JP2002233581A - Organism-tissue adhesive applicator - Google Patents

Organism-tissue adhesive applicator

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Publication number
JP2002233581A
JP2002233581A JP2001033756A JP2001033756A JP2002233581A JP 2002233581 A JP2002233581 A JP 2002233581A JP 2001033756 A JP2001033756 A JP 2001033756A JP 2001033756 A JP2001033756 A JP 2001033756A JP 2002233581 A JP2002233581 A JP 2002233581A
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chemical
tissue adhesive
adhesive applicator
biological tissue
solution
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JP2001033756A
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JP3857059B2 (en
Inventor
Masao Ikeda
Yukihiko Sakaguchi
幸彦 坂口
昌夫 池田
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Sumitomo Bakelite Co Ltd
住友ベークライト株式会社
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Abstract

PROBLEM TO BE SOLVED: To provide an organism-tissue adhesive applicator avoiding clogging even if used intermittently. SOLUTION: The organism-tissue adhesive applicator is for applying a medicinal solution having one or more components. The applicator is provided with a suction mechanism 12 with a capacity to temporarily retain at least one medicinal solution is provided in a certain position of each medicinal solution flow passage 10 leading to a medicinal solution discharge nozzle 2.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【発明の属する技術分野】本発明は、主に複数成分系製剤として適用される組織接着剤の塗布用具に関するものであり、特に肝臓や肺の切除断端や消化管の縫合部の止血閉鎖などに好適な、生体の患部に噴霧して塗布するための生体組織接着剤塗布用具に関する。 The present invention relates generally relates to applicator of tissue adhesive which is mainly applied as multiple-component formulations, such as in particular hemostatic closure of the stapling portion of the surgical margins and digestive tract of the liver and lungs a suitable relates biological tissue adhesive applicator for applying by spraying onto the affected area of ​​a living body.

【0002】 [0002]

【従来の技術】繊維素原(フィブリノゲン)は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。 BACKGROUND ART fibrinogen (fibrinogen) is a coagulation factor plays a very important role present in the final stage of the so-called blood clotting cascade. フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。 Fibrinogen, for example in the activation of blood coagulation system after injury, by thrombin, is converted to insoluble fibrin which plays an important contribution to hemostasis and wound healing from its soluble form. この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。 The tissue adhesive the principles of the final phase utilizing the blood coagulation it has been developed, as an adhesive for the suture substitute soft organs such as the liver or spleen in surgery, or have been used as sutures adjuvant. 同時に、幅広い臨床の現場で応用されている。 At the same time, it has been applied in a wide range of clinical settings.
近年、2本のシリンジ体に収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して、射出させた2液を霧状に噴霧して混合するスプレー塗布法が普及し始めている。 Recently, two syringes body housed fibrinogen solution and thrombin solution was injected at the same time, by using the sterilized gas, a spray coating method for mixing by spraying a 2 solution was injected into mist has begun to spread . このような器具の好適な例は、例えばWO94/7420号に記載されている。 Suitable examples of such devices are described, for example, No. WO94 / 7420.

【0003】しかしながら本器具を用いた不具合が、塗布処置が時間間隔のある複数回にわたる、いわゆる間欠使用の場においてしばしば発生していた。 However problem using this instrument, over a plurality of times the coating treatment with a time interval, often have occurred in the field of so-called intermittent use. すなわち塗布処置が複数回にわたる場合においてスプレー本体は数分間放置される一般的な使用方法において、放置時間の後に再度塗布を試みるとノズル先端にて薬液の詰まりが生じ、場合によっては解除不可能な強固な詰まりが生じて、その後の塗布処置が不可能となってしまう現象で、 That is, in typical use spray body to be left for several minutes when the coating treatment of multiple-clogging of the chemical liquid occurs at the nozzle tip attempt to re-applied after a leave-in time, in some cases impossible released robust jam occurs, a phenomenon that is subsequently applied treatment becomes impossible,
これはスプレー塗布法に特に多く見られる現象であるが他の塗布法でも発生するものであり、その多くは残圧による薬液の滲出での二液接触や長時間放置による薬液の高粘度化によるものである。 According While this is a phenomenon which is particularly common in the spray coating method are those also occur in other coating methods, high viscosity of the liquid medicine by many of two-liquid contact and prolonged standing in exudation of the liquid medicine by residual pressure it is intended. これを克服するべく構造を有する塗布用具はなく、術者によっては間欠使用の合間に塗布用具の先端をふき取るなどの処置を取るようなことがあるが、操作上煩雑なばかりか衛生上好ましくなく問題であった。 No application tool having a structure to overcome this, it is possible that take an action such as wiping the tip of the applicator in between the intermittent use by the surgeon, not preferable operational on complicated only or sanitary It was a problem a.

