JP6544097B2 - Drug supply device - Google Patents

Description

  The present disclosure relates to drug delivery devices, and more particularly to devices that can be used to deliver bioadhesives to target sites.

  Bioadhesives are used for adhesion and hemostasis of tissue that has been cut by surgery. As a bioadhesive, for example, a two-component bioadhesive composed of a drug solution containing fibrinogen and a thrombin-containing drug solution is known.

  As a method of applying such a two-component bioadhesive agent to a target site, a method of simultaneously discharging two chemical solutions from a supply device to mix and apply, or a method of discharging one of the chemical solutions in advance Then, there is a method of discharging and mixing the other chemical solution. These methods are properly used depending on the shape and position of the application site.

  In either method, it is important that the two solutions be mixed until they are discharged from the supply device so that the adhesive does not clog. On the other hand, a supply device for supplying a bioadhesive to a target site is required to have a combination of two medical solution supply paths, considering the burden on the subject and the ease of operation under an endoscope. Be For this reason, a delivery instrument in the form of a multi-lumen catheter having two lumens is known (see, for example, Patent Document 1).

JP 2003-250806 A

  However, the conventional delivery device has the problem that the other drug solution flows back into the lumen from the tip end and the adhesive hardens in the lumen. Further, in order to prevent the tissue from being damaged by the delivery device, the tip of the delivery device is preferably curved. However, if the distal end of the supply instrument is chamfered as it is to form a curved surface, the side wall becomes thin and it tends to damage biological tissue.

  Even in the case of a drug solution other than a bioadhesive, it is not preferable that mixing due to backflow of the drug solution occurs. Further, the same problem occurs when three or more lumens and three or more chemical solutions are supplied.

  An object of the present disclosure is to provide a drug supply device that is less likely to cause mixing due to backflow of a drug solution at the tip end portion and is less likely to damage living tissue.

  One aspect of the drug delivery device of the present disclosure comprises a tube having a curved distal end, each having a plurality of lumens opening at the distal end, wherein at least one of the plurality of lumens has a diameter at the distal end It is smaller than the diameter in the other part.

  In one aspect of the drug delivery device, at least one lumen may have an intermediate portion of progressively smaller diameter.

  In one embodiment of the drug delivery device, the septum between the two lumens may be thicker at the tip than at other portions.

  In one aspect of the drug delivery device, the plurality of lumens are different in thickness from one another, and in the thickest lumen, the diameter at the tip is smaller than the diameter at the other part. it can.

  In one aspect of the drug delivery device, the plurality of lumens may be configured such that the diameter at the tip is smaller than the diameter at the other portion.

  According to the drug supply device of the present disclosure, it is possible to make it difficult to cause mixing due to backflow of the drug solution at the tip, and to make it difficult to damage living tissue.

It is a schematic diagram which shows the drug supply instrument which concerns on one Embodiment. It is sectional drawing which shows the structure of the front-end | tip part of a drug supply instrument. It is sectional drawing which shows the modification of the front-end | tip part of a drug supply instrument. It is sectional drawing which shows the modification of the front-end | tip part of a drug supply instrument. It is a sectional view showing an example of a hub used for a medicine supply instrument.

  In the present disclosure, the side to be the patient side when using the drug supply device will be described as the front end, and the opposite side as the rear end.

  As shown in FIG. 1, the drug supply device of this embodiment is a multi-lumen tube 101 having two lumens penetrating from the front end to the rear end and not in communication with each other, and the respective lumens at the rear end. And the connector 103 connected via the connection pipe 102.

