CN219517430U - Device of accurate nose district injection - Google Patents

Abstract

The utility model relates to a medical instrument, in particular to a device for precisely spraying nasal and olfactory regions. The device comprises a spray head assembly, a push injector assembly, a medicine suction assembly and a quantitative clamp; the spray head assembly comprises a spray head, a water core and a water pipe; the injector assembly comprises a push rod and an injector cylinder, wherein the tail end of the push rod extends out of the tail end of the injector cylinder; the utility model has the advantages that the simple water pipe is added to accelerate the liquid in the flow channel, so that the liquid medicine can be better sprayed in the nasal-olfactory region, and the deposition rate of the medicine in the nasal-olfactory region is improved. The utility model has simple structure and low cost, and is suitable for industrialized production.

Description

Device of accurate nose district injection

Technical Field

The present utility model relates to medical devices and, more particularly, to a drug delivery device for delivering a drug to the mucosa of the nasal olfactory region.

Background

With the continuous development of medical technology, nasal cavity sprayers have been popular for the public because of their low risk, rapid therapeutic effect, non-invasive treatment, etc., and they spray the liquid medicine into the nasal cavity for treating various diseases in the nasal cavity. Nasal administration is a mode of rapidly reaching the drug effect, and the main component of the drug can circulate the olfactory nerve (olfan yneuralathway) and the trigeminal nerve path (trigeminal neuralpathway) distributed on the nasal mucosa, enter the nasal beak migration path (RMS) to reach the olfactory bulb (olfan ybulb), enter the perivascular path (peri-vascular path) in the brain and the central nervous system, so that the main component of the drug can avoid blood-brain barrier (BBB) to reach the action site and brain of the central nerve. The medicine can pass through the nasal cavity olfactory region of the upper nasal passage and bypass the blood brain barrier to access the brain directly.

However, there are only two nasal delivery devices available for delivering a drug to the upper nasal passages, the first device being a nasal delivery device from impel corporation, but the delivery device being a propellant-adding means to bring the drug to the upper nasal passages; another type is a nasal sprayer disclosed in fig. 4 of CN115068795a, which uses a hand pump or high air pressure to release the drug to make the drug enter the patient's upper nasal passages after forming an atomized state through an atomizer, and such a nasal sprayer is suitable for use in a multi-dose repeated administration scenario.

In the actual use of the medicine, the unavoidable use is to the condition of spraying singly, and the advantage of the single nasal sprayer: the medicine liquid is extracted when in use, so that the medicine liquid can be stored for a long time; the device is thrown once after single use, so that the pollution problem of liquid medicine or the device is avoided.

For a single dose nasal spray for delivering a drug to the upper nasal meatus, the method adopted by the aptar company in patent application CN201980046077.3, adopted by the method, requires the use of a steel needle to puncture the rubber stopper, and has the advantages of not simple structure and certain danger; other types of single-dose nasal sprayers generally include a nozzle and a stem, wherein the stem is used to connect with an injection device, a drug solution is guided to the nozzle through the stem, and the drug is sprayed into a mist form through the nozzle.

Therefore, how to provide a nasal cavity administration spraying device which can be used for single-dose administration, has a simple structure and good atomization effect, and can be used for delivering medicines to the nasal olfaction area of the upper nasal meatus, and the problem to be solved is solved.

Disclosure of Invention

Therefore, the technical problem to be solved by the utility model is to overcome the defect that a drug administration spraying device in the prior art is difficult to achieve a better atomization effect, so as to provide a device for precisely spraying the nasal olfaction area.

In order to solve the above technical problems, the present utility model provides a device for precisely spraying nasal and olfactory regions, comprising:

a spray head assembly and a injector assembly;

the spray head assembly comprises a spray head, a water core and a water pipe, wherein the top end of the spray head is provided with a spray hole, the water core is connected with the spray head and the water pipe, a cyclone groove is formed in the inner wall of the top end of the spray head, the center of the cyclone groove is concentric with the spray hole, and the water core and the water pipe are sequentially and fixedly arranged at one end, close to the spray hole, inside the spray head;

the injector assembly comprises a push rod and an injector cylinder, and the tail end of the push rod extends out of the tail end of the injector cylinder; the injector assembly is detachably arranged in the spray head;

the injector component and the spray head component form a liquid medicine flow passage communicated with the inside.

