CN110691583A - 口腔用组合物 - Google Patents
口腔用组合物 Download PDFInfo
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- CN110691583A CN110691583A CN201880035202.6A CN201880035202A CN110691583A CN 110691583 A CN110691583 A CN 110691583A CN 201880035202 A CN201880035202 A CN 201880035202A CN 110691583 A CN110691583 A CN 110691583A
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Abstract
一种口腔用组合物，含有以提取物纯成分计为0.00001～0.05质量％的(A)植物提取物，以及0.00001～0.01质量％的(B)选自N‑(4‑氰基甲基苯基)‑2‑异丙基‑5‑甲基环己烷甲酰胺(B‑1)和N‑(2‑(2‑吡啶基)乙基)‑2‑异丙基‑5‑甲基环己烷甲酰胺(B‑2)中的1种以上，(A)/(B)以质量比计为0.02～100。上述口腔用组合物还含有0.0001～0.01质量％的(C)选自单琥珀酸薄荷酯、N‑{(乙氧基羰基)甲基}‑对‑薄荷烷‑3‑甲酰胺和乳酸薄荷酯中的1种以上。本发明可以提供口腔内的粘腻感的改善效果优异且具有优异的清爽感赋予效果、适宜用于口臭抑制的口腔用组合物。
Description
技术领域
本发明涉及作为口臭的原因的口腔内的粘腻感的改善效果优异且具有赋予优异的清爽感的效果、适宜用于口臭抑制的口腔用组合物。
背景技术
迄今为止，已知：对抑制口臭来说，用杀菌剂进行的口臭致病菌的杀菌；使用除臭剂、口臭原因物质的产生抑制剂等有效成分是有效的，人们建议混合了这些成分的口腔用组合物。例如，唇形科、芸香科等植物提取物已知为口臭抑制成分，除此以外，还建议了将植物的提取物作为用于口臭防止的有效成分混合的口腔用组合物(专利文献1～3：日本特开2005-289918号公报、日本专利第5776364号公报、日本特开2016-112634号公报)。混合有这些植物提取物的口腔用组合物对减少口臭的原因成分例如挥发性硫、甲硫醇等有效，具有作为呼气(对人)的口臭防止效果。
但是，近年来，尽管实际上没有被他人能感知的口臭(呼气口臭)，但是由于对口腔内的不快感而感觉到像是有口臭，而抱有可能对他人有口臭这样的口臭不安的情况在增加。因此，考虑如果可以消除这样的口臭不安，那么就可以得到口臭被抑制的令人满意的效果感。
现有技术文献
专利文献
【专利文献1】日本特开2005-289918号公报
【专利文献2】日本专利第5776364号公报
【专利文献3】日本特开2016-112634号公报
【专利文献4】日本特开2014-125440号公报
【专利文献5】日本特开2015-182983号公报
【专利文献6】日本特开2016-102076号公报
【专利文献7】日本特表2014-507440号公报
【专利文献8】日本特表2012-508741号公报
【专利文献9】日本特表2011-520925号公报
【专利文献10】日本特开2013-112634号公报
发明内容
发明要解决的课题
但是，以迄今为止的以抑制口臭为目的的口腔用组合物，并不能赋予连上述这样的口臭不安也可以消除这样的充分的效果感，期望得到改善。
本发明鉴于上述情况而完成，目的在于提供口腔内的粘腻感的改善效果优异、且具有赋予优异的清爽感的效果的口腔用组合物。
解决课题的手段
