94 is not particularly limited, and various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber can be used.

  As shown in FIGS. 1 and 2, the nozzle 4 is installed on the front plate 72 of the applicator main body 7. The nozzle 4 has passed through the gas G (gas) that has passed through the tube 10, the first liquid L 1 that has passed through the reduced diameter portion 22 of the first syringe 2, and the reduced diameter portion 22 of the second syringe 3. The second liquid L2 is discharged (spouted).

  As shown in FIGS. 5 to 9, the nozzle 4 is connected to the reduced diameter portion 22 of the first syringe 2, and the first inner tube 44 a through which the first liquid L <b> 1 passes and the second syringe 3 is reduced. Connected to the second tube 101, the second inner tube 44b through which the second liquid L2 passes, the outer tube 43 into which the first inner tube 44a and the second inner tube 44b are inserted, and the second tube 101. A supply pipe (gas supply pipe) 46 for supplying the gas G into the outer pipe 43 and a fixing member 41 for fixing the nozzle 4 to the front plate 72 of the applicator main body 7 (this fixing member 41 is shown in FIGS. It is omitted in the figure).

  The first inner pipe 44a, the second inner pipe 44b, the outer pipe 43, and the supply pipe 46 are each made of a hard material, made of a soft material, an elastic material, or the like, and has flexibility. Good. In this embodiment, it has flexibility. Examples of the constituent material of the first inner tube 44a include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, and acrylonitrile-butadiene-styrene copolymer. Various soft or hard resins such as polyester, polyester such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12), natural Various rubber materials such as rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, and various thermoplastic elastomers such as polyurethane, polyester, polyamide, olefin, and styrene Stainless steel, aluminum, various metal materials such as copper or copper-based alloy, various kinds of glass, alumina, various ceramics such as silica and the like.

  Since the first inner tube 44a and the second inner tube 44b have substantially the same configuration, the first inner tube 44a will be described as a representative.

  The first inner tube 44 a is formed of a long tubular body, and the base end portion thereof is connected (fitted) to the reduced diameter portion 22 of the first syringe 2.

  Further, the first inner tube 44a has a first liquid discharge port 442a opened at the tip thereof. That is, the distal end portion of the first inner tube 44a constitutes the first liquid discharge port 442a. The first liquid discharge port 442a is a part that discharges the first liquid L1 that flows out from the reduced diameter portion 22 of the first syringe 2 when the pusher 26 of the first syringe 2 is pressed.

  The first inner tube 44a has a circular cross-sectional shape (shape) of an inner periphery (inner peripheral surface) 443 and an outer periphery (outer peripheral surface) 444, respectively. That is, when the nozzle 4 is viewed from the tip end side, the shapes of the inner circumference 443 and the outer circumference 444 of the first inner tube 44a are each circular. Therefore, as shown in FIG. 10, the inner periphery 443 and the outer periphery 444 of the first liquid discharge port 442a are also circular.

  Further, as shown in FIG. 10, the thickness of the tube wall of the first liquid discharge port 442a is constant along the circumferential direction. Thereby, the inner periphery 443 and the outer periphery 444 of the first liquid discharge port 442a are arranged concentrically.

  The second inner tube 44b also has a second liquid discharge port 442b opened at the tip thereof, and has the same configuration as the first inner tube 44a described above.

  The central axis (axis) 440a of the first inner tube 44a and the central axis (axis) 440b of the second inner tube 44b are parallel to each other. Thereby, the outer diameter (thickness) of the nozzle 4, particularly the proximal end side of the nozzle 4, can be reduced (thinned).

  Together with the first inner tube 44a and the second inner tube 44b, the supply tube 46 is also inserted into the outer tube 43 (see FIGS. 5 to 9). The supply pipe 46 is formed of a long tubular body, and a base end portion 462 thereof is connected to the second tube 101. The base end portion 462 is located between the base end portion of the first inner pipe 44a and the base end portion of the second inner pipe 44b that are arranged side by side.

  In addition, the supply pipe 46 has a distal end 463 positioned at the proximal end (in the middle) of the outer pipe 43. The gas G is ejected from the tip 463, whereby the gas G is supplied into the outer tube 43.

  Further, the vicinity of the tip 463 of the supply pipe 46 is liquid-tightly fixed to the inner peripheral surface 431 of the outer pipe 43 through the fixing portion 48 together with the first inner pipe 44a and the second inner pipe 44b. The material of the fixing portion 48 is not particularly limited, and for example, the materials mentioned in the description of the seal member 94 can be used.

  The first inner pipe 44a, the second inner pipe 44b, and the supply pipe 46 are collectively stored in the outer pipe 43. The outer tube 43 is formed of a long tubular body, and a base end portion thereof is connected to a distal end opening 412 of the fixing member 41.

  As described above, the distal end 463 of the supply pipe 46 is located at the proximal end portion of the outer pipe 43, and the gas G is supplied into the outer pipe 43 through the distal end 463. The supplied gas G passes between the outer tube 43, the first inner tube 44a, and the second inner tube 44b (gap).

  As shown in FIGS. 5 to 10, the outer tube 43 has two lumens opened at the tip (tip portion) thereof, that is, a first lumen 433 a and a second lumen 433 b. The first lumen 433a and the second lumen 433b are provided so that their center lines (axis lines) are parallel to each other and are close to each other, and a communication portion 438 provided along the longitudinal direction thereof. By this, it communicates along the longitudinal direction. The communication portion 438 passes between a first adjacent portion 446a and a second adjacent portion 446b, which will be described later, and is connected to the central axes 440a and 440b (the central axis of the first lumen 433a and the central axis of the second lumen 433b). Arranged along parallel axes. Therefore, the first lumen 433a and the second lumen 433b in the vicinity of the first adjacent portion 446a and the second adjacent portion 446b communicate with each other through the communication portion 438.