Preferably, the head of the push rod is provided with a butyl rubber plug.

Preferably, the proximal end of the spray head is provided with a limit structure, and the length from the spray hole to the limit structure is 20 mm-30 mm, more preferably 22 mm-28 mm, and even more preferably 24 mm-26 mm; most preferably 25mm.

Preferably, the tail end of the push rod is detachably provided with a dosing clamp.

Preferably, the water core is circumferentially provided with a water passing groove, the water core comprises a water core front end and a water core rear end, the water passing groove is arranged at the water core rear end, the end part of the water core rear end is concave and is internally recessed to be communicated with the water passing groove, and the end part of the water core front end is a circular plane.

Preferably, the connection mode of the spray head and the rear end of the water core is interference connection, clamping connection or threaded connection, and further preferably, interference connection.

Preferably, the head-end liquid suction port of the injector assembly has an inner diameter greater than the inner diameter of the water tube.

Preferably, the inner diameter of the injector cylinder is 2.5-3.5 mm.

Preferably, the nasal olfactory mucosa spray administration device is made of PP material.

Compared with the prior art, the utility model has the following beneficial effects:

the nasal spray administration device can carry out nasal spray administration on the liquid medicament, and the spraying effect is better than that of the prior art. In the technical scheme of this patent application, increase a water pipe, can accelerate the velocity of flow of liquid medicine to better formation spraying improves the district deposition rate of sniffing of medicine. The utility model has simple structure and low cost, and is suitable for industrialized production.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a nasal spray delivery device according to the present utility model;

FIG. 2 is a schematic diagram of a construction of a syringe assembly according to the present utility model;

FIG. 3 is a schematic view of a showerhead assembly according to the present utility model;

FIG. 4 is a schematic view of the water core of the present utility model;

fig. 5 is a schematic view of a pipette head assembly;

FIG. 6 is a schematic illustration of the structure of a nasal spray delivery device without a water line;

in the figure, a 1-spray head assembly, a 11-spray head, a 12-water pipe, a 13-water core, a 131-water core front end, a 132-water core rear end, a 133-water passing tank, a 2-injector assembly, a 21-injector cylinder, a 22-butyl rubber plug, a 23-push rod, a 3-limiting structure, a 4-liquid suction head assembly, a 41-liquid suction head protective cap and a 42-liquid suction head are arranged.

Detailed Description

The assay methods of the present application will be described in further detail below with reference to specific examples. It is to be understood that the following examples are illustrative only and are not to be construed as limiting the scope of the utility model. All techniques implemented based on the above description of the utility model are intended to be included within the scope of the utility model.

In the description of the present patent application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, only for convenience in describing the present patent application and simplifying the description, and do not indicate or imply that the devices or elements being referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present patent application. Moreover, the terms "first," "second," "third," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In this application, unless specifically stated otherwise, the term "connected" includes both contacting and non-contacting connections, as determined by the actual use.

Example 1

The utility model provides a device for precisely spraying nasal olfaction area, as shown in figures 1-4, comprising:

a spray head assembly 1 and a injector assembly 2;

the spray head assembly 1 comprises a spray head 11, a water core 13 and a water pipe 12, wherein a spray hole is formed in the top end of the spray head 11, the water core 13 is connected with the spray head 11 and the water pipe 12, a cyclone groove is formed in the inner wall of the top end of the spray head 11, and the water core 13 and the water pipe 12 are sequentially and fixedly arranged at one end, close to the spray hole, of the spray head 11; the injector assembly 2 comprises a push rod 23, an injector cylinder 21, optionally provided with a butyl rubber plug 22 at the head; the tail end of the push rod 23 extends out of the tail end of the injector cylinder 21; the injector assembly 2 is detachably arranged inside the spray head 11;

the injector assembly 2 and the spray head assembly 1 form a liquid medicine flow passage with the inside communicated.

