CN219071639U - Nasal spray administration device and spray system comprising same - Google Patents

Abstract

A nasal spray delivery device for use with a syringe, the nasal spray delivery device comprising a nozzle and a syringe adapter. Wherein, be formed with the liquid collecting port at the distal end of nozzle, liquid collecting port intercommunication nozzle's inside and outside, the cylinder joint includes nozzle connecting portion, and the nozzle is connected on nozzle connecting portion. Wherein a nozzle core is integrally formed on a distal end of the nozzle connecting portion of the syringe adapter, and a flow passage is formed between an outer wall of the nozzle core and an inner wall of the nozzle. The structure is helpful for simplifying the structure of the nasal cavity spray administration device, improving the molding precision of the nozzle core, ensuring the relative position fixation of the nozzle core and the rest part of the syringe joint, and stabilizing the spray effect. And also relates to a spray system comprising the nasal spray delivery device.

Description

Nasal spray administration device and spray system comprising same

Technical Field

The utility model belongs to the field of medical instruments, and particularly relates to a nasal cavity spray drug delivery device which can supply drugs to a human body in the form of drug mist.

Background

Nebulizers are widely used in the medical field, which are capable of delivering drugs to the interior of the human body in the form of a spray, for example, in the form of a spray to the nasal cavity, which can be used for the treatment of related diseases, vaccines, in particular for respiratory infections, etc.

Among them, there are various forms of spray devices for nasal administration, such as bottled multi-dose nasal spray pumps, pre-filled single/double dose nasal spray devices, syringe type nasal spray devices, and the like. Among these, the most suitable for mass applications are syringe type nasal spray devices. The syringe type nasal spray device is used in the following manner: firstly, the medicine in the liquid state, the semi-liquid state and the like is inhaled into the injector, then the spray head is arranged on the needle seat of the injector, the plunger of the injector is quickly pushed, so that the medicine in the injector generates high pressure, is further accelerated in the spray head, is sprayed out in a spray mode under the action of the pressure, and is applied to the nasal cavity, in particular to the nasal mucosa.

The syringe type nasal spray device has been found to have problems during use, mainly that the consistency of the spray is sometimes difficult to ensure. The reason for this is that the spraying effect is required to be high in coaxiality of the assembly of the components of the spraying device, the insertion depth of the shaft center, and the like. If the control is not good during the assembly, the problems of large spray particle size, uneven particle size, deviation of spray or error of angle (too large or too small angle), incomplete spray form and the like are generated.

Accordingly, there is a need for a syringe type nasal spray device having a further improved structure to solve the above-mentioned problems of the prior art.

Disclosure of Invention

The present utility model has been made to solve the above-disclosed technical problems occurring in the prior art. The present utility model aims to provide an improved nasal spray delivery device, in particular a syringe type nasal spray delivery device, which can prevent, or at least reduce, the difference of spray effects and ensure the consistency of spray particles, spray patterns, spray forms, etc. of each spray.

The nasal spray administration device of the present utility model is used together with a syringe, and comprises a nozzle, a liquid collecting port formed at a distal end of the nozzle, the liquid collecting port communicating an inside and an outside of the nozzle, and a cylinder joint comprising a nozzle connecting portion to which the nozzle is connected. Wherein a nozzle core is integrally formed on a distal end of the nozzle connecting portion of the syringe adapter, and a flow passage is formed between an outer wall of the nozzle core and an inner wall of the nozzle.

By integrally forming the nozzle core on the cylinder joint, the number of parts of the nasal cavity spray administration device is reduced, thereby simplifying the structure of the nasal cavity spray administration device, improving the molding accuracy of the nozzle core, and ensuring the relative position fixation of the nozzle core and the rest of the cylinder joint, so that the fit can be well controlled in the radial and axial directions. Therefore, the nasal cavity spray drug delivery device can prevent the problems of spray effect difference and the like caused by factors such as assembly pressure, assembly force points, simplified positioning, stopping and limiting.

Preferably, an accelerating channel is formed between the nozzle core and the inner wall of the nozzle, and the accelerating channel is communicated between the liquid collecting port and the flow channel, wherein an inlet of the accelerating channel is connected with the flow channel, and an outlet of the accelerating channel is connected with the liquid collecting port. The accelerating channel can improve the flowing speed of the liquid medicine, thereby improving the atomization effect.

