JP2020156738A - Biological adhesive applicator - Google Patents

Abstract

To provide a biological adhesive applicator which can suction a liquid from a discharge port side of a liquid flowing pipe to a pump part side in a more excellent manner.SOLUTION: A biological adhesive applicator includes a gas chamber 20 having a gas introduction part 22 and a gas jetting part 24 and a plurality of liquid flowing pipes (for example, a first liquid flowing pipe 31 and a second liquid flowing pipe 32) which pass through an inner space 21 of the gas chamber 20 and have discharge ports 31a, 32a arranged in the vicinity of the gas jetting part 24. The biological adhesive applicator applies liquids on a biological tissue by spraying and mixing the liquids 38, 39 respectively discharged from the plurality of the liquid flowing pipes by energizing with a gas jetted from the gas jetting part 24. A specific liquid flowing pipe (for example, the first liquid flowing pipe 31) which is at least the one liquid flowing pipe out of the plurality of the liquid flowing pipes has a plurality of pump parts 40 constituted of sites different from each other in an axial direction of the specific liquid flowing pipe.SELECTED DRAWING: Figure 2

Description

The present invention relates to a bioadhesive coating tool.

As the bioadhesive coating tool, there is a bioadhesive coating tool including a gas chamber having a gas introduction portion and a gas ejection portion, and a plurality of liquid flow pipes passing through the internal space of the gas chamber. Each liquid flow pipe has a discharge port arranged in the vicinity of the gas ejection part. Such a bio-adhesive coating tool sprays and mixes the liquid discharged from the discharge ports of a plurality of liquid flow pipes by the gas ejected from the gas ejection portion to apply the liquid to the biological tissue. It is configured to do.
In such a bioadhesive coating tool, a coagulated product of the liquid leaked from the discharge port of the liquid flow pipe may grow.

Patent Document 1 includes a pump portion (expansion / contraction portion of the same document) in which a liquid flow pipe is compressed and contracted by an external pressure of a gas introduced into a gas chamber (nozzle body of the same document) and is restored when the external pressure becomes smaller. It is stated that.
According to the technique of Patent Document 1, after the discharge of the liquid and the introduction of the gas are stopped, the pump portion is restored, so that the liquid can be sucked from the discharge port side of the liquid flow pipe to the pump portion side, and as a result. , It is possible to suppress the occurrence of a phenomenon in which a solidified liquid dripping from the discharge port of the liquid flow pipe grows.

JP-A-2018-201726

However, according to the study of the inventor of the present application, there is still room for improvement in the technique of Patent Document 1 with respect to the structure for sucking the liquid from the discharge port side of the liquid flow pipe to the pump portion side.

The present invention has been made in view of the above problems, and provides a bioadhesive coating tool having a structure capable of better sucking liquid from the discharge port side of a liquid flow pipe to the pump portion side. Is.

The present invention includes a gas chamber having a gas introduction section into which a gas is introduced and a gas ejection section for ejecting the gas.
A plurality of liquid flow pipes that pass through the internal space of the gas chamber and have discharge ports arranged in the vicinity of the gas ejection portion.
With
A bioadhesive coating tool that sprays and mixes liquids discharged from the discharge ports of the plurality of liquid flow pipes and applies the liquids to the living tissue by urging the liquids discharged from the gas ejection portions with the gas ejected from the gas ejection portion. And
The specific liquid flow pipe, which is at least one of the plurality of liquid flow pipes, has a plurality of pump portions each composed of different parts in the axial direction of the specific liquid flow pipe.
In the specific liquid flow pipe, the portion located between the plurality of pump portions is a constricted portion having a smaller diameter than the pump portion.
Each of the plurality of pump units is compressed by the gas pressure when the gas is introduced into the gas chamber to reduce the internal volume, and is elastically restored when the introduction of the gas into the gas chamber is stopped. Provided is a bioadhesive coating tool.

According to the present invention, it is possible to better suck the liquid from the discharge port side of the liquid flow pipe to the pump portion side.

It is a figure which shows the whole structure of the bio-adhesive coating tool which concerns on 1st Embodiment. It is a plan sectional view (cross-sectional view along the line II-II of FIG. 1) of the spray unit of the bio-adhesive coating tool which concerns on 1st Embodiment. It is a front view which shows the tip part of the spray unit of the bio-adhesive coating tool which concerns on 1st Embodiment. It is sectional drawing along the IV-IV line of FIG. 5 (a) and 5 (b) are views showing a specific liquid flow tube of the bioadhesive coating tool according to the first embodiment, of which FIG. 5 (a) is an enlarged cross-sectional view around the pump portion. FIG. 5B is a plan view showing the entire main body of the first liquid flow pipe constituting the specific liquid flow pipe. 6 (a) and 6 (b) are cross-sectional views taken along the VI-VI line of FIG. 5 (a), of which FIG. 6 (a) shows a state in which the pump portion is compressed, and FIG. (B) shows the restored state of the pump unit. It is an enlarged sectional view around the pump part of the specific liquid flow tube of the bio-adhesive coating tool which concerns on 2nd Embodiment. It is an enlarged cross-sectional view around the pump part of the specific liquid flow tube of the bio-adhesive coating tool which concerns on 3rd Embodiment. 9 (a) and 9 (b) are enlarged views showing the periphery of the pump portion of the specific liquid flow tube of the bioadhesive coating tool according to the fourth embodiment, of which FIG. 9 (a) is a cross-sectional view. FIG. 9B is a plan view. 10 (a) and 10 (b) are diagrams showing a specific liquid flow tube of the bioadhesive coating tool according to the modified example of the fourth embodiment, of which FIG. 10 (a) shows the specific liquid flow tube. It is a top view which shows the whole of the 1st liquid flow pipe main body which comprises, and FIG. 10 (b) is the enlarged sectional view around the pump part.

Hereinafter, embodiments of the bioadhesive coating tool of the present invention will be described with reference to the drawings.
It should be noted that the embodiments described below are merely examples for facilitating the understanding of the present invention, and do not limit the present invention. That is, the shapes, dimensions, arrangements, and the like of the members described below can be changed and improved without departing from the spirit of the present invention.
Further, in all the drawings, similar components are designated by the same reference numerals, and duplicate description will be omitted as appropriate.
In the following, the side where the liquid is discharged in the bioadhesive coating tool is referred to as the tip side or the front side, and the opposite side is referred to as the base end side or the rear side. In addition, the horizontal direction that is orthogonal to the front-back direction is called the lateral direction, and of the lateral directions, the left side when the bioadhesive coating tool is viewed from the front side is called the left direction, and the right side is called the right direction. .. However, the provision of these directions is for convenience, and does not limit the direction at the time of manufacturing or using the bioadhesive coating tool.
Further, the description of the shape of each part of each liquid flow pipe is a description of the shape in a natural state other than the compressed state, unless otherwise specified.

[First Embodiment]
First, the first embodiment will be described with reference to FIGS. 1 to 6 (b).
The left side in FIG. 2 is the front, and the right side in FIG. 2 is the rear. FIG. 3 shows an excerpt of the tip portion of the spray unit 10 from the structure of the spray unit 10 viewed from the left in FIG. FIG. 5A is a cross-sectional view taken along the axis of the first liquid flow pipe 31.

As shown in any one of FIGS. 1 to 6 (b), the bioadhesive coating tool 100 according to the present embodiment has a gas introduction unit 22 (FIG. 1) into which gas is introduced and a gas ejection unit 22 (FIG. 1) for ejecting gas. The gas chamber 20 (FIGS. 1 and 2) having the portions 24 (FIGS. 1, 3 and 4) and the gas ejection portion 24 passing through the internal space 21 (FIG. 2) of the gas chamber 20. Two liquid flow pipes (for example, as shown in FIG. 2, a first liquid flow pipe 31 and a second liquid flow pipe 32) having discharge ports 31a and 32a (FIGS. 1 and 2) arranged in the vicinity. Liquid flow pipe) and. The bioadhesive coating tool 100 includes liquids 38 and 39 (FIGS. 3 and 4, respectively) discharged from the discharge ports 31a and 32a of the plurality of liquid flow pipes (first liquid flow pipe 31, second liquid flow pipe 32). 6 (a) and 6 (b)) are configured to be sprayed and mixed and applied to a living tissue by urging the gas ejected from the gas ejecting portion 24.
The specific liquid flow pipe (in the case of this embodiment, the first liquid flow pipe 31), which is at least one liquid flow pipe among the plurality of liquid flow pipes (first liquid flow pipe 31, second liquid flow pipe 32), is It has a plurality of pump units 40 (FIGS. 2, FIG. 5 (a) and FIG. 5 (b)), which are configured by different portions in the axial direction of the specific liquid flow pipe. In the case of the present embodiment, the first liquid flow pipe 31 has, for example, two pump units 40, a first pump unit 41 and a second pump unit 42.
Further, in the specific liquid flow pipe (first liquid flow pipe 31), the portion located between the plurality of pump portions 40 is a constricted portion 37 having a smaller diameter than the pump portion 40 (FIG. 5 (a), FIG. It is 5 (b)).
The plurality of pump units 40 are configured to be compressed by the gas pressure when the gas is introduced into the gas chamber 20 to reduce the internal volume, and to be elastically restored when the introduction of the gas into the gas chamber 20 is stopped. Has been done.

