JP6864840B2 - Drug supply equipment - Google Patents

Description

The present disclosure relates to a drug supply device, and more particularly to a device that can be used to supply a bioadhesive to a target site.

A bioadhesive is used for adhesion of tissues cut by surgery, hemostasis, and the like. As a bioadhesive, for example, a two-component bioadhesive composed of a chemical solution containing fibrinogen and a drug solution containing thrombin is known.

As a method of applying such a two-component bioadhesive to the target site, a method of simultaneously discharging two chemicals from a supply device to mix and apply, or a method of discharging one of the chemicals in advance and applying the adhesive is performed. After that, there is a method of discharging the other chemical solution and mixing it. These methods are appropriately used depending on the shape and position of the application site.

In either method, it is important that the two chemicals are mixed until they are ejected from the feeder so that the adhesive does not harden. On the other hand, a supply device that supplies the bioadhesive to the target site is required to have an integrated supply route for the two chemical solutions, considering the burden on the subject and the ease of operation under the endoscope. Be done. For this reason, a supply device that has become a multi-lumen catheter having two lumens is known (see, for example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2003-250806

However, the conventional supply device has a problem that the other chemical solution flows back into the lumen from the tip portion and the adhesive hardens in the lumen.

Even in the case of a chemical solution other than the bioadhesive, it is not preferable that the chemical solution is mixed due to the backflow of the chemical solution. Further, the same problem occurs when three or more lumens are supplied and three or more chemical solutions are supplied.

An object of the present disclosure is to make it possible to realize a drug supply device in which mixing due to backflow of a drug solution is unlikely to occur at the tip portion.

One aspect of the drug feeding device of the present disclosure comprises a tube having a curved tip, each having a plurality of lumens opening at the tip, at least one of the plurality of lumens having a diameter at the tip. It is smaller than the diameter in other parts.

In one aspect of the drug delivery device, the at least one lumen may have an intermediate portion that gradually diminishes in diameter.

In one aspect of the drug delivery device, the septum between the two lumens may be thicker at the tip than the rest.

In one aspect of the drug supply device, the plurality of lumens may be different in thickness from each other, and the diameter at the tip of the thickest lumen may be smaller than the diameter at the other portion. it can.

In one aspect of the drug feeding device, each of the plurality of lumens may be configured such that the diameter at the tip is smaller than the diameter at the other portion.

According to the drug supply device of the present disclosure, it is possible to prevent mixing of the drug solution due to backflow at the tip portion.

It is a schematic diagram which shows the drug supply device which concerns on one Embodiment. It is sectional drawing which shows the structure of the tip part of the drug supply device. It is sectional drawing which shows the deformation example of the tip part of a drug supply device. It is sectional drawing which shows the deformation example of the tip part of a drug supply device. It is sectional drawing which shows an example of the hub used for the drug supply apparatus.

In the present disclosure, the side that becomes the patient side when using the drug supply device will be described as the front end, and the opposite side will be described as the rear end.

As shown in FIG. 1, the drug supply device of the present embodiment has a multi-lumen tube 101 having two lumens penetrating from the tip to the rear end and not communicating with each other, and the respective tubes at the rear end. And a connector 103 connected via a connecting pipe 102.

As shown in FIG. 2, the tube 101 has a curved surface whose tip is connected to the side surface without a step. For example, the tip can be substantially hemispherical or bell-shaped. The first lumen 111 and the second lumen 112 provided on the tube 101 each have an opening at a curved tip. Further, in the first lumen 111 and the second lumen 112, the diameters φ1a and φ2a of the opening at the tip are larger than the diameters φ1b and φ2b of the portion other than the tip. Specifically, the first lumen 111 and the second lumen 112 have a normal diameter portion 122 provided on the rear end side and a narrow diameter portion 121 provided on the front end side and having a smaller diameter than the normal diameter portion 122. And an intermediate portion 123 that connects the normal diameter portion 122 and the narrow diameter portion 121. At the rear end of the tube 101, the diameters of the first lumen 111 and the second lumen 112 are larger than the diameter of the normal diameter portion 122, and the outer diameter is also thicker so that the connecting pipe 102 can be connected. There is. However, if the connection pipe 102 can be connected, the normal diameter portion 122 may be provided up to the rear end portion.