Further, the acceleration channel may be formed at least one of the following positions:

between the inner wall of the nozzle and the outer wall of the nozzle core,

between the inner wall of the nozzle and the top of the nozzle core.

For the design of the acceleration channel, the size of the inlet of the acceleration channel is larger than the size of the outlet of the acceleration channel. Here, the dimension may refer to, for example, the width of the inlet and the outlet, or the like.

It is also preferable that the outlet of the acceleration channel is aligned with the tangential direction of the outer circumference of the liquid collecting port. In this way, the ejected chemical liquid can be given high-speed centrifugal rotation inertia, thereby obtaining better atomization particle diameter and atomization angle.

Preferably, the nozzle core is formed in a solid column shape. The solid columnar form allows the nozzle core to have sufficient strength to bear against the acceleration slot in the nozzle, thereby enabling a stable acceleration channel to be formed, and thus a stable spray effect. Further, the solid nozzle core contributes to a reduction in the residual amount of the chemical solution.

Preferably, at least one communication hole is formed at the top of the nozzle connection part, the communication hole communicating with the flow passage. For example, a pair of communication holes may be formed at both sides of the nozzle core. The shape of the communication hole may be any suitable shape such as rectangular, circular, polygonal, etc.

Preferably, at least one first positioning rib is formed on the inner wall of the nozzle, wherein the first positioning ribs are distributed along the circumferential direction of the nozzle. Alternatively or additionally, formed on the nozzle core. There is at least one second positioning bead, wherein the second positioning bead is distributed along the circumference of the nozzle core. The first and second locating ribs help ensure that the nozzle and syringe adapter are coaxial during assembly. For example, two or more first positioning ribs and two or more second positioning ribs may be provided.

Preferably, a finger grip is formed at the proximal end of the barrel adapter. When spraying, when the thumb of an operator pushes the push rod of the injector, the index finger and the middle finger can buckle the finger buckling plate, so that the problems of loosening, leakage and the like between the syringe joint and the injector in the spraying process are prevented.

Preferably, the nasal spray delivery device further comprises a filling portion disposed in the barrel adapter, the filling portion filling a gap in a distal end of a hub of the syringe when the nasal spray delivery device is mounted to the syringe. Thus, the residual amount of the used liquid medicine can be reduced.

Preferably, at least one pair of core rectifying holes is formed on the nozzle connecting portion of the cylinder joint. The core correcting hole can prevent uneven wall thickness of a product caused by deflection of a mold during injection molding.

Also relates to a spray system comprising a syringe and a nasal spray delivery device mounted on the syringe, wherein the nasal spray delivery device is a nasal spray delivery device as described above.

Preferably, the nasal spray delivery device is mounted on the syringe by one of the following means:

the syringe is inserted into the inner cavity of the syringe connector;

the needle seat of the injector is fixedly connected in the inner cavity of the needle cylinder joint;

a convex rib is formed on one of the needle seat of the injector and the inner wall of the needle cylinder joint, a convex rib groove is formed on the other one of the needle seat of the injector and the inner wall of the needle cylinder joint, and the convex rib can be matched in the convex rib groove; and

a male luer fitting is formed on the proximal end of the barrel fitting and a female luer fitting is formed on the hub of the syringe, the male luer fitting mating with the female luer fitting to form a luer connection.

Drawings

Embodiments of the present utility model will be more clearly understood from the structure shown in the accompanying drawings, in which:

fig. 1 shows a cross-sectional view of a first embodiment of the nasal spray delivery device of the present utility model mounted on a syringe, wherein the nasal spray delivery device and syringe are shown prior to being fully installed.

Fig. 2 shows another cross-sectional view of the syringe and nasal spray delivery device of fig. 1, with the syringe and nasal spray delivery device fully installed.

Fig. 3 shows a cross-sectional view of the nozzle of the nasal spray delivery device of fig. 1.

Fig. 4 shows a cross-sectional view of the syringe adapter of the nasal spray delivery device of fig. 1.

Fig. 5 shows a side view of the nozzle of fig. 3.

Fig. 6 is a sectional view taken along line C-C of fig. 5.

Fig. 7 is a perspective view of the syringe adapter of fig. 4.

Fig. 8a is an enlarged perspective view of a portion B in fig. 7.