According to the present embodiment, since the specific liquid flow pipe (first liquid flow pipe 31) has the pump unit 40, the introduction of gas into the gas chamber 20 is stopped and the pump unit 40 is compressed. In the process of restoration, the liquid 38 can be sucked from the discharge port 31a side of the specific liquid flow pipe to the pump portion 40 side. Therefore, since it is possible to suppress the liquid 38 from dripping from the discharge port 31a, it is possible to suppress the occurrence of the phenomenon that the coagulated product of the liquid 38 dripping from the discharge port 31a grows.
Moreover, in the case of the present embodiment, the specific liquid flow pipe has a plurality of pump units 40 each formed by different parts in the axial direction of the specific liquid flow pipe. Therefore, the liquid 38 can be sucked from the discharge port 31a side to the pump part 40 side with a stronger suction force than in the case where there is only one pump part 40. Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the discharge port 31a and the phenomenon that the coagulated product of the liquid 38 dripping from the discharge port 31a grows.
As a result, when the gas is introduced into the gas chamber 20 again and the liquids 38 and 39 are discharged from each liquid flow pipe, and the sprayed and mixed liquids 38 and 39 are applied to the living tissue, the discharge of the specific liquid flow pipe is performed. The liquid 38 can be smoothly discharged from the outlet 31a.

As shown in FIG. 1, the bioadhesive coating tool 100 includes at least a spray unit 10.
As shown in FIG. 2, the spray unit 10 includes a gas chamber 20 and a plurality of liquid flow pipes inserted through the gas chamber 20 (in the case of the present embodiment, the first liquid flow pipe 31 and the second liquid flow pipe 32). ), And is configured.
In the case of the present embodiment, in addition to the spray unit 10, the bioadhesive coating tool 100 includes, for example, two injection tools 80, a plunger holder 83, an air filter unit 85, a regulator 90, and an air supply tube 91. , Is equipped.

Each injector 80 has a syringe 81 and a plunger 82 inserted into the syringe 81.
One injection tool 80 is connected to the spray unit 10 so that the tip end portion of the syringe 81 of the injection tool 80 communicates with the base end portion of the first liquid flow tube 31. The other injection tool 80 is connected to the spray unit 10 so that the tip end portion of the syringe 81 of the injection tool 80 communicates with the base end portion of the second liquid flow pipe 32.
On the other hand, the injection tool 80 is used for injecting, for example, a liquid 38 containing fibrinogen or the like, which has a high viscosity and easily coagulates, into the first liquid flow pipe 31.
The other injection tool 80 is used, for example, to inject a liquid 39 containing thrombin or the like into the second liquid flow pipe 32.
The plunger holder 83 is used to hold the proximal end of the plunger 82 of the two injectors 80. The operator using the bioadhesive coating tool 100 holds the proximal ends of the two plungers 82 using the plunger holder 83 and pushes the two plungers 82 into the corresponding syringes 81, thereby causing the two plungers 82. Can be pushed into each syringe 81 in synchronization with each other.
When the plunger 82 of one of the injection tools 80 is pushed into the syringe 81, the liquid 38 is injected into the first liquid flow pipe 31, and the liquid 38 is discharged from the discharge port 31a at the tip of the first liquid flow pipe 31.
When the plunger 82 of the other injection tool 80 is pushed into the syringe 81, the liquid 39 is injected into the second liquid flow pipe 32, and the liquid 39 is discharged from the discharge port 32a at the tip of the second liquid flow pipe 32.

The downstream end of the air filter unit 85 is connected to the base end (upstream end) of the gas introduction portion 22 of the gas chamber 20. The air filter unit 85 includes an air filter (not shown) that removes impurities from the gas supplied from the gas supply source. The air filter unit 85 has a connecting portion 85a to which the air supply tube 91 is connected at the upstream end of the air filter unit 85.
The air supply tube 91 is a flexible tube. A first connector 92a such as a female connector is provided at the base end of the air supply tube 91, and a second connector 92b such as a male connector is provided at the tip of the air supply tube 91.
The first connector 92a is connected to the gas outlet end of the regulator 90. The second connector 92b is connected to the connection portion 85a of the air filter unit 85. As a result, the regulator 90 and the air filter unit 85 are connected to each other via the regulator 90.
A gas supply source (not shown) such as a gas cylinder is connected to the gas introduction end of the regulator 90.
The gas supplied from the gas supply source to the regulator 90 is decompressed by the regulator 90 to a pressure suitable for use of the bioadhesive coating tool 100, and is passed through the air supply tube 91 and the air filter unit 85 in this order to the gas introduction unit. It is introduced from 22 into the internal space 21 of the gas chamber 20.
The gas introduced into the internal space 21 is ejected from the gas ejection portion 24 formed at the tip end portion of the gas chamber 20. The gas ejection unit 24 is composed of, for example, one or a plurality of pores, and the gas introduced into the internal space 21 is vigorously ejected from the gas ejection unit 24.
During the period when the gas is introduced from the gas introduction unit 22 into the gas chamber 20, the internal space 21 is maintained at a pressure higher than the atmospheric pressure.

When using the bioadhesive coating tool 100, the operator operates the plunger holder 83 to push the syringes 81 of the two injection tools 80 into each plunger 82 while introducing gas into the gas chamber 20.
As a result, the liquids 38 and 39 can be discharged from the discharge ports 31a and 32a of the first liquid flow pipe 31 and the second liquid flow pipe 32 while ejecting the gas from the gas ejection portion 24.
Therefore, the liquids 38 and 39 discharged from the discharge ports 31a and 32a can be sprayed and mixed and applied to the living tissue by urging the liquids 38 and 39 discharged from the gas ejection portions 24 with the gas ejected from the gas ejection portion 24, respectively.

As shown in FIG. 2, the spray unit 10 includes, for example, a chamber main body 50, a proximal end side member 60, a distal end side member 70, a first liquid flow pipe main body 33, and a second liquid flow pipe main body 34, which are described below, respectively. It is configured to prepare.
Of these, the gas chamber 20 is mainly composed of the chamber main body 50 and the proximal end side member 60, and the first liquid flow pipe 31 is mainly composed of the first liquid flow pipe main body 33 and a part of the distal end side member 70. The second liquid flow pipe 32 is mainly composed of the second liquid flow pipe main body 34 and the other part of the tip side member 70.

As shown in FIGS. 1 and 2, the chamber body 50 is a hollow member, and is formed, for example, in a bell shape that is flat in the vertical direction and tapered forward. The internal space of the chamber body 50 constitutes the internal space 21.
The chamber body 50 includes a gas introduction section 22. The gas introduction portion 22 is formed in a tubular shape, and projects upward (for example, diagonally upward and rearward) from the top surface of the chamber body 50, for example.
The chamber main body 50 is formed symmetrically, for example, and the portion of the chamber main body 50 other than the gas introduction portion 22 is also formed symmetrically in the vertical direction.
The tip 52 of the chamber body 50 has two insertion holes 52a (FIGS. 3 and 4) arranged side by side with each other. Each insertion hole 52a penetrates the tip end portion 52 in the front-rear direction, and communicates the internal space of the chamber body 50 (that is, the internal space 21) and the space in front of the chamber body 50 with each other.
The proximal end portion 51 of the chamber body 50 has a proximal end side opening 51a that opens rearward.