By reducing the diameter of the opening at the tip, it is possible to prevent the drug solution from flowing back into the lumen. When the entire diameter of the lumen itself is reduced, it becomes difficult to supply a highly viscous chemical solution. However, since the diameter is reduced only at the tip portion, the supply of the chemical solution is not significantly affected.

Further, when the normal diameter portion 122 is directly opened to the curved tip, the cross section of the side wall having a thin and sharp point is exposed at the tip, which may damage the living tissue. However, in the present embodiment, since the diameter of the opening is small, the thickness of the cross section of the side wall is increased, and it is possible to make it difficult to damage the living tissue. When the opening is provided on the side surface of the tube, the problem that the cross section of the side wall becomes sharp does not occur, but it becomes difficult to determine the discharge direction of the chemical solution under the endoscope. With the configuration as in this embodiment, since the discharge direction of the chemical solution coincides with the direction of the tip, there is an advantage that the operation under the endoscope becomes easy.

In the present embodiment, the narrow diameter portion 121 is formed by reducing the diameter of the normal diameter portion 122 substantially evenly. In this way, molding becomes easy. Further, since the thickness of the partition wall portion between the first lumen 111 and the second lumen 112 becomes thicker at the tip, it becomes difficult for the drug solution to diffuse from one lumen to the other lumen. It is also possible to reduce the diameter to the outside of the tube to further increase the distance of the opening. It is also possible to reduce the diameter toward the center of the tube from the viewpoint of making the side wall as thick as possible.

When supplying a bioadhesive composed of a first chemical solution containing fibrinogen and a second chemical solution containing thrombin, for example, the diameter of the tube 101 is set to about 3 mm, and the normal diameter of the first cavity 111 is set. The diameter of the portion 122 is about 1.1 mm, the diameter of the normal diameter portion 122 of the second lumen 112 is about 0.7 mm, the first chemical solution having high viscosity is supplied through the first lumen, and the second The drug solution can be supplied through the second lumen. In this case, the diameters of the narrow diameter portions 121 of the first lumen 111 and the second lumen 112 can be about 0.5 mm, respectively. Further, the length of the intermediate portion 123 can be about 2 mm.

The tube 101 can be a flexible tube, and is preferably made of a soft resin without particular limitation. For example, it may be polyurethane, polysilicon, polyamide or the like. By pressurizing the tip of the tube 101 while heating it using a mold, the tip can be rounded and the lumen can be reduced in diameter.

In the case of multi-lumen, it is difficult to reduce the diameter by connecting a separate nozzle to the tip of the tube from the viewpoint of alignment. It is also difficult to secure the connection strength between the nozzle and the tube. On the other hand, it is relatively easy to process the tip of the tube using a mold or the like, and problems such as connection strength do not occur.

In the present embodiment, an example is shown in which a narrow diameter portion 121 having a substantially constant diameter is provided at the tip, and the normal diameter portion 122 and the narrow diameter portion 121 are connected by an intermediate portion 123 whose diameter gradually decreases. However, the diameter of the opening at the tip may be smaller than that of the normal diameter portion 122, and the intermediate portion 123 may be directly opened at the tip without the narrow diameter portion 121 as shown in FIG. Further, the narrow diameter portion 121 may be provided only in one lumen, and the length and position of the intermediate portion 123 may be different between the first lumen 111 and the second lumen 112. .. From the viewpoint of smoothly supplying the chemical solution, it is preferable that the normal diameter portion 122 and the narrow diameter portion 121 are connected via an intermediate portion 123 whose diameter changes continuously. However, as shown in FIG. 4, there may be no intermediate portion 123, and a step may be formed between the normal diameter portion 122 and the narrow diameter portion 121. It is also possible to configure one lumen without the intermediate portion 123.

