JP2010125229A - Medicine administration device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine administration device, dynamically and simply varying the positional distribution of quantity of medicine administered. <P>SOLUTION: This medicine administration device for administering medicine to internal organs of mammals including human beings includes: a tube 2 for guiding medicine pushed out from a medicine administration device body for pushing out the medicine with variable push-out force of the medicine to the internal organ side; and at least one catheter provided at the distal end of the tube 2 and having a medicine administration part 8, the side surface of which is provided with a plurality of medicine discharge holes 9-11 formed different in size of opening. The positional distribution of quantity of medicine administered from the medicine discharge holes 9-11 is dynamically varied by changing the push-out force for the medicine. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a drug administration device for administering a drug to a body organ of a mammal including a human.

  Conventionally, a catheter that administers a drug by inserting a puncture needle into a body organ of a mammal including a human is known (see Patent Document 1).

JP-A-3-57457

  However, since the conventional catheter basically administers the drug only to one point inside the internal organ, even if it is desired to administer the drug to the affected part having a certain volume, the affected part is separated from the administration position. I couldn't get much of the drug around.

  In particular, a body organ to which a drug is administered changes the position, size, or shape of a diseased site depending on the effect of drug administration. For this reason, when a medicine is continuously administered, it is desirable that the positional distribution of the amount of the medicine to be administered can be dynamically changed in response to a change in the position, size, or shape of the affected part.

  Here, when the positional distribution of the amount of drug to be administered is changed using the conventional catheter described above, it is necessary to remove the catheter once attached and reattach the catheter to a new position. In addition to the burden on doctors, there is a problem that the burden on mammals including humans to be administered is large.

  This invention is made in view of the above, Comprising: It aims at providing the chemical | medical agent administration apparatus which can change the positional distribution of the chemical | medical agent dose administered dynamically and easily.

  In order to solve the above-described problems and achieve the object, a drug administration device according to the present invention is a drug administration device that administers a drug to a body organ of a mammal including a human, and the pressure for extruding the drug is variable. A drug administration device main body for extruding the drug, a tube for guiding the drug extruded from the drug administration device main body to the internal organ side, and a plurality of drug discharge holes provided at the distal end of the tube and having different opening sizes are formed on the side surface And at least one catheter having a drug administration section.

  In the medicine administration device according to the present invention, in the invention described above, the plurality of medicine ejection holes may include a size of an opening that ejects the medicine at a predetermined pushing pressure of the medicine and a size of an opening that does not eject the medicine. It is characterized by including.

  In the medicine administration device according to the present invention, in the invention described above, the medicine administration section includes a plurality of medicine administration sections, each medicine administration section has a plurality of medicine ejection holes having the same opening size, and has at least two The size of the openings of the plurality of medicine discharge holes is different between the medicine administration portions.

  The drug administration device according to the present invention is characterized in that, in the above-described invention, a stopper that contacts the surface of the internal organ is provided between the tube and the drug administration unit.

  The drug administration device according to the present invention is characterized in that, in the above-described invention, the stopper can be adjusted and moved in the axial direction of the tube and the drug administration unit.

  The drug administration device according to the present invention is characterized in that, in the above-described invention, the drug administration device further comprises a connecting part for detachably connecting the tube and the drug administration part.

  In the drug administration device according to the present invention, the drug administration unit includes a plurality of drug administration units, and the connection unit couples a drug administration unit selected from the plurality of drug administration units to the tube. It is characterized by that.

  In the medicine administration device according to the present invention, in the above-described invention, the tube is branched toward the medicine administration section in the middle of the tube, and the medicine administration section is provided in each branched tube. It is characterized by.

  The drug administration device according to the present invention is characterized in that, in the above-described invention, the drug administration device main body is provided with a pressure control means for controlling an extrusion pressure of the drug.

  According to this invention, a drug administration unit having a tube that guides the drug pushed out from the drug administration device main body toward the internal organ, and a plurality of drug ejection holes provided at the tip of the tube and having different opening sizes on the side surface The main body of the medicine administration device changes the push-out pressure of the medicine, thereby dynamically and easily distributing the positional distribution of the amount of medicine ejected from the plurality of medicine ejection holes. Can be changed.

  Embodiments of a drug administration device according to the present invention will be described below in detail with reference to the drawings. The present invention is not limited to the embodiments.

(Embodiment 1)
FIG. 1 is a schematic diagram showing a state in which the drug administration device according to Embodiment 1 of the present invention is applied to a human body. FIG. 2 is a schematic diagram illustrating a detailed configuration of a drug administration unit of the drug administration device illustrated in FIG. 1. FIG. 3 is a cross-sectional view taken along line AA of the drug administration unit shown in FIG. In FIG. 1, a drug such as an anticancer drug of about several tens ml is continuously and intensively discharged over a long period of about one week to the surface of a body organ 4 such as a liver such as a mammal including a human. This shows the case of planned administration. In addition, the chemical | medical agent here contains a liquid and a gel-form chemical | medical agent.

