JP2010252924A - Catheter and medication administering device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a catheter and a medication administering device having a simple configuration which can widen the administration area of a medication or the like. <P>SOLUTION: The medication administering device comprises a catheter 1 which is formed as an elongated tubular body 2 having an inner channel, the catheter being provided with a first medication inlet 5 which introduces a medication into the inner channel, a second medication inlet 6 which introduces a medication into the inner channel, and a plurality of through-holes 4 which are formed in the side surface of the tubular body 2 at positions between the first medication inlet 5 and the second medication inlet 6 and connect the inner channel and the outside, a pump 7 which communicates with the first medication inlet 5 of the catheter 1 and discharges the medication to the through-hole 4 side, and a pump 8 which communicates with the second medication inlet 6 of the catheter 1 and discharges the medication to the through-hole 4 side. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a catheter that is inserted into a living body and discharges a drug from a plurality of through holes arranged on a side surface, and a drug administration device using the catheter.

  Conventionally, a catheter inserted into a human or a mammal other than a human has an elongated tubular shape having a channel therein. A portion of the tubular casing that is inserted into the body is provided with a through-hole that communicates the internal channel with the outside for the purpose of discharging medicine or the like. Some catheters are provided with a plurality of through holes on the side surface so that the medicine can be discharged from a plurality of through holes on the side surface to a wide area. In a catheter having a plurality of through holes on this side, a drug is delivered from a drug delivery source such as a pump, taken from the proximal end side of the catheter toward the internal channel, and discharged from the plurality of through holes into the body.

Special table 2003-504132 gazette

  However, when a medicine is introduced in one direction from the proximal end with a conventional catheter, the amount of medicine discharged is not the same in the through hole near the proximal end and the through hole near the distal end. That is, even when a sufficient discharge amount is obtained at the through hole close to the proximal end, the medicine is sequentially discharged through the through hole in the middle, and the pressure of the medicine in the internal channel is reduced. As a result, there is often a case where a sufficient discharge amount cannot be obtained at the through hole near the tip, and the discharge amount gradually decreases as the position of the through hole changes from the base end to the tip.

  Such a phenomenon in which the discharge amount is gradually reduced limits the length of a region where a plurality of through holes are provided on the side surface of the catheter. That is, the conventional catheter has a problem in that the range in which the drug can be administered with one catheter is limited.

  This invention is made in view of the above, Comprising: It aims at providing the catheter and chemical | medical agent administration apparatus which can widen the administration range of a chemical | medical agent etc. with a simple structure.

  In order to solve the above-mentioned problems and achieve the object, a catheter according to the present invention has an elongated tubular housing having an internal channel, and includes a first drug intake port for taking a drug into the internal channel, A second drug intake for taking a drug into an internal channel; and a side surface of the tubular housing between the first drug intake and the second drug intake; And a plurality of through holes communicating with each other.

  Moreover, the catheter according to the present invention is characterized in that, in the above-described invention, a bent portion bent in a U-shape is provided in the middle of the elongated tubular casing.

  The catheter according to the present invention further includes a branching device for branching one flow path from the drug delivery source toward the first drug intake port and the second drug intake port in the above invention. It is characterized by having.

  In the catheter according to the present invention, in the above invention, the internal channel includes a first internal channel communicating with the first drug intake port and a second internal channel communicating with the second drug intake port. And the plurality of through holes include a plurality of first through holes that communicate between the first internal channel and the outside, and a plurality of second holes that communicate between the second internal channel and the outside. A range including the through holes, wherein the first internal channel and the second internal channel are separated from each other, and the first through holes are located in the axial direction of the tubular casing; It is characterized in that at least a part overlaps the range in which the through hole is located.

  The drug administration device according to the present invention has an elongated tubular casing having an internal channel, a first drug intake port for taking a drug into the internal channel, and a second drug taking the drug into the internal channel. An inlet, and a plurality of through-holes that are located on a side surface of the tubular housing and are located between the first drug inlet and the second drug inlet and communicate with the internal channel and the outside. And at least one drug delivery source in direct or indirect communication with the first drug inlet and the second drug inlet of the catheter.

  In the medicine administration device according to the present invention, in the above invention, the medicine delivery source includes a first medicine delivery source communicating directly or indirectly with the first medicine intake port of the catheter, and a first medicine delivery source of the catheter. And a second drug delivery source different from the first drug delivery source communicating directly or indirectly with the second drug intake port.