本发明人认为：为了达到上述目的，特别是改善被认为是口臭不安感的主因的口腔内的粘腻感、清爽感少之类的不快感，提高口臭抑制的效果感是有效的，并着眼于该点，进一步地进行研究。结果发现，选择植物的提取物和冷感剂中的特定成分，分别以特定量且特定比例并用两种成分时，能够得到改善口腔内的粘腻感、且即使经时也赋予持续的高清爽感的优异的作用效果。而且，将两成分的并用体系混合到口腔用组合物中时，除了口腔内的粘腻感的改善效果优异之外，也能够发挥上述这样的持续的且优异的清爽感赋予效果，此外，口腔内刺激被抑制，能够赋予良好的使用感，由此，口臭抑制的效果感也增高，不仅抑制对人的口臭也能够消除口臭不安感，从而完成本发明。
即，本发明可以提供一种口腔用组合物，其含有以提取物纯成分计为0.00001～0.05质量％的(A)植物提取物，和0.00001～0.01质量％的(B)选自N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺(B-2)中的1种以上，(A)/(B)以质量比计为0.02～100，由此，其口腔内的粘腻感的改善效果优异，且具有优异的清爽感赋予效果，使用感也良好。
进一步地详述，如下述的比较例也有所示，单独使用(A)成分或(B)成分时，几乎没有口腔内的粘腻感改善效果和清爽感赋予效果(比较例1～15)。因而，由该结果并不能认为并用两者可提高两种作用效果，但由下述的实施例也可明确，本发明中组合(A)成分和(B)成分时，两者的混合量分别在特定范围内且(A)/(B)的质量比在特定范围内时，两成分协同地发挥作用，抑制口腔内刺激，粘腻感的改善效果和清爽感赋予效果都增强，发挥格外显著的作用效果。这样的本发明的作用效果是(A)和(B)成分的组合所特异的，而用同样地具有冷感或清凉化作用的薄荷醇、薄荷油或单琥珀酸薄荷酯代替(B)成分与(A)成分并用时，作用效果差(比较例16～18)，此外，将(B)成分以外的N-取代-对-薄荷烷-甲酰胺和(A)成分并用时作用效果也差。
专利文献4～9(日本特开2014-125440号公报、日本特开2015-182983号公报、日本特开2016-102076号公报、日本特表2014-507440号公报、日本特表2012-508741号公报、日本特表2011-520925号公报)公开了通过作为冷凉化或清凉化剂的N-取代-对-薄荷烷-甲酰胺改善清凉感、爽快感的口腔用组合物，专利文献10(日本特开2013-112634号公报)公开了含有对-薄荷烷-3,8-二醇异构体混合物的口腔用组合物。与此相对地，本发明通过(A)和(B)成分的并用而改善口腔内的粘腻感和赋予清爽感，从专利文献4～10并不能予测到这样的技术思想。
因此，本发明提供下述的口腔用组合物。
〔1〕一种口腔用组合物，其含有
以提取物纯成分计为0.00001～0.05质量％的(A)植物提取物，和
0.00001～0.01质量％的(B)选自N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺(B-2)中的1种以上，
(A)/(B)以质量比计为0.02～100。
〔2〕根据〔1〕所述的口腔用组合物，其中，
(A)植物提取物为选自迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶、黄檗、钓樟(Lindera umbellata)、胡椒木(Zanthoxylum piperitum)、百里香、白桦、芍药、柳栎(Quercus salicina)、儿茶钩藤(Uncaria gambir.)、姜黄、丁子香(Syzygiumaromaticum)、甜叶菊、无患子(Sapindus mukorossi)、马郁兰(Origanum majorana)、蜜蜂花(Melissa officinalis)、紫苏、月桂树、桉树、可乐树、罗汉果、山茶(Camelliajaponica)、丁香、众香树、苏木(Caesalpinia sappan)、紫草根(lithospermum root)、大黄、连翘、陈皮、桂皮、牛至、罗勒、香薷(Elsholtzia ciliata)、牡丹皮和毗黎勒(Terminalia bellerica)中的1种以上的植物提取物。