【0004】 [0004]

【発明が解決しようとする課題】本発明は、従来のこのような問題点を解決することを目的とするもので、間欠使用において詰まりの生じ難い生体組織接着剤塗布用具を提供するものである。 The present invention is to challenge it to solve the above-aims to solve the above problems, and provides a resulting hard biological tissue adhesive applicator clogging in the intermittent use .

【0005】 [0005]

【課題を解決するための手段】即ち本発明は、(1)1 Means for Solving the Problems] The present invention provides (1) 1
成分以上の薬液を塗布するための塗布用具において、薬液吐出ノズルにつながる各薬液流通路の任意位置に少なくとも1つの薬液を一時的に貯留する容積をもつ吸引機構が設けられていることを特徴とする生体組織接着剤塗布用具、(2)吸引機構の構造が、構造体の変形による容積の変化により吸引圧力を発生させる構造である(1)記載の生体組織接着剤塗布用具、(3)塗布用具には後端に複数の薬液注入口、中央付近に無菌ガス注入口、更に先端に各薬液注入口が設けられ、薬液流通路と連通する複数の薬液吐出ノズル、及び各薬液吐出ノズルに対して同軸且つ外側略環状に配置された無菌ガス噴出口が設けられている(1)又は(2)記載の生体組織接着剤塗布用具。 In application tool for applying the above chemical ingredients, and characterized in that the suction mechanism having a volume for temporarily storing at least one chemical is provided in an arbitrary position of the medical liquid flow passages leading to the solution discharge nozzle biological tissue adhesive applicator which, (2) structure of the suction mechanism, a change in volume due to deformation of the structure which is a structure that generates a suction pressure (1), wherein the biological tissue adhesive applicator, (3) coating multiple chemical inlet at the rear end to the tool, a sterile gas inlet in the vicinity of the center, and each chemical inlet is provided at the tip, a plurality of chemical dispensing nozzle communicating with medical liquid flow path, and for each solution discharge nozzle coaxially and sterilized gas ejecting ports arranged on the outside substantially annular is provided (1) or (2) a biological tissue adhesive applicator according Te. (4)ガス流通路の開閉機構と吸引機構の操作機構が連動している(1)〜(3)記載のいずれかの生体組織接着剤塗布用具である。 (4) a closing mechanism and operating mechanism of the suction mechanism is integrated (1) to (3) any biological tissue adhesive applicator according to the gas flow passage.

【0006】 [0006]

【発明の実施の形態】以下、図面をもとに本発明について詳細に説明する。 DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail based on the drawings. 図1及び図2は共に本発明の一実施例となる生体組織接着剤塗布用具の中でもスプレー塗布法に用いる塗布用具の一例であり、図1は本発明の一実施例の断面図で、(a)は側面、(b)は上面から見た断面を示したものである。 1 and 2 is an example of a applicator for use in spray coating, among both an embodiment become biological tissue adhesive applicator of the present invention, FIG. 1 is a sectional view of an embodiment of the present invention, ( a) is an illustration of a side, a cross section seen from (b) is a top. 図2は本発明の一実施例の噴霧時と噴霧休止時の状態を示す図で(a)は噴霧時、 Figure 2 is a diagram showing a state at the time of spraying time and spraying rest of one embodiment of the present invention (a) during spraying,
(b)は噴霧休止時の断面図である。 (B) is a sectional view at the time of spraying rest.