  As shown in FIG. 10, each of the first lumen 433a and the second lumen 433b has a circular cross-sectional shape (shape) of the inner periphery (inner peripheral surface) 434. That is, when the nozzle 4 is viewed from the distal end side, the shapes of the inner circumferences 434 of the first lumen 433a and the second lumen 433b are circular. The radius r of the first lumen 433a having the above shape (the same applies to the second lumen 433b) is set larger than the radius R of the outer periphery 444 of the first liquid discharge port 442a of the first inner tube 44a. The first inner tube 44a is inserted (arranged) into the first lumen 433a, and the second inner tube 44b is inserted (arranged) into the second lumen 433b. The positions of the distal end surface of the first inner tube 44a, the distal end surface of the second inner tube 44b, and the distal end surface of the outer tube 43 in the longitudinal direction (axial direction) of the outer tube 43 are the same.

  The outer pipe 43 has a gas jet opening 42 that opens at the tip and is disposed around the first liquid discharge port 442a and the second liquid discharge port 442b, from which the gas G supplied from the supply pipe 46 is jetted. ing. Between the inner peripheral surface 431 of the outer tube 43 and the outer peripheral surface 444 of the first inner tube 44a and the outer peripheral surface 444 of the second inner tube 44b at the tip (tip portion) of the nozzle 4, that is, the first inner Gas between the inner peripheral surface 443 of the cavity 433a and the outer peripheral surface 444 of the first inner tube 44a and between the inner peripheral surface 443 of the second lumen 433b and the outer peripheral surface 444 of the second inner tube 44b. The jet nozzle 42 is configured.

  Further, the first liquid discharge port 442a and the second liquid discharge port 442b are respectively opposite to each other through the first adjacent portion 446a and the second adjacent portion 446b adjacent to each other, the first adjacent portion 446a and the central axis 440a. It has the 1st distal part 447a and the 2nd adjacent part 446b, and the 2nd distal part 447b on the opposite side via the central axis 440b.

  In addition, the gas ejection port 42 is a region on the first distal portion 447a side from the central shaft 440a and a region on the second distal portion 447b side from the central shaft 440b, as compared to the region 51 between the central shaft 440a and the central shaft 440b. 52 is unevenly distributed. That is, when the nozzle 4 is viewed from the tip side, the area of the gas outlet 42 is larger than the region 51 between the central axis 440a and the central axis 440b, and the first distal portion 447a side and the central axis 440a. The region 52 on the second distal portion 447b side is larger than the central axis 440b.

  In the present embodiment, when the nozzle 4 is viewed from the tip side, the first liquid discharge port 442a is eccentric to the first adjacent portion 446a side with respect to the first lumen 433a, and the second liquid discharge port 442b is the second. The first adjacent portion 446a and the second adjacent portion 446b are in contact with each other via the communicating portion 438, which is eccentric to the second adjacent portion 446b side with respect to the lumen 433b. That is, the first inner tube 44a and the second inner tube 44b are in contact with each other along the longitudinal direction thereof via the communication portion 438.

  Thereby, the ejection amount of the gas G becomes larger from the first distal portion 447a and the second distal portion 447b side than from the first adjacent portion 446a and the second adjacent portion 446b side. As a result, the first liquid L1 discharged from the first liquid discharge port 442a and the second liquid L2 discharged from the second liquid discharge port 442b flow in directions approaching each other, and thereby The first liquid L1 and the second liquid L2 are reliably mixed.

  Here, when the nozzle 4 is viewed from the front end side, the area of the gas outlet 42 in the region 51 between the central axis 440a and the central axis 440b is S1, the first distal portion 447a side and the center from the central axis 440a. When the area of the gas outlet 42 in the region 52 on the second distal portion 447b side from the shaft 440b is S2, the ratio S1 / S2 is preferably about 0.1 to 0.3, and 0.13 It is more preferably about ˜0.23, and further preferably about 0.17 to 0.22. Thereby, the 1st liquid L1 and the 2nd liquid L2 are mixed more reliably.

  Moreover, the 1st adjacent part 446a and 2nd adjacent part 446b are adhere | attached by adhesion | attachment, a fusion | melting, etc., for example. That is, the first inner tube 44a and the second inner tube 44b are fixed along the longitudinal direction thereof. This fixing portion is located at the communication portion 438. As a result, of the first liquid discharge port 442a and the second liquid discharge port 442b, the first adjacent portion 446a and the second adjacent portion 446b and portions in the vicinity thereof are located in the first lumen 433a and the second lumen 433b. The first liquid discharge port 442a and the second liquid discharge port 442b are in contact with the inner periphery (inner peripheral surface) 434, and are fixed with respect to the first lumen 433a and the second lumen 433b. That is, the first inner tube 44a and the second inner tube 44b abut against the inner circumference 434 of the first lumen 433a and the second lumen 433b, and are fixed to the first lumen 433a and the second lumen 433b. The

  Thereby, the gas ejection port 42 is maintained constant, so that the gas G can be ejected uniformly and reliably through the gas ejection port 42. Thereby, the first liquid L1 and the second liquid L2 are surely atomized and ejected.

  In addition, it is not necessary to separately provide a fixing member for fixing the first liquid discharge port 442a and the second liquid discharge port 442b to the first lumen 433a and the second lumen 433b, thereby reducing the manufacturing process. In addition, the number of parts can be reduced.

  In addition, the radius R of the outer periphery 444 of the first liquid discharge port 442a and the second liquid discharge port 442b is not particularly limited. For example, when the applicator 1 is used in laparoscopic surgery, it is 0.2 to 1 mm. Is preferable, and it is more preferable that it is 0.4-0.8 mm.

  In order to manufacture the nozzle 4, first, an outer tube 43 having a first lumen 433a and a second lumen 433b, a first inner tube 44a, and a second inner tube 44b are prepared.

  Next, the first inner tube 44a and the second inner tube 44b are fixed by, for example, adhesion or melting.

Next, the first inner tube 44 a and the second inner tube 44 b are inserted into the outer tube 43 from the proximal end side of the outer tube 43. That is, the first inner tube 44a and the second inner tube 44b are inserted into the first lumen 433a and the second lumen 433b, respectively. Accordingly, as described above, the first inner tube 44a and the second inner tube 44b abut against the inner circumference 434 of the first lumen 433a and the second lumen 433b, and the first lumen 433a and the second lumen It is fixed to 433b.
In this way, the nozzle 4 can be easily manufactured.