〔3〕根据〔2〕所述的口腔用组合物，其中，(A)植物提取物为选自迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶和黄檗中的1种以上的植物的提取物。
〔4〕根据〔1〕～〔3〕中任一项所述的口腔用组合物，其中，所述口腔用组合物还含有0.0001～0.01质量％的(C)选自单琥珀酸薄荷酯、N-{(乙氧基羰基)甲基}-对-薄荷烷-3-甲酰胺和乳酸薄荷酯中的1种以上。
〔5〕根据〔1〕～〔4〕中任一项所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂或漱口剂。
〔6〕根据〔5〕所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂，还含有8～70质量％的(D)研磨剂。
发明效果
本发明可以提供，作为口臭的原因的口腔内的粘腻感的改善效果优异且具有优异的清爽感赋予效果、使用感也良好的口腔用组合物。本发明的口腔用组合物口臭抑制实际感觉高，适宜用于口臭抑制。
具体实施方式
以下，进一步地详细说明本发明。本发明的口腔用组合物分别以特定量且特定比例含有(A)植物提取物，和(B)选自N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺(B-2)中的1种以上。
(A)植物提取物是植物的提取物，将其与(B)成分并用，从而起到降低口腔内粘腻感的作用。
此处，作为提取物原料的植物，可列举迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子(特别是柿子的鞣质)、刀豆、橄榄(特别是橄榄的叶)、茶叶、黄檗(特别是黄檗的树皮)、钓樟、胡椒木、百里香、白桦、芍药、柳栎、儿茶钩藤、姜黄、丁子香、甜叶菊、无患子、马郁兰、蜜蜂花、紫苏、月桂树、桉树、可乐树、罗汉果、山茶、丁香、众香树、苏木、紫草根、大黄、连翘、陈皮、桂皮、牛至、罗勒、香薷、牡丹皮、毗黎勒等。它们中，优选迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶、黄檗、钓樟、胡椒木，更优选迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶、黄檗，进一步地优选迷迭香、黄芩、胡萝卜、鼠尾草、甘草。
植物提取物的提取方法可以使用公知的方法，可以在通常的提取条件进行。
具体地，植物提取物，可以通过使用极性溶剂、非极性溶剂或者极性溶剂和非极性溶剂的混合溶剂对原料植物、别是将叶和茎粉碎做成粉状物质进行提取而获得。作为上述提取溶剂，可列举例如水、乙醚、氯化乙烯、二恶烷、丙酮、乙醇、甲醇、乙酸乙酯、丙二醇、丁二醇、甘油等极性溶剂，或者正己烷、石油醚、轻石油(ligroin)、环己烷、四氯化碳、氯仿、二氯甲烷、1,2-二氯乙烷、甲苯、苯等非极性溶剂，或它们的混合溶剂。
作为优选的提取溶剂，为水、碳原子数为1～5的低级一元醇(特别是甲醇、乙醇、丙醇、异丙醇等)、二醇(特别是丙二醇、丁二醇等)，或者它们的混合溶剂。混合溶剂优选为水与低级一元醇或二醇的混合比率为10：90～90：10(质量比)的溶剂。提取溶剂可以仅为水。
此外，也可以使用以提取残渣作为原料用上述溶剂提取处理的植物提取物。
这样的(A)植物提取物也可以使用市售品。具体地，可使用丸善制药株式会社、株式会社山田药研等的市售品。
(A)植物提取物的混合量，作为不包括提取溶剂的提取物纯成分，为整个组合物的0.00001～0.05(质量％，以下相同)，优选0.0001～0.005％，更优选0.0002～0.005％。混合量小于0.00001％时，粘腻感的改善效果差。大于0.05％时，刺激过强。