  The drug administration device according to the present invention is characterized in that, in the above-mentioned invention, a bent portion bent in a U-shape is provided in the middle of the elongated tubular casing of the catheter.

  In the drug administration device according to the present invention, in the above invention, the drug delivery source is a single device, and the catheter has one flow path from the single drug delivery source to the first channel. And a branching device for branching toward the second drug inlet and the second drug inlet.

  In the medicine administration device according to the present invention, in the above invention, the catheter is connected to the first internal channel communicating with the first medicine inlet and the second medicine inlet. A plurality of first through holes communicating with the first inner channel and the outside, and the second inner channel communicating with the outside. A plurality of second through holes, wherein the first internal channel and the second internal channel are separated from each other, and the plurality of first through holes are located in an axial direction of the tubular casing. The range and the range in which the plurality of second through holes are located at least partially overlap.

  The drug administration device according to the present invention has an elongated tubular casing having an internal channel, a catheter having a plurality of through-holes communicating with the internal channel and the outside on a side surface, and the internal channel of the catheter At least one drug delivery source for delivering the drug to the plurality of through-holes through the internal channel in opposite directions from both ends of the catheter. It is characterized by sending out.

  According to this invention, it has an elongated tubular housing having an internal channel, and a first drug intake port for taking a drug into the internal channel, a second drug intake port for taking a drug into the internal channel, A catheter having a plurality of through-holes that are located on a side surface of a tubular housing and are located between the first drug inlet and the second drug inlet and communicate with the internal channel and the outside. Since the medicine is discharged from the first medicine inlet and the second medicine inlet to the plurality of through holes in opposite directions, the medicine can be discharged from the plurality of through holes. With a simple configuration, the administration range of drugs and the like can be widened.

FIG. 1 is a schematic diagram showing a schematic configuration of a catheter according to Embodiment 1 of the present invention. FIG. 2 is a schematic diagram showing a schematic configuration of a drug administration device using the catheter shown in FIG. FIG. 3 is a diagram illustrating a discharge amount distribution of a plurality of through holes when a medicine is delivered from the first medicine intake port using only one pump. FIG. 4 is a diagram showing a discharge amount distribution of a plurality of through holes when a medicine is delivered from the second medicine intake port using only one pump. FIG. 5 is a diagram showing a discharge amount distribution of a plurality of through holes when a drug is discharged from both ends of the first drug intake port and the second drug intake port by two pumps. FIG. 6 is a schematic diagram showing a configuration in the vicinity of the through hole of the catheter according to the second embodiment of the present invention. FIG. 7 is a schematic diagram showing a configuration in the vicinity of a through hole of a catheter according to a modification of the second embodiment of the present invention. FIG. 8 is a schematic diagram showing a configuration in the vicinity of the through hole of the catheter according to the third embodiment of the present invention. FIG. 9 is a schematic diagram showing a configuration in the vicinity of a through hole of a catheter according to a modification of the third embodiment of the present invention. FIG. 10 is a schematic diagram showing a schematic configuration of a catheter according to the fourth embodiment of the present invention. FIG. 11 is a schematic diagram showing a schematic configuration of a catheter according to Embodiment 5 of the present invention. FIG. 12 is a schematic diagram showing a schematic configuration of a catheter according to Embodiment 6 of the present invention. FIG. 13: is a schematic diagram which shows schematic structure of the catheter concerning the modification 1 of Embodiment 6 of this invention. FIG. 14 is a schematic diagram showing a configuration in the vicinity of the through hole of the catheter according to the second modification of the sixth embodiment of the present invention. FIG. 15 is a schematic diagram illustrating a configuration in the vicinity of a through hole of a catheter according to a third modification of the sixth embodiment of the present invention.

  Hereinafter, with reference to drawings, a catheter which is a form for carrying out the present invention and a medicine administration device using the same will be described.

(Embodiment 1)
FIG. 1 is a schematic diagram showing a schematic configuration of a catheter according to Embodiment 1 of the present invention. As shown in FIG. 1, the catheter 1 comprises the elongate tubular housing 2 which has the internal channel 3, and has the several through-hole 4 which connects the internal channel 3 and the exterior on the side surface. The entire catheter 1 is formed of a biocompatible material, such as polyurethane, elastic silicon, Teflon (registered trademark), polyvinyl chloride, polyethylene or the like.

