WO2024061337A1

WO2024061337A1 - Nasal spray administration device and spraying system comprising same

Info

Publication number: WO2024061337A1
Application number: PCT/CN2023/120569
Authority: WO
Inventors: 丁要武
Original assignee: 天舟医疗(苏州)有限公司
Priority date: 2022-09-23
Filing date: 2023-09-22
Publication date: 2024-03-28
Also published as: CN117504070A

Abstract

Provided is a nasal spray administration device, which is used together with an injection syringe. The nasal spray administration device comprises a nozzle and a syringe connector. A liquid collecting opening is formed in a distal end of the nozzle. The liquid collecting opening allows an interior and an exterior of the nozzle to be communicated. The syringe connector comprises a nozzle connecting part, and the nozzle is connected to the nozzle connecting part. A nozzle core is integrally formed at an end of a distal side of the nozzle connecting part of the syringe connector, and a flow channel is formed between an outer wall of the nozzle core and an inner wall of the nozzle. By means of the structure, the structure of the nasal spray administration device can be simplified easily, the molding precision of the nozzle core can be improved, and the relative position of the nozzle core and the rest part of the syringe connector is ensured to be fixed, so that the spraying effect is stabilized. The present invention further relates to a spraying system comprising the nasal spray administration device.

Description

Nasal spray delivery device and spray system including the device

Technical field

The invention belongs to the field of medical devices, and specifically relates to a nasal spray drug delivery device, which can supply medicine to the human body in the form of medicine mist.

Background technique

Spray devices are widely used in the medical field. They can non-invasively deliver drugs in the form of spray into the human body. For example, they can provide drugs in the form of spray to the nasal cavity. These drugs can be drugs to treat related diseases, or vaccines, Especially vaccines for respiratory infectious diseases, etc.

Among them, spray devices for administering drugs through the nasal cavity come in many forms, such as bottled multi-dose nasal spray pumps, prefilled single-dose/double-dose nasal spray devices, syringe-type nasal spray devices, etc. Among them, the most suitable for high-volume applications is the syringe-type nasal spray device. The specific way to use the syringe-type nasal spray device is as follows: first inhale the drug in liquid, semi-liquid, etc. state into the syringe, then install the spray head on the needle seat of the syringe, and quickly push the plunger of the syringe to make the contents of the syringe The drug generates high pressure, is further accelerated in the spray head, is sprayed out in the form of a spray under the action of pressure, and is applied to the nasal cavity, specifically to the nasal mucosa.

Syringe-type nasal spray devices have been found to have some problems during use, mainly because the consistency of the spray is sometimes difficult to ensure. The main reason is that the spray effect has relatively high requirements on the coaxiality of the components of the spray device and the insertion depth of the axis. If the control is not good during assembly, there will be problems such as large spray particle size, uneven particle size, spray deflection or angle error (the angle is too large or too small), and incomplete spray shape.

Therefore, there is a need to further improve the structure of the syringe-type nasal spray device to solve the above-mentioned problems existing in the prior art.

Contents of the invention

The present invention is made to solve the technical problems existing in the prior art disclosed above. The object of the present invention is to provide an improved nasal spray delivery device, specifically a syringe-type nasal spray delivery device, which can prevent, or at least reduce, the difference in spray effect and ensure the spray quality of each spray. Consistency of particles, spray pattern, spray morphology, etc.

The nasal spray administration device of the present invention is used together with a syringe. The nasal spray administration device includes a nozzle and a syringe connector, wherein a liquid collection port is formed at the distal end of the nozzle, and the liquid collection port communicates with the inside and outside of the nozzle, and the needle The cartridge adapter includes a nozzle connection portion to which the nozzle is connected. Wherein, a nozzle core is integrally formed on the distal end of the nozzle connection part of the syringe connector, and a flow channel is formed between the outer wall of the nozzle core and the inner wall of the nozzle.

By integrally forming the nozzle core on the syringe connector, the number of components of the nasal spray delivery device is reduced, thereby simplifying the structure of the nasal spray delivery device, improving the molding accuracy of the nozzle core, and ensuring that the nozzle core is in perfect contact with the needle. The relative position of the remainder of the barrel joint is fixed, allowing for good control of the fit in both radial and axial directions. In this way, the nasal spray delivery device of the present invention can prevent problems such as differences in spray effects caused by factors such as assembly pressure, assembly focus, streamlined positioning, and stop limits.