(B)成分选自N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺(B-2)，优选N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)。另外，作为(B)成分，可使用(B-1)成分或(B-2)成分，此外，从效果显现的角度考虑，也可使用(B-1)和(B-2)成分。
(B)成分的混合量为整个组合物的0.00001～0.01％，优选0.00003～0.005％。小于0.00001％时，粘腻感的改善效果和清爽感的赋予效果差。大于0.01％时，有刺激过强、后味变差的情况。
另外，(B-1)成分、(B-2)成分的各自的混合量，可以在上述(B)成分的混合量的范围内设定。
本发明中，表示(A)成分和(B)成分的混合比例的(A)/(B)，以质量比计，为0.02～100，优选0.05～20，更优选0.2～5。在该范围内时，粘腻感的改善效果和清爽感的赋予效果均优异，此外，令人满意地抑制刺激。小于0.02时，不能使清爽感的赋予效果充分地持续，刺激也增强。大于100时，刺激增强。
本发明中，优选进一步混合(C)选自单琥珀酸薄荷酯、N-{(乙氧基羰基)甲基}-对-薄荷烷-3-甲酰胺和乳酸薄荷酯中的1种或2种以上。在(A)和(B)成分中组合混合(C)成分时，粘腻感的改善效果进一步地提高。
(C)成分优选是单琥珀酸薄荷酯、N-{(乙氧基羰基)甲基}-对-薄荷烷-3-甲酰胺，更优选是单琥珀酸薄荷酯。
(C)成分的混合量优选为整个组合物的0.0001～0.01％，更优选0.0003～0.005％。在该范围内时，进一步地提高粘腻感的改善效果。大于0.01％时，有刺激增强后味变差的情况。
本发明的口腔用组合物可以制备成固体、液体、液状、膏状、凝胶状等形态，可以制成膏状洁齿剂、液体洁齿剂、液状洁齿剂、润制洁齿剂(tooth wet-powder)等洁齿剂；漱口剂、口腔清凉剂等各种剂型，特别适宜为洁齿剂或漱口剂，尤其适宜为洁齿剂，也可为含研磨剂的膏状洁齿剂。其制造方法可以采用适应剂型的通常方法。
进一步地，本发明中，根据组合物的目的、剂型等，在不损害本发明效果的范围内，可以根据需要混合上述成分以外的适宜的公知成分。例如，为膏状洁齿剂时，可列举研磨剂、粘结剂、润湿剂、表面活性剂、甜味剂、防腐剂、pH调节剂、香料、药效成分等。为漱口剂时，可列举润湿剂、表面活性剂、甜味剂、防腐剂、pH调节剂、香料、药效成分等。
作为研磨剂，可列举二水合磷酸一氢钙或无水磷酸一氢钙、磷酸二氢钙、磷酸三钙、焦磷酸钙等磷酸钙系化合物；沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等二氧化硅系研磨剂；碳酸钙等碳酸钙系研磨剂；氢氧化钙、氢氧化铝、磷酸三镁、碳酸镁、硫酸钙、膨润土、羟基磷灰石，可以使用它们中的1种或混合2种以上。它们之中，特别是沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅等以硅酸盐为主成分的二氧化硅系研磨剂、碳酸钙系研磨剂，尤其优选沉淀二氧化硅等二氧化硅系研磨剂。
研磨剂，特别是沉淀二氧化硅优选粒径为1～40μm的研磨粒子，此外进一步地，BET比表面积优选为每1g80～250平方米。上述粒径是用粒度分布测定装置(日机装株式会社制，麦奇克粒度分布计，分散剂；水)测定的值。
作为这样的二氧化硅系研磨剂，可以使用市售品，可列举例如HUBER公司制造的Zeodent124、Zeodent113；Rhodia公司制造的TIXOSIL 73、TIXOSIL 63；Degussa公司制造的Sident 3、Sident 20；多木化学株式会社制造的硅酸锆、硅酸铝等。
研磨剂的混合量优选为整个组合物的8～70％，特别优选10～50％。
此外，研磨剂可为颗粒状，作为具有研磨性的成分，可以混合颗粒。颗粒是使水不溶性粉体形成为颗粒状的粒子，可以是将二氧化硅凝胶粉碎而成的颗粒、为了粒状化而使用了粘合剂的粒化物。