  1 to 3, a drug administration device 100 includes a catheter 1 and a drug administration device body 3 that supplies a drug to the catheter. The catheter 1 includes a tube 2 formed of flexible polyethylene having biocompatibility, and a drug administration formed of hard titanium or molded polyethylene terephthalate (PET) resin provided at the distal end of the tube 2. Part 8. The drug administration unit 8 is punctured into the internal organ 4. A stopper 7 is provided between the tube 2 and the drug administration unit 8, and the stopper 7 is applied to the surface of the internal organ 4 to define the relative position between the internal organ 4 and the drug administration unit 8. The stopper 7 can be moved and adjusted along the axial direction of the catheter 1.

  The drug administration device body 3 is fixed to the body surface 6 and supplies the drug to the catheter 1 side as described above. The drug administration device body 3 includes a drug reservoir 3a that stores the drug, a pump 3b that pushes the drug in the drug reservoir 3a toward the catheter 1, and a control that variably controls the push-out pressure of the drug by performing drive control of at least the pump 3b. It has a part 3c. That is, the medicine administration device main body 3 variably controls the medicine extrusion pressure by the controller 3c. The drug administration device main body 3 does not have to be attached to the body surface 6, and can be configured to be embedded in the body or to be spaced apart from the body, for example.

  The drug administration section 8 is formed with a flow path provided along the axial direction inside, and this flow path is connected to a flow path inside the tube 2. As shown in FIG. 2, a plurality of drug discharge holes 9 to 11 are provided on the side of the drug administration unit 8, and the drug is applied to the affected area 5 from the internal flow path via the drug discharge holes 9 to 11. Exhaled and administered.

  The medicine discharge holes 9 to 11 have different hole diameters, and are formed such that the hole diameters Ra, Rb, and Rc of the medicine discharge holes 9, 10, and 11 are sequentially reduced. In FIG. 2, the openings of the hole diameters Ra to Rc are circular. When the pressure for pushing out the medicine is the same, more medicine is ejected in the order of the medicine ejection holes 9, 10, 11. That is, when the arrangement intervals of the medicine ejection holes 9, 10, 11 are the same, the amount of medicine administered per unit time administered from the area of the medicine ejection holes 9 is the largest and is administered from the area of the medicine ejection holes 11. The amount of drug administered per unit time is the smallest.

  In addition, as shown in FIG. 3, although the medicine discharge holes 9-11 are arrange | positioned so that the chemical | medical agent administration which arranged in the straight line in the axial direction may be biased to one side surface of a side part, it does not restrict to this, As shown in FIG. 4, medicine discharge holes 9 (9a, 9b) may be provided on both sides. Furthermore, a plurality of medicine discharge holes may be provided in different radial directions. Moreover, if the medicine discharge hole is a side portion of the medicine administration section 8, it can be arranged at any position, any distribution, and any hole diameter size and shape. Furthermore, in addition to the side part of the medicine administration part 8, a medicine discharge hole may be provided at the tip part.

  Here, since the hole diameters Ra, Rb, and Rc have different opening sizes, the following effects occur. FIG. 5 is a diagram showing the pressure P dependence of the flow rate Q when the hole diameters are different. As shown in FIG. 5, each of the hole diameters Ra to Rc does not depend on the size of the hole diameter, and the drug flow rate Q increases as the drug pressure P increases. Here, in the case of the largest hole diameter Ra and the next largest hole diameter Rb, the flow rate Q increases with an increase in the pressure P starting from 0, whereas the pressure P increases in the case of the smallest hole diameter Rc. Is 0, the flow rate Q is 0, and the drug begins to flow only when the pressure P reaches P2. That is, in the case of the small hole diameter Rc, a state where the medicine does not flow occurs. The value of the pressure P2 at which the drug begins to flow is the size of the hole, the surface tension of the drug (drug solution), the drug (drug solution) in the state where the drug administration unit 8 gets wet with the drug or the state where the drug is repelled, and the drug administration unit 8 It is determined by the molecular action of the material.

  When the pressure P depends on the flow rate Q with the size of the hole diameter as a parameter, when the medicine is pushed out at a pressure P1 smaller than the pressure P2, the medicine discharge holes 9 and 10 having the hole diameters Ra and Rb are used. In the case where only the medicine is administered and the medicine is pushed out at a large pressure P3 that is equal to or higher than the pressure P2, the medicine is administered from all the medicine ejection holes 9, 10, 11 having the hole diameters Ra, Rb, Rc. As a result, by changing the pressure P for pushing out the medicine, the flow rate of the medicine administration can be changed, and the position distribution of the medicine administration can be changed dynamically. Actually, even at the same pressure P, the discharge flow rate of the downstream, that is, the front end side drug discharge hole is affected and changed by the discharge flow rate of the upstream drug discharge hole.