  As shown in FIG. 2, the tube 101 has a curved surface whose tip is connected to the side surface without any step. For example, the tip can be generally hemispherical or bell shaped. The first lumen 111 and the second lumen 112 provided in the tube 101 are respectively opened at the curved tip. Also, in the first lumen 111 and the second lumen 112, the diameters φ1a and φ2a of the opening at the tip are larger than the diameters φ1b and φ2b of the portion other than the tip. Specifically, the first lumen 111 and the second lumen 112 have a normal diameter portion 122 provided on the rear end side and a narrow diameter portion 121 provided on the front end side and smaller in diameter than the normal diameter portion 122. And an intermediate portion 123 connecting the normal diameter portion 122 and the narrow diameter portion 121. In the rear end portion of the tube 101, the diameters of the first lumen 111 and the second lumen 112 are larger than the diameter of the normal diameter portion 122 and the outer diameter is larger so that the connection tube 102 can be connected. There is. However, if the connection pipe 102 can be connected, the normal diameter portion 122 may be formed up to the rear end.

  By reducing the diameter of the tip opening, it is possible to make it difficult for the drug solution to flow back into the lumen. When the entire diameter of the lumen itself is reduced, it becomes difficult to supply a high viscosity drug solution. However, since the diameter is reduced only at the tip end, the supply of the chemical solution is not significantly affected.

  Further, when the normal diameter portion 122 is directly opened at the curved end, the cross section of the thin and sharp side wall is exposed at the end, which may damage the living tissue. However, in the present embodiment, since the diameter of the opening is reduced, the thickness of the cross section of the side wall is increased, and the biological tissue can be hardly damaged. When the opening is provided on the side surface of the tube, the problem that the cross section of the side wall becomes sharp does not occur, but it becomes difficult to determine the discharge direction of the chemical solution under the endoscope. If it is a structure like this embodiment, since the discharge direction of a chemical | medical solution corresponds with the direction of the front-end | tip, the advantage that the operation under an endoscope becomes easy is acquired.

  In the present embodiment, the narrow diameter portion 121 is formed by reducing the diameter of the normal diameter portion 122 substantially equally. In this way, molding becomes easy. In addition, since the thickness of the partition between the first lumen 111 and the second lumen 112 becomes thicker at the tip, it becomes difficult for the drug solution to diffuse from one lumen to the other lumen. It is also possible to reduce the outside diameter of the tube in order to further increase the opening distance. It is also possible to reduce the diameter near the center of the tube from the viewpoint of making the side wall as thick as possible.

  In the case of supplying a bioadhesive comprising a first drug solution containing fibrinogen and a second drug solution containing thrombin, for example, the diameter of the tube 101 is about 3 mm, and the normal diameter of the first lumen 111 The diameter of the portion 122 is about 1.1 mm, the diameter of the normal diameter portion 122 of the second lumen 112 is about 0.7 mm, and the first drug solution with high viscosity is supplied from the first lumen, and the second The drug solution can be made chest cavity by the second lumen. In this case, the diameters of the narrow diameter portion 121 of the first lumen 111 and the second lumen 112 can be respectively about 0.5 mm. Further, the length of the middle portion 123 can be about 2 mm.

  The tube 101 can be a flexible tube, and is not particularly limited, but preferably made of a soft resin. For example, polyurethane, polysilicon or polyamide can be used. The distal end portion of the tube 101 can be rolled while the diameter of the lumen is reduced by pressurizing with heating using a mold.

  Connecting a separate nozzle to the tip of the tube and reducing the diameter is difficult in the case of multi-lumen in terms of alignment. In addition, it is also difficult in terms of securing the connection strength between the nozzle and the tube. On the other hand, it is relatively easy to process the tip of the tube using a mold or the like, and problems such as connection strength do not occur.

  In this embodiment, an example is shown in which the narrow diameter portion 121 having a substantially constant diameter is provided at the tip, and the normal diameter portion 122 and the narrow diameter portion 121 are connected by the intermediate portion 123 whose diameter gradually decreases. However, the diameter of the opening at the end may be smaller than that of the normal diameter portion 122, and the narrow portion 121 may not be present as shown in FIG. 3, and the intermediate portion 123 may be directly opened at the end. Moreover, the narrow diameter portion 121 may be provided only in one lumen, and the length and position of the middle portion 123 may be different between the first lumen 111 and the second lumen 112. . From the viewpoint of smoothly supplying the chemical solution, it is preferable that the normal diameter portion 122 and the narrow diameter portion 121 be connected via the intermediate portion 123 whose diameter continuously changes. However, as shown in FIG. 4, the intermediate portion 123 may not be present, and a step may be generated between the normal diameter portion 122 and the narrow diameter portion 121. Moreover, it can also be set as the structure which does not have the intermediate part 123 in one lumen.