  In the configuration shown in FIG. 10, the first liquid discharge port 442a (first inner tube 44a) and the second liquid discharge port 442b (second inner tube 44b) have the same size. The first lumen 433a and the second lumen 433b are also the same size. In the applicator 1, since the first lumen 433a and the second lumen 433b are formed corresponding to the first liquid discharge port 442a and the second liquid discharge port 442b, respectively, for example, it is applied to the affected area. The sizes of the first liquid discharge port 442a and the second liquid discharge port 442b can be made different from each other according to the mixed liquid (the type of the first liquid L1 and the second liquid L2). Thus, the sizes of the first lumen 433a and the second lumen 433b can also be appropriately changed.

  Moreover, as shown in FIG. 1, it is preferable that the nozzle 4 can be bent (or bent) in the vicinity of the tip portion thereof as necessary. Thereby, for example, when using the applicator 1 in laparoscopic surgery, the operation of inserting the tip of the nozzle 4 into the abdominal cavity can be facilitated.

  As shown in FIG. 10 (also in FIG. 1), a marker 437 is provided on the outer surface of the nozzle 4 (outer tube 43) so that the direction in which the two liquid discharge ports 442a and 442b are arranged can be visually confirmed. . Thereby, when using the applicator 1, the application | coating operation can be performed confirming the juxtaposition direction of the two liquid discharge ports 442a and 442b.

  Moreover, as shown in FIGS. 5-9, in the base end part (middle) of the 1st inner pipe 44a and the base end part (middle) of the 2nd inner pipe 44b, respectively, in the vicinity of the applicator main body 7, A volume increasing / decreasing portion (flow path forming member) 441 that deforms so as to increase or decrease the internal volume is provided. The volume increasing / decreasing unit 441 in the first inner pipe 44 a and the volume increasing / decreasing unit 441 in the second inner pipe 44 b are arranged at symmetrical positions via the supply pipe 46.

  An expansion portion (balloon) 461 that expands and contracts according to the flow rate (supply amount) of the gas G is provided in the supply pipe 46. The expansion part 461 is disposed at a position corresponding to each volume increasing / decreasing part 441. That is, the expansion part 461 is disposed between the volume increasing / decreasing part 441 of the first inner pipe 44a and the volume increasing / decreasing part 441 of the second inner pipe 44b. The extension portion 461 arranged at such a position is set to have a thickness (tube wall) thinner than the surrounding (front and rear) portions. As a result, the gas G is supplied (inflows) into the expansion portion 461 so that the gas G is reliably expanded, and the supply of the gas G is stopped to reliably contract. The expansion part 461 functions as a deformation means for deforming each volume increasing / decreasing part 441 so that the volume increases or decreases by expansion / contraction.

  As shown in FIGS. 5 and 9, in the natural state, the expanded portion 461 has an outer diameter that is slightly larger than the outer diameter of the supply pipe 46 before and after that, that is, is most contracted. In this state, the expansion part 461 may be in contact with each volume increasing / decreasing part 441 so as not to be pressed, or may be separated from each volume increasing / decreasing part 441. In the configuration shown in FIGS. 5 and 9, the expansion portion 461 is in contact with the volume increasing / decreasing portions 441 so as not to be pressed. At this time, each volume increasing / decreasing unit 441 has a maximum volume. The “natural state” refers to a state where no external force is applied, that is, a state where the gas G is not supplied inside.

  Moreover, as shown in FIGS. 6-8, when gas is supplied to the supply pipe | tube 46, the expansion part 461 is expanded also by supplying gas also to the inside. The expanded expanded portion 461 presses (presses) the volume increasing / decreasing portions 441 against the respective elastic forces of the volume increasing / decreasing portions 441. Thereby, each volume of each volume increase / decrease part 441 reduces. Note that the degree of pressing of the expanded expansion portion 461 against the volume increase / decrease portion 441 is set such that the inner peripheral surfaces of the volume increase / decrease portions 441 do not adhere to each other.

  Further, when the expanded expansion part 461 contracts again, the pressure on each volume increasing / decreasing part 441 is released. Thereby, each volume increase / decrease part 441 each restore | restores by own elasticity (refer FIG. 9).

  The nozzle 4 also has a ring (band) 47 that collectively holds the volume increasing / decreasing portion 441 of the first inner tube 44a, the volume increasing / decreasing portion 441 of the second inner tube 44b, and the expanding portion 461 from the outside. Yes. The ring 47 is formed, for example, by winding a band made of a plastic material. The ring 47 regulates the positional relationship between the two volume increasing / decreasing portions 441 and the expansion portion 461 regardless of the expansion / contraction of the expansion portion 461. Thereby, when the expansion part 461 expands, each volume increasing / decreasing part 441 is reliably pressed by the expanded expansion part 461.

  As described above, in the applicator 1, the volumes of the volume increasing / decreasing units 441 and 441 are reliably changed by the expansion / contraction of the expansion unit 461.

  As shown in FIGS. 1 and 2, the fixing member 41 is disposed at the proximal end portion of the nozzle 4. The fixing member 41 is configured by a hollow body having a distal end opening 412 and a proximal end opening 411. The proximal end of the outer tube 43 is airtightly connected to the distal end opening 412, and the proximal end opening 411 is connected and fixed to the front plate 72 of the applicator main body 7. Further, on the inner side of the fixing member 41, a connection portion between the first inner tube 44a and the first syringe 2, a connection portion between the second inner tube 44b and the second syringe 3, and the tube 10 of the supply tube 46 are connected. The connecting portion (base end portion 462) is located. Thereby, each connection part can be covered and therefore each connection part can be protected.

  Next, the first syringe 2 filled with the first liquid L1 and the second syringe 3 filled with the second liquid L2 are loaded, and the cylinder 300 is ready for use. The operating state of the applicator 1 in a state of being connected to will be described.

  The first syringe 2 and the second syringe 3 are respectively filled with the first liquid L1 and the second liquid L2 having a sufficient amount of liquid necessary for applying to the affected area. Further, the cylinder 300 has the valve 301 in an open state, so that the gas G can be supplied to the applicator 1.