As shown in FIG. 2, the proximal end side member 60 includes, for example, a plate-shaped main body 61, a pair of left and right syringe mounting portions 62a and 62b to which the syringe 81 of the injection tool 80 is mounted (connected), respectively, and later described. A pair of left and right liquid flow pipe mounting portions 63a and 63b to which the base end portions 33a and 34a of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 are mounted, and a partition wall constituent portion 65, respectively. Have.
The main body 61 is formed, for example, in the shape of a long flat plate in the left-right direction, and the plate surface of the main body 61 faces in the front-rear direction. The main body portion 61 is attached to the base end portion 51 so as to close the base end side opening 51a of the chamber main body 50.
The internal space 21 is defined by an inner peripheral surface of the chamber main body 50 and a front surface of the main body 61.
The syringe mounting portion 62a on the left side protrudes rearward from the left end portion of the main body portion 61, and the syringe mounting portion 62b on the right side protrudes rearward from the right end portion of the main body portion 61.
The liquid flow pipe mounting portion 63a on the left side protrudes forward from the left end portion of the main body portion 61, and the liquid flow pipe mounting portion 63b on the right side protrudes forward from the right end portion of the main body portion 61. The liquid flow pipe mounting portions 63a and 63b are arranged in the internal space 21.
The syringe mounting portion 62a and the liquid flow tube mounting portion 63a are arranged coaxially with each other with the left end portion of the main body portion 61 in between, and the syringe mounting portion 62b and the liquid flow tube mounting portion 63b are arranged with the main body portion 61. They are arranged coaxially with each other with the right end of the.
A pair of left and right through holes 64a and 64b are formed in the base end side member 60.
The through hole 64a on the left side penetrates the base end side member 60 back and forth from the rear end of the syringe mounting portion 62a to the front end of the liquid flow tube mounting portion 63a, and the through hole 64b on the right side is the syringe mounting portion. The base end side member 60 penetrates back and forth from the rear end of 62b to the front end of the liquid flow tube mounting portion 63b.
The partition wall component 65 is a plate-shaped portion extending forward from the central portion in the lateral direction of the front surface of the main body 61, and the plate surface of the partition wall component 65 faces in the left-right direction. ..
The partition wall component 65 constitutes a partition wall 25 that divides the internal space 21 to the left and right.
A gas introduction portion 22 is arranged on the upper side of the partition wall portion 25 (partition wall constituent portion 65). The downstream end of the gas introduction portion 22 straddles the partition wall constituent portion 65 on the left and right. Therefore, the gas introduced from the gas introduction portion 22 into the internal space 21 is distributed to the left half region and the right half region in the internal space 21 by the partition wall portion 25.

As shown in FIG. 2, the tip side member 70 constitutes, for example, the first discharge pipe 71 that constitutes the tip of the first liquid flow pipe 31 and the tip of the second liquid flow pipe 32. It has a second discharge pipe 72, and a connecting portion 73 that connects the first discharge pipe 71 and the second discharge pipe 72 to each other.
The first discharge pipe 71 and the second discharge pipe 72 are each formed in a circular tubular shape, are separated from each other, and are arranged in parallel with each other.
The connecting portion 73 connects, for example, the central portion of the first discharge pipe 71 in the axial direction and the central portion of the second discharge pipe 72 in the axial direction to each other.
Therefore, for example, the planar shape of the tip side member 70 is H-shaped.

In the first discharge pipe 71, the portion protruding toward the base end side from the connecting portion 73 is the holding portion 71a that holds the tip end portion 33b of the first liquid flow pipe main body 33, and is closer to the tip end side than the connecting portion 73. The protruding portion is the protruding portion 71b.
In the second discharge pipe 72, the portion protruding toward the base end side from the connecting portion 73 is the holding portion 72a that holds the tip end portion 34b of the second liquid flow pipe main body 34, and is closer to the tip end side than the connecting portion 73. The protruding portion is the protruding portion 72b.
The opening at the tip of the first discharge pipe 71, that is, the opening at the tip of the protruding portion 71b constitutes the discharge port 31a. The opening at the tip of the second discharge pipe 72, that is, the opening at the tip of the protruding portion 72b constitutes the discharge port 32a.

As described above, the tip 52 of the chamber body 50 has two insertion holes 52a arranged side by side.
The protruding portions 71b and 72b of the tip end side member 70 are inserted into the left and right insertion holes 52a from the rear of the tip end portion 52. That is, the protruding portion 71b is inserted into the insertion hole 52a on the left side, and the protruding portion 72b is inserted into the insertion hole 52a on the right side.
The protruding portions 71b and 72b slightly protrude forward from the front surface of the tip portion 52.
The connecting portion 73 is sandwiched between, for example, the rear surface of the tip portion 52 and the front end surface of the partition wall constituent portion 65. As a result, it is restricted that the tip side member 70 is displaced rearward relative to the tip end portion 52 (that is, the protrusions 71b and 72b are displaced rearward from the insertion holes 52a).
The axial direction of each of the first discharge pipe 71 and the second discharge pipe 72 extends in the front-rear direction.

As shown in FIG. 3, in the case of the present embodiment, the gas chamber 20 has a gas ejection portion 24 on the left side arranged in the vicinity of the discharge port 31a and a gas ejection portion on the right side arranged in the vicinity of the discharge port 32a. It has a part 24 and.
The gas ejection portion 24 on the left side is formed by a portion located around the protrusion 71b in the opening at the tip of the insertion hole 52a on the left side.
The gas ejection portion 24 on the right side is formed by a portion located around the protrusion 72b in the opening at the tip of the insertion hole 52a on the right side.

As shown in FIG. 3, a plurality of (for example, four) fixing ribs 52b protruding inward in the radial direction of each insertion hole 52a are formed on the inner peripheral surface of each insertion hole 52a. The plurality of fixed ribs 52b of each insertion hole 52a are arranged at predetermined intervals (for example, equiangular intervals) in the circumferential direction of each insertion hole 52a.
The protrusion 71b of the first discharge pipe 71 is press-fitted into the insertion hole 52a on the left side, and each fixed rib 52b of the insertion hole 52a on the left side is press-fitted to the outer peripheral surface of the protrusion 71b.
The protruding portion 72b of the second discharge pipe 72 is press-fitted into the insertion hole 52a on the right side, and each fixed rib 52b of the insertion hole 52a on the right side is pressed against the outer peripheral surface of the protruding portion 72b.
Therefore, the protruding portion 71b is fixed to the insertion hole 52a on the left side, and the protruding portion 72b is fixed to the insertion hole 52a on the right side.

The gas chamber 20 has a gas flow passage 23 (FIG. 4) that guides the gas introduced into the internal space 21 to each gas ejection portion 24.
In the case of the present embodiment, the gas chamber 20 has a gas flow passage 23 on the left side for guiding the gas to the gas ejection portion 24 on the left side and a gas flow passage 23 on the right side for guiding the gas to the gas ejection portion 24 on the right side.
The gap between the outer peripheral surface of the protruding portion 71b and the inner peripheral surface of the left insertion hole 52a constitutes the gas flow passage 23 on the left side, and the outer peripheral surface of the protruding portion 72b and the inner peripheral surface of the left insertion hole 52a. The gap between the surfaces constitutes the gas flow passage 23 on the right side.
That is, each gas flow passage 23 is an aggregate of a plurality of (for example, four in the case of the present embodiment) gas flow passages partitioned by the fixed ribs 52b.
The opening at the tip of the gas flow passage 23 is the gas ejection portion 24. That is, each of the left and right gas ejection portions 24 is an aggregate of a plurality of (for example, four in the case of the present embodiment) openings.
As described above, since the projecting portions 71b and 72b slightly project forward from the insertion holes 52a, the gas ejection portions 24 are arranged in the vicinity of the discharge ports 31a and 31b. Therefore, the liquids 38 and 39 discharged from the discharge ports 31a and 32a can be sprayed and mixed in the form of mist by the gas ejected from each gas ejection portion 24 to the outside.

The connecting portion 73 covers, for example, the side surface of the first discharge pipe 71 opposite to the side of the second discharge pipe 72, and is opposite to the side of the first discharge pipe 71 in the second discharge pipe 72. It covers the side of the side.
As a result, a narrow gap is formed between the connecting portion 73 and the inner peripheral surface of the chamber body 50 in the vicinity of the tip portion 52.
The gas in the internal space 21 is guided to the gas flow passage 23 through these gaps.

The material constituting the gas chamber 20, that is, the material constituting the chamber body 50, the proximal end side member 60, and the distal end side member 70 is not particularly limited, but for example, the chamber main body 50, the proximal end side member 60, and the distal end side member are not particularly limited. Reference numeral 70 denotes, for example, a resin or the like.
It is preferable that the volume of the gas chamber 20 does not substantially change depending on the gas pressure in the internal space 21. Therefore, it is preferable that the chamber body 50, the proximal end side member 60, and the distal end side member 70 are made of a hard resin.