【0007】本発明による生体組織接着剤塗布用具の好適な例は、図1に示すようにスプレーヘッド(1)の後端に2本の薬液注入口(4)と中央付近に無菌ガス注入口(5)が設けられ、先端には複数の薬液吐出ノズル(2)と、各薬液吐出に同軸で且つ外側に略環状に配置された薬液を噴霧するための無菌ガス噴出口(3)が備えられている。 Suitable examples of [0007] the present invention by the biological tissue adhesive applicator is trailing the two chemical inlet of the spray head (1) as shown in FIG. 1 (4) and the sterilized gas inlet near the center (5) it is provided with a plurality of solution discharge nozzle (2) at the tip, sterile gas ports for spraying the chemical liquid is disposed in a substantially annular and outwardly coaxially to each solution discharge (3) is provided with It is. スプレーヘッド(1)内は、薬液流通路(10)と無菌ガス流通路とに分かれ、例えば薬液注入口(4)と薬液吐出ノズル(2)をチューブで連結させ薬液流通路(10)とすることによりそれぞれの流通路を区分けすることが出来るが、スプレーヘッド(1)の成形品そのものに無菌ガス流通路と区分けされた薬液流通路(10)を予め施しても何ら構わない。 Spray head (1) in the divided into medical liquid flow path (10) and the sterilized gas flow passage, for example chemical inlet (4) and the medical liquid flow path solution discharge nozzle (2) is connected by a tube (10) Although it is possible to partition the respective flow path by, may no be subjected medical liquid flow path is divided sterile gas flow path in the molded article itself of the spray head (1) to (10) in advance. また、無菌ガス注入口の端末には予め無菌フィルター(6)を設置しておくことも望ましい実施例の一つである。 Further, the terminal of the sterile gas inlet is also one of preferred embodiments that you set up the previously sterile filter (6).

【0008】更に無菌ガスの開閉を行う手段の一実施例としてガス開閉装置(7)を設けている。 [0008] further gas control device (7) provided as an example of means for opening and closing the sterilized gas. 本例におけるガス開閉装置(7)には外周に孔を設けた回転軸(8) Rotary shaft having a hole in the outer periphery the gas switchgear (7) in this example (8)
があり、無菌ガス注入口(5)を回転させ、回転軸(8)の孔と軸受け(9)に設けられた孔との位置を合わせることにより無菌ガス流通路が開口され、位置を異にすることによりガス流を遮断するものである。 There is, rotated sterilized gas inlet (5), sterilized gas flow path is opened by aligning the positions of the provided holes in the hole and the bearing of the rotary shaft (8) (9), different from the position it is intended to cut off the gas flow by. このガス開閉装置(7)は後に説明する吸引機構(12)の操作機構と連動しており一連の操作でガス流の開閉と吸引機構(12)の操作を行うことが出来るものである。 The gas control device (7) are those that can be operated in opening and closing the suction mechanism of the gas flow (12) in a series of operations are interlocked with operating mechanism of the suction mechanism described later (12). 薬液流通路(10)は薬液注入口(4)と薬液吐出ノズル(2)との途中に分岐部(11)を持ち、分岐部(1 Medical liquid flow path (10) is chemical inlet (4) and middle branch of the solution discharge nozzle (2) has a (11), the branch section (1
1)は内容積を変化させることの可能な吸引機構(1 1) It possible suction mechanism for changing the internal volume (1
2)に通じている。 It leads to 2).