  Further, in the applicator 1, a force that creates a gap 98 between the seal member 94 and the flange portion 95 against the force (biasing force) of the urging portion 96 that presses the flange portion 95 against the seal member 94, that is, a force. The pressing force in the direction of the arrow C that tilts the second connecting portion 92 from the first posture to the second posture causes the pusher 26 of the first syringe 2 and the pusher 26 of the second syringe 3 to move. It is set to be larger than the force to move in the distal direction. As a method for performing such setting, for example, various conditions such as the spring constant of the urging portion 96, the viscosity of each liquid, and the inner diameter of each outer cylinder 21 can be set as appropriate.

  For such an applicator 1, first, for example, an index finger is hung on the finger hanging portion 751 of the applicator main body 7, a middle finger is hung on the finger hanging portion 752, and a thumb is hung on the pressing portion 82 of the operation portion 8. At this time, the first liquid L1 is not supplied to the first inner pipe 44a, the second liquid L2 is not supplied to the second inner pipe 44b, and the gas G is supplied also to the supply pipe 46. It has not been done (see FIG. 5). For this reason, the gas G, the first liquid L1, and the second liquid L2 are not discharged from the nozzle 4. Moreover, since the expansion part 461 is not expanded, the compression to each volume increase / decrease part 441 by it is not made.

  Next, when the pressing portion 82 is pressed with the thumb in this state, first, the second connecting portion 92 is tilted, and a gap 98 is formed between the seal member 94 and the flange portion 95. Gas G circulates through (see FIG. 4). As a result, the gas G flows into the supply pipe 46 via the second tube 102, flows into the outer pipe 43 of the nozzle 4 from the tip 463 of the supply pipe 46, and the first lumen 433 a and the first inner It flows in the distal direction between the tube 44a and between the second lumen 433b and the second inner tube 44b, and is ejected from the gas ejection port 42 at high speed (see FIG. 6). The ejection amount of the gas G is larger from the first distal portion 447a and the second distal portion 447b than from the first adjacent portion 446a and the second adjacent portion 446b. At this time, since the expansion portion 461 expands, each volume increasing / decreasing portion 441 is compressed. The expansion of the expansion part 461 is maintained until the supply of the gas G to the expansion part 461 is stopped.

  Further, the pressing operation with respect to the pressing portion 82 by the thumb has not reached the entire operation portion 8, that is, the respective pushers 26 are moved in the distal direction. For this reason, the first liquid L1 and the second liquid L2 are not yet supplied to the first inner pipe 44a and the second inner pipe 44b.

  Further, when the pressing portion 82 is pressed, the tilt of the second connecting portion 92 becomes a limit, and the pressing force from the thumb is transmitted to the connecting portion 81 via the pressing portion 82. As a result, the connecting portion 81 (the entire operation portion 8) starts to move, so that the first liquid L1 is pushed out from the first syringe 2 and the second liquid L2 is pushed out from the second syringe 3 as well. . The pushed-out first liquid L1 passes through the volume increasing / decreasing unit 441 while being compressed by the expansion unit 461, and further toward the distal end, that is, to the first liquid discharge port 442a of the first inner tube 44a. It ejects from there (see FIG. 7). Further, the second liquid L2 passes through the volume increasing / decreasing portion 441 that is still compressed by the expansion portion 461, and reaches the second liquid discharge port 442b of the second inner tube 44b in substantially the same manner as the first liquid L1. From there, the liquid is discharged (see FIG. 7).

  The discharged first liquid L1 and second liquid L2 are entrained in the gas G ejected at high speed. Thereby, the 1st liquid L1 and the 2nd liquid L2 become mist form, respectively, are mutually mixed, and are apply | coated to an affected part. At this time, since the amount of gas G ejected from the first distal portion 447a and the second distal portion 447b is larger than that of the first adjacent portion 446a and the second adjacent portion 446b, the first liquid discharge The first liquid L1 discharged from the outlet 442a and the second liquid L2 discharged from the second liquid discharge port 442b each flow in directions approaching each other, whereby the first liquid L1 and the second liquid L2 are discharged. The liquid L2 is reliably mixed. Further, since the first liquid discharge port 442a of the first inner tube 44a and the second liquid discharge port 442b of the second inner tube 44b are fixed with respect to the first lumen 433a and the second lumen 433b, the gas G Is sprayed uniformly. Thereby, each of the first liquid L1 and the second liquid L2 is reliably atomized, so that the first liquid L and the second liquid L2 are reliably mixed and applied to the affected part.

  After the application of a predetermined amount to the affected area is completed, when the pressing force applied to the thumb pressing section 82 (operation section 8) is loosened, the movement of the entire operation section 8 is first stopped. Thereby, the movement of each pusher 26 is stopped, and thus the ejection of the first liquid L1 and the second liquid L2 is stopped (see FIG. 8). At this time, since the 2nd attitude | position of the 2nd connection part 92 by the press of the press part 82 is maintained, the gas G is still injecting (refer FIG. 8).

  Furthermore, when the pressing force of the thumb against the pressing portion 82 is loosened, the thumb that has been pressing the pressing portion 82 is finally separated from the pressing portion 82. Thereby, the pressing force with respect to the second connection portion 92 is released, and the second connection portion 92 returns to the first posture. Thereby, the gap 98 between the seal member 94 and the flange portion 95 disappears, that is, the seal member 94 and the entire periphery of the peripheral edge portion 951 of the flange portion 95 are in close contact with each other (see FIG. 3). At this time, the supply of the gas G to the supply pipe 46 is stopped, so that the ejection of the gas G from the gas outlet 42 is also stopped (see FIG. 9).

  Further, when the supply of the gas G to the supply pipe 46 is stopped, the expansion portion 461 contracts (see FIG. 9). As a result, the pressure applied to each volume increasing / decreasing unit 441 of the expansion unit 46 is released, and the volume of each volume increasing / decreasing unit 441 is higher than that in a state of discharging the liquid (first liquid L1, second liquid L2). Also increases (increases). By increasing the volume, the leading end P1 of the first liquid L1 is drawn to the rear end side of the first liquid discharge port 442a of the first inner tube 44a, and the leading end P2 of the second liquid L2 is also second. The inner tube 44b is drawn to the rear end side of the second liquid discharge port 442b (see FIG. 9).