As shown in FIG. 2, each of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 is a tubular member.
The base end portion 33a of the first liquid flow pipe main body 33 is attached to the liquid flow pipe mounting portion 63a (held by the liquid flow pipe mounting portion 63a) by being externally inserted into, for example, the liquid flow pipe mounting portion 63a. .. The tip portion 33b of the first liquid flow tube main body 33 is attached (held by the holding portion 71a) to the holding portion 71a by being externally inserted into the holding portion 71a, for example. Then, the opening at the base end of the syringe mounting portion 62a and the discharge port 31a at the tip of the first discharge pipe 71 communicate with each other via the through hole 64a, the first liquid flow pipe main body 33, and the first discharge pipe 71. ing. The first liquid flow pipe 31 is composed of a first liquid flow pipe main body 33, a first discharge pipe 71, and a through hole 64a of a base end side member 60.
Similarly, the base end portion 34a of the second liquid flow pipe main body 34 is mounted on the liquid flow pipe mounting portion 63b by being externally inserted into, for example, the liquid flow pipe mounting portion 63b (held by the liquid flow pipe mounting portion 63b). Has been done. The tip end portion 34b of the second liquid flow tube main body 34 is attached (held by the holding portion 72a) to the holding portion 72a by being externally inserted into the holding portion 72a, for example. Then, the opening at the base end of the syringe mounting portion 62b and the discharge port 32a at the tip of the second discharge pipe 72 communicate with each other via the through hole 64b, the second liquid flow pipe main body 34, and the second discharge pipe 72. ing. The second liquid flow pipe 32 is composed of a second liquid flow pipe main body 34, a second discharge pipe 72, and a through hole 64b of the base end side member 60.
The holding portion 71a, the first liquid flow pipe main body 33, and the liquid flow pipe mounting portion 63a are arranged in one (left side) region of the internal space 21 partitioned by the partition wall portion 25, and the holding portion 72a, the second The liquid flow pipe main body 34 and the liquid flow pipe mounting portion 63b are arranged in the other (right side) region of the internal space 21 partitioned by the partition wall portion 25.

As shown in FIG. 2, the first liquid flow pipe main body 33 has a plurality of pump units 40. More specifically, in the case of the present embodiment, the first liquid flow pipe main body 33 has two pump parts 40, a first pump part 41 and a second pump part 42. The second pump unit 42 is arranged on the upstream side (base end side) of the first liquid flow pipe 31 (specific liquid flow pipe) with respect to the first pump unit 41.
Each pump unit 40 is a portion of the first liquid flow pipe 31 having a larger compression ratio (ratio of internal volume reduction) due to external pressure (gas pressure in the internal space 21) than a portion other than the pump unit 40.
Each pump portion 40 has a larger inner diameter and outer diameter (average value of inner diameter and average value of outer diameter) than, for example, a portion of the first liquid flow pipe 31 other than the pump portion 40.
Each of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 is integrally molded with a flexible material such as an elastomer (for example, silicone rubber).
In the case of the present embodiment, the first liquid flow pipe main body 33 (the first liquid flow pipe 31) is locally thinly formed in each pump part 40. Therefore, the first liquid flow tube main body 33 is locally and flexibly configured in each pump section 40 (although the entire body is integrally molded of the same material). However, the present invention is not limited to this example, and the portion of the first liquid flow pipe 31 that constitutes each pump portion 40 may be locally composed of a material that is more flexible than the other portions.

As shown in FIGS. 5A and 5B, the first pump portion 41 has, for example, a cylindrical portion 45 and a tapered portion 46 connected to the tip end side of the cylindrical portion 45. Further, the second pump portion 42 has, for example, a cylindrical portion 45 and a tapered portion 46 connected to the proximal end side of the cylindrical portion 45.

The cylindrical portion 45 of the first pump portion 41 has, for example, a cylindrical main portion 45a and a pump portion rib 45b formed on the outer peripheral surface of the main portion 45a. That is, a pump portion rib 45b is formed on the outer peripheral surface of the first pump portion 41.
The inner and outer diameters of the main portion 45a are constant, and therefore the wall thickness of the main portion 45a is constant.
The number of pump portion ribs 45b included in the cylindrical portion 45 of the first pump portion 41 is not particularly limited, and may be one or a plurality.
In the case of the present embodiment, the cylindrical portion 45 of the first pump portion 41 has, for example, a plurality of (for example, three) pump portion ribs 45b that are separated from each other in the axial direction of the first pump portion 41.
Each pump portion rib 45b may extend in the circumferential direction of the pump portion 40 (first pump portion 41), and does not necessarily have to orbit 360 degrees in the circumferential direction of the pump portion 40. Further, the pump portion rib 45b may be an aggregate of a plurality of ribs intermittently arranged in the circumferential direction of the pump portion 40.
In the case of the present embodiment, each pump portion rib 45b orbits 360 degrees in the circumferential direction of the pump portion 40.
The tapered portion 46 of the first pump portion 41 has, for example, an inner diameter that is tapered toward the tip side and an outer diameter that is tapered toward the tip side. The wall thickness of the tapered portion 46 gradually increases toward the tip side.

The cylindrical portion 45 of the second pump portion 42 is formed, for example, in the same shape and dimensions as the cylindrical portion 45 of the first pump portion 41. That is, the pump portion rib 45b is also formed on the outer peripheral surface of the second pump portion 42.
The inner diameter of the tapered portion 46 of the second pump portion 42 is tapered toward the proximal end side, for example. The outer diameter of the tapered portion 46 of the second pump portion 42 is tapered toward the proximal end side in the front portion (tip side portion) of the tapered portion 46, and the rear portion of the tapered portion 46. At (base end side part), it is constant. For example, the wall thickness of the tapered portion 46 of the second pump portion 42 is constant at the front portion of the tapered portion 46, and gradually increases toward the proximal end side at the rear portion of the tapered portion 46. ing.

In the first liquid flow pipe main body 33, the portion other than the pump portion 40 has a smaller compression ratio (ratio at which the internal volume is reduced) due to the external pressure (gas pressure in the internal space 21) than the pump portion 40.
The first liquid flow pipe main body 33 has a non-pump unit 35 located closer to the tip side than the first pump unit 41 and a non-pump unit located closer to the base end side than the second pump unit 42 as parts other than the pump unit 40. It has a portion 36 and a constricted portion 37 located at a boundary between the first pump portion 41 and the second pump portion 42 (between the first pump portion 41 and the second pump portion 42).

As shown in FIGS. 5A and 5B, the inner circumference of the portion (constricted portion 37) located at the boundary between the first pump portion 41 and the second pump portion 42 in the first liquid flow pipe 31. A ring-shaped boundary rib 37b is formed on the surface.
That is, the boundary rib 37b protrudes inward in the radial direction at the portion located at the boundary between the first pump portion 41 and the second pump portion 42.
As a result, the inner diameter of the first liquid flow pipe 31 is locally reduced in the constricted portion 37. That is, the constricted portion 37 has a smaller diameter than the pump portion 40.
In the case of the present embodiment, the inner diameter of the constricted portion 37 is smaller than the inner diameter of the end on the constricted portion 37 side in each of the two adjacent pump portions 40 with the constricted portion 37 in between. That is, the inner diameter of the constricted portion 37 is smaller than the inner diameter of the base end of the cylindrical portion 45 of the first pump portion 41, and the inner diameter of the constricted portion 37 is smaller than the inner diameter of the tip of the cylindrical portion 45 of the second pump portion 42. Is small.
The boundary rib 37b may extend in the circumferential direction of the first liquid flow pipe 31, and does not necessarily have to orbit 360 degrees in the circumferential direction of the first liquid flow pipe 31. Further, the boundary rib 37b may be an aggregate of a plurality of ribs intermittently arranged in the circumferential direction of the first liquid flow pipe 31.
In the case of the present embodiment, the boundary rib 37b orbits 360 degrees in the circumferential direction of the first liquid flow pipe 31.

The constricted portion 37 is configured to include a cylindrical main portion 37a and a boundary rib 37b protruding inward in the radial direction from the main portion 37a.
In the case of the present embodiment, the outer diameter of the main portion 45a of the cylindrical portion 45 of the first pump portion 41, the outer diameter of the main portion 37a of the constricted portion 37, and the main portion 45a of the cylindrical portion 45 of the second pump portion 42. The outer diameters are equal to each other.
Further, the inner diameter of the main portion 45a of the cylindrical portion 45 of the first pump portion 41, the inner diameter of the main portion 37a of the constricted portion 37, and the inner diameter of the main portion 45a of the cylindrical portion 45 of the second pump portion 42 are equal to each other. ..
The inner peripheral surface of the main portion 37a that defines the inner diameter of the main portion 37a does not exist as an entity, and the inner circumference of the virtual constricted portion 37 when the boundary rib 37b is removed from the constricted portion 37. It is a face.
In other words, the boundary rib 37b is in the radial direction of the first pump portion 41 and the second pump portion 42 as compared with the inner peripheral surface of the main portion 45a of the cylindrical portion 45 of the first pump portion 41 and the second pump portion 42. This is the part that protrudes inward.
Therefore, as shown in FIG. 5A, the protruding height (protruding length) H2 of the boundary rib 37b is from the inner peripheral surface of the main portion 45a of the cylindrical portion 45 of the first pump portion 41 and the second pump portion 42. This is the protruding height of the boundary rib 37b.
On the other hand, the protruding height of the pump portion rib 45b of the first pump portion 41 is the protruding height of the pump portion rib 45b from the outer peripheral surface of the main portion 45a of the cylindrical portion 45 of the first pump portion 41. Similarly, the protruding height of the pump portion rib 45b of the second pump portion 42 is the protruding height of the pump portion rib 45b from the outer peripheral surface of the main portion 45a of the cylindrical portion 45 of the second pump portion 42. In the case of the present embodiment, the protruding height of the pump portion rib 45b of the first pump portion 41 and the protruding height of the pump portion rib 45b of the second pump portion 42 are equal to each other, and both are H1 shown in FIG. 5 (a). Is.