Fig. 8b is a cross-sectional view of the portion shown in fig. 8 a.

Fig. 9 is an enlarged perspective view of a modification of the portion B in fig. 7.

Fig. 10a is an enlarged perspective view of another modification of the portion B in fig. 7.

Fig. 10b is a cross-sectional view of the portion shown in fig. 10 b.

Fig. 11 shows a cross-sectional view of a nasal spray delivery device mounted on a syringe according to a second embodiment of the present utility model, wherein the nasal spray delivery device and the syringe are shown prior to being mounted.

Fig. 12 shows another cross-sectional view of the syringe and nasal spray delivery device of fig. 11, with the syringe and nasal spray delivery device mounted together.

Fig. 13a shows a cross-sectional view of the nozzle of the nasal spray delivery device of fig. 11.

Fig. 13b shows a cross-sectional view of the syringe adapter of the nasal spray delivery device of fig. 11.

Fig. 13c shows a cross-sectional view of the filling portion of the nasal spray delivery device of fig. 11.

Fig. 14 shows a cross-sectional view of a nasal spray delivery device mounted on a syringe according to a third embodiment of the present utility model, wherein the nasal spray delivery device and the syringe are shown prior to being mounted.

Fig. 15 shows another cross-sectional view of the syringe and nasal spray delivery device of fig. 14, with the syringe and nasal spray delivery device mounted together.

Fig. 16 shows a cross-sectional view of a nasal spray delivery device mounted on a syringe according to a fourth embodiment of the present utility model, wherein the nasal spray delivery device and the syringe are shown prior to being mounted.

Fig. 17 shows another cross-sectional view of the syringe and nasal spray delivery device of fig. 16, with the syringe and nasal spray delivery device mounted together.

Fig. 18a shows a cross-sectional view of the nozzle of the nasal spray delivery device of fig. 16.

Fig. 18b shows a cross-sectional view of the syringe adapter of the nasal spray delivery device of fig. 16.

Detailed Description

In order to facilitate an understanding of the present utility model, a detailed description of specific embodiments of the nasal spray delivery device of the present utility model will be provided below with reference to the accompanying drawings. It is to be understood that the drawings illustrate only the preferred embodiments of the utility model and are not to be considered limiting of the scope of the utility model. Various obvious modifications, variations, equivalent substitutions of the utility model will be apparent to those skilled in the art based on the embodiments shown in the drawings, and the technical features of the different embodiments described below can be arbitrarily combined with each other without contradiction, and these fall within the scope of the utility model.

In the following detailed description of the utility model, terms such as "proximal", "distal", and the like are used with respect to the operator in use, where "proximal" refers to the end proximal to the operator and "distal" is the end opposite "proximal" and distal from the operator.

< first embodiment >

Fig. 1 to 8b relate to a nasal spray delivery device 100 according to a first embodiment of the present utility model. In fig. 1 and 2, a cross-sectional view of a spray system of a syringe 10 together with a nasal spray delivery device 100 is shown, wherein fig. 1 shows the spray system in assembly, fig. 2 shows the spray system in assembly, and fig. 3 and 4 show cross-sectional views of a nozzle 110 and a syringe adapter 120, respectively, of the nasal spray delivery device 100.

It can be seen that in the first embodiment, assembly of nasal spray delivery device 100 and syringe 10 is accomplished by inserting barrel 11 of syringe 10 directly into the interior cavity of barrel fitting 120.

Nasal spray delivery device 100 includes a nozzle 110 and a syringe adapter 120, nozzle 110 and syringe adapter 120 being connectable together in a manner known in the art, such as a collar-groove configuration, a threaded configuration, and the like.

Fig. 5 shows a side view of the nozzle 110, while fig. 6 is a cross-sectional view taken along line C-C in fig. 5. The nozzle 110 has a substantially conical shape, and a liquid collecting port 111 is provided at a distal end of the nozzle 110, so that the chemical liquid can be discharged from the liquid collecting port 111 during the administration of the atomized medicine.