Preferably, an acceleration channel is formed between the nozzle core and the inner wall of the nozzle, and the acceleration channel is connected between the liquid collection port and the flow channel, wherein the inlet of the acceleration channel is connected to the flow channel, and the outlet of the acceleration channel is connected to the liquid collection port. Mouth connection. This acceleration channel can increase the flow speed of the medical liquid, thereby improving the atomization effect.

Further, the acceleration channel may be formed at at least one of the following locations:

Between the inner wall of the nozzle and the outer wall of the nozzle core,

Between the inner wall of the nozzle and the top of the nozzle core.

For the design of the acceleration channel, the size of the entrance of the acceleration channel is larger than the size of the outlet of the acceleration channel. Here, the so-called size may refer to the width of an inlet and an outlet, etc., for example.

In addition, preferably, the outlet of the acceleration channel is aligned with the tangential direction of the outer circle of the liquid collecting port. In this way, the sprayed liquid can be given high-speed centrifugal rotation inertia, thereby obtaining better atomized particle size and atomization angle.

Preferably, the nozzle core is formed into a solid column. The solid column shape allows the nozzle core to have sufficient strength to abut against the acceleration groove in the nozzle, thereby forming a stable acceleration channel and thus stabilizing the spray effect. Moreover, the solid nozzle core helps to reduce the residual amount of the liquid medicine.

Preferably, at least one communication hole is formed on the top of the nozzle connection part, and the communication hole is connected with the flow channel. For example, a pair of communication holes may be formed on both sides of the nozzle core. The shape of the communication hole can be any suitable shape such as rectangle, circle, polygon, etc.

Preferably, at least one first positioning rib is formed on the inner wall of the nozzle, wherein the first positioning rib The ribs are distributed along the circumference of the nozzle. Alternatively or additionally, formed on the nozzle core. There is at least one second positioning rib, wherein the second positioning rib is distributed along the circumference of the nozzle core. The first positioning rib and the second positioning rib help ensure that the nozzle and the syringe joint are coaxial during assembly. For example, two or more first positioning ribs and two or more second positioning ribs may be provided.

Preferably, a finger pressure buckle plate is formed at the proximal end of the syringe connector. When spraying, when the operator's thumb pushes the push rod of the syringe, the index finger and middle finger can hold the finger pressure buckle plate, thereby preventing problems such as loosening and leakage between the syringe connector and the syringe during the spraying process.

Preferably, the nasal spray drug delivery device further comprises a filling part, which is arranged in the syringe joint, and when the nasal spray drug delivery device is mounted on the syringe, the filling part fills the gap in the distal end of the needle seat of the syringe, thereby reducing the residual amount of the drug solution after use.

Preferably, at least one pair of core correction holes is formed on the nozzle connection portion of the syringe connector. This core correction hole can prevent uneven product wall thickness caused by mold deflection during injection molding.

It also relates to a spray system, which includes a syringe and a nasal spray delivery device installed on the syringe, wherein the nasal spray delivery device is the nasal spray delivery device as described above.

Preferably, the nasal spray delivery device is installed on the syringe in one of the following ways:

The barrel of the syringe is inserted into the lumen of the barrel connector;

The needle seat of the syringe is fixedly connected to the inner cavity of the syringe connector;

A raised rib is formed on one of the inner walls of the needle seat and the syringe connector of the syringe, and a raised rib groove is formed on the other of the inner wall of the needle seat and the syringe connector, and the raised rib can fit in the raised rib groove; and

A male Luer connector is formed on the proximal end of the syringe connector, and a female Luer connector is formed on the needle seat of the syringe. The male Luer connector cooperates with the female Luer connector to form a Luer connection.

Description of the drawings

Specific embodiments of the present invention may be more clearly understood from the structure shown in the accompanying drawings, in which:

Figure 1 shows a cross-sectional view of a nasal spray administration device mounted on a syringe according to a first embodiment of the present invention, which shows the state before the nasal spray administration device and the syringe are completely installed.

Figure 2 shows another cross-sectional view of the syringe and nasal spray delivery device shown in Figure 1, wherein the syringe and nasal spray delivery device are completely installed together.

FIG. 3 shows a cross-sectional view of the nozzle of the nasal spray delivery device in FIG. 1 .

FIG. 4 shows a cross-sectional view of the syringe connector of the nasal spray delivery device in FIG. 1 .