Here, the protruding height H1 of the pump portion rib 45b is smaller than the protruding height H2 of the boundary rib 37b.
In the case of the present embodiment, an example in which the pump portion rib 45b is formed on the outer peripheral surface of the pump portion 40 will be described. However, the present invention is not limited to this example, and the present invention is not limited to this example, and the pump portion rib 45b is formed on the inner peripheral surface of the pump portion 40. May be formed. That is, the pump portion rib 45b may be formed on the inner peripheral surface of the main portion 45a. Further, the pump portion rib 45b may be formed on both the outer peripheral surface and the inner peripheral surface of the pump portion 40.
Further, in the case of the present embodiment, an example in which each of the plurality of pump units 40 (for example, both the first pump unit 41 and the second pump unit 42) has the pump unit rib 45b will be described. Not limited to the example, at least one or more of the plurality of pump units 40 may have the pump unit rib 45b.
As described above, on at least one outer peripheral surface or inner peripheral surface of the first pump portion 41 and the second pump portion 42, a pump portion rib 45b having a lower profile (smaller protrusion height) than the boundary rib 37b is formed. Has been done.

The constriction 37 is reinforced by a boundary rib 37b (which is taller than the pump rib 45b). Therefore, the constricted portion 37 has a smaller compression ratio due to the external pressure (gas pressure in the internal space 21) than the pump portion 40.
In the case of the present embodiment, the size of the boundary rib 37b in the axial direction of the first liquid flow pipe main body 33 is larger than the size of the pump portion rib 45b in the axial direction of the first liquid flow pipe main body 33. Therefore, the constricted portion 37 is more firmly reinforced by the boundary rib 37b.

The non-pump portion 35 located on the tip end side of the first pump portion 41 is, for example, a straight tubular straight pipe portion 35a connected to the tip end side of the tapered portion 46 of the first pump portion 41 and a straight pipe portion 35a. It has a tip portion 35b connected to the tip side.
The non-pump portion 35 is formed, for example, with a constant inner diameter over the entire non-pump portion 35.
The straight pipe portion 35a has a constant outer diameter throughout.
The inner diameter and outer diameter of the straight pipe portion 35a are equal to the inner diameter and outer diameter at the tip of the tapered portion 46 of the first pump portion 41.
The outer diameter of the base end of the tip portion 35b is equal to the outer diameter of the tip of the straight pipe portion 35a.
The outer diameter of the tip portion 35b is tapered toward the tip side at the rear portion (base end side portion) of the tip portion 35b, and at the front portion (tip end side portion) of the tip portion 35b. It is constant.

The non-pump portion 36 located on the proximal end side of the second pump portion 42 includes, for example, a straight tubular straight pipe portion 36a connected to the proximal end side of the tapered portion 46 of the second pump portion 42 and a straight pipe portion. It has a proximal end portion 36b, which is connected to the proximal end side of the 36a.
The non-pump portion 36 is formed, for example, with a constant inner diameter over the entire non-pump portion 36.
The straight pipe portion 36a has a constant outer diameter throughout.
The inner diameter and outer diameter of the straight pipe portion 36a are equal to the inner diameter and outer diameter at the base end of the tapered portion 46 of the second pump portion 42.
The outer diameter of the base end portion 36b is equal to the outer diameter of the straight pipe portion 36a at the rear portion (base end side portion) of the base end portion 36b, and at the front portion (tip end side portion) of the base end portion 36b. , Is relatively small.

Here, as described above, the holding portion 71a is inserted into the tip portion 33b of the first liquid flow tube main body 33, and the tip portion 33b is held by the holding portion 71a.
Similarly, the liquid flow pipe mounting portion 63a is inserted into the base end portion 33a of the first liquid flow pipe main body 33, and the base end portion 33a is held by the liquid flow pipe mounting portion 63a.
The tip portion 33b includes at least the tip portion of the tip portion 35b, and may include the entire tip portion 35b and the tip portion of the straight pipe portion 35a.
The base end portion 33a includes at least the base end portion of the base end portion 36b, and may include the entire base end portion 36b and the base end portion of the straight pipe portion 36a.
Since the tip end portion 33b and the base end portion 33a are held by the holding portion 71a and the liquid flow pipe mounting portion 63a, respectively, they are not substantially compressed by the external pressure (gas pressure in the internal space 21).
That is, even if the tip portion 33b is formed thinner than the straight pipe portion 35a (or the portion of the straight pipe portion 35a excluding the portion constituting the tip portion 33b), it does not function as the pump portion 40. , Not the pump unit 40. Similarly, even if the base end portion 33a is formed thinner than the straight pipe portion 36a (or the portion of the straight pipe portion 36a excluding the portion constituting the base end portion 33a), the pump portion 40 may be formed. Since it does not function, it is not the pump unit 40.
That is, the pump portion 40 is different from the portion (tip portion 33b or base end portion 33a) directly held by another member in the first liquid flow pipe main body 33.
In the case of the present embodiment, the pump portion 40 is a portion of the first liquid flow pipe main body 33 other than the pump portion 40, and is a local portion as compared with a portion which is neither the tip portion 33b nor the base end portion 33a. It is formed thin (the average wall thickness is small).

In the case of the present embodiment, for example, the inner diameter of the straight pipe portion 35a is smaller than the inner diameter of the straight pipe portion 36a, and the outer diameter of the straight pipe portion 35a is smaller than the outer diameter of the straight pipe portion 36a.
Further, the outer diameter of the tip portion 35b is further smaller than the outer diameter of the straight pipe portion 35a.
Therefore, as shown in FIG. 2, a sufficient gap can be secured between the outer peripheral surface of the tip portion 33b and the inner peripheral surface of the chamber body 50, so that the gas in the internal space 21 can be passed through the gas flow passage 23. It is possible to smoothly eject the gas from the gas ejection unit 24 via the gas ejection unit 24.

It is preferable that the plurality of pump portions 40 are arranged at the tip end side portion of the first liquid flow pipe main body 33. By doing so, the liquid 38 can be more preferably sucked from the discharge port 31a side of the specific liquid flow pipe to the pump portion 40 side. In the case of the present embodiment, the tip-side half portion of the first liquid flow pipe main body 33 includes the entire first pump portion 41 and at least the front end portion of the second pump portion 42.

The second liquid flow tube main body 34 is formed, for example, in a straight tubular shape (the entire outer diameter and inner diameter are substantially constant).
The first liquid flow pipe main body 33 (however, the plurality of pump portions 40 are excluded) is formed to be thicker than, for example, the second liquid flow pipe main body 34. For example, the outer diameter of the second liquid flow pipe main body 34 is smaller than the outer diameter of the first liquid flow pipe main body 33, and the inner diameter of the second liquid flow pipe main body 34 is larger than the inner diameter of the first liquid flow pipe main body 33. small.

Next, the operation will be described.

When using the bioadhesive coating tool 100, the air filter unit 85 is connected to the gas introduction unit 22, the second connector 92b of the air supply tube 91 is connected to the connection portion 85a, and the first connector 92a is connected to the regulator 90. , The regulator 90 is connected to a gas supply source such as a gas cylinder.
Further, the tip of the syringe 81 of one injection tool 80 is connected to the syringe mounting portion 62a of the spray unit 10, and the tip of the syringe 81 of the other injection tool 80 is connected to the syringe mounting portion 62b. The syringe 81 of one injection tool 80 stores a high-viscosity liquid 38 containing fibrinogen and the like, and the syringe 81 of the other injection tool 80 stores a liquid 39 containing thrombin and the like.