  FIG. 6 is a diagram illustrating an example of a specific size and arrangement of medicine discharge holes. As shown in FIG. 6, in the drug administration unit 18 which is an example of the drug administration unit 8, regions 15 b and 15 a having a plurality of drug ejection holes with small hole diameters are provided on the distal end side and the proximal end side, A region 14 having a plurality of medicine discharge holes having a large hole diameter is provided between the regions 15b and 15a. In this case, at the initial stage of drug administration, the drug extrusion pressure is increased, the drug is administered from all the drug ejection holes, and the drug is administered to the region E1 of the affected area 5. Thereafter, when the affected area 5 is contracted as shown in FIG. 6, the drug extruding pressure is decreased, the drug is administered only from the drug discharge hole in the region 14, and the region E2 in the degenerated affected area 5 is Administer drugs. Thereby, a medicine can be effectively administered only to an affected part which is a medicine administration object.

  Here, in the first embodiment, since a plurality of medicine discharge holes are provided, even if a clogged medicine discharge hole occurs, backup discharge that discharges medicine from other unfilled medicine discharge holes is possible. It becomes.

  Further, in the first embodiment, the medicine administration device main body 3 is adapted to discharge while changing the medicine extrusion pressure, as shown in FIG. In FIG. 7, a drug is discharged at a large pressure Pa in a period Ta, a drug is discharged at a small pressure Pb in a period Tb, and pressure pulsations are generated by alternately repeating the periods Ta and Tb. To prevent clogging. The drug discharge flow rate in this case is the total discharge flow rate that is time-averaged from each drug discharge hole at each pressure Pa and Pb. Here, when the repetition frequency is high, the pressure Pb may be zero. Further, when changing the discharge flow rate, pulse width control for changing the ratio of the period Ta to the period Tb may be performed, or the pressure Pa (amplitude) of the period Ta may be changed.

(Embodiment 2)
Next, a second embodiment of the present invention will be described. In the second embodiment, a plurality of drug administration units are provided. FIG. 8 is a schematic diagram showing a schematic configuration of a drug administration device according to Embodiment 2 of the present invention. As shown in FIG. 8, the drug administration device 200 is provided with a plurality of catheters 1 (1 a to 1 c) from the drug administration device main body 3. Each catheter 1a-1c has a tube 2 (2a-2c) and a drug administration part 8 (8a-8c), respectively, and a stopper 7 is provided between each tube 2a-2c and each drug administration part 8a-8c. (7a-7c) are provided.

  In the second embodiment, the drug administration device main body 3 controls the push-out pressure of the drug with respect to the catheters 1a to 1c to change the positional distribution of the discharge flow rate with respect to the affected part 5, and the drug administration part of each catheter 1a to 1c. The positional distribution of the discharge flow rate of the drug in the axial direction of the drug administration units 8a to 8c is changed according to the size, arrangement, shape, etc. of the plurality of drug discharge holes formed in 8a to 8c.

  In addition, as shown in FIG. 9, it is good also as the catheter 21 branched to the some catheter from the middle of a catheter. The catheter 21 shown in FIG. 9 has one tube 22 connected to the side of the drug administration device main body 3, branches from the distal end of the tube 22 into three tubes 22a to 22c, and has three tubes 22a to 22c at the distal end. The drug administration units 8a to 8c are connected to each other.

  In this case, the drug administration device main body 3 of the drug administration device 300 controls the push-out pressure of the drug with respect to one catheter 21, but the size of the drug discharge hole provided in each drug administration unit 8a to 8c, The positional distribution of the medicine discharge flow rate can be dynamically changed depending on the arrangement, shape, and the like.

  FIG. 10 is a diagram illustrating an example of drug discharge holes of the drug administration units 8a to 8c. Each drug administration part 8a-8c shown in FIG. 10 is provided with a drug administration hole having a small hole diameter at the distal end side and the base part side, a drug administration hole having a large hole diameter is provided at the center part, and each drug administration part A plurality of drug administration holes 8a to 8c are the same.

  Moreover, FIG. 11 is a figure which shows another example of the medicine discharge hole of each medicine administration part 8a-8c. Each drug administration unit 8a to 8c shown in FIG. 11 is provided with a plurality of small drug discharge holes having the same hole diameter, and the drug administration unit 8b has a plurality of large same hole diameters. Discharge holes are provided, and the drug administration portion 8c is provided with a plurality of small and identical drug discharge holes having the same hole diameter. Here, the drug administration portions 8a and 8b have the same plurality of hole diameters, but have different hole diameters from the drug administration portions 8a and 8b. Further, the drug administration part 8c has a plurality of different hole diameters.

