JP2008161240A - Medicine application tube - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine application tube easily inserted into a body cavity even when a diameter of a conduit leading to an organ in the body cavity is not determined, and surely and intensively applying a medicine to an object part. <P>SOLUTION: A medicine discharge hole 4 is provided on the tip part peripheral wall of a tube main body 1, and a pair of expansion partition members 5 and 5 which can be elastically expanded and contracted in a radial direction are provided on the outer peripheral part of the tube main body 1 holding the medicine discharge hole 4 therebetween. The medicine application tube is inserted into the body cavity, and the expansion partition members 5 and 5 are expanded by the pressure of a fluid supplied through a lumen inside the tube main body 1 in the state of directing the medicine discharge hole 4 to the target part and are brought into press contact with conduit walls at both sides of the target part. In the state, the medicine supplied through the lumen inside the tube main body 1 into a conduit part surrounded by the expansion partition members 5 and 5 is discharged from the medicine discharge hole 4 and applied. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a drug application tube that administers or applies a drug such as a reagent, a therapeutic drug, and an anesthetic to a predetermined location in a body cavity.

  As a drug administration method for diagnosis and treatment, it is widely performed to insert a catheter or tube into a body cavity and directly administer it from the distal end to various organs or predetermined sites. Thus, according to the method of administering a drug using a catheter or a tube, compared with the case where the drug is administered by means such as oral or intravenous injection, a reagent or therapeutic agent is placed at a predetermined target location in the body cavity. Since an anesthetic and other drugs can be administered intensively, it is extremely efficient. For this reason, not only can diagnosis and treatment be performed with higher accuracy, but also treatment using the drug can be performed effectively, and the risk of side effects due to the action of the drug on the site where no drug administration is required. Can be reduced.

  As a method of applying a drug to a target site in a body cavity without using a catheter or a tube, conventionally, a member containing or holding a drug or the like, for example, a cotton swab in which a drug is applied and impregnated on a tip cotton ball, or a tip There is widely known a method for applying a drug using a rod-like body impregnated with and held by a flocking provided in the part or a spherical sponge.

  On the other hand, as a method of applying a drug to a target site in a body cavity using a catheter or a tube, a drug is discharged or ejected from the tip toward the target site, or the drug is held in the tip opening. In addition, a method of spraying or administering a drug toward a target site when the tip reaches a target site has been developed.

  For example, in Patent Document 1, after inserting a tube having a plurality of drug discharge holes at the distal end to a target location in the body cavity, the drug is fed into the tube by the operation of a pump installed outside, A method of injecting a drug from the drug release hole into a target site is described.

  Patent Document 2 discloses an ultrasonic wave provided on the proximal side of a tube after a tube provided with a spray agent container for holding a spray agent such as a chemical solution in a tip opening is inserted into a body cavity. An ultrasonic spray tube is described in which the spraying agent is atomized to be released by operating a vibrator.

Further, in Patent Document 3, a tube in which a holding part that holds a magnetic drug is provided in a distal end opening and a magnet piece that is slidable toward and away from the holding part is slidably mounted is provided in the magnet. The medicine is made available for administration by inserting the medicine into the holding part with the piece and inserting it to the target location in the body cavity. When the target is reached, the magnet piece is retracted to release the holding force. A magnetic delivery catheter is described.
JP-A-2-239875 JP 2001-25467 A JP 2002-345968 A

  However, in the case of a member having a cotton ball or the like in which a drug is applied and impregnated at the tip thereof, such as a cotton swab, without using the catheter or tube, when the member is inserted into a body cavity duct, There is a problem that the surface of a sphere or the like is in sliding contact with the inner wall of the pipe and the drug is applied to the inner wall or drops off and the drug cannot be effectively applied to the target site. Such a problem also occurs when the tube or catheter is inserted into a body cavity with the drug held on the outer periphery of the tip.

  On the other hand, as described in Patent Document 1, a method of injecting a drug through a tube to a target site, or when a drug is held in the distal end of a tube as described in Patent Documents 2 and 3 However, as described in Patent Document 1, in the method of injecting a drug from the tip of the tube to the target site as in Patent Document 1, if the drug solution is ejected, the organ or the like may be damaged by the pressure. If the jet power is weakened, it may be difficult to administer the drug to the target site.

  In addition, according to the tubes and catheters described in Patent Documents 2 and 3, the structure is complicated by requiring means for holding the medicine in the distal end portion thereof, means for releasing the holding, and the like, and the cost is increased. In addition, in any means, the medicine is applied by injection or the like from a position away from the target site in the body cavity, so that the drug is applied and administered to a part other than the target site. In other words, there is a problem that the amount of medicine used is more than necessary.