The gas supplied from the gas supply source is introduced into the internal space 21 of the gas chamber 20 via the air supply tube 91 and the air filter unit 85 via the decompression by the regulator 90. As a result, the gas is ejected from each gas ejection unit 24.
Then, with the discharge ports 31a and 32a of the spray unit 10 facing the target biological tissue (for example, an organ in the living body), the operator uses the plunger holder 83 to use the plunger holder 83 to make the plungers of the two syringes 80. The proximal ends of the 82 are held together and the two plungers 82 are pushed into the corresponding syringes 81, respectively.
As a result, the liquid 38 is injected from the syringe 81 of one injection tool 80 into the first liquid flow pipe 31, and the liquid 39 is injected from the syringe 81 of the other injection tool 80 into the second liquid flow pipe 32. Therefore, while the liquid 38 is discharged from the discharge port 31a of the first liquid flow pipe 31, the liquid 39 is discharged from the discharge port 32a of the second liquid flow pipe 32.
That is, the liquids 38 and 39 are discharged from the discharge ports 31a and 32a while the gas is ejected from the gas ejection portions 24.
As a result, the liquid 38 discharged from the discharge port 31a is urged and sprayed mainly by the gas ejected from the gas ejection portion 24 in the vicinity of the discharge port 31a, and the liquid 39 discharged from the discharge port 32a is sprayed. It can be urged and sprayed mainly by the gas ejected from the gas ejection portion 24 near the discharge port 32a. Therefore, the mist-like liquid 38 and the liquid 39 can be mixed and applied to the target biological tissue.
The liquid 38 and the liquid 39, which are atomized and sprayed and mixed, function as an adhesive (bioadhesive). That is, the action of thrombin changes fibrinogen to fibrin, which causes the adhesive to solidify.

After that, the operator stops pushing each plunger 82 into each syringe 81 in order to finish the application of the adhesive to the living tissue.
Here, during the period in which the gas is introduced into the internal space 21, the pressure of the gas in the internal space 21 is increased. Therefore, at least after stopping the pushing of each plunger 82 into each syringe 81 until the introduction of gas into the gas chamber 20 is stopped, each pump unit 40 is inside the internal space 21. It is compressed by the gas pressure, and the internal volume of each pump unit 40 is reduced.
In the compressed state of the pump unit 40, as shown in FIG. 6A, the portions facing each other in the cross section of the pump unit 40 are in contact with each other or in close proximity to each other. Therefore, the internal volume of the pump unit 40 is reduced as compared with the internal volume in the natural state.

Further, after that, the introduction of gas into the gas chamber 20 is stopped. Then, since the pressure of the gas in the internal space 21 decreases, each pump unit 40 is restored to its natural shape, that is, its cross-sectional shape is cylindrical as shown in FIG. 6B, due to the elastic restoring force. To do. Therefore, the internal volume of each pump unit 40 expands as compared with the compressed state.
Therefore, since the inside of each pump unit 40 temporarily becomes negative pressure, the liquid 38 can be sucked from the discharge port 31a side of the first liquid flow pipe 31 to the pump unit 40 side. That is, in the process of stopping the introduction of gas into the gas chamber 20 and restoring the pump portion 40 from the compressed state to the natural state, the liquid 38 is sucked from the discharge port 31a side to the pump portion 40 side.
Therefore, since it is possible to suppress the liquid 38 from dripping from the discharge port 31a, it is possible to suppress the occurrence of the phenomenon that the coagulated product of the liquid 38 dripping from the discharge port 31a grows. The liquid 38 sucked by the pump unit 40 is the liquid 38 on the discharge port 31a side of the pump unit 40. For example, the liquid 38 outside the discharge port 31a (the liquid 38 dripping outside) or the discharge port 31a. The liquid 38 in front of the above is included.
In the case of the present embodiment, since the first liquid flow pipe 31 has a plurality of pump units 40, the liquid 38 can be sucked with a stronger suction force than when there is only one pump unit 40. Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the discharge port 31a and the phenomenon that the coagulated product of the liquid 38 dripping from the discharge port 31a grows.
Therefore, when the gas is introduced into the gas chamber 20 again and the liquids 38 and 39 are discharged from each liquid flow pipe to apply the sprayed and mixed liquids 38 and 39 to the living tissue, the first liquid flow pipe 31 The liquid 38 can be smoothly discharged from the discharge port 31a.

The following effects can also be obtained by having the first liquid flow pipe 31 having a plurality of pump units 40.
When the gas is introduced into the gas chamber 20 again and the liquids 38 and 39 are discharged from the liquid flow pipes, each pump unit 40 is in a compressed state. Therefore, the liquid 38 stored in each pump unit 40 is immediately pushed out to the discharge port 31a side. Therefore, when the injection of the liquid 38 by the plunger 82 is restarted, the liquid 38 is quickly discharged from the discharge port 31a with good responsiveness.

Further, in the case of the present embodiment, the specific liquid flow pipe having the plurality of pump units 40 is the first liquid flow pipe 31 for circulating the highly viscous liquid 38 containing fibrinogen and the like. Therefore, the viscosity of the liquid 38 causes the liquid 38 to return to the discharge port 31a side due to its own weight or the like after the liquid 38 is sucked to the pump unit 40 side by the pump unit 40 restoring to the natural state. It can be suppressed.

In the case of this embodiment, each pump portion 40 has a pump portion rib 45b. Therefore, it is possible to sufficiently secure the elastic restoring force that each pump portion 40 tries to restore to the cylindrical natural state. That is, the pump portion rib 45b promotes the restoration of each pump portion 40.

Further, in the first liquid flow pipe 31, a ring-shaped boundary rib 37b is formed on the inner peripheral surface of the portion (constricted portion 37) located at the boundary between the first pump portion 41 and the second pump portion 42. The portion is reinforced by a boundary rib 37b. As a result, each pump unit 40 can be individually reduced and restored, and the restoration of each pump unit 40 can be promoted by the boundary rib 37b.

[Second Embodiment]
Next, the second embodiment will be described with reference to FIG. 7. FIG. 7 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow tube (first liquid flow tube 31) of the bioadhesive coating tool according to the present embodiment, and is a cross section along the axis of the first liquid flow tube 31. It is a figure.
The bioadhesive coating tool according to the present embodiment is different from the bioadhesive coating tool 100 according to the first embodiment in the following aspects, and is otherwise different from the bioadhesive coating tool 100 according to the first embodiment. It is configured in the same manner as the bioadhesive coating tool 100 according to the above.

Also in the case of the present embodiment, the bioadhesive coating tool is used as a plurality of pump units 40 on the upstream side of the first pump unit 41 and the specific liquid flow pipe (first liquid flow pipe 31) from the first pump unit 41. Includes a second pump section 42 located in.
In the case of the present embodiment, the bioadhesive coating tool is configured such that the first pump section 41 restores faster than the second pump section 42 after the introduction of gas into the gas chamber 20 is stopped.
Therefore, first, of the first pump unit 41 and the second pump unit 42, the liquid 38 is discharged from the discharge port 31a side by the first pump unit 41 arranged closer to the discharge port 31a (tip side). After sucking quickly, the liquid 38 can be further sucked toward the proximal end side by the second pump unit 42.
Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the discharge port 31a and the phenomenon that the coagulated product of the liquid 38 dripping from the discharge port 31a grows.

In the case of the present embodiment, since the second pump unit 42 is configured more flexibly than the first pump unit 41, the first pump unit 41 becomes the second pump unit after the introduction of gas into the gas chamber 20 is stopped. It is designed to restore faster than 42.
After the introduction of gas into the gas chamber 20 is stopped, the pump unit 40 is restored to its natural cylindrical shape by the elastic force (elastic restoring force) of the pump unit 40. The larger the elastic restoring force, the faster the pump unit 40 restores to the natural state.
In the present embodiment, since the second pump section 42 is configured to be more flexible than the first pump section 41, the elastic restoring force of the first pump section 41 is larger than the elastic restoring force of the second pump section 42. ..
Since the compression ratio of the second pump unit 42 due to the gas pressure in the internal space 21 is larger than the compression ratio of the first pump unit 41 due to the gas pressure, the volume of the liquid 38 that can be sucked by the second pump unit 42. Can be secured more sufficiently.
As a method of forming the second pump part 42 more flexibly than the first pump part 41, a method of forming the second pump part 42 with a material more flexible than the first pump part 41, the second pump part 42 is the first. A method of differentiating the molding conditions of the second pump section 42 and the first pump section 41 so as to be more flexible than the pump section 41, and changing the wall thickness of the first pump section 41 to the wall thickness of the second pump section 42. There is a method of making it larger than the thickness.

In the case of the present embodiment, as shown in FIG. 7, the wall thickness of the first pump section 41 is larger than the wall thickness of the second pump section 42, so that the second pump section 42 is more flexible than the first pump section 41. The first pump unit 41 is restored faster than the second pump unit 42 after the introduction of the gas into the gas chamber 20 is stopped.
Since the wall thickness of the first pump section 41 is larger than the wall thickness of the second pump section 42, the compression ratio of the second pump section 42 due to the gas pressure in the internal space 21 is the first pump due to the gas pressure. It becomes larger than the compression ratio of the part 41.