A perspective view of the syringe adapter 120 is shown in fig. 7, while fig. 8a and 8B show an enlarged view and a cross-sectional view of portion B of fig. 7. A nozzle connection 122 is formed at a distal end portion of the syringe adapter 120 for achieving connection between the syringe adapter 120 and the nozzle 110. Specifically, a first connection portion, which may be a collar, an external thread, or the like, is formed on the outer surface of the nozzle connection portion 122. Accordingly, a second connection portion, such as a groove, an internal thread, or the like, which is matched with the first connection portion, is formed on the inner surface of the nozzle 110. In the exemplary configuration shown in the figures, the first connection is in the form of a male ring and the second connection is in the form of a female groove. However, it will be appreciated by those skilled in the art that the first and second connection portions may take other configurations known to those skilled in the art.

In the present utility model, a nozzle core 121 is also integrally formed on the syringe adapter 120, the nozzle core 121 being specifically formed on the distal end of the nozzle connecting portion 122. When the nozzle 110 is mounted to the cylinder joint 120, a flow passage is formed between the outer wall of the nozzle core 121 and the inner wall of the nozzle 110, the flow passage being in communication with the liquid collecting port 111, in which the liquid medicine from the syringe 10 can flow and be ejected from the liquid collecting port 111.

The nozzle core 121 is preferably also provided in the form of a solid cylinder, so that it is ensured that the nozzle core 121 has sufficient strength to be able to abut against an accelerating groove (not shown) in the nozzle 110, so that a stable accelerating channel can be formed, effectively accelerating the liquid medicine from the syringe 10, and thus optimizing the atomization of the liquid medicine. The acceleration passage communicates, for example, between the flow passage and the liquid collection port 111. Specifically, an inlet of the acceleration channel is connected to the flow channel, and an outlet of the acceleration channel is connected to the liquid collecting port 111. In this way, the medical fluid from the syringe 10 can flow through the flow passage and the acceleration passage, and then the atomized medical fluid is ejected from the liquid collecting port 111.

The acceleration channel may be formed between the inner wall of the nozzle 110 and the outer wall of the nozzle core 121, between the inner wall of the nozzle 110 and the top of the nozzle core 121, or both. Preferably, the size (e.g., width) of the inlet of the acceleration channel is set to be larger than the size (e.g., width) of the outlet of the acceleration channel, so that the acceleration effect on the liquid medicine can be obtained.

Further preferably, the direction of the outlet of the acceleration channel is set to be aligned with the tangential direction of the outer circumference of the liquid collection port 111. This maximizes the inertial force of centrifugal rotation of the chemical solution at the time of discharge from the nozzle 110, thereby further improving the atomization effect, for example, the atomization particle diameter and the atomization angle.

Preferably, as can be seen more clearly in fig. 6, at least one, preferably two or more first positioning ribs 112 are provided on the inner side (or inner wall) of the nozzle 110 near its end. The first locating rib 112 helps ensure coaxial alignment between the nozzle 110 and the syringe adapter 120 when the nozzle 110 is connected to the syringe adapter 120.

Further, referring to fig. 8a and 8b, at least one communication hole 123 is formed at the top of the nozzle connection part 122 of the syringe adapter 120, the communication hole 123 communicating the inside and outside of the nozzle connection part 122, specifically, with a flow channel between the outer wall of the nozzle core 121 and the inner wall of the nozzle 110, so that the communication hole 123 allows the liquid medicine from the syringe 10 to flow into the flow channel. In the exemplary configuration shown in the figures, two communication holes 123 are included, one on each side of the nozzle core 121, preferably 180 ° apart from each other. Of course, other numbers of communication holes 123 may be provided as needed.

Preferably, a filling portion 126 is also formed in the barrel adapter 120, the filling portion 126 being capable of mating with, and specifically extending into, a gap 13 in a hub on the end of the barrel 11 of the injector 10. When the plunger 12 of the syringe 10 is pushed to the bottom at the time of injecting the medical fluid, the clearance left at the tip of the needle holder can be reduced or even eliminated as much as possible, thereby minimizing the residual medical fluid after one injection. In fig. 8b, a filling portion 126 of an exemplary construction is shown, which is integrally formed with the nozzle core 121 and is located inside the syringe adapter 120 opposite the nozzle core 121.

The filler 126 may take other forms as well, as will be described in more detail below.