Example 2

This embodiment is a preferable example of embodiment 1. As shown in fig. 1 to 5, comprises a spray head assembly 1 and a injector assembly 2; the spray head assembly comprises a spray head 11, a water core 13 and a water pipe 12, wherein the spray head 11 is provided with spray holes; the water core is as shown in fig. 5, the water core 13 is an integrally formed solid body, the water core 13 comprises a water core front end 131 and a water core rear end 132, the water core front end 131 is of a regular cylinder shape, one or more water passing grooves 133 are axially arranged in the water core, the water passing grooves 133 are arranged at the water core rear end 132, the end part of the water core rear end 132 is concave and communicated with the water passing grooves, the end part of the water core front end 131 is of a circular plane, the diameter of the water core rear end 132 is larger than that of the water core front end 131, and the water core rear end and the inner wall of the spray nozzle can be in interference connection, clamping connection or threaded connection, preferably interference connection. The inner wall of the top end of the spray head 11 is provided with a cyclone groove, the center of the cyclone groove is concentric with the spray hole, and a circular plane of the end part of the front end 131 of the water core and the cyclone groove on the inner wall of the top end of the spray head form a spray hole vortex chamber. The water core rear end 132 is connected with the upper end of the water pipe 12, and the water core 13, the water pipe 12 and the spray head 11 are axially fixed relatively.

The injector assembly 2 comprises a push rod 23, an injector cylinder 21 and a butyl rubber plug 22 arranged at the head of the push rod, wherein the tail end of the push rod 23 extends out of the tail end of the injector cylinder 21; the injector component is detachably arranged in the spray head 11 and is communicated with the lower end of the water pipe 12; the inner diameter of the liquid suction port at the head end of the injector cylinder 21 is larger than the inner diameter of the water pipe 12.

The push rod 23 is also provided with a detachable quantitative clamp for removing air in the cavity, filling liquid medicine and quantifying the medicine when the medicine is administrated to the nasal olfactory area; the dosing clip may be of a conventional dosing clip construction in the art, and is not limited thereto, and is not shown in the drawings for the purpose of enabling dosing.

The proximal end of the spray head 11 is also provided with the limit structure 3, when the spray head 11 stretches into a specific position inside the nostril, the spray head 11 can be positioned by the limit structure 3, so that a patient can conveniently and easily make the spray head 11 reach the position most suitable for spraying inside the nostril through the limit structure 3 when in use, and the convenience and the accuracy of operation are greatly improved. In the present embodiment, the length from the nozzle hole of the nozzle 11 to the limit structure is 20mm to 30mm, more preferably 22mm to 28mm, still more preferably 24mm to 26mm; most preferably 25mm, as deep as possible into the olfactory region of the nasal cavity is achieved within the acceptable comfort of the patient to match the jetting effect and increase the rate of drug deposition in the olfactory region.

Comparative example 1:

a device for accurate nasal olfactory ejection, as shown in fig. 6, comprising a spray head assembly and a injector assembly; the spray head assembly comprises a spray head 11 and a water core 13, wherein a cyclone groove is formed in the inner wall of the top end of the spray head 11, and the water core 13 is fixedly arranged at the top end of the inner part of the spray head 11; the injector assembly comprises a push rod 23 and an injector cylinder 21, and the head part of the push rod is provided with a butyl rubber plug 22; the tail end of the push rod 23 extends out of the tail ends of the injector cylinder 21 and the spray head 11; the injector assembly is detachably arranged in the spray head; the injector component and the spray head component form a liquid medicine flow passage communicated with the inside. After sucking the liquid medicine and discharging air, when the structure is adopted to administer medicine to the nasal cavity, the push rod is rapidly pushed in 1 second, the spraying distance is shorter, the olfactory region is difficult to reach, and the spraying particles are larger, so that the absorption of mucous membrane in the olfactory region is not facilitated. With this structure, it is difficult to achieve a high deposition rate in the olfactory region by administering the drug to the nasal cavity.

The operation and use method of the utility model for spraying the liquid medicine to the nasal cavity olfactory region is as follows, as shown in figures 1-5:

1) Sucking the liquid medicine: the pipette head assembly 4 is lifted up, the pipette head assembly 4 is mounted on the head of the syringe assembly 2, the pipette head cap 41 is removed, and the drug solution is sucked from the drug vial.

2) Mounting the injector assembly 2 into the nozzle assembly 1: the injector assembly 1 is mounted into the nozzle 11 using the injector cap 41 to remove the pipette tip 42 from the injector head, hold the injector cartridge.