【0009】吸引機構(12)は薬液噴霧時には図2 [0009] The suction mechanism (12) is at the time of the chemical spray Figure 2
(a)に示すようにガス開閉装置(7)と連結されている回転軸(8)と一体のカム(13)に押さえられ萎縮状態にある。 In atrophic state being pressed to the gas switchgear (7) rotary axis is coupled with (8) and integral with the cam (13) as shown in (a). この時吸引機構(12)は可能な限り内容積の少ない状態であることが操作性や薬液の節約の面から望ましく、構造上可能であれば図のように分岐部(1 Bifurcation as in this case the suction mechanism (12) that is less state of the internal volume as possible undesirable from the viewpoint of saving of operability and chemical, structural possible view (1
1)への開口部を閉塞することが好ましい。 It is preferable to close the opening to 1). 噴霧終了時には図2(b)のようにカム(13)の押さえから開放され、吸引機構(12)自身の復元力により内容積が拡張し、薬液吐出ノズル(2)から分岐部(11)までの間の内腔に滞留している薬液を吸引し、薬液吐出ノズル(2)付近の薬液を薬液流通路(10)内部へと後退させる。 During completion of spraying is released from the pressing of the cam (13) as shown in FIG. 2 (b), the internal volume is expanded by the restoring force of the suction mechanism (12) itself, from the solution discharge nozzle (2) to the branch unit (11) chemical solution suction that remaining in the lumen between the retracts the chemical near solution discharge nozzle (2) medical liquid flow path (10) to the inside.

【0010】この吸引機構(12)の内容積は分岐部(11)から薬液吐出ノズル(2)までの内腔の容積が目安であり、それ以上の容積の場合には外気を吸引機構(12)内に吸引してしまい再度薬液噴霧を行う際に吸引した外気が不規則かつ断続的に薬液に混入するなどし、噴霧が一定でなくなる等の悪影響を及ぼすことが考えられるため好ましくなく、吸引機構(12)の内容積をAとして分岐部(11)から薬液吐出ノズル(2)までの内腔容積をBとすると、A/B=0.5〜1.0が好ましく、より好ましくはA/B=0.5〜0.75である。 [0010] The internal volume of the suction mechanism (12) is a volume measure of the lumen of the branch portion (11) until the solution discharge nozzle (2), the suction mechanism outside air in the case of more volume (12 ) sucked outdoor air in performing again chemical spray will be sucked is like mixed into the irregular and intermittent chemical in the spray is not preferable because it is considered that adverse effects such as no longer constant, suction When the internal volume of mechanism (12) and the inner space volume of the branch section as a from (11) to the solution discharge nozzle (2) B, a / B = 0.5~1.0, more preferably a is /B=0.5~0.75.

【0011】吸引機構(12)は内容積を変化させて吸引させる方法が最も簡単であり小型化などの面で好ましいが、特にこれに限定するものではなく、例えば操作性を考慮して無菌ガスの圧力を利用した半自動的な機構、 [0011] suction mechanism (12) is the easiest way to suction by changing the internal volume is preferred in terms of downsizing, not particularly limited thereto, for example, sterile gas in consideration of operability semi-automatic mechanism that uses the pressure of,
又はボタンやレバー等による無菌ガス噴出操作と連動した手段でもよい。 Or by a means in conjunction with a sterile gas ejection operation by a button or lever or the like. スプレー塗布法以外の塗布においては無菌ガスを使用しないためこの限りではなく、単に吸引機構(12)の操作性のみ考慮すればよい。 This is not as long as it does not use the sterilized gas in the coating other than the spray coating method, it may be simply considered only operation of the suction mechanism (12).

【0012】全ての構成部品の材質は特に限定されるものではないが、少なくとも薬液と接触する吸引機構(1 [0012] Without being limited all material components in particular, the suction mechanism in contact with at least a chemical solution (1
2)、薬液注入口(4)、薬液吐出ノズル(2)薬液流通路(10)の材質は医療用プラスチック材料であり、 2) chemical inlet (4), the material of the solution discharge nozzle (2) medical liquid flow path (10) is a medical grade plastic material,
且つ薬液に影響を及ぼさないものであることが求められる。 And it is required are those that do not affect the chemical.