  As described above, the leading end P1 of the first liquid L1 and the leading end P2 of the second liquid L2 are drawn, whereby the first liquid discharge port 442a of the first inner pipe 44a and the second liquid discharge of the second inner pipe 44b. In the vicinity of the outlet 442b, the first liquid L1 and the second liquid L2 can be prevented from being mixed and solidified. As a result, clogging occurring at the first liquid discharge port 442a of the first inner tube 44a, the second liquid discharge port 442b of the second inner tube 44b, and the gas outlet 42 after use (after application) of the applicator 1 ( It is possible to reliably prevent the first liquid L1 and the second liquid L2 from mixing and adhering to a solidified product). Then, the applicator 1 in a state where the clogging does not occur can be used again for application to the affected area. At this time, a uniform gas G is ejected, so that a mixed liquid in which the first liquid L and the second liquid L2 are uniformly mixed can be applied.

  The applicator 1 is configured such that the gas G is discharged from the nozzle 4 prior to the first liquid L1 and the second liquid L2. Thereby, it is possible to prevent only the first liquid L1 and the second liquid L2 from being ejected and applied to the affected area. Further, the first liquid L1 and the second liquid L2 are surely sprayed in the form of mist by the gas G ejected in advance, so that these liquids are reliably mixed.

  Further, in the applicator 1, the gas G is configured to stop ejecting later than the first liquid L1 and the second liquid L2. Thereby, when each liquid remains (attaches) to each discharge port by stopping the ejection of each liquid, the gas G can blow off these remaining liquids. Therefore, the first liquid L1 and the second liquid L2 react at the first liquid discharge port 442a of the first inner tube 44a, the second liquid discharge port 442b of the second inner tube 44b, and the gas outlet 42. Inconvenience (for example, clogging due to coagulation) caused by the above can be prevented more reliably. Then, the applicator 1 in a state in which this inconvenience has not occurred can be used again for application to the affected area. In addition, when the applicator 1 is used again, the gas G is uniformly ejected, so that a mixed liquid in which the first liquid L and the second liquid L2 are uniformly mixed can be applied.

  The first embodiment can be applied to fifth and sixth embodiments described later.

Second Embodiment
FIG. 11: is the figure (front view) which looked at the nozzle in 2nd Embodiment of the applicator of this invention from the front end side.

  Hereinafter, the second embodiment of the nozzle and applicator of the present invention will be described with reference to this figure, but the description will focus on the differences from the first embodiment described above, and the description of the same matters will be omitted. .

  The second embodiment is the same as the first embodiment except that the shapes of the first lumen 433a and the second lumen 433b are different.

  As shown in FIG. 11, in the nozzle 4 of the applicator 1, when the nozzle 4 is viewed from the distal end side, the first adjacent portion 446 a side from the central axis 440 a of the first inner tube 44 a of the first lumen 433 a. The shape of the inner periphery 434 of the portion and the shape of the inner periphery 434 of the portion of the second lumen 433b closer to the second adjacent portion 446b than the central axis 440b of the second inner tube 44b are arcuate, respectively, and the first lumen 433a The shape of the inner periphery 434 of the portion on the first distal portion 447a side from the central axis 440a of the second inner periphery and the shape of the inner periphery 434 of the portion of the second lumen 433b on the second distal portion 447b side of the second lumen 433b are respectively polygonal It is part of the shape.

  Further, the radius r2 of the arc-shaped portion of the first lumen 433a is equal to the radius of the outer periphery 444 of the first liquid discharge port 442a (first inner tube 44a), and they are in close contact with each other, so that the second lumen 433b The radius r2 of the arc-shaped portion is equal to the radius of the outer periphery 444 of the second liquid discharge port 442b (second inner tube 44b), and they are in close contact with each other.

  In the region 52 on the right side in FIG. 11, the inner periphery 434 of the first lumen 433a and the outer periphery 444 of the first liquid discharge port 442a (first inner tube 44a) are in contact with each other through two contact points 45. . Similarly, in the region 52 on the left side in FIG. 11, the inner periphery 434 of the second lumen 433b and the outer periphery 444 of the second liquid discharge port 442b (second inner tube 44b) are in contact with each other by two contact points 45. Yes.

  Thereby, the first inner tube 44a and the second inner tube 44b are more reliably fixed to the first lumen 433a and the second lumen 433b, respectively. For this reason, the 1st inner pipe 44a and the 2nd inner pipe 44b do not need to adhere. Needless to say, the first inner tube 44a and the second inner tube 44b may be fixed.

  This second embodiment can be applied to fifth and sixth embodiments described later.

<Third Embodiment>
FIG. 12: is the figure (front view) which looked at the nozzle in 3rd Embodiment of the applicator of this invention from the front end side.

  Hereinafter, the third embodiment of the nozzle and applicator of the present invention will be described with reference to this figure, but the description will focus on the differences from the second embodiment described above, and the description of the same matters will be omitted. .

  The third embodiment is the same as the second embodiment except that the shapes of the first lumen 433a and the second lumen 433b are different.

  As shown in FIG. 12, in the nozzle 4 of the applicator 1, when viewed from the tip side, the nozzle 4 is closer to the first adjacent portion 446a than the central axis 440a of the first inner tube 44a of the first lumen 433a. The shape of the inner periphery 434 of the portion and the shape of the inner periphery 434 of the portion of the second lumen 433b closer to the second adjacent portion 446b than the central axis 440b of the second inner tube 44b are arcuate, respectively, and the first lumen 433a The shape of the inner periphery 434 of the portion on the first distal portion 447a side from the central axis 440a of the second inner periphery and the shape of the inner periphery 434 of the portion of the second lumen 433b on the second distal portion 447b side of the second lumen 433b are respectively polygonal Each of the corners has a rounded shape.

  In the region 52 on the right side in FIG. 12, the inner periphery 434 of the first lumen 433a and the outer peripheral surface 444 of the first liquid discharge port 442a (first inner tube 44a) are in contact with each other by one contact 45. . Similarly, in the region 52 on the left side in FIG. 12, the inner periphery 434 of the second lumen 433b and the outer periphery 444 of the second liquid discharge port 442b (second inner tube 44b) are in contact with each other by one contact 45. Yes.