研磨剂可以将上述粒径1～40μm的研磨粒子和上述颗粒。
作为粘结剂，可以混合黄原胶、羧甲基纤维素钠、聚丙烯酸钠、海藻酸钠、聚乙烯吡咯烷酮、卡拉胶、甲基纤维素、羟乙基纤维素钠、黄蓍胶、刺梧桐胶、阿拉伯胶、槐豆胶、聚乙烯醇、羧乙烯基聚合物、卡波姆(carbopol)、硅酸镁铝(Veegum)、海藻酸丙二醇酯等有机粘结剂；增稠性二氧化硅、硅酸铝等无机粘结剂。它们可以使用1种或2种以上。使用有机粘结剂时，粘结剂的混合量为整个组合物的0.8～5％，特别优选1～3％，使用无机粘结剂时，粘结剂的混合量为整个组合物的0.5～10％，特别优选1～8％。
作为润湿剂，可列举山梨糖醇、木糖醇等糖醇、丙二醇、甘油等多元醇。混合量通常为整个组合物的5～50％，特别优选20～45％。
作为表面活性剂，可列举阴离子型表面活性剂、非离子型表面活性剂、两性表面活性剂。特别优选阴离子型表面活性剂。
作为阴离子型表面活性剂，可列举烷基硫酸盐、α-烯烃磺酸盐、氢化椰油脂肪酸单甘油酯单硫酸盐、月桂醇磺基乙酸酯盐、N-甲基-N-酰基牛磺酸盐等N-酰基牛磺酸盐；酰基肌氨酸盐、N-酰基-L-谷氨酸盐等酰基氨基酸盐。它们可以使用1种或2种以上。其中，从起泡性、泡沫质量良好的角度考虑，优选含有磺酸基的阴离子型表面活性剂，更优选烷基硫酸盐、α-烯烃磺酸盐。作为上述盐，可列举钠盐、钾盐、铵盐等，特别优选钠盐。
烷基硫酸盐的烷基的碳原子数优选为12～14，具体地，作为烷基硫酸盐，可列举月桂基硫酸钠、肉豆蔻酰基硫酸钠。
作为α-烯烃磺酸盐，可以使用碳原子数为14～16的α-烯烃磺酸的钠、钾等碱金属盐，其中优选碳原子数14的α-烯烃磺酸盐，特别优选钠盐(通用名：十四碳烯磺酸钠)。
例如为洁齿剂时，表面活性剂、特别是阴离子型表面活性剂的混合量优选整个组合物的0.6～2.5％，更优选1～2.5％。为漱口剂时，该混合量优选整个组合物的0～1.0％，特别优选0～0.3％。
作为甜味剂，可列举糖精钠、甜菊苷、甜叶菊提取物、对甲氧基肉桂醛、新橙皮苷二氢查尔酮、紫苏葶、甘草甜素、奇异果甜蛋白、天冬酰基苯丙氨酸甲酯等。作为防腐剂，可列举对羟基苯甲酸酯、苯甲酸钠等。
作为pH调节剂，可列举柠檬酸、乳酸等有机酸和其盐类；盐酸、氢氧化钠、氢氧化钾、磷酸氢二钠、磷酸二氢钠等无机化合物。
作为香料，可列举公知的口腔用香料，例如薄荷醇、茴香脑、香芹酮、丁香酚、柠檬烯、正癸醇、香茅醇、α-松油醇、乙酸香茅酯、桉树脑、芳樟醇、乙基芳樟醇、香草醛、百里酚、留兰香油、薄荷油、柠檬油、橙油、鼠尾草油、迷迭香油、桂皮油、多香果油(pimenta oil)、桂叶油、紫苏油、冬青油、丁香油、桉叶油等。
作为药效成分，可以混合葡聚糖酶、淀粉酶、蛋白酶、葡聚糖变构水解酶等酶；氨甲环酸、ε-氨基己酸、薁、甘草酸盐、甘草次酸盐等抗炎剂；氯化钠、维生素类、尿囊素类等细胞活化剂；异丙基甲基苯酚、十六烷基氯化吡啶、苯扎氯铵、桧木醇(hinokitiol)、溶菌酶氯化物等杀菌剂；铜叶绿素、葡萄糖酸铜等水溶性铜化合物；牙结石预防剂；维生素E等血液循环促进剂；丙氨酸、甘氨酸、脯氨酸等氨基酸类。另外，药效成分的混合量，可以在不妨碍本发明效果的范围内，取有效量。
进一步地，作为任意成分，可以在不妨碍本发明效果的范围混合云母钛、氧化钛、膨润土等无机化合物；微晶纤维素等纤维素系的有机粉末；琼脂、明胶、淀粉、葡甘露聚糖等天然高分子化合物；聚乙酸乙烯酯、丙烯酸树脂、聚氨酯、聚酯、聚氯乙烯、尼龙粉末、聚乙烯粉末等合成高分子化合物或它们的共聚物；巴西棕榈蜡、松香、米糠蜡、微晶蜡、蜂蜡和石蜡等蜡类；十六烷醇、硬脂醇等高级醇；聚异丁烯；聚丁二烯；硅酮；天然橡胶。
另外，作为溶剂，通常使用纯化水。此外，也可混合乙醇等碳原子数1～3的低级一元醇。上述低级一元醇的混合量可为整个组合物的0～10％。
【实施例】