In this embodiment, an example is shown in which both the first lumen 111 and the second lumen 112 are reduced in diameter at the tip. However, it is also possible to have a configuration in which only one lumen is reduced in diameter. For example, when a thick lumen and a thin lumen are provided, the thicker lumen is more likely to regurgitate. Therefore, by reducing the diameter of the thicker lumen to make the opening smaller, the regurgitation of the drug solution is performed. It is possible to make it difficult for the mixture to occur. Further, when a high-viscosity chemical solution and a low-viscosity chemical solution are supplied, the low-viscosity chemical solution pushes away the high-viscosity chemical solution and does not easily flow back. Therefore, in this case, if the opening on the chemical solution side, which has a low viscosity and is likely to flow back, is made small, it is possible to prevent mixing of the chemical solution due to backflow. Further, when one chemical solution is first applied to the target site and then the other chemical solution is supplied, the opening on the side of the chemical solution to be supplied later may be reduced. Further, if the diameter of the normal diameter portion 122 of one lumen is sufficiently small, it is not necessary to reduce the diameter.

In the present embodiment, an example is shown in which the diameter of the normal diameter portion 122 is different between the first lumen 111 and the second lumen 112. However, the diameters of the normal diameter portions 122 of the first lumen 111 and the second lumen 112 may be the same.

The method of connecting the connector 103 to the rear end of the tube 101 can be appropriately selected. For example, using a hub 130 having a first plug 131 and a second plug 132 that can be inserted into the first lumen 111 and the second lumen 112, respectively, as shown in FIG. 5, the connecting tube 102 and the connector. 103 can be connected. The hub 130 can be formed of, for example, a resin such as polycarbonate or acrylonitrile-butadiene-styrene (ABS). The hub 130 and the tube 101 can be adhered to each other with an adhesive or the like. The connecting tube 102 can be a flexible tube or the like. The connector 103 can be a female luer connector or the like that can be connected to a syringe or the like. However, it is also possible to connect other appliances without using a connector.

The drug supply device of the present embodiment can also be used for supplying a bioadhesive other than the two-component bioadhesive composed of fibrinogen and thrombin. Further, it is not limited to the two-component bioadhesive, and can be used for supplying various drugs that are preferably not mixed until they are supplied to the target site. Further, if three or more lumens are provided, it is possible to supply three or more liquids.

The drug supply device of the present disclosure is useful as a drug supply device or the like that supplies a plurality of drug solutions because mixing of the drug solution due to backflow is unlikely to occur at the tip portion.

101 Tube 102 Connection tube 103 Connector 111 First lumen 112 Second lumen 121 Narrow diameter portion 122 Normal diameter portion 123 Intermediate portion 130 Hub 131 First plug 132 Second plug

Claims (5)

A drug supply device that supplies and applies drugs to the affected area.
A flexible tube having a curved tip, each having a plurality of lumens that open on the tip and at a position offset from the tip to the proximal side.
At least one of the plurality of lumens has a diameter at the tip portion smaller than a diameter at the other portion.
A drug supply device in which a drug flowing through the lumen is discharged from the opening to the outside of the drug supply device and mixed. The drug supply device according to claim 1, wherein the at least one lumen has an intermediate portion whose diameter gradually decreases. At least one of the lumens has a narrow diameter portion of constant diameter.
The drug supply device according to claim 1 or 2, wherein the narrow diameter portion opens at the tip portion. The plurality of said lumens are different in thickness from each other.
The drug supply device according to any one of claims 1 to 3, wherein the diameter at the tip portion of the thickest lumen is smaller than the diameter at the other portion. The drug supply device according to any one of claims 1 to 4, wherein each of the plurality of lumens has a diameter at the tip portion smaller than a diameter at the other portion.

Images