  The catheter 1 includes a first drug intake 5 that is an opening in which one end of a tubular casing 2 introduces a drug into the internal channel 3 and communicates with the internal channel 3, and the other end of the tubular casing 2 is connected to the internal channel 3. A drug is taken into the channel 3 and has a second drug intake 6 which is an opening communicating with the internal channel 3. Further, the plurality of through holes 4 are all located between the first drug intake 5 and the second drug intake 6 on the side surface of the tubular casing 2.

  Here, when the medicine is delivered from the two openings of the first medicine inlet 5 and the second medicine inlet to the inside of the internal channel 3, that is, toward the plurality of through holes 4, The medicine taken from both ends flows through the internal channel 3 in the opposite directions, and the medicine is eventually discharged into the body from the plurality of through holes 4 between the two openings.

  FIG. 2 is a schematic diagram showing a schematic configuration of a drug administration device using the catheter shown in FIG. As shown in FIG. 2, the catheter 1 is inserted into the administration target 10 such as a tumor in the body via the body surface 11, and the through hole 4 is arranged in the administration target 10.

  A pump 7 as a first medicine delivery source is connected to and communicates with the first medicine inlet 5 of the catheter 1, and a second medicine delivery source is connected to the second medicine inlet 6. The pump 8 is connected and communicated. In FIG. 2, the pump 7 and the pump 8 are directly connected to the catheter 1, respectively, but may be indirectly connected and communicated via other members. Moreover, although the pumps 7 and 8 are attached to the body surface 11, it is not restricted to this, You may be embedded in the body and may be provided apart from the body.

  Here, the medicine discharge amount distribution from each through hole 4 when the catheter 1 and the pumps 7 and 8 are used will be described. As shown in FIG. 1, the plurality of through holes 4 are described assuming that through holes 4 a, 4 b, 4 c, 4 d having the same diameter are sequentially arranged in the axial direction from the first drug intake 5 side. To do.

  First, FIG. 3 is a diagram showing the discharge amount distribution of the through holes 4a to 4d when only the pump 7 is used. In this case, the discharge amount decreases sequentially in the order of the through holes 4a → 4b → 4c → 4d. This is a pressure reducing effect in which medicines are sequentially discharged from the through-holes as they are separated from the pump 7, and the discharge pressure gradually decreases, and as a result, the discharge amount decreases.

  Similarly, FIG. 4 is a diagram showing the discharge amount distribution of the through holes 4a to 4d when only the pump 8 is used. In this case, the discharge amount decreases sequentially in the order of the through holes 4d → 4c → 4b → 4a. This is a pressure reducing effect in which medicines are sequentially discharged from the through-holes as the distance from the pump 8 increases. As a result, the discharge pressure gradually decreases, and as a result, the discharge amount decreases.

  On the other hand, FIG. 5 shows the discharge amount distributions of the through holes 4a to 4d when the drugs are discharged from both ends of the first drug intake 5 and the second drug intake 6 by the pumps 7 and 8. FIG. In this case, the discharge amount distribution is a combination of the discharge amount distributions shown in FIGS. 3 and 4, and the influence of the pressure reduction effect due to the positions of the through holes 4a to 4d is reduced, and a substantially uniform discharge amount distribution is obtained. That is, as shown in FIG. 2, the delivery amount of each through hole 4 (4 a to 4 d) is substantially constant by delivering the drug from both end sides of the catheter 1 and discharging it from the plurality of through holes 4 on the side surface. can do. Moreover, since the influence of the pressure reducing effect is reduced, the axial region in which the through hole 4 is provided can be widened. The effect of uniforming the discharge amount distribution and widening the discharge area is obtained when a plurality of through holes 4 are provided.

(Embodiment 2)
Next, a second embodiment of the present invention will be described. In the first embodiment described above, the tubular housing 2 is linear, but in this second embodiment, as shown in FIG. 6, a U-shape is formed in the middle of the elongated tubular housing 2 of the catheter 1. A bent portion 12 that is bent is provided. The plurality of through holes 4 are provided on one side surface of the bent portion 12. In the second embodiment, if the bent portion 12 is inserted into the administration target 10, the insertion of the catheter 1 into the administration target 10 can be performed from one direction, so that the procedure can be simplified.

  As shown in FIG. 7, a through hole 4 ′ may be further provided on the other side surface of the bent portion 12 so that the medicine can be discharged from both sides of the side surface of the bent portion 12.