As shown in FIG. 7, the wall thickness of the main portion 45a of the cylindrical portion 45 of the first pump portion 41 is T1, and the wall thickness of the main portion 45a of the cylindrical portion 45 of the second pump portion 42 is T2.
In the case of the present embodiment, the wall thickness T1 is set to a size larger than the wall thickness T2. Along with this, the average wall thickness of the first pump portion 41 including the cylindrical portion 45 and the tapered portion 46 is the average wall thickness of the entire second pump portion 42 including the cylindrical portion 45 and the tapered portion 46. It is larger than the thickness.

In the case of the present embodiment, the protruding height and number of the pump portion ribs 45b in the first pump portion 41 and the protruding height and number of the pump portion ribs 45b in the second pump portion 42 are equal to each other.
However, the present invention is not limited to this example, and the first method is to make the protruding height of the pump portion rib 45b in the first pump portion 41 larger than the protruding height of the pump portion rib 45b in the second pump portion 42. The overall average wall thickness of the pump unit 41 is made larger than the overall average wall thickness of the second pump unit 42, and after the introduction of gas into the gas chamber 20 is stopped, the first pump unit 41 moves to the second pump. It may be restored faster than the unit 42. Further, by making the arrangement density of the pump portion rib 45b in the first pump portion 41 higher than the arrangement density of the pump portion rib 45b in the second pump portion 42, the overall average wall thickness of the first pump portion 41 can be increased. Even if the wall thickness of the second pump section 42 is made larger than the overall average wall thickness, and the first pump section 41 is restored faster than the second pump section 42 after the introduction of gas into the gas chamber 20 is stopped. Good.

[Third Embodiment]
Next, the third embodiment will be described with reference to FIG. FIG. 8 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive coating tool according to the present embodiment, and is a cross section along the axis of the first liquid flow pipe 31. It is a figure.
The bioadhesive coating tool according to the present embodiment is different from the bioadhesive coating tool 100 according to the first embodiment or the bioadhesive coating tool according to the second embodiment in the points described below. In other respects, it is configured in the same manner as the bio-adhesive coating tool 100 according to the first embodiment or the bio-adhesive coating tool according to the second embodiment.

In the case of this embodiment, the internal volume of the second pump unit 42 is larger than the internal volume of the first pump unit 41. The internal volume referred to here means the internal volume when each pump unit 40 is in a natural state.
Since the internal volume of the second pump unit 42 is larger than the internal volume of the first pump unit 41, the liquid that can be sucked by the second pump unit 42 is larger than the volume of the liquid 38 that can be sucked by the first pump unit 41. The volume of 38 is large. Therefore, the liquid 38 sucked by the first pump unit 41 can be more reliably sucked by the second pump unit 42.
As shown in FIG. 8, the axial length dimension of the cylindrical portion 45 of the first pump portion 41 is L11, and the axial length dimension of the cylindrical portion 45 of the second pump portion 42 is L21.
In the case of the present embodiment, the length dimension L21 is larger than the length dimension L11, and accordingly, the cylindrical portion 45 is larger than the total internal volume of the first pump portion 41 including the cylindrical portion 45 and the tapered portion 46. The overall internal volume of the second pump portion 42 including the tapered portion 46 is increased.
Also in the case of this embodiment, the inner diameter of the main portion 45a of the cylindrical portion 45 in the first pump portion 41 and the inner diameter of the main portion 45a of the cylindrical portion 45 in the second pump portion 42 are equal to each other.
However, the present invention is not limited to this example, and by making the inner diameter of the main portion 45a of the cylindrical portion 45 of the second pump portion 42 larger than the inner diameter of the main portion 45a of the cylindrical portion 45 of the first pump portion 41. , The internal volume of the second pump unit 42 may be larger than the internal volume of the first pump unit 41.

[Fourth Embodiment]
Next, the fourth embodiment will be described with reference to FIGS. 9 (a) and 9 (b). 9 (a) and 9 (b) are enlarged views showing the periphery of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive coating tool according to the fourth embodiment. 9 (a) is a cross-sectional view along the axis of the first liquid flow pipe 31, and FIG. 9 (b) is a plan view.
The bioadhesive coating tool according to the present embodiment is the bioadhesive coating tool 100 according to the first embodiment, the bioadhesive coating tool according to the second embodiment, or the third embodiment in the following points. The bioadhesive coating tool 100 according to the first embodiment, the bioadhesive coating tool according to the second embodiment, or the third embodiment is different from the bioadhesive coating tool according to the above. It is configured in the same manner as the bioadhesive coating tool.

As shown in FIGS. 9A and 9B, the bioadhesive coating tool according to the present embodiment has a plurality of pump units 40 as a specific liquid flow pipe (first liquid) rather than the second pump unit 42. It further includes a third pump unit 43 located on the upstream side of the distribution pipe 31).
Therefore, the liquid 38 can be sucked from the discharge port 31a side to the pump portion 40 side with a stronger suction force.

In the case of the present embodiment, the constricted portion 37 is arranged between the first pump unit 41 and the second pump unit 42, and between the second pump unit 42 and the third pump unit 43, respectively.
In the case of the present embodiment, the second pump portion 42 does not include the tapered portion 46 and is composed of the cylindrical portion 45.
Further, the third pump unit 43 has, for example, the cylindrical portion 45 and the tapered portion 46 connected to the base end side of the cylindrical portion 45, similarly to the second pump portion 42 described in the first embodiment. Have.
In the case of the present embodiment, for example, the protruding height and the arrangement density of the pump portion rib 45b of each pump portion 40 are equal to each other.

<Modified example of the fourth embodiment>
Next, a modified example of the fourth embodiment will be described with reference to FIGS. 10 (a) and 10 (b). 10 (a) and 10 (b) are enlarged views showing the periphery of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive coating tool according to the modified example of the fourth embodiment. Of these, FIG. 10 (a) is a cross-sectional view along the axis of the first liquid flow pipe 31, and FIG. 10 (b) is a plan view.
The bioadhesive coating tool according to this modification is different from the bioadhesive coating tool according to the fourth embodiment in the following description, and in other respects, it is the same as the fourth embodiment. It is configured in the same manner as the bioadhesive coating tool.

As shown in FIG. 10A, in the case of this modification, the inner and outer diameters of the non-pump portion 35 are constant over the entire non-pump portion 35.

As shown in FIGS. 10A and 10B, in the case of this modification, the number of pump portion ribs 45b in each pump portion 40 is, for example, two. Along with this, for the cylindrical portion 45 of each pump portion 40, the outer diameter of the main portion 45a is equal to or larger than the axial dimension of the cylindrical portion 45.
Therefore, it is easier to sufficiently secure the compression ratio (rate at which the internal volume is reduced) of each pump portion 40 (cylindrical portion 45) due to the external pressure (gas pressure in the internal space 21).

The present invention is not limited to the above embodiments and modifications thereof, and includes various modifications, improvements, and the like as long as the object of the present invention is achieved.

For example, in the above, the number of liquid flow pipes included in the bioadhesive coating tool 100 is 2, and one liquid flow pipe (for example, the first liquid flow pipe 31) has a plurality of pump units 40. An example of a liquid flow pipe has been described. However, the present invention is not limited to this example, and the bioadhesive coating tool 100 may include three or more liquid flow tubes, or the number of specific liquid flow tubes may be two or more. Further, all the liquid flow tubes included in the bioadhesive coating tool 100 may be specific liquid flow tubes.
However, it is preferable that the liquid flow tube for circulating a highly viscous liquid containing fibrinogen or the like is a specific liquid flow tube.

Further, even when the specific liquid flow pipe has three or more pump units 40, the restoration speed of the pump units 40 located on the more advanced side is faster as in the second embodiment. It is also preferable.
For example, in the fourth embodiment or a modification thereof, the overall average wall thickness of the first pump unit 41 is made larger than the overall average wall thickness of the second pump unit 42, and the entire second pump unit 42 is formed. The average wall thickness is made larger than the overall average wall thickness of the third pump unit 43. As a result, after the introduction of gas into the gas chamber 20 is stopped, the first pump unit 41 restores faster than the second pump unit 42, and the second pump unit 42 restores faster than the third pump unit 43. it can. By doing so, the liquid 38 is quickly sucked from the discharge port 31a side by the first pump unit 41, and then the liquid 38 is further sucked to the base end side by the second pump unit 42, and then the second pump unit 42 sucks the liquid 38. The liquid 38 can be further sucked toward the base end side by the 3 pump unit 43.
More specifically, for example, the protruding height of the pump portion rib 45b in the first pump portion 41 is made larger than the protruding height of the pump portion rib 45b in the second pump portion 42, and the protruding height of the pump portion rib in the second pump portion 42 is increased. The protruding height of the 45b can be made larger than the protruding height of the pump portion rib 45b in the third pump portion 43.