  Furthermore, in the actual body cavity duct, the diameter of the duct is often not determined. Therefore, a tube or the like is inserted into the duct and the drug is applied to or delivered to the target site through the duct. If the tube has a relatively large diameter, resistance may be generated when the tube is inserted into the tube or when the tube passes through the tube, and the tube may be damaged. For this reason, in general, large and small diameter tubes and catheters are prepared, and inserted while sequentially replacing the small diameter tube and the large diameter tube. In addition, in a method in which a drug is held at the tip of a rod-like body, tube, or catheter, and this drug is directly applied to a target site, the tube is passed when these tips pass through the body cavity. There is a possibility that the medicine may fall off due to frictional force or deformation with the inner wall by sliding contact with the inner wall of the road. Therefore, it is necessary to prepare a plurality of tubes and the like.

  The present invention has been made in view of such problems. The object of the present invention is to apply a plurality of drugs when a drug is applied to a target site in a body cavity through the diameter of a body cavity where the diameter is not fixed. It is an object of the present invention to provide a drug application tube that can be reliably and easily applied to a dissolution site by inserting a single tube once without using a tube.

  To achieve the above object, the drug application tube of the present invention is a drug application tube for inserting a drug into a body cavity and applying the drug to a target site, as described in claim 1, and supplying the drug inside A flexible tube main body provided with a lumen and a fluid supply lumen and having a drug discharge hole communicating with the drug supply lumen on the peripheral wall, and the drug discharge hole sandwiched between the outer peripheral surface of the tube main body It consists of a pair of expansion partition members that can be expanded and contracted in the radial direction. The expansion partition members are normally contracted in diameter and are in contact with the outer peripheral surface of the tube body, and are supplied through the fluid supply lumen. It is configured to expand by fluid pressure.

  In the medicine application tube configured as described above, the invention according to claim 2 is characterized in that a plurality of medicine discharge holes are provided in the circumferential wall portion at the distal end portion of the tube body at small intervals in the circumferential direction.

  Further, in the invention according to claim 3, the expansion partition member is formed of a cylindrical member having elasticity, and both end portions thereof are closely fixed to the outer peripheral surface of the tube body, and the cylindrical portion between the both end portions is disposed inside. It is configured to expand in the radial direction by the supplied fluid pressure.

  According to a fourth aspect of the present invention, in addition to the pair of expansion partition members provided so as to sandwich the drug release hole, the outer expansion partition member is provided at a position spaced from at least one of these expansion partition members. It is provided.

  According to the first aspect of the present invention, a drug discharge hole is provided in the peripheral wall portion of the tube main body, and an expansion partition member that can be expanded and contracted is mounted on the outer peripheral surface of the tube main body across the drug discharge hole. Since the expansion partition member is reduced in diameter and is in contact with the outer peripheral surface of the tube main body, the outer diameter of these expansion partition members is substantially the same as the outer diameter of the tube main body, and the body cavity duct is extremely thin. However, the tube main body can be smoothly inserted to the target location, and the drug discharge hole provided in the peripheral wall portion of the tube main body is in contact with the wall surface of the target site at the target location of the small diameter pipe line. Thus, the medicine supplied through the medicine supply lumen in the tube body can be reliably and intensively applied to the target site from the medicine discharge hole.

  Further, when the pipe diameter of the target location in the body cavity is large, when the peripheral wall portion of the tube main body provided with the drug release hole reaches the target location, the pair of the pipes arranged so as to sandwich the drug release hole. These expansion partition members are expanded by the fluid pressure supplied through the fluid supply lumen provided in the tube body, so that the outer peripheral surfaces of these expansion partition members are brought into pressure contact with the wall surface of the pipe line with the target portion interposed therebetween. Therefore, the tube body can be fixed in a state where the drug discharge hole is accurately directed to the target site, and the drug discharged from the drug discharge hole can be placed in the duct portion surrounded by the expansion partition members. It can be filled and applied reliably and efficiently to the target site existing between the extended partition members.

  As described above, since the pair of expansion partition members are expanded with the drug discharge hole directed toward the target site and are pressed against both side wall portions of the target site, the drug discharge hole is discharged. Therefore, it is possible to perform a quick and reliable treatment with a minimum amount of medicine without the need for an excessive amount of medicine. Even if the size of the body cavity duct changes, a single drug application tube can easily and efficiently apply a drug application treatment to a target site.