(Embodiment 3)
Next, a third embodiment of the present invention will be described. In this Embodiment 3, as shown in FIG. 8, the branching device 13 is further provided in the both ends of the catheter of Embodiment 2 which has the bending part 12. As shown in FIG. The branching device 13 branches one flow path 14 from the medicine delivery source toward the first medicine inlet 5 and the second medicine inlet 6. Thereby, one pump as a medicine delivery source is sufficient. The branching device 13 may have a configuration in which a flow rate adjusting function or the like is further added.

  Similarly to FIG. 7, a through hole may be further provided on the other side surface of the bent portion 12 so that the medicine can be discharged from both sides of the side surface of the bent portion 12 (see FIG. 9).

(Embodiment 4)
Next, a fourth embodiment of the present invention will be described. In the third embodiment described above, it is assumed that the catheter has the bent portion 12, but in the fourth embodiment, as shown in FIG. 10, the catheter without the bent portion 12 shown in FIG. 1 is provided with a branching device 13a for connecting the first drug intake port 5 and the second drug intake port 6 to each other, that is, a flow path 14 to which one pump is connected. That is, the branching portion 13a branches the medicine that has flowed in through the flow path 14 and sends the medicine from the first medicine inlet 5 and the second medicine inlet 6 toward the through hole 4, respectively. . Also in this case, the same effects as those of the first embodiment can be obtained with a simple configuration using only one pump.

(Embodiment 5)
Next, a fifth embodiment of the present invention will be described. In the fifth embodiment, as shown in FIG. 11, the housing 2 of the catheter 1 can be inserted into the medicine ejection section 20 where the plurality of through holes 4 are located and the medicine ejection section 20. The two conduit portions 21 and 22 are separated from each other. The positions of the conduit portions 21 and 22 with respect to the medicine discharge portion 20 can be adjusted in the axial direction. That is, after the conduit parts 21 and 22 are moved to an appropriate position with respect to the medicine discharge part 20, the position is fixed with an adhesive or the like, thereby obtaining a desired catheter.

  With this configuration, the medicine is discharged only from the through holes 31 that are not covered with the conduit portions 21 and 22 among the plurality of through holes 4, and the medicine is discharged from the through holes 30 covered with the conduit portions 21 and 22. Is not discharged. Therefore, the through-hole to be used can be limited according to the situation by appropriately adjusting the position of the conduit parts 21 and 22 with respect to the medicine discharge part 20. Thereby, an appropriate drug administration site can be precisely selected and set according to the situation such as the size of the administration target 10.

(Embodiment 6)
Next, a sixth embodiment of the present invention will be described. As shown in FIG. 12, the catheter 41 according to the sixth embodiment includes a first internal channel 43a in which an internal channel 43 corresponding to the internal channel 3 communicates with a first drug intake 45, and a second drug. A second internal channel 43b in communication with the intake 46.

  And since the 1st internal channel 43a and the 2nd internal channel 43 are isolate | separated by the partition 47, for example, a chemical | medical agent cannot move across the two internal channels 43a and 43b. The plurality of through holes include a plurality of first through holes 44 that communicate between the first internal channel 43a and the outside, and a plurality of second through holes 45 that communicate between the second internal channel 43b and the outside. It is divided. That is, the medicine that has passed through the first internal channel 43 a is discharged from the plurality of first through holes 44, and the medicine that has passed through the second internal channel 43 b is discharged from the plurality of second through holes 45. That is, there are two combinations of the internal channels 43a and 43b and the through holes 44 and 45, respectively.

  Here, in the axial direction of the tubular casing 42, at least a part of the range in which the plurality of first through holes 44 are located and the range in which the plurality of second through holes 45 are located are overlapped. Yes. For this reason, the discharge amount distribution from the first through hole 44 has a profile as shown in FIG. 3, and the discharge amount distribution from the second through hole 45 has a profile as shown in FIG. In this overlapping range, since the total discharge amount of the first through hole 44 and the second through hole 45 contributes, the overall discharge amount distribution has a profile as shown in FIG. Almost uniform at the position of the through hole.

(Modification 1 of Embodiment 6)
Next, a first modification of the sixth embodiment of the present invention will be described. In the first modification, the configuration of the sixth embodiment is applied to the second embodiment, and has a bent portion 52 corresponding to the bent portion 12 as shown in FIG. The bent portion 52 is coupled by a coupling member 51. In the first modification of the sixth embodiment, if the bent portion 52 is inserted into the administration target 10 as in the second embodiment, the insertion of the catheter 41 into the administration target 10 can be performed from one direction. The procedure can be simplified.