FIG. 5 shows a side view of the nozzle of FIG. 3 .

FIG. 6 is a cross-sectional view taken along line C-C of FIG. 5 .

FIG. 7 is a perspective view of the syringe connector of FIG. 4 .

FIG. 8 a is an enlarged perspective view of portion B in FIG. 7 .

FIG. 8b is a cross-sectional view of the portion shown in FIG. 8a.

FIG. 9 is an enlarged perspective view of a modification of part B in FIG. 7 .

FIG. 10a is an enlarged perspective view of another modification of part B in FIG. 7 .

Figure 10b is a cross-sectional view of the portion shown in Figure 10b.

Figure 11 shows a cross-sectional view of a nasal spray administration device mounted on a syringe according to the second embodiment of the present invention, which shows the state before the nasal spray administration device and the syringe are installed.

Figure 12 shows another cross-sectional view of the syringe and nasal spray delivery device shown in Figure 11, wherein the syringe and nasal spray delivery device are installed together.

Figure 13a shows a cross-sectional view of the nozzle of the nasal spray delivery device of Figure 11.

FIG. 13 b shows a cross-sectional view of the syringe connector of the nasal spray delivery device in FIG. 11 .

Figure 13c shows a cross-sectional view of the filling portion of the nasal spray delivery device of Figure 11 .

Figure 14 shows a cross-sectional view of a nasal spray administration device mounted on a syringe according to the third embodiment of the present invention, which shows the state before the nasal spray administration device and the syringe are installed.

Figure 15 shows another cross-sectional view of the syringe and nasal spray delivery device shown in Figure 14, wherein the syringe and nasal spray delivery device are installed together.

Figure 16 shows a cross-sectional view of a nasal spray administration device mounted on a syringe according to the fourth embodiment of the present invention, which shows the state before the nasal spray administration device and the syringe are installed.

Figure 17 shows another cross-sectional view of the syringe and nasal spray delivery device shown in Figure 16, wherein the syringe and nasal spray delivery device are installed together.

Figure 18a shows a cross-sectional view of the nozzle of the nasal spray delivery device of Figure 16.

Figure 18b shows a cross-sectional view of the syringe connector of the nasal spray delivery device of Figure 16.

Detailed ways

In order to facilitate understanding of the present invention, specific embodiments of the nasal spray delivery device of the present invention will be described in detail below with reference to the accompanying drawings. It should be understood that what is shown in the drawings is only a preferred embodiment of the present invention and should not be construed as limiting the scope of the present invention. Those skilled in the art can make various obvious modifications, variations, and equivalent substitutions to the present invention on the basis of the embodiments shown in the drawings, and under the premise of non-conflict, the following description of the different embodiments The technical features can be combined with each other arbitrarily, and these all fall within the scope of the present invention.

In the following detailed description of the present invention, terms such as "proximal" and "distal" are used relative to the operator, where "proximal" refers to the location close to the operator. The "far end" is the end opposite to the "near end" and away from the operator.

Figures 1 to 8b relate to the nasal spray delivery device 100 according to the first embodiment of the present invention. 1 and 2 show cross-sectional views of a spray system composed of a syringe 10 and a nasal spray delivery device 100, where FIG. 1 shows the spray system being assembled, FIG. 2 shows the assembled spray system, and FIG. 3 and 4 respectively show cross-sectional views of the nozzle 110 and the syringe connector 120 of the nasal spray administration device 100.

It can be seen that in the first embodiment, the assembly of the nasal spray administration device 100 and the syringe 10 is achieved by directly inserting the syringe 11 of the syringe 10 into the inner cavity of the syringe connector 120 .

The nasal spray drug delivery device 100 includes a nozzle 110 and a syringe connector 120. The nozzle 110 and the syringe connector 120 can be connected together by existing methods such as a convex ring-groove structure and a threaded structure.

Fig. 5 shows a side view of the nozzle 110, and Fig. 6 is a cross-sectional view taken along line C-C in Fig. 5. The nozzle 110 is substantially conical, and a liquid collecting port 111 is provided at the distal end of the nozzle 110, from which the liquid medicine can be sprayed during atomization administration.