As shown in fig. 7, a finger grip 127 is also formed on an end of the syringe adapter 120 opposite the nozzle connection 122. When using nasal spray delivery device 100 for spraying, a user (e.g., a physician, etc.) may grasp finger grip 127 with the index and middle fingers while pushing plunger 12 of syringe 10 with the thumb. Thus, the more compressed the nasal spray delivery device 100 is between the barrel adapter 120 and the syringe 10 during pushing of the push rod 12, so that the nasal spray delivery device 100 does not loosen from the syringe 10 due to an increase in the pressure of the medical fluid, or at least the risk of loosening is reduced.

Fig. 9 shows a modified structure of the nozzle connecting portion 122 portion of the cylinder joint 120, in which it can be seen that at least one, preferably two or more second positioning ribs 124 are formed on the nozzle core 121. The second locating ribs 124 may facilitate coaxial alignment of the nozzle 110 and the syringe adapter 120 when the nozzle 110 and the syringe adapter 120 are mounted together.

As will be appreciated by those skilled in the art, nasal spray delivery device 100 may include one of first positioning rib 112 on nozzle 110 and second positioning rib 124 on syringe adapter 120 as described above, and may also include both first positioning rib 112 and second positioning rib 124.

Fig. 10a and 10b illustrate another variation of the nozzle connection 122 portion of the syringe adapter 120. Wherein at least one pair of core rectifying holes 125 is formed on the nozzle connecting portion 122. By way of the core print-out apertures 125, the core print-out apertures 125 may help to avoid or reduce the risk of mold core deflection during molding of the syringe adapter 120, thereby helping to improve wall thickness uniformity of the manufactured syringe adapter 120.

In the configuration shown in fig. 10a and 10b, two core straightening bores 125 (one of which is shown) are included that are 180 ° apart from each other. Those skilled in the art will appreciate that any suitable number of core print apertures 125 may be provided as desired, and that the core print apertures 125 may be suitably arranged, such as uniform spacing between adjacent core print apertures 125 or non-uniform spacing.

The core correcting hole 125 is shown as being substantially rectangular, but the core correcting hole 125 may be provided in other shapes as required.

< second embodiment >

Fig. 11 to 13c relate to the structure of a nasal spray delivery device 200 according to a second embodiment of the present utility model. The specific structure described above with respect to the first embodiment is also applicable to the second embodiment without contrary description or conflict. The structure of the second embodiment different from the first embodiment will be specifically described below.

Fig. 11 shows a cross-sectional view of the nasal spray delivery device 200 and the syringe 20 to which the nasal spray delivery device 200 is to be attached, and fig. 12 shows a cross-sectional view of the nasal spray delivery device 200 and the syringe 20 connected to each other.

In the second embodiment, the barrel adapter 220 of the nasal spray delivery device 200 is attached to the hub 21 of the syringe 20. As seen in fig. 12, the needle hub 21 of the syringe 20 is inserted into the interior cavity of the barrel adapter 220.

Fig. 13 a-13 c show cross-sectional views of nozzle 210, syringe adapter 220, and filling portion 226 mounted in syringe adapter 220, respectively, of nasal spray delivery device 200. As can be seen in connection with fig. 11 and 12, the filling portion 226 is sleeved on the lower end of the nozzle core 221 inside the cylinder joint 220. The filling portion 226 may fill a gap on the distal end of the needle hub 21 of the syringe 20 when the syringe 20 is coupled to the nasal spray delivery device 200.

The needle hub 21 may be secured in the interior cavity of the syringe adapter 220 by means such as glue bonding.

< third embodiment >

Fig. 14 and 15 relate to the structure of a nasal spray delivery device 300 according to a third embodiment of the present utility model. The specific structures described above with respect to the first and second embodiments are also applicable to the third embodiment without contrary description or conflict. The structure of the third embodiment different from the first and second embodiments will be specifically described below.

In the third embodiment, the nasal spray delivery device 300 is provided therein with the rib groove 321, and the rib groove 321 is specifically formed on the inner wall of the cylinder joint of the nasal spray delivery device 300. Correspondingly, ribs 31 are formed on the outer surface of the hub of the syringe 30. When the syringe 30 and the nasal spray delivery device 300 are mounted together, the ribs 31 on the syringe 30 can fit into, e.g., snap together, the ribs 321 of the nasal spray delivery device 300. When installed, the engagement between the ribs 31 and the rib grooves 321 helps prevent the syringe 30 from being disengaged from the nasal spray delivery device 300.