  According to the invention of claim 2, a plurality of the drug release holes are provided in the circumferential wall portion at the distal end portion of the tube body at small intervals in the circumferential direction, so that the target site can be obtained without changing the direction of the drug release holes. The drug can be applied to the entire wall of the wall.

  According to the invention of claim 3, the expansion partition member is made of a cylindrical member having elasticity, and both end portions thereof are closely fixed to the outer peripheral surface of the tube main body, and the cylindrical portion between the both end portions is fixed. Since it is configured to expand in the radial direction by the fluid pressure supplied to the inside, the expansion partition member can be greatly expanded in the radial direction with both ends fixed to the outer peripheral surface of the tube body as fulcrums, Therefore, even if the tube body has a small diameter, the tube body can be expanded according to the diameter and size of the target part in the body cavity and the outer peripheral surface thereof can be reliably pressed against the inner wall of the target part.

  Furthermore, according to the invention according to claim 4, apart from the pair of expansion partition members provided so as to sandwich the drug release hole, the outer expansion partition member is located at a position spaced from at least one of these expansion partition members. For example, the pair of expansion partition members farthest from the drug discharge hole are expanded across the drug discharge hole, while the other expansion partition members existing between these expansion partition members are contracted. By setting the state, the application area of the drug released from the drug release hole can be widened. Therefore, even if the length of the target site to be treated in the body cavity duct is long, the target is correspondingly increased. It is possible to apply a medicine by a single operation on the part, and the application area can be adjusted according to the length and width of the target part.

  Next, a specific embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a simplified side view of a drug application tube, FIG. 2 is an enlarged longitudinal side view of the distal end portion thereof, and FIG. In these drawings, the drug application tube A has a fixed length and a fixed diameter, and has a drug supply lumen 2 and a fluid supply lumen 3 provided therein, and the drug supply lumen 2 is formed on the peripheral wall portion at the front part. A flexible tube main body 1 provided with a drug discharge hole 4 communicating with the tip, and elastically expandable and contractible attached to the outer peripheral surface of the tip of the tube main body 1 with the drug discharge hole 4 interposed therebetween. A pair of expansion partition members 5 and 5, and the tip of the fluid supply lumen 3 is communicated with the inner peripheral surface side of the expansion partition members 5 and 5, and the fluid pressure supplied from the fluid supply lumen 3 Expansion The expansion members 5 and 5 are configured to expand in the radial direction, and in the normal state, the expansion partition members 5 and 5 are reduced in diameter by the elastic force, and the inner peripheral surface thereof is the outer peripheral surface of the tube body 1. Holds contact. In addition, you may mount | wear with the expansion partition member 5 in the state which left the inner peripheral surface except the both ends, and the slight clearance gap with respect to the outer peripheral surface of the tube main body 1. FIG.

  Specifically, the tube main body 1 has a certain length and has a suitable rigidity so that an operation force such as insertion at the proximal end portion can be smoothly transmitted to the distal end side in use. The medicine supply lumen 2 and the fluid supply lumen 3 are provided in the inside of the rod body and have a diameter in a circular cross section. The tube body 1 extends from the distal end of the medicine supply lumen 2. A plurality of the drug discharge holes 4 are formed radially toward the outer peripheral surface of the tube body, and the drug discharge holes 4 are opened on the outer peripheral surface of the tube body 1 at small intervals in the circumferential direction.

  Further, if the tube body 1 has a corner on the distal end surface, when inserted into a body cavity, the tube body 1 may be caught on the channel wall of the body cavity, making smooth insertion difficult, and As shown in FIG. 1, the distal end surface of the tube body 1 is melted and molded by thermal processing to form a semicircular or spindle-shaped distal end surface 1a that protrudes forward. is doing. Note that another member formed in a semicircular shape or a spindle shape may be fixed to the distal end surface of the tube body 1 without being subjected to thermal processing. A connection connector 6 having a supply port 6 a for supplying a drug to the drug supply lumen 2 and a supply port 6 b for supplying a fluid to the fluid supply lumen 3 is connected to the proximal end surface of the tube body 1.

  Although it does not specifically limit as a material which comprises the tube main body 1, For example, polyolefin resin, such as ethylene, alpha-olefin copolymers, such as polyethylene and an ethylene-propylene copolymer, polypropylene, a propylene-alpha-olefin copolymer Ethylene-vinyl acetate copolymer; flexible polymer materials such as polyester resins such as polyethylene terephthalate, polyvinyl chloride, polytetrafluoroethylene, polyurethane, silicone rubber, and natural rubber.