以下，通过实施例和比较例、处方例具体地说明本发明，但是本发明并不限于下述的实施例。另外，除非另有说明，否则下述的例中，％均表示质量％。
[实施例、比较例]
分别按照通常方法制备表1～6所示的组成的洁齿剂组合物(膏状洁齿剂)或漱口剂，收纳于通常的口腔用制剂容器(膏状洁齿剂：层压管，漱口剂：瓶)。将其用作样品，按照下述所示的方法评价。结果一并记于表1～6。表中的(A)成分的混合量的数值为不包括提取溶剂的提取物纯成分量。
<使用的原料>
(A)成分
《A1：迷迭香提取物》
商品名：迷迭香提取物-J，提取溶剂：50％乙醇，使用部位：叶
生产商：丸善制药株式会社
《A2：黄芩提取物》
商品名：黄芩提取物-J，提取溶剂：50％乙醇，使用部位：根
生产商：丸善制药株式会社
《A3：胡萝卜提取物》
商品名：胡萝卜提取物，提取溶剂：50％乙醇，使用部位：根
生产商：丸善制药株式会社
《A4：鼠尾草提取物》
商品名：一串红((Salvia splendens)提取物，提取溶剂：50％乙醇，使用部位：叶生产商：丸善制药株式会社
《A5：甘草提取物》
商品名：甘草提取物，提取溶剂：50％乙醇，使用部位：根
生产商：丸善制药株式会社
《A6：刀豆提取物》
商品名：AOF刀豆提取物-HBG，提取溶剂：50％1,3-丁二醇，使用部位：种子
生产商：株式会社山田药研
《A7：柿子鞣质提取物》
商品名：Pancil BA-200E-1，提取溶剂：水，使用部位：果实
生产商：Rilis科学工业
《A8：当归提取物》
商品名：当归提取物-JC，提取溶剂：50％乙醇，使用部位：根
生产商：丸善制药株式会社
《A9：橄榄叶提取物》
商品名：橄榄提取物-BG，提取溶剂：50％丁二醇，使用部位：叶
生产商：丸善制药株式会社
(B)成分
《B1：N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺》
商品名：Ever CoolG-180，生产商：奇华顿日本株式会社
《B2：N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺》
商品名：Ever CoolG-190，生产商：奇华顿日本株式会社
(C)成分
《C1：单琥珀酸薄荷酯》
商品名：Physcool，生产商：V.MANE FILS公司
《C2：N-{(乙氧基羰基)甲基}-对-薄荷烷-3-甲酰胺》
商品名：WS-5，生产商：德之馨公司
《C3：乳酸薄荷酯》
商品名：Frescolat ML，生产商：德之馨公司
另外，分别使用下述的表7～15所示的香料组合物A～P作为香料。
<评价方法>
通过4名受试者评价。
在牙刷(CLINICA ADVANTAGE牙刷，4列紧凑常规款，狮王株式会社制)上放置作为样品的洁齿剂组合物1g，进行3分钟刷牙后，用10mL的水漱1次口腔内。样品为漱口剂时，含10mL于口中，漱口30秒后，吐出。分别按照下述的评分标准判定使用后的口腔内的粘腻感、使用后经过60分钟后的口腔内的清爽感、口腔内刺激(刚使用后的口腔内的刺激感的有无)，求得4人的平均分，按照下述的评价标准进行评价。
<口腔内的粘腻感>
评分标准
5：完全未感觉到
4：几乎未感觉到
3：说不准是否感觉到
2：感觉到一些
1：感觉强烈
评价标准
◎：4分以上
○：3分以上且小于4分
×：小于3分
<口腔内的清爽感>
评分标准
5：感觉强烈
4：感觉到
3：说不准是否感觉到了
2：几乎未感觉到
1：完全未感觉到
评价标准
◎：4分以上
○：3分以上且小于4分
×：小于3分
<口腔内刺激>
评分标准
5：完全未感觉到
4：几乎未感觉到
3：说不准是否感觉到
2：感觉到一些
1：感觉强烈
评价标准
◎：4分以上
○：3分以上且小于4分
×：小于3分
【表1】
【表2】
【表3】
*；漱口剂
【表4】
【表5】
【表6】
以下显示处方例。使用原料与上述相同。
[处方例1]洁齿剂
(A)/(B)＝0.2
[处方例2]漱口剂