Further, contrary to the second embodiment, the pump unit 40 located closer to the proximal end side may be configured to have a faster restoration speed.
For example, by making the overall average wall thickness of the second pump unit 42 larger than the overall average wall thickness of the first pump unit 41, after the introduction of gas into the gas chamber 20 is stopped, the second pump The unit 42 can be restored faster than the first pump unit 41.
In this case, since the elastic restoring force of the second pump portion 42 located on the proximal end side is larger, first, the liquid 38 on the distal end side as a whole is sucked from the second pump portion 42, and then the liquid 38 is positioned on the distal end side. The liquid 38 can be further sucked from the discharge port 31a side by the first pump unit 41.
In this case, the compression ratio of the first pump unit 41 due to the gas pressure in the internal space 21 is larger than the compression ratio of the second pump unit 42 due to the gas pressure.
More specifically, for example, the protruding height of the pump portion rib 45b in the second pump portion 42 can be made larger than the protruding height of the pump portion rib 45b in the first pump portion 41.

Further, even when the specific liquid flow pipe has three or more pump units 40, the restoration speed of the pump unit 40 located on the proximal end side is faster, contrary to the second embodiment. It is also preferable to have a configuration.
For example, in the fourth embodiment or a modification thereof, the overall average wall thickness of the first pump unit 41 is made smaller than the overall average wall thickness of the second pump unit 42, and the entire second pump unit 42 The average wall thickness is made smaller than the overall average wall thickness of the third pump unit 43. As a result, after the introduction of gas into the gas chamber 20 is stopped, the third pump unit 43 restores faster than the second pump unit 42, and the second pump unit 42 restores faster than the first pump unit 41. it can. By doing so, the liquid 38 is rapidly sucked from the discharge port 31a side by the third pump unit 43, the liquid 38 is further sucked by the second pump unit 42, and then the liquid 38 is further sucked by the first pump unit 41. Further, the liquid 38 can be sucked.
More specifically, for example, the protruding height of the pump portion rib 45b in the second pump portion 42 is made larger than the protruding height of the pump portion rib 45b in the first pump portion 41, and the protruding height of the pump portion rib in the third pump portion 43 is increased. The protruding height of the 45b can be made larger than the protruding height of the pump portion rib 45b in the second pump portion 42.

Further, in the above, the first liquid flow pipe 31 is configured by combining a plurality of members (first liquid flow pipe main body 33, tip side member 70 and base end side member 60), and the second liquid flow pipe Although 32 has also been described as an example in which a plurality of members (second liquid flow pipe main body 34, tip side member 70, and base end side member 60) are combined, each liquid flow pipe is integrally formed as a whole. It may be composed of a single member.

In addition, each of the above embodiments or modifications can be appropriately combined as long as the gist of the present invention is not deviated.

The present embodiment includes the following technical ideas.
(1) A gas chamber having a gas introduction section into which a gas is introduced and a gas ejection section for ejecting the gas.
A plurality of liquid flow pipes that pass through the internal space of the gas chamber and have discharge ports arranged in the vicinity of the gas ejection portion.
With
A bioadhesive coating tool that sprays and mixes liquids discharged from the discharge ports of the plurality of liquid flow pipes and applies the liquids to the living tissue by urging the liquids discharged from the gas ejection portions with the gas ejected from the gas ejection portion. And
The specific liquid flow pipe, which is at least one of the plurality of liquid flow pipes, has a plurality of pump portions each composed of different parts in the axial direction of the specific liquid flow pipe.
In the specific liquid flow pipe, the portion located between the plurality of pump portions is a constricted portion having a smaller diameter than the pump portion.
Each of the plurality of pump units is compressed by the gas pressure when the gas is introduced into the gas chamber to reduce the internal volume, and is elastically restored when the introduction of the gas into the gas chamber is stopped. Bio-adhesive coating tool.
(2) The plurality of pump units include a first pump unit and a second pump unit arranged on the upstream side of the specific liquid flow pipe with respect to the first pump unit.
The bioadhesive coating tool according to (1), wherein the first pump portion is configured to restore faster than the second pump portion after the introduction of the gas into the gas chamber is stopped.
(3) The bioadhesive coating tool according to (2), wherein the second pump portion is configured more flexibly than the first pump portion.
(4) The bioadhesive coating tool according to (2) or (3), wherein the wall thickness of the first pump portion is larger than the wall thickness of the second pump portion.
(5) The bioadhesive coating tool according to any one of (2) to (4), wherein the internal volume of the second pump portion is larger than the internal volume of the first pump portion.
(6) In the specific liquid flow pipe, a ring-shaped boundary rib is formed on the inner peripheral surface of the portion located at the boundary between the first pump portion and the second pump portion (1) to (1). The bioadhesive coating tool according to any one of 5).
(7) The rib of a pump portion having a height lower than that of the boundary rib is formed on at least one outer peripheral surface or inner peripheral surface of the first pump portion and the second pump portion (6). Bio-adhesive coating tool.
(8) In any one of (2) to (7), the plurality of pump units further include a third pump unit arranged on the upstream side of the specific liquid flow pipe with respect to the second pump unit. The bioadhesive coating tool described.

10 Spray unit 20 Gas chamber 21 Internal space 22 Gas introduction part 23 Gas flow passage 24 Gas ejection part 25 Partition wall part 31 First liquid flow pipe (liquid flow pipe, specific liquid flow pipe)
31a Discharge port 32 Second liquid flow pipe (liquid flow pipe)
32a Discharge port 33 1st liquid flow pipe body 33a Base end 33b Tip 34 2nd liquid flow pipe 34a Base 34b Tip 35 Non-pump 35a Straight pipe 35b Tip 36 Non-pump 36a Straight pipe 36b Base end 37 Constriction 37a Main part 37b Boundary ribs 38, 39 Liquid 40 Pump part 41 First pump part 42 Second pump part 43 Third pump part 45 Cylindrical part 45a Main part 45b Pump part rib 46 Tapered part 50 Chamber Main body 51 Base end 51a Base end side opening 52 Tip end 52a Insertion hole 52b Fixed rib 60 Base end side member 61 Main body 62a, 62b Syringe mounting 63a, 63b Liquid flow pipe mounting 64a, 64b Through hole 65 Partition wall configuration Part 70 Tip side member 71 First discharge pipe 71a, 72a Holding part 71b, 72b Protruding part 72 Second discharge pipe 73 Connecting part 80 Injection tool 81 Syringe 82 Plunger 83 Plunger holder 85 Air filter unit 85a Connection part 90 Regulator 91 Air supply Tube 92a 1st connector 92b 2nd connector 100 Bioadhesive coating tool

Claims (8)

A gas chamber having a gas introduction section into which gas is introduced and a gas ejection section for ejecting the gas.
A plurality of liquid flow pipes that pass through the internal space of the gas chamber and have discharge ports arranged in the vicinity of the gas ejection portion.
With
A bioadhesive coating tool that sprays and mixes liquids discharged from the discharge ports of the plurality of liquid flow pipes and applies the liquids to the living tissue by urging the liquids discharged from the gas ejection portions with the gas ejected from the gas ejection portion. And
The specific liquid flow pipe, which is at least one of the plurality of liquid flow pipes, has a plurality of pump portions each composed of different parts in the axial direction of the specific liquid flow pipe.
In the specific liquid flow pipe, the portion located between the plurality of pump portions is a constricted portion having a smaller diameter than the pump portion.
Each of the plurality of pump units is compressed by the gas pressure when the gas is introduced into the gas chamber to reduce the internal volume, and is elastically restored when the introduction of the gas into the gas chamber is stopped. Bio-adhesive coating tool. The plurality of pump units include a first pump unit and a second pump unit arranged on the upstream side of the specific liquid flow pipe with respect to the first pump unit.
The bioadhesive coating tool according to claim 1, wherein the first pump unit is configured to restore faster than the second pump unit after the introduction of the gas into the gas chamber is stopped. The bioadhesive coating tool according to claim 2, wherein the second pump portion is configured more flexibly than the first pump portion. The bioadhesive coating tool according to claim 2 or 3, wherein the wall thickness of the first pump portion is larger than the wall thickness of the second pump portion. The bioadhesive coating tool according to any one of claims 2 to 4, wherein the internal volume of the second pump portion is larger than the internal volume of the first pump portion. Any of claims 2 to 5 in which a ring-shaped boundary rib is formed on the inner peripheral surface of a portion of the specific liquid flow pipe located at the boundary between the first pump portion and the second pump portion. The bioadhesive coating tool according to item 1. The bioadhesive according to claim 6, wherein a pump portion rib having a height lower than that of the boundary rib is formed on at least one outer peripheral surface or inner peripheral surface of the first pump portion and the second pump portion. Applying tool. The bioadhesive according to any one of claims 2 to 7, further comprising a third pump unit arranged upstream of the specific liquid flow pipe as the plurality of pump units. Applying tool.

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