(Modification 2 of Embodiment 6)
Next, a second modification of the sixth embodiment of the present invention will be described. In the second modification, the configuration of the sixth embodiment is applied to the third embodiment. As shown in FIG. 14, as shown in FIG. 14, the both ends of the catheter of the first modification having the bent portion 52 are further branched. A container 13 is provided. This branching device 13 branches one flow path 14 from a medicine delivery source toward a first medicine inlet 45 and a second medicine inlet 46. Thereby, one pump as a medicine delivery source is sufficient.

(Modification 3 of Embodiment 6)
Next, a third modification of the sixth embodiment of the present invention will be described. In the third modification, the configuration of the sixth embodiment is applied to the fourth embodiment. As shown in FIG. 15, both ends of the catheter 41, that is, the first drug intake 45 and the second drug intake 45 are used. A branching device 13a for connecting the medicine intake 46 and the flow path 14 to which one pump is connected is provided. That is, the branching portion 13a branches the medicine flowing in through the flow path 14 and sends it out from the first medicine inlet 45 and the second medicine inlet 46 toward the through holes 44 and 45, respectively. I have to. Also in this case, the same effects as those of the first embodiment can be obtained with a simple configuration using only one pump.

1, 41 Catheter 2, 42 Tubular housing 3, 43, 43a, 43b Internal channel 4, 30, 31, 44, 45 Through hole 5, 45 First drug intake 6, 46 Second drug intake 7, DESCRIPTION OF SYMBOLS 8 Pump 10 Administration target 11 Body surface 12,52 Bending part 13 Branch device 14 Flow path 20 Drug discharge part 21,22 Conduit part 47 Partition 51 Binding member

Claims (10)

An elongated tubular housing with an internal channel;
A first drug intake for taking a drug into the internal channel;
A second drug intake for taking a drug into the internal channel;
A plurality of through-holes located on a side surface of the tubular casing between the first drug intake and the second drug intake and communicating the internal channel with the outside;
A catheter characterized by comprising:   The catheter according to claim 1, further comprising a bent portion bent in a U shape in the middle of the elongated tubular casing.   The catheter according to claim 1, further comprising a branching device for branching one flow path from a drug delivery source toward the first drug intake port and the second drug intake port. The internal channel includes a first internal channel in communication with the first drug intake and a second internal channel in communication with the second drug intake;
The plurality of through holes include a plurality of first through holes that communicate the first internal channel and the outside, and a plurality of second through holes that communicate the second internal channel and the outside,
The first internal channel and the second internal channel are separated from each other;
The range in which the plurality of first through holes are positioned in the axial direction of the tubular casing and the range in which the plurality of second through holes are positioned at least partially overlap with each other. The catheter described. An elongated tubular housing having an internal channel, a first drug intake for taking a drug into the internal channel, a second drug intake for taking a drug into the internal channel, and a side of the tubular housing A catheter having a plurality of through holes located between the first drug inlet and the second drug inlet and communicating the internal channel with the outside;
At least one drug delivery source in direct or indirect communication with the first drug inlet and the second drug inlet of the catheter;
A drug administration device comprising:   The drug delivery source communicates directly or indirectly to a first drug inlet of the catheter and the first drug source communicates directly or indirectly to a second drug inlet of the catheter. The drug administration device according to claim 5, further comprising a second drug delivery source different from the drug delivery source.   6. The drug administration device according to claim 5, further comprising a bent portion bent in a U shape in the middle of the elongated tubular casing of the catheter. The drug delivery source is a single device;
The catheter further includes a branching device for branching one flow path from the single drug delivery source toward the first drug intake port and the second drug intake port. Item 6. The drug administration device according to Item 5. The catheter is
The internal channel includes a first internal channel in communication with the first drug intake and a second internal channel in communication with the second drug intake;
The plurality of through holes include a plurality of first through holes that communicate the first internal channel and the outside, and a plurality of second through holes that communicate the second internal channel and the outside. ,
The first internal channel and the second internal channel are separated from each other;
The range in which the plurality of first through holes are positioned in the axial direction of the tubular casing and the range in which the plurality of second through holes are positioned at least partially overlap with each other. The pharmaceutical administration device described. A catheter having an elongated tubular housing having an internal channel and having a plurality of through-holes communicating with the internal channel and the outside on a side surface;
At least one drug delivery source for delivering a drug to the internal channel of the catheter;
Have
The drug delivery device is characterized in that the drug delivery source delivers a drug in opposite directions from both ends of the catheter through the internal channel toward the plurality of through holes.

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