【0013】最後にフィブリノゲン溶液とトロンビン溶液による生体組織接着剤の塗布操作の一実施例を図2を用いて述べる。 [0013] discussed Finally an embodiment of the coating operation of a biological tissue adhesive according fibrinogen solution and thrombin solution with reference to FIG. 先ずフィブリノゲン溶液を充填したシリンジ(14)とトロンビン溶液を充填したシリンジ(1 First fibrinogen solution was filled with thrombin solution syringe (14) filled with a syringe (1
4)の先端をスプレーヘッド(1)の後端の薬液注入口(4)に接続する。 The tip of 4) connected to the rear end of the chemical inlet of the spray head (1) (4). 次に無菌ガス注入口(5)に無菌フィルター(6)を介して無菌ガス供給源を接続し、適切なガス流量を保つ。 Then the sterilized gas inlet (5) through the sterile filter (6) connects the sterile gas supply source, ensure proper gas flow. そして一般的には止血するべく患部へスプレーヘッド(1)の先端を向けてシリンジ(1 And generally toward the distal end of the spray head into the affected so as to hemostasis (1) syringe (1
4)の押し子を加圧することにより薬液吐出ノズル(2)よりフィブリノゲン溶液とトロンビン溶液が無菌ガス噴出口(3)より噴出された無菌ガスによりせん断,混合され噴霧となり患部に塗布され止血がなされることとなる。 Solution discharge nozzle by pressurizing the pusher 4) (2) from fibrinogen solution and thrombin solution is sterilized gas jet port (3) shearing by the ejected sterile gas from being applied hemostasis is made in mixed affected area becomes spray The Rukoto.

【0014】噴霧を停止するとほぼ同時に吸引機構(1 [0014] When you stop the spray at about the same time the suction mechanism (1
2)が作動し、薬液吐出ノズル(2)から分岐部(1 2) is activated, the branch portion from the solution discharge nozzle (2) (1
1)までの薬液の吸引がなされる。 1) of the chemical liquid to the suction is performed. 薬液吐出ノズル(2)付近に滞留する薬液が排除されるため、噴霧休止時の液垂れ等による二液接触による凝固や、薬液の乾燥による高粘度化等の詰まり発生の要因を防ぐことができ、噴霧の再開が可能となるものである。 Since the chemical liquid remaining in the vicinity of the solution discharge nozzle (2) is eliminated, it is possible to prevent solidification or by two-liquid contact by dripping or the like at the time of spraying pause, the cause of occurrence of clogging or the like high viscosity due to drying of the drug solution one in which the spray of resumption is possible.

【0015】 [0015]

【発明の効果】以上に述べた如く、本生体組織接着剤塗布用具を用いれば、薬液吐出ノズル付近に滞留する薬液が排除されるため、噴霧を停止している間の液垂れ等による二液接触による凝固や、薬液の乾燥による高粘度化等の詰まり発生の要因を防ぐことができ、極めて有用である。 As mentioned above, according to the present invention, the use of the present biological tissue adhesive applicator, for chemical staying in the vicinity of the solution discharge nozzle is eliminated, two liquid by dripping or the like during the stop spraying coagulation by contact or can prevent the cause of clogging occurrence of high viscosity due to drying of the drug solution, is very useful.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の一実施例となる生体組織接着剤塗布用具の一例を示す図で、(a)は側面、(b)は上面からの断面を示したものである。 [1] a diagram showing an example of the one embodiment the biological tissue adhesive applicator of the present invention, (a) is a side, (b) shows the cross section from the top.

【図2】本発明の一実施例となる生体組織接着剤塗布用具の噴霧時、噴霧休止時の内部構造の一例を示す図で、 [2] During spraying of an embodiment become biological tissue adhesive applicator of the present invention, a diagram showing an example of the internal structure at the time of spraying pause,
(a)は噴霧時の平面断面図、(b)は噴霧休止時の平面断面図である。 (A) is a plan sectional view at the time of spraying is a plan sectional view at (b) is spray pause.