  The third embodiment can be applied to fifth and sixth embodiments described later.

<Fourth embodiment>
FIG. 13: is the figure (front view) which looked at the nozzle in 4th Embodiment of the applicator of this invention from the front end side.

  Hereinafter, the fourth embodiment of the nozzle and applicator of the present invention will be described with reference to this figure, but the description will focus on the differences from the first embodiment described above, and the description of the same matters will be omitted. .

  As shown in FIG. 13, in the nozzle 4 of the applicator 1 of the fourth embodiment, the outer tube 43 has one lumen 433 that opens to the tip, and the first liquid discharge port 442a (first The first inner pipe 44a) and the second liquid discharge port 442b (second inner pipe 44b) are collectively inserted (arranged).

  Further, when the nozzle 4 is viewed from the distal end side, the shape of the inner periphery 434 of the lumen 433 is a rectangle (quadrangle). The length of the long side of the rectangle is equal to the total length of the diameter (radius R × 2) of the outer periphery 444 of the first liquid discharge port 442a and the diameter (radius R × 2) of the outer periphery 444 of the second liquid discharge port 442b. Or it is set slightly smaller than that. The length of the short side of the rectangle is set to be equal to or slightly smaller than the diameter (radius R × 2) of the outer periphery 444 of the first liquid discharge port 442a and the second liquid discharge port 442b.

  The inner periphery 434 of the lumen 433 and the outer peripheral surface 444 of the first liquid discharge port 442a (first inner tube 44a) are in contact with each other at three contact points 45, and among these, in the region 52 on the right side in FIG. One contact 45 is in contact. Similarly, the inner periphery 434 of the lumen 433 and the outer peripheral surface 444 of the second liquid discharge port 442b (second inner tube 44b) are in contact with each other at three contact points 45. In the region 52 on the left side in FIG. The contact 45 is in contact.

  Thereby, the first inner tube 44a and the second inner tube 44b are more reliably fixed to the lumen 433, respectively. For this reason, the 1st inner pipe 44a and the 2nd inner pipe 44b do not need to adhere. Needless to say, the first inner tube 44a and the second inner tube 44b may be fixed.

  Further, in the lumen 433 of the outer tube 43, a pair of ribs (convex projections) is used as an opening closing portion that closes at least a part of the tip opening of the outer tube 43 in the vicinity of the first adjacent portion 446a and the second adjacent portion 446b. Article 439) is provided.

  Each rib 439 is in contact with the outer peripheral surface 444 of the first liquid discharge port 442a (first inner tube 44a) and the outer peripheral surface 444 of the second liquid discharge port 442b (second inner tube 44b). . Thereby, the first inner tube 44a and the second inner tube 44b are more reliably fixed to the lumen 433, respectively.

  Each of the ribs 439 may be formed on the outer tube 43, or may be formed of a separate member from the outer tube 43 so that it is inserted (installed) into the lumen 433 of the outer tube 43. It may be.

  The fourth embodiment can be applied to fifth and sixth embodiments described later.

<Fifth Embodiment>
FIG. 14: is a perspective view which shows the front end side of the nozzle in 5th Embodiment of the applicator of this invention. For convenience of explanation, the upper side in FIG. 14 is referred to as “front end” and the lower side is referred to as “rear end (base end)”.

  Hereinafter, the fifth embodiment of the nozzle and applicator of the present invention will be described with reference to this figure, but the description will focus on the differences from the fourth embodiment described above, and the description of the same matters will be omitted. .

  In the fifth embodiment, the first liquid discharge port 442a (first inner tube 44a) and the second liquid discharge port 442b (second inner tube 44b) are different in shape and do not have a pair of ribs 439. Is the same as in the fourth embodiment.

  As shown in FIG. 14, in the nozzle 4 of the applicator 1, the first adjacent portion 446a and the second adjacent portion 446b are proximal to the first distal portion 447a and the second distal portion 447b, respectively. Is located.

  In the illustrated configuration, the front end surface 445 of the first liquid discharge port 442a and the front end surface 445 of the second liquid discharge port 442b are respectively connected to the central axis 440a of the first inner tube 44a and the central axis 440b of the second inner tube 44b. The first adjacent portion 446a is located proximal to the first distal portion 447a and the second adjacent portion 446b is proximal to the second distal portion 447b. It is designed to be located on the side.

  As a result, generally, the first liquid L1 discharged from the first liquid discharge port 442a and the second liquid L2 discharged from the second liquid discharge port 442b are ejected in a direction approaching each other, thereby The first liquid L1 and the second liquid L2 are reliably mixed.

  In addition, the distance H between the first adjacent portion 446a and the first distal portion 447a in the direction of the central axis 440a (longitudinal direction) is not particularly limited. For example, when the applicator 1 is used in laparoscopic surgery, It is preferably about 1 to 1.0 mm, and more preferably about 0.5 to 0.8 mm.

  The first adjacent portion 446a and the second adjacent portion 446b are located on the proximal end side from the distal end surface of the outer tube 43, and the first distal portion 447a, the second distal portion 447b, and the outer tube 43 The position in the longitudinal direction of the outer tube 43 is coincident with the distal end surface.

  Thereby, since the 1st liquid L1 and the 2nd liquid L2 are partly mixed in the lumen | bore 433, and are entrained in the gas G which ejected, it can mix more reliably.

The front end surface 445 of the first liquid discharge port 442a and the front end surface 445 of the second liquid discharge port 442b are flat surfaces, but are not limited thereto, and may be, for example, a curved concave surface, a curved convex surface, or the like. .
The fifth embodiment can be applied to the first to fourth embodiments.

<Sixth Embodiment>
FIG. 15: is a perspective view which shows the front end side of the nozzle in 6th Embodiment of the applicator of this invention. For convenience of explanation, the upper side in FIG. 15 is referred to as “tip”, and the lower side is referred to as “rear end (base end)”.