A perspective view of the syringe adapter 120 is shown in FIG. 7 , and FIGS. 8 a and 8 b show an enlarged view and a cross-sectional view of part B in FIG. 7 . A nozzle connection portion 122 is formed at a distal portion of the syringe connector 120 for connecting the syringe connector 120 and the nozzle 110 . Specifically, a first connection part is formed on the outer surface of the nozzle connection part 122, and the first connection part may be a convex ring, an external thread, or other structures. Correspondingly, a second connection part matching the first connection part, such as a groove, an internal thread and the like, is formed on the inner surface of the nozzle 110 . In the exemplary structure shown in the figure, the first connecting portion is a convex ring-shaped type, the second connecting part is in the form of a groove. However, those skilled in the art will know that the first connecting portion and the second connecting portion can also adopt other structures known to those skilled in the art.

In the present invention, a nozzle core 121 is also integrally formed on the syringe connector 120, and the nozzle core 121 is specifically formed on the distal end of the nozzle connection part 122. When the nozzle 110 is installed on the syringe connector 120, a flow channel is formed between the outer wall of the nozzle core 121 and the inner wall of the nozzle 110. The flow channel is connected to the liquid collection port 111, and the medical liquid from the syringe 10 can be collected in the liquid collecting port 111. flows in the flow channel and is ejected from the liquid collection port 111.

The nozzle core 121 is preferably also configured in a solid columnar form, which can ensure that the nozzle core 121 has sufficient strength and can resist the acceleration groove (not shown) in the nozzle 110, thereby forming a stable acceleration channel. , effectively accelerating the medical liquid from the syringe 10, thereby optimizing the atomization of the medical liquid. This accelerating channel is connected between the above-mentioned flow channel and the liquid collecting port 111, for example. Specifically, the inlet of the acceleration channel is connected to the flow channel, and the outlet of the acceleration channel is connected to the liquid collection port 111 . In this way, the medical liquid from the syringe 10 can flow through the flow channel and the acceleration channel, and then the atomized medical liquid is ejected from the liquid collection port 111 .

The acceleration channel may be formed between the inner wall of the nozzle 110 and the outer wall of the nozzle core 121, or between the inner wall of the nozzle 110 and the top of the nozzle core 121, or both. Preferably, the size (e.g., width) of the inlet of the acceleration channel is set to be larger than the size (e.g., width) of the outlet of the acceleration channel, so as to achieve an acceleration effect on the liquid medicine.

Further preferably, the direction of the outlet of the acceleration channel is set to be aligned with the tangential direction of the outer circle of the liquid collecting port 111 . This can maximize the inertial force of the centrifugal rotation of the chemical liquid when it is discharged from the nozzle 110, thereby further improving the atomization effect, for example, making the atomized particle size and atomization angle better.

Preferably, as can be seen more clearly from FIG. 6 , at least one, preferably two or more first positioning positions are provided on the inner side (or inner wall) of the nozzle 110 near its end. Convex rib 112. When connecting the nozzle 110 to the syringe connector 120 , the first positioning rib 112 helps ensure coaxiality between the nozzle 110 and the syringe connector 120 .

8a and 8b, at least one communication hole 123 is formed on the top of the nozzle connection portion 122 of the syringe connector 120, and the communication hole 123 communicates with the inside and outside of the nozzle connection portion 122, specifically with the nozzle core 121. The flow channel between the outer wall and the inner wall of the nozzle 110 is connected, so that the communication hole 123 allows the medical liquid from the syringe 10 to flow into the flow channel. An example as shown in Figure The structure includes two communication holes 123, respectively located on both sides of the nozzle core 121, preferably 180° apart from each other. Of course, other numbers of communication holes 123 can also be provided as needed.

Preferably, a filling portion 126 is also formed in the syringe connector 120, and the filling portion 126 can cooperate with the gap 13 in the needle seat on the end of the syringe 11 of the syringe 10, specifically extend into the gap 13. middle. When spraying the medical solution, when the push rod 12 of the syringe 10 is pushed to the bottom, the gap left at the end of the needle seat can be minimized or even eliminated, thereby minimizing the remaining medical solution after one injection. An exemplary structure of the filling portion 126 is shown in FIG. 8 b , which is integrally formed with the nozzle core 121 and located inside the syringe connector 120 opposite the nozzle core 121 .

Fill 126 may also take other forms, as will be described in greater detail below.