【符号の説明】 DESCRIPTION OF SYMBOLS

1 スプレーヘッド 2 薬液吐出ノズル 3 無菌ガス噴出口 4 薬液注入口 5 無菌ガス注入口 6 無菌フィルター 7 ガス開閉装置 8 回転軸 9 軸受け 10 薬液流通路 11 分岐部 12 吸引機構 13 カム 14 シリンジ 1 spray head 2 solution discharge nozzle 3 sterile gas ejection ports 4 chemical inlet 5 sterilized gas inlet 6 sterile filter 7 Gas switchgear 8 rotary shaft 9 bearing 10 medical liquid flow path 11 branch part 12 suction mechanism 13 cam 14 syringe

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl. 7識別記号 FI テーマコート゛(参考) B05B 7/06 B05B 7/06 Fターム(参考) 4C060 CC01 CC11 DD01 4C167 AA67 CC06 4F033 QA01 QB02Y QB03X QB12Y QB17 QC06 QD02 QD21 QD23 QE05 QE23 QF02Y QF08X QF11X QF17Y ────────────────────────────────────────────────── ─── of the front page continued (51) Int.Cl. 7 identification mark FI theme Court Bu (reference) B05B 7/06 B05B 7/06 F-term (reference) 4C060 CC01 CC11 DD01 4C167 AA67 CC06 4F033 QA01 QB02Y QB03X QB12Y QB17 QC06 QD02 QD21 QD23 QE05 QE23 QF02Y QF08X QF11X QF17Y

Claims (4)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 1成分以上の薬液を塗布するための塗布用具において、薬液吐出ノズルにつながる各薬液流通路の任意位置に少なくとも1つの薬液を一時的に貯留する容積をもつ吸引機構が設けられていることを特徴とする生体組織接着剤塗布用具。 1. A coating tool for applying one or more components of the chemical solution, the suction mechanism is provided with a volume for temporarily storing at least one chemical at any position of the respective liquid medicine flow passages leading to the solution discharge nozzle and biological tissue adhesive applicator, characterized in that it is.
  2. 【請求項2】 吸引機構の構造が、構造体の変形による容積の変化により吸引圧力を発生させる構造である請求項1記載の生体組織接着剤塗布用具。 2. A structure of the suction mechanism, the structure is a claim 1 biological tissue adhesive applicator according to generate a suction pressure by the change in volume due to deformation of the structure.
  3. 【請求項3】 塗布用具には後端に複数の薬液注入口、 3. A plurality of liquid injection port in the rear end to the application tool,
    中央付近に無菌ガス注入口、更に先端に各薬液注入口が設けられ、薬液流通路と連通する複数の薬液吐出ノズル、及び各薬液吐出ノズルに対して同軸且つ外側略環状に配置された無菌ガス噴出口が設けられている請求項1 Sterilized gas inlet in the vicinity of the center, and each chemical inlet is provided at the distal end, the chemical liquid passage and a plurality of chemical dispensing nozzle communicating, and sterile gas is arranged coaxially and outwardly substantially annular for each solution discharge nozzle claim ejection port is provided 1
    又は2記載の生体組織接着剤塗布用具。 Or a biological tissue adhesive applicator according.
  4. 【請求項4】 ガス開閉装置と吸引機構の操作が連動している請求項1〜3記載のいずれかの生体組織接着剤塗布用具。 4. A gas switchgear with any of the biological tissue adhesive applicator of claim 1, wherein the operation is interlocked to a suction mechanism.
JP2001033756A 2001-02-09 2001-02-09 Biological tissue adhesive applicator Active JP3857059B2 (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
WO2018221666A1 (en) * 2017-05-31 2018-12-06 住友ベークライト株式会社 Biological tissue adhesive application tool and drug solution injection tool for living body

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
WO2018221666A1 (en) * 2017-05-31 2018-12-06 住友ベークライト株式会社 Biological tissue adhesive application tool and drug solution injection tool for living body

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