Those skilled in the art will appreciate that the locations of the ribs and ribs may be interchanged, such as by providing ribs on the outer surface of the hub and ribs on the inner wall of the barrel fitting.

< fourth embodiment >

Fig. 16 to 18b relate to the structure of a nasal spray delivery device 400 according to a fourth embodiment of the present utility model. The specific structures described above with respect to the first to third embodiments are also applicable to the fourth embodiment without contrary description or conflict. The structure of the fourth embodiment different from the first to third embodiments will be specifically described below.

In a fourth embodiment, the connection between nasal spray delivery device 400 and syringe 40 is made by a luer connector. As can be clearly seen from fig. 16, a female luer fitting 41 is formed on the hub of the syringe 40. Fig. 18a and 18b show cross-sectional views of the nozzle 410 and the syringe adapter 420, respectively, of the nasal spray delivery device 400, with a male luer adapter 421 formed at the proximal end of the syringe adapter 420. When the nasal spray delivery device 400 is connected to the syringe 40, the male luer 421 is fitted into the female luer 41, thereby achieving the connection, as shown in fig. 17.

Claims (12)

1. A nasal spray administration device for use with a syringe, wherein the nasal spray administration device comprises a nozzle and a barrel connector, a liquid collecting port is formed at a distal end of the nozzle, the liquid collecting port communicates with an inside and an outside of the nozzle, the barrel connector comprises a nozzle connecting portion to which the nozzle is connected, characterized in that a nozzle core is integrally formed at a distal end of the nozzle connecting portion of the barrel connector, and a flow passage is formed between an outer wall of the nozzle core and an inner wall of the nozzle.

2. The nasal spray delivery device of claim 1, wherein an acceleration channel is formed between the nozzle core and an inner wall of the nozzle, the acceleration channel being in communication between the liquid collection port and the flow channel, wherein an inlet of the acceleration channel is connected to the flow channel and an outlet of the acceleration channel is connected to the liquid collection port.

3. The nasal spray delivery device of claim 2, wherein the acceleration channel is formed in at least one of the following locations:

between the inner wall of the nozzle and the outer wall of the nozzle core,

between the inner wall of the nozzle and the top of the nozzle core.

4. The nasal spray delivery device of claim 2, wherein the inlet of the acceleration channel has a size that is larger than the size of the outlet of the acceleration channel, and/or

The outlet of the accelerating channel is aligned with the tangential direction of the excircle of the liquid collecting port.

5. The nasal spray delivery device of claim 2, wherein the nozzle core is formed in a solid cylindrical shape.

6. The nasal spray delivery device of claim 1, wherein at least one communication hole is formed at a top of the nozzle connection part, the communication hole being in communication with the flow passage.

7. The nasal spray delivery device of claim 1, wherein at least one first locating rib is formed on an inner wall of the nozzle, wherein the first locating rib is distributed along a circumferential direction of the nozzle; and/or

At least one second positioning rib is formed on the nozzle core, wherein the second positioning ribs are distributed along the circumferential direction of the nozzle core.

8. The nasal spray delivery device of claim 1, wherein a finger grip is formed at a proximal end of the barrel adapter.

9. The nasal spray delivery device of claim 1, further comprising a filling portion disposed in the syringe adapter, the filling portion filling a gap in a distal end of a hub of the syringe when the nasal spray delivery device is mounted to the syringe.

10. The nasal spray delivery device of claim 1, wherein at least one pair of core alignment holes are formed in the nozzle connection portion of the syringe adapter.

11. A spray system comprising a syringe and a nasal spray delivery device mounted on the syringe, wherein the nasal spray delivery device is a nasal spray delivery device according to any one of claims 1 to 10.

12. The spray system of claim 11, wherein the nasal spray delivery device is mounted on the syringe by one of:

the syringe of the injector is inserted into the inner cavity of the syringe connector;

the needle seat of the injector is fixedly connected in the inner cavity of the needle cylinder joint;

a rib is formed on one of the needle seat of the injector and the inner wall of the syringe connector, a rib groove is formed on the other of the needle seat of the injector and the inner wall of the syringe connector, and the rib can be matched in the rib groove; and

a male luer fitting is formed on the proximal end of the barrel fitting and a female luer fitting is formed on the hub of the syringe, the male luer fitting mating with the female luer fitting to form a luer connection.

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