As shown in FIG. 7 , a finger pressure buckle plate 127 is also formed on the end of the syringe connector 120 opposite to the nozzle connection part 122 . When the nasal spray administration device 100 is used for spraying, the user (such as a doctor, etc.) can push the push rod 12 of the syringe 10 with his thumb and hold the finger pressure plate 127 with his index finger and middle finger. In this way, during the process of pushing the push rod 12, the pressure between the syringe connector 120 of the nasal spray administration device 100 and the syringe 10 will become tighter and tighter, so that the nasal spray administration device 100 will not stop due to the increase in the pressure of the medicinal solution. The syringe 10 can come loose, or at least the risk of loosening can be reduced.

Figure 9 shows a modified structure of the nozzle connecting portion 122 of the syringe adapter 120, in which it can be seen that at least one, preferably two or more second positioning ribs are formed on the nozzle core 121 124. The second positioning ribs 124 may assist in coaxial alignment of the nozzle 110 and the syringe adapter 120 when the nozzle 110 and the syringe adapter 120 are installed together.

Those skilled in the art will know that the nasal spray delivery device 100 may include one of the above-mentioned first positioning ribs 112 on the nozzle 110 and the second positioning ribs 124 on the syringe connector 120, or the first positioning ribs 124 on the syringe connector 120. Both positioning ribs 112 and second positioning ribs 124 are included.

Figures 10a and 10b show another variant structure of the nozzle connection portion 122 portion of the syringe adapter 120. Among them, at least one pair of core correction holes 125 is formed on the nozzle connection part 122 . Through the core correction hole 125, during the process of molding the syringe connector 120, the core correction hole 125 can help avoid or reduce the risk of mold core deflection, thereby helping to improve the quality of the manufactured needle. Wall thickness uniformity of barrel joint 120.

In the structure shown in Figures 10a and 10b, there are two core correction holes 125 (one of which is shown in the figure) spaced 180° from each other. Those skilled in the art will know that any appropriate number of core correction holes 125, and the core correction holes 125 can also be arranged appropriately, for example, the intervals between two adjacent core correction holes 125 are even or uneven.

In addition, the core correction hole 125 shown in the figure is substantially rectangular, but the core correction hole 125 can also be provided in other shapes as needed.

Figures 11 to 13c relate to the structure of a nasal spray delivery device 200 according to the second embodiment of the present invention. In the absence of contrary description or conflict, the specific structures described above with respect to the first embodiment also apply to the second embodiment. The structure of the second embodiment that is different from the first embodiment will be described in detail below.

Figure 11 shows a cross-sectional view of the nasal spray delivery device 200 and the syringe 20 to which the nasal spray delivery device 200 will be installed. Figure 12 shows a cross-sectional view of the nasal spray delivery device 200 and the syringe 20 that are connected to each other.

In the second embodiment, the syringe connector 220 of the nasal spray administration device 200 is connected to the needle hub 21 of the syringe 20 . As seen in FIG. 12 , the needle hub 21 of the syringe 20 is inserted into the lumen of the barrel adapter 220 .

Figures 13a to 13c respectively show cross-sectional views of the nozzle 210, the syringe connector 220 and the filling part 226 installed in the syringe connector 220 of the nasal spray administration device 200. As can be seen from FIGS. 11 and 12 , the filling part 226 is sleeved on the lower end of the nozzle core 221 inside the syringe connector 220 . When the syringe 20 is connected to the nasal spray delivery device 200, the filling portion 226 can fill the gap on the end of the needle hub 21 of the syringe 20.

The needle hub 21 can be fixed in the inner cavity of the syringe connector 220 by means such as glue bonding.

14 and 15 relate to the structure of a nasal spray administration device 300 according to the third embodiment of the present invention. In the absence of contrary description or conflict, the specific structures described above with respect to the first and second embodiments also apply to the third embodiment. The structure of the third embodiment that is different from the first and second embodiments will be specifically described below.

In the third embodiment, the nasal spray administration device 300 is provided with a rib groove 321 , and the rib groove 321 is specifically formed on the inner wall of the syringe connector of the nasal spray administration device 300 . relatively, A raised rib 31 is formed on the outer surface of the needle seat of the syringe 30 . When the syringe 30 and the nasal spray administration device 300 are installed together, the ribs 31 on the syringe 30 can fit into the rib grooves 321 of the nasal spray administration device 300, for example, snap together. When installed, the engagement between the protruding ribs 31 and the protruding rib grooves 321 helps prevent the syringe 30 from being detached from the nasal spray delivery device 300 .