  The tube body 1 can be manufactured using such a material by a molding means such as extrusion molding, injection molding, blow molding, dipping molding, etc., but is preferably manufactured by extrusion molding. After this extrusion molding, the tip surface 1a is formed into a semicircular shape or a spindle shape by thermal processing as described above.

  On the other hand, the outer peripheral surfaces of the front side and the rear side when the drug discharge hole 4 provided in the distal portion of the tube body 1 is set at the center and both sides thereof, that is, the distal end side is the front side and the proximal end side is the rear side. Further, the pair of front and rear expansion partition members 5 and 5 mounted so as to sandwich the medicine supply lumen 4 from the front and rear are made of a cylindrical member having elasticity that can expand and contract in the length direction and the radial direction. With the inner peripheral surfaces of the members 5 and 5 in contact with the outer peripheral surface of the tube main body 1 or slightly separated from each other, the front and rear end portions thereof are hermetically intimately adhered to the outer peripheral surface of the tube main body 1 and fixed. In addition, as shown in FIG. 2, a fluid injection hole that communicates from the front and rear ends of the fluid supply lumen 3 between the inner peripheral surface of these front and rear expansion partition members 5 and 5 and the outer peripheral surface of the tube body 1. 3a and 3b are provided, respectively. The fluid is supplied from the main body 3 into the front and rear expansion partition members 5 and 5 through these fluid injection holes 3a and 3b, so that the expansion partition members 5 and 5 are expanded and expanded in the outer diameter direction with both ends as fulcrums. It is configured to have a diameter.

  Note that the pair of front and rear expansion partition members 5 and 5 may be mounted directly on the outer peripheral surface of the tube main body 1, but as shown in FIG. 2, the expansion partition members 5 and 5 on the outer peripheral surface of the tube main body 1. Are provided with circumferential grooves 7 and 7 having a depth substantially equal to the thickness of the expansion partition member 5 and capable of accommodating the expansion partition members 5 and 5 over their entire length. The extended partition members 5 and 5 are respectively fitted in the grooves 7 and 7 and stored in a state where the inner peripheral surface thereof is in contact with the bottom surface of the groove, or in a state where there is a slight gap, and only the both end portions of the peripheral groove 7 are stored. It is desirable that the front and rear end portions are hermetically fixed.

  The material of the cylindrical member constituting these extended partition members 5 and 5 is not particularly limited, but for example, natural rubber; silicone rubber; urethane rubber; thermoplastics such as polyolefin elastomer, polystyrene elastomer, polyamide elastomer, etc. Elastomers; polyolefin resins such as polyethylene and ethylene-propylene copolymers such as ethylene-α-olefin copolymers; polypropylene and propylene-α-olefin copolymers; ethylene-vinyl acetate copolymers; soft polyvinyl chloride; Polyurethane, polyisoprene and the like can be mentioned. In these materials, when the extended partition member 5 made of natural rubber, silicone rubber, urethane rubber, various elastomers or the like is used, it can be elastically greatly expanded and contracted in the body cavity. can it be done It is suitable.

  In order to manufacture the extended partition member 5 using such a material, it can be performed by molding means such as extrusion molding, injection molding, blow molding, dipping molding and the like, similar to the tube main body 1. In order to hermetically fix the both ends of the extended partition member 5 to the outer peripheral surface of the tube main body 1 or the front and rear outer peripheral surfaces of the circumferential groove 7 provided in the tube main body 1, a method by thermal fusion or bonding A method using an agent, a method of binding and fixing the both ends with a yarn, and the like can be employed.

  The drug application tube A configured as described above has a reduced diameter without causing the pair of front and rear expansion partition members 5 and 5 disposed across the drug discharge hole 4 provided at the tip of the tube body 1 to expand by fluid pressure. When the medicine discharge hole 4 inserted into the body cavity B as shown in FIG. 4 and opened from the peripheral wall portion at the tip reaches the target location in the body cavity B as shown in FIG. A fluid is supplied to the fluid supply lumen 3 and injected into the pair of front and rear expansion partition members 5 and 5 through the fluid injection holes 3a and 3b. As the fluid, a gas such as air, water, physiological saline, a gel-like liquid, or the like can be used.