  In the present embodiment, an example is shown in which both the first lumen 111 and the second lumen 112 are contracted at the tip. However, only one of the lumens may be configured to be reduced in diameter. For example, when a thick lumen and a thin lumen are provided, the thicker lumen is more likely to backflow, so the diameter of the thicker lumen may be reduced to make the opening smaller. Mixing can be less likely to occur. Further, in the case of supplying a high viscosity chemical solution and a low viscosity chemical solution, it is difficult for the low viscosity chemical solution to push back the high viscosity chemical solution and cause backflow. Therefore, in this case, if the opening on the side of the drug solution which has a low viscosity and which easily flows back can be reduced, mixing due to the back flow of the drug solution can be made difficult to occur. Further, in the case where one of the chemical solutions is first applied to the target site and then the other chemical solution is supplied, the opening on the side of the chemical solution to be supplied later may be reduced. Furthermore, when the diameter of the normal diameter portion 122 of one lumen is sufficiently small, it is not necessary to reduce the diameter.

  In the present embodiment, an example in which the diameter of the normal diameter portion 122 is different between the first lumen 111 and the second lumen 112 has been shown. However, the diameters of the normal diameter portions 122 of the first lumen 111 and the second lumen 112 may be equal.

  The method of connecting the connector 103 to the rear end of the tube 101 can be selected as appropriate. For example, as shown in FIG. 5, using the hub 130 having the first plug 131 and the second plug 132 which can be inserted into the first lumen 111 and the second lumen 112, respectively, the connecting tube 102 and the connector 103 can be connected. The hub 130 can be formed of, for example, a resin such as polycarbonate or acrylonitrile-butadiene-styrene (ABS). The hub 130 and the tube 101 can be bonded by an adhesive or the like. The connection pipe 102 can be a flexible tube or the like. The connector 103 can be a female luer connector or the like that can be connected to a syringe or the like. However, it is also possible to connect other appliances without passing through the connector.

  The drug supply device of the present embodiment can also be used to supply a bioadhesive other than a two-component bioadhesive comprising fibrinogen and thrombin. Moreover, it can be used not only for a two-part bioadhesive agent, but also for the supply of various medicines preferably not mixed until being supplied to a target site. Moreover, if three or more lumens are provided, three or more medicines can be supplied.

  The drug supply device of the present disclosure is not only difficult to cause mixing due to backflow of the drug solution at the tip end, but is also useful as a drug supply device or the like for supplying a plurality of drug solutions.

DESCRIPTION OF SYMBOLS 101 Tube 102 Connection tube 103 Connector 111 1st lumen 112 2nd lumen 121 Narrow diameter part 122 Normal diameter part 123 Middle part 130 Hub 131 1st plug 132 2nd plug

Claims (4)

A tube having a curved tip and a plurality of lumens each opening at the tip,
At least one of the plurality of the lumen, the diameter of the tip, rather smaller than the diameter of the other portions,
A drug delivery device , wherein the septum between the two lumens is thicker at the tip than at other parts .   The drug delivery device according to claim 1, wherein the at least one lumen comprises an intermediate portion of progressively smaller diameter. The plurality of lumens differ in thickness from one another;
The drug delivery device according to claim 1 or 2 , wherein in the thickest lumen, the diameter at the tip is smaller than the diameter at the other part. The drug supply device according to any one of claims 1 to 3 , wherein the diameter of each of the plurality of lumens at the tip is smaller than the diameter at the other part.

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