Those skilled in the art will know that the locations of the raised ribs and raised rib grooves can also be interchanged. For example, a raised rib groove is provided on the outer surface of the needle seat, and a raised rib is provided on the inner wall of the needle barrel connector.

Figures 16 to 18b relate to the structure of a nasal spray delivery device 400 according to the fourth embodiment of the present invention. In the absence of contrary description or conflict, the specific structures described above with respect to the first to third embodiments are also applicable to the fourth embodiment. The structure of the fourth embodiment that is different from the first to third embodiments will be described in detail below.

In the fourth embodiment, the connection between the nasal spray delivery device 400 and the syringe 40 is achieved through a Luer connector. As can be clearly seen in Figure 16, a female luer connector 41 is formed on the needle seat of the syringe 40. Figures 18a and 18b respectively show cross-sectional views of the nozzle 410 and the syringe connector 420 of the nasal spray delivery device 400, wherein a male luer connector 421 is formed at the proximal end of the syringe connector 420. When the nasal spray delivery device 400 is connected to the syringe 40, the male luer connector 421 is fitted into the female luer connector 41 to achieve connection, as shown in FIG. 17 .

Claims

A nasal spray administration device used together with a syringe, wherein the nasal spray administration device includes a nozzle and a syringe connector, wherein a liquid collection port is formed at the distal end of the nozzle , the liquid collection port communicates with the inside and outside of the nozzle, the syringe connector includes a nozzle connection part, and the nozzle is connected to the nozzle connection part, characterized in that, the nozzle connection of the syringe connector A nozzle core is integrally formed on the distal end of the part, and a flow channel is formed between the outer wall of the nozzle core and the inner wall of the nozzle.
The nasal spray delivery device according to claim 1, wherein an acceleration channel is formed between the nozzle core and the inner wall of the nozzle, and the acceleration channel is connected between the liquid collection port and the flow channel. wherein the inlet of the acceleration channel is connected to the flow channel, and the outlet of the acceleration channel is connected to the liquid collection port.
The nasal spray delivery device of claim 2, wherein the acceleration channel is formed at at least one of the following locations:

between the inner wall of the nozzle and the outer wall of the nozzle core,

between the inner wall of the nozzle and the top of the nozzle core.
The nasal spray delivery device according to claim 2, wherein the size of the inlet of the acceleration channel is larger than the size of the outlet of the acceleration channel, and/or

The outlet of the acceleration channel is aligned with the tangential direction of the outer circle of the liquid collection port.
The nasal spray delivery device according to claim 2, wherein the nozzle core is formed into a solid column shape.
The nasal spray delivery device according to claim 1, wherein at least one communication hole is formed on the top of the nozzle connection part, and the communication hole is connected with the flow channel.
The nasal spray drug delivery device according to claim 1, characterized in that at least one first positioning rib is formed on the inner wall of the nozzle, wherein the first positioning rib is distributed along the circumference of the nozzle; and/or

At least one second positioning rib is formed on the nozzle core, wherein the second positioning rib is distributed along the circumferential direction of the nozzle core.
The nasal spray delivery device according to claim 1, wherein the syringe connector The proximal end is formed with an acupressure gusset plate.
The nasal spray drug delivery device according to claim 1, wherein the nasal spray drug delivery device further includes a filling part, and the filling part is provided in the syringe connector. When the nasal spray drug delivery device is installed, When onto the syringe, the filling portion fills the gap in the distal end of the needle hub of the syringe.
The nasal spray delivery device of claim 1, wherein at least one pair of core correction holes is formed on the nozzle connection portion of the syringe connector.
A spray system, the spray system includes a syringe and a nasal spray administration device installed on the syringe, characterized in that the nasal spray administration device is as described in any one of claims 1 to 10 Nasal spray delivery device.
The spray system of claim 11, wherein the nasal spray delivery device is installed on the syringe in one of the following ways:

The barrel of the syringe is inserted into the inner cavity of the barrel connector;

The needle seat of the syringe is fixedly connected in the inner cavity of the syringe connector;

A raised rib is formed on one of the inner wall of the needle seat of the syringe and the syringe connector, and a raised rib groove is formed on the other of the inner wall of the needle seat of the syringe and the syringe connector. The ribs can fit in the convex rib grooves; and

A male Luer connector is formed on the proximal end of the syringe connector, and a female Luer connector is formed on the needle seat of the syringe. The male Luer connector cooperates with the female Luer connector to form a Luer connection. .