  Hereinafter, the sixth embodiment of the nozzle and applicator of the present invention will be described with reference to this figure, but the description will focus on the differences from the fifth embodiment described above, and the description of the same matters will be omitted. .

  The sixth embodiment is the same as the fifth embodiment except that the shapes of the first liquid discharge port 442a (first inner tube 44a) and the second liquid discharge port 442b (second inner tube 44b) are different.

  As shown in FIG. 15, in the nozzle 4 of the applicator 1, the first liquid discharge port 442a and the second liquid discharge port 442b each have a step, and the first adjacent portion 446a is caused by each step. The first distal portion 447a is located on the proximal side, and the second adjacent portion 446b is located on the proximal side with respect to the second distal portion 447b.

  Since the first inner tube 44a and the second inner tube 44b have substantially the same configuration, the first inner tube 44a will be described as a representative.

  The portion 4451 on the first adjacent portion 446a side of the central axis 440a of the distal end surface 445 of the first liquid discharge port 442a is located on the proximal side of the portion 4451 on the first distal portion 447a side of the central axis 440a.

  The portions 4451 and 4452 of the distal end surface 445 are perpendicular to the central axis 440a, and the side surface 448 between the portions 4451 and 4452 of the distal end surface 445 is parallel to the central axis 440a. The portions 4451 and 4452 and the side surface 448 of the tip surface 445 are flat.

  In the present invention, the present invention is not limited to this, and the portions 4451 and 4452 and the side surface 448 of the distal end surface 445 may be, for example, a curved concave surface, a curved convex surface, or the like.

Further, the portions 4451 and 4452 of the front end surface 445 and the side surface 448 may be inclined with respect to the central axis 440a.
The fifth embodiment can be applied to the first to fourth embodiments.

  As described above, the nozzle and the applicator of the present invention have been described based on the illustrated embodiment, but the present invention is not limited to this, and the configuration of each part is an arbitrary configuration having the same function. Can be replaced. Moreover, other arbitrary structures and processes may be added to the present invention.

  Further, the present invention may be a combination of any two or more configurations (features) of the above embodiments. For example, any one of the first to fourth embodiments may be combined with any one of the fifth and sixth embodiments.

  The nozzle of the present invention may have three or more inner tubes. For example, you may have a 3rd inner pipe | tube.

  Moreover, in the said embodiment, although comprised so that 2 types of liquids from which a liquid composition differs may be ejected, in this invention, it is not restricted to this, For example, 3 or more types of liquids may be ejected.

  Moreover, the use of the nozzle of this invention is not specifically limited, For example, it can apply to various sprayers. In addition, in the said embodiment, the applicator was demonstrated as one Embodiment (subordinate concept) of a sprayer.

It is a perspective view which shows 1st Embodiment of the applicator of this invention. It is a perspective view which shows 1st Embodiment of the applicator of this invention. It is AA sectional view taken on the line of the opening-closing means of the applicator shown in FIG. 1 (The figure which shows the state by which the gas flow path was interrupted | blocked). It is AA sectional view taken on the line of the opening-closing means of the applicator shown in FIG. 1 (The figure which shows the state by which the gas flow path was open | released). FIG. 2 is a schematic partial longitudinal sectional view of a nozzle and syringe of the applicator shown in FIG. FIG. 2 is a schematic partial longitudinal sectional view of a nozzle and syringe of the applicator shown in FIG. FIG. 2 is a schematic partial longitudinal sectional view of a nozzle and syringe of the applicator shown in FIG. FIG. 2 is a schematic partial longitudinal sectional view of a nozzle and syringe of the applicator shown in FIG. FIG. 2 is a schematic partial longitudinal sectional view of a nozzle and syringe of the applicator shown in FIG. It is the figure (front view) which looked at the nozzle of the applicator shown in FIG. 1 from the front end side (arrow B direction in FIG. 1). It is the figure (front view) which looked at the nozzle in 2nd Embodiment of the applicator of this invention from the front end side. It is the figure (front view) which looked at the nozzle in 3rd Embodiment of the applicator of this invention from the front end side. It is the figure (front view) which looked at the nozzle in 4th Embodiment of the applicator of this invention from the front end side. It is a perspective view which shows the front end side of the nozzle in 5th Embodiment of the applicator of this invention. It is a perspective view which shows the front end side of the nozzle in 6th Embodiment of the applicator of this invention. It is a fragmentary longitudinal cross-sectional view of the 1st syringe (a 2nd syringe is also the same) with which the applicator shown in FIG. 1 is loaded.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Applicator 2 1st syringe (1st liquid supply means)
20 Space (Liquid storage space)
21 outer cylinder 22 reduced diameter part (mouth)
23 Flange 24 Gasket 25 Hollow part 26 Pusher (plunger rod)
27 Main body 28 Head 29 Flange 3 Second syringe (second liquid supply means)
4 nozzle 41 fixing member 411 proximal end opening 412 distal end opening 42 gas outlet 43 outer tube 431 inner peripheral surface 433 lumen 433a first lumen 433b second lumen 434 inner periphery 437 marker 438 communicating portion 439 rib 44a first 1 inner pipe 44b 2nd inner pipe 440a, 440b central axis 441 Volume increase / decrease part (flow path forming member)
442a First liquid discharge port 442b Second liquid discharge port 443 Inner periphery (inner peripheral surface)
444 outer periphery (outer peripheral surface)
445 Front end surface 4451, 4452 Portion 446a First adjacent portion 446b Second adjacent portion 447a First distal portion 447b Second distal portion 448 Side surface 45 Contact 46 Supply pipe (gas supply pipe)
461 Expansion part (balloon)
462 Base end portion 463 Tip end 47 Ring 48 Fixing portion 51, 52 Region 7 Applicator main body 71 Base portion 711, 712 Recess 713 Guide 72 Front plate (first engagement portion)
721, 722 Groove 73 Rear plate (second engaging portion)
731 and 732 Recessed parts 751 and 752 Finger hooking part 8 Operation part 81 Connection part 811 and 812 Recessed part 813 Cylindrical part 82 Press part 83 Rail part 9 Opening and closing means (valve mechanism)
91 First connection portion 911 Step portion 912 Storage portion 913 Reduced diameter portion 914 Inner peripheral portion 92 Second connection portion 921 Lower end portion 922 Outer portion 93 Valve portion 94 Seal member 941 Inner peripheral portion 942 Outer peripheral portion 95 Flange portion 951 Periphery Part 96 Biasing part 961 Upper end part 962 Lower end part 97, 98 Gap 10 Tube (gas flow path)
101 first tube 102 second tube 300 cylinder (gas supply means)
301 Valve G gas (sterile gas)
L1 1st liquid L2 2nd liquid P1, P2 tip