  Furthermore, as shown in FIG. 12, the lengths of the drug administration sections 8a to 8c may be different. When the puncture depth is different, the depth of drug administration can be set.

(Embodiment 3)
Next, a third embodiment of the present invention will be described. In the third embodiment, as shown in FIG. 13, one tube 2 and one drug administration unit 38a to 38c selected from the plurality of drug administration units 38a to 38c are made detachable. ing. That is, as shown in FIG. 13, while providing the connection part 34 at the front-end | tip of the tube 2, the connection parts 34a-34c are each provided in the base of each chemical | medical agent administration part 38a-38c, and are formed detachably by screwing etc. Yes.

  The drug administration units 38a to 38c may be selected as the drug administration units 8a to 8c shown in the second embodiment. In this case, it is necessary to provide the connection part 34 in each tube 2a-2c, 22a-22c.

  By providing such various detachable drug administration portions 38a to 38c, changes in the positional distribution of the drug with respect to various affected areas can be performed more finely.

It is a schematic diagram which shows the state by which the chemical | medical agent administration apparatus concerning Embodiment 1 of this invention was applied to the human body. It is a schematic diagram which shows the detailed structure of the chemical | medical agent administration part of the chemical | medical agent administration apparatus shown in FIG. It is an AA line sectional view of a medicine administration part. It is an AA line sectional view to a modification of a medicine administration part. It is a figure which shows the pressure dependence of the flow volume which made the hole diameter the parameter. It is a figure which shows the application example of a chemical | medical agent administration part. It is a figure which shows the medicine discharge pressure waveform which shows an example of the medicine administration control by the medicine administration apparatus main body. It is a schematic diagram which shows schematic structure of the chemical | medical agent administration apparatus which is Embodiment 2 of this invention. It is a schematic diagram which shows schematic structure of the modification of the chemical | medical agent administration apparatus which is Embodiment 2 of this invention. It is a mimetic diagram showing an example of a medicine discharge hole formed in a plurality of medicine administration parts. It is a mimetic diagram showing an example of a medicine discharge hole formed in a plurality of medicine administration parts. It is a mimetic diagram showing an example of a medicine discharge hole formed in a plurality of medicine administration parts. It is a schematic diagram which shows the structure of the chemical | medical agent administration part of the chemical | medical agent administration apparatus which is Embodiment 3 of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,1a-1c, 21 Catheter 2,2a-2c, 22,22a-22c Tube 3 Drug administration apparatus main body 3a Drug reservoir 3b Pump 3c Control part 4 Internal organ 5 Affected part 6 Body surface 7, 7a-7c Stopper 8, 8a -8c, 18, 38a-38c Drug administration part 9-11, 9a, 9b Drug discharge hole 34, 34a-34c Connecting part 100, 200, 300 Drug administration device

Claims (9)

A drug administration device for administering a drug to a body organ of a mammal including a human,
A drug administration device main body for extruding the drug in a variable pressure state of the drug;
The tube which guides the medicine pushed out from the medicine administration device main body to the internal organ side, and at least one medicine administration portion provided at the distal end of the tube and having a plurality of medicine ejection holes having different opening sizes on the side surface A catheter,
A drug administration device comprising:   2. The drug administration device according to claim 1, wherein the plurality of drug discharge holes include a size of an opening that discharges the drug at a predetermined pressure of pushing out the drug and a size of an opening that does not discharge the drug. . The drug administration section is plural,
Each drug administration section has a plurality of drug ejection holes having the same opening size, and the size of the plurality of drug ejection holes is different between at least two drug administration sections. Item 2. The drug administration device according to Item 1.   The drug administration device according to claim 1, wherein a stopper that contacts the surface of the internal organ is provided between the tube and the drug administration unit.   The drug administration device according to claim 4, wherein the stopper can be adjusted and moved in an axial direction of the tube and the drug administration unit.   The drug administration device according to claim 1, further comprising a connecting part that detachably connects the tube and the drug administration part. The drug administration section is plural,
The drug administration device according to claim 6, wherein the coupling unit couples a drug administration unit selected from a plurality of the drug administration units to the tube.   The drug administration device according to claim 1, wherein the tube is branched toward the drug administration part in the middle of the tube, and the drug administration part is provided in each of the branched tubes.   The drug administration device according to claim 1, wherein the drug administration device main body includes a pressure control unit that controls an extrusion pressure of the drug.

Images