3) Emptying and quantifying: the quantitative clamp is fixed on the tail of the push rod 23, the push rod 23 is pushed to the quantitative clamp, and the nasal spray device finishes quantitative administration at the moment, so that nasal administration can be carried out.

4) Nasal administration: taking out the quantitative clamp, clamping the spray head by the index finger and the middle finger, keeping the head upright, inserting the spray head 11 into the nasal cavity along the nasal septum at a certain angle direction with the horizontal plane, and stopping the insertion until the limit structure 3 stops. The index finger and the middle finger are placed at the corresponding pressing positions of the spray head 11, the push rod 23 is propped against by the thumb, and the spray head is quickly pushed upwards until the spray head cannot be pushed upwards, for example, the spray head is quickly pushed in 1 second, and then one quantitative spray administration is completed.

The working principle of the fluid flowing process and finally forming spray in the utility model is as follows:

when nasal cavity is administrated, the push rod 23 of the injector is quickly pushed, liquid flows to the water pipe 12, flows to the rear end 132 of the water core after the acceleration action of the water pipe 12, and reaches the spray hole vortex chamber formed by the circular plane of the front end 131 of the water core and the plane of the cyclone slot positioned on the inner wall of the spray head 11 through the spray channel, and when passing through the spray hole vortex chamber, the liquid forms a plurality of liquid flows through the channel of the cyclone slot to collide at the spray hole to form mist, namely tiny particles, so that a spray effect is formed.

It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While obvious variations or modifications are contemplated as falling within the scope of the present application.

Claims (11)

1. A device for precise nasal olfactory ejection, comprising:

a spray head assembly (1) and a injector assembly (2);

the spray head assembly (1) comprises a spray head (11), a water core (13) and a water through pipe (12), wherein a spray hole is formed in the center of the top end of the spray head (11), the water core (13) is connected with the spray head (11) and the water through pipe (12), a cyclone groove is formed in the inner wall of the top end of the spray head (11), the center of the cyclone groove is concentric with the spray hole, and the water core (13) and the water through pipe (12) are sequentially and fixedly arranged at one end, close to the spray hole, inside the spray head (11;

the injector assembly (2) comprises a push rod (23) and an injector cylinder (21), wherein the tail end of the push rod (23) extends out of the tail end of the injector cylinder (21); the injector assembly (2) is detachably arranged in the spray head (11);

the injector component (2) and the spray head component (1) form a liquid medicine flow passage with the inside communicated.

2. The device for accurate nasal and olfactory ejection according to claim 1, wherein the material of the nozzle assembly (1) and the injector assembly (2) is PP material.

3. The device for accurate nasal olfactory spraying according to claim 1, characterized in that the head of the push rod (23) is provided with a butyl rubber plug (22).

4. A device for accurate nasal and olfactory spraying according to claim 3, characterized in that the proximal end of the spray head (11) is provided with a limit structure (3), the length from the spray orifice to the limit structure (3) being 20 mm-30 mm.

5. The device for accurate nasal olfactory area spraying according to claim 4, characterized in that the length of the spray orifice to the limit structure (3) is 22 mm-28 mm.

6. The device for accurate nasal olfactory area spraying according to claim 4, characterized in that the length of the spray orifice to the limit structure (3) is 24 mm-26 mm.

7. The device for accurate nasal olfactory spraying according to claim 4, characterized in that the tail end of the push rod (23) is detachably provided with a dosing clip.

8. The device for accurate nasal sniffing zone injection according to claim 7, wherein the water core (13) is circumferentially arranged with a water trough (133), the water core comprises a water core front end (131) and a water core rear end (132), the water trough (133) is arranged at the water core rear end (132), the end of the water core rear end (132) is concave and communicated with the water trough, and the end of the water core front end (131) is a circular plane.

9. The device for accurate nasal sniffing zone spraying according to claim 8, wherein the connection mode of the spray head (11) and the water core rear end (132) is one selected from interference connection, clamping connection or threaded connection.

10. The device for accurate nasal olfactory (hci) spraying according to claim 9, characterized in that the head-end liquid suction port of the injector assembly (2) has an inner diameter larger than the inner diameter of the water tube (12).

11. The device for accurate nasal olfactory emission according to claim 10, characterized in that the inner diameter of the injector cartridge (21) is 2.5-3.5 mm.