Claims (14)

Liquids having different liquid compositions pass through the inside, and a first inner pipe and a second inner pipe whose central axes are parallel to each other;
A nozzle having the first inner pipe and the second inner pipe inserted therein, and an outer pipe through which gas passes between the first inner pipe and the second inner pipe,
The first inner tube and the second inner tube each have a first liquid discharge port and a second liquid discharge port that are open at the tip and discharge the liquid,
The outer tube has a gas outlet opening at the tip, arranged around the first liquid outlet and the second liquid outlet, and from which the gas is jetted.
The first liquid discharge port and the second liquid discharge port are respectively opposite to each other via a first adjacent portion and a second adjacent portion that are adjacent to each other, and the first adjacent portion and the central axis of the first inner tube. The first distal portion and the second adjacent portion, and a second distal portion opposite to the central axis of the second inner tube,
The nozzle, wherein the first adjacent portion and the second adjacent portion are located on the proximal side with respect to the first distal portion and the second distal portion, respectively.   The front end surface of the first liquid discharge port and the front end surface of the second liquid discharge port are inclined with respect to the central axis of the first inner tube and the central axis of the second inner tube, respectively. 2. The tilt according to claim 1, wherein the first adjacent portion is located proximal to the first distal portion and the second adjacent portion is located proximal to the second distal portion due to inclination. The nozzle described.   The first liquid discharge port and the second liquid discharge port each have a step, and the first adjacent portion is located on the proximal side with respect to the first distal portion due to the step, The nozzle according to claim 1, wherein the second adjacent portion is located on the proximal side with respect to the second distal portion.   The gas ejection port has a side closer to the first distal portion than the center axis of the first inner tube and the region between the center axis of the first inner tube and the center axis of the second inner tube. The nozzle according to any one of claims 1 to 3, wherein the nozzle is unevenly distributed toward a region on the second distal portion side with respect to a central axis of the second inner tube. A first inner pipe and a second inner pipe through which liquids having different liquid compositions pass;
A nozzle having the first inner pipe and the second inner pipe inserted therein, and an outer pipe through which gas passes between the first inner pipe and the second inner pipe,
The first inner tube and the second inner tube each have a first liquid discharge port and a second liquid discharge port that are open at the tip and discharge the liquid,
The outer tube has a gas outlet opening at the tip, arranged around the first liquid outlet and the second liquid outlet, and from which the gas is jetted.
The first liquid discharge port and the second liquid discharge port are respectively opposite to each other via a first adjacent portion and a second adjacent portion that are adjacent to each other, and the first adjacent portion and the central axis of the first inner tube. The first distal portion and the second adjacent portion, and a second distal portion opposite to the central axis of the second inner tube,
The gas ejection port has a side closer to the first distal portion than the center axis of the first inner tube and the region between the center axis of the first inner tube and the center axis of the second inner tube. A nozzle characterized by being unevenly distributed toward the region on the second distal portion side with respect to the central axis of the second inner tube.   The nozzle according to claim 5, wherein a central axis of the first inner pipe and a central axis of the second inner pipe are parallel to each other.   The outer tube has a first lumen and a second lumen that open at the distal end, the first liquid discharge port is inserted into the first lumen, and the second liquid discharge port is inserted into the second lumen. The nozzle according to claim 5 or 6, wherein the outlet is inserted and arranged. When the nozzle is viewed from the tip side, the outer shapes of the first liquid discharge port and the second liquid discharge port are each circular,
The shape of the inner periphery of the first lumen is circular, and the radius thereof is larger than the radius of the outer periphery of the first liquid discharge port, and the first liquid discharge port is the first with respect to the first lumen. 1 Eccentric to adjacent side,
The shape of the inner periphery of the second lumen is a circle, and the radius thereof is larger than the radius of the outer periphery of the second liquid discharge port, and the second liquid discharge port is the first with respect to the second lumen. The nozzle according to claim 7, wherein the nozzle is eccentric toward the two adjacent portions. When the nozzle is viewed from the tip side, the outer shapes of the first liquid discharge port and the second liquid discharge port are each circular,
The shape of the inner periphery of the portion of the first lumen on the side of the first adjacent portion from the central axis of the first inner tube and the side of the second adjacent portion of the second lumen from the central axis of the second inner tube The shape of the inner circumference of each part is arcuate,
The shape of the inner circumference of the first distal portion side portion of the first lumen from the central axis of the first inner tube and the second distal end of the second lumen from the central axis of the second inner tube The nozzle according to claim 7, wherein the shape of the inner periphery of the portion side portion is a part of a polygon or each corner is rounded.   When the nozzle is viewed from the tip side, the radius of the arc-shaped portion of the first lumen is substantially equal to the radius of the outer periphery of the first liquid discharge port, and the arc-shaped portion of the second lumen The nozzle according to claim 9, wherein the radius of the portion and the radius of the outer periphery of the second liquid discharge port are substantially equal. The outer tube has a communication portion that connects the first lumen and the second lumen in the vicinity of the first adjacent portion and the second adjacent portion,
The nozzle according to any one of claims 7 to 10, wherein the first adjacent portion and the second adjacent portion are in contact with each other through the communication portion. The outer tube has one lumen opened at a tip, and the first liquid discharge port and the second liquid discharge port are collectively inserted and arranged in the lumen.
The nozzle according to claim 5 or 6, further comprising an opening closing portion that closes at least a part of a tip opening of the outer tube in the vicinity of the first adjacent portion and the second adjacent portion.   The nozzle according to any one of claims 1 to 12, wherein the first adjacent portion and the second adjacent portion are in contact with each other.   An applicator comprising the nozzle according to claim 1.

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