  When fluid is injected into the expansion partition members 5 and 5, these expansion partition members 5 and 5 expand due to the fluid pressure and expand larger than the outer diameter of the tube body 1, and as shown in FIG. The tube main body 1 can be fixed in a state where the target part of the target part is pressed against the wall surface of the target part of the body cavity B on both sides of the target part and the drug release hole 4 faces the target part. In this state, when the liquid medicine 8 (medical solution) is supplied from the connection connector 6 side into the medicine supply lumen 2 in the tube main body 1, the medicine 8 is fed from the medicine discharge hole 4 to the front and rear as shown in FIG. It is discharged into a pipe line part surrounded by a pair of expansion partition members 5, 5, and can be applied intensively to the target site in a state where leakage from the target part is prevented by the expansion partition members 5, 5. .

  When the supply of fluid into the expansion partition members 5 and 5 is stopped after the drug 8 is applied to the target site, the expansion partition members 5 and 5 are reduced in diameter by the elastic restoring force, and the inner peripheral surface thereof is the outer periphery of the tube main body 1. In this state, the tube body 1 is pulled out of the body and used for the next drug application. In addition, when the diameter of the target location in the duct of the body cavity B is small enough to contact the outer peripheral surface of the tube body 1, the drug release hole 4 is not expanded without expanding the expansion partition members 5 and 5. What is necessary is just to perform the application | coating treatment of a chemical | medical agent in the state orientated so that it may touch the target site | part of the target location.

  In the above-described embodiment, the range in which the medicine 8 from the medicine discharge hole 4 can be applied is set invariably by the distance between the pair of front and rear expansion partition members 5, 5. The range can be changed by attaching three or more 5 to the outer peripheral surface of the tube body 1 at appropriate intervals.

  For example, as shown in FIG. 7, the tube main body 1 is appropriately spaced rearward from the rear expansion partition member 5 in the pair of front and rear expansion partition members 5 and 5 disposed with the medicine discharge hole 4 interposed therebetween. A separate expansion partition member 5A is mounted on the outer peripheral surface so as to be expandable and contractible, and three fluid supply lumens 31, 32, which supply fluid to the expansion partition members 5, 5, 5A in the tube body 1 respectively. 33 is provided, and when the range of the target part is long, the fluid supply lumens are provided to the outermost expansion partition members 5 and 5A, that is, the front expansion partition member 5 and the rearmost expansion partition member 5A. While expanding by supplying fluid through 31 and 33, the expansion partition member 5 on the rear side disposed in the middle part of these expansion partition members 5 and 5A is kept in a reduced diameter state. Drug from drug release hole 4 When releasing 8, it can be applied to drug 8 into the front and rear extension wider than between the partition member 5,5 (long) target site.

The simplified side view of this invention chemical | medical agent application tube. The enlarged vertical side view of the front part. The longitudinal front view. The simplified side view of the state inserted in the duct of a body cavity. The simplified side view of the state which extended the expansion partition member. The simplified side view of the state which has discharge | released the chemical | medical agent from the chemical | medical agent discharge hole. The simplified side view which shows another embodiment of this invention.

Explanation of symbols

A medicine application tube 1 tube body 2 medicine supply lumen 3 fluid supply lumen 4 medicine discharge hole 5 expansion partition member 7 circumferential groove 8 medicine

Claims (4)

  A drug application tube for inserting a drug into a body cavity and applying a drug to a target site, wherein a drug supply lumen and a fluid supply lumen are provided therein, and a drug discharge hole communicating with the drug supply lumen is provided in a peripheral wall portion A flexible tube main body provided and a pair of expansion partition members that can be expanded and contracted in the radial direction and are attached to the outer peripheral surface of the tube main body with the drug discharge hole interposed therebetween. In the drug application tube, the diameter of the tube is in contact with the outer peripheral surface of the tube main body and is expanded by the fluid pressure supplied through the fluid supply lumen.   2. The drug application tube according to claim 1, wherein a plurality of drug release holes are provided at small intervals in a circumferential direction on a peripheral wall portion at a distal end portion of the tube main body.   The expansion partition member is made of a cylindrical member having elasticity, and both end portions thereof are closely fixed to the outer peripheral surface of the tube body, and the cylindrical portion between the both end portions is expanded in the radial direction by the fluid pressure supplied to the inside. The drug application tube according to claim 1, wherein the drug application tube is configured as described above.   2. An outer expansion partition member is provided at a position spaced from at least one of these expansion partition members separately from the pair of expansion partition members provided so as to sandwich the medicine discharge hole. Or the chemical | medical agent application tube of Claim 3.

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