(A)/(B)＝0.04
[处方例3]漱口剂
(A)/(B)＝0.04
【表7】
【表8】
| 风味香精1 | 质量份 |
| 芳樟醇 | 1 |
| 薄荷呋喃 | 1 |
| 茴香脑 | 1 |
| 薄荷酮 | 1 |
| 乙酸薄荷酯 | 1 |
| 合计 | 5 |
【表9】
| 风味香精2 | 质量份 |
| 橙油 | 1 |
| 精制橙油(去除80％前馏分) | 1 |
| 柠檬油 | 1 |
| 精制柠檬油(去除95％前馏分) | 1 |
| 白柠檬油 | 1 |
| 橘子油 | 1 |
| 柚子油 | 1 |
| 柠檬醛 | 1 |
| 癸醛 | 1 |
| 合计 | 9 |
【表10】
| 风味香精3 | 质量份 |
| 茴香油 | 1 |
| 桉叶油 | 1 |
| 桂皮油 | 1 |
| 丁香油 | 1 |
| 百里香油 | 1 |
| 鼠尾草油 | 1 |
| 小豆蔻油 | 1 |
| 芫荽油 | 1 |
| 迷迭香油 | 1 |
| 月桂油 | 1 |
| 甘菊油 | 1 |
| 葛缕子油 | 1 |
| 罗勒油 | 1 |
| 合计 | 13 |
【表11】
| 风味香精4 | 质量份 |
| 冬青油 | 1 |
| 乳香油 | 1 |
| 薰衣草油 | 1 |
| 橙花油(Orange-flower oil) | 1 |
| 柠檬草油 | 1 |
| 茉莉油 | 1 |
| 玫瑰油 | 1 |
| 鸢尾油 | 1 |
| 香草 | 1 |
| 合计 | 9 |
【表12】
| 风味香精5 | 质量份 |
| 3-l-甲氧基-1,2-丙二醇 | 1 |
| 薄荷基甘油醚 | 1 |
| 千日菊提取物(含70％千日菊酰胺) | 1 |
| 氧化芳樟醇 | 1 |
| 香兰基丁基醚 | 1 |
| 异胡薄荷醇 | 1 |
| 辣椒提取物 | 1 |
| 姜提取物 | 1 |
| 胡椒(pepper)提取物 | 1 |
| 合计 | 9 |
【表13】
| 风味香精6 | 质量份 |
| 麦芽酚 | 1 |
| 乙基麦芽酚 | 1 |
| 香草醛 | 1 |
| 乙基香草醛 | 1 |
| 呋喃醇 | 1 |
| 乙基环戊烯醇酮 | 1 |
| 3-羟基-4,5-二甲基呋喃-2-酮 | 1 |
| 甲基环戊烯醇酮 | 1 |
| 2-甲基丁酸 | 1 |
| 乙酸 | 1 |
| 丙酸 | 1 |
| 合计 | 11 |
【表14】
| 风味香精7 | 质量份 |
| 对甲氧基肉桂醛 | 1 |
| 顺式-3-己烯醇 | 1 |
| 反式-2-己烯醛 | 1 |
| 十一内酯 | 1 |
| 癸内酯 | 1 |
| 丁酸乙酯 | 1 |
| 乙酸异戊酯 | 1 |
| 苯甲醛 | 1 |
| 乙酸己酯 | 1 |
| 2-甲基丁酸乙酯 | 1 |
| 苄基醇 | 1 |
| α-松油醇 | 1 |
| 乙酸芳樟酯 | 1 |
| 苯基缩水甘油酸乙酯 | 1 |
| 苯基乙基醇 | 1 |
| 己酸烯丙酯 | 1 |
| 辛醇 | 1 |
| 肉桂酸甲酯 | 1 |
| 甲基庚炔碳酸盐(methyl heptin carbonate) | 1 |
| 紫罗兰酮 | 1 |
| 乙基-β-甲基硫代丙酸酯 | 1 |
| 顺式-6-壬烯醇 | 1 |
| 7-甲基-3,5-二氢-2H-苯并二氧杂环庚烯-3-酮 | 1 |
| 茉莉酮酸甲酯 | 1 |
| 合计 | 24 |
【表15】
| 溶剂 | 质量份 |
| 乙醇 | 1 |
| 丙二醇 | 1 |
| 甘油脂肪酸酯 | 1 |
| 三乙酸甘油酯 | 1 |
| 合计 | 4 |
Claims (6)
1.一种口腔用组合物，其含有
以纯提取物计为0.00001～0.05质量％的(A)植物提取物，和
0.00001～0.01质量％的(B)选自N-(4-氰基甲基苯基)-2-异丙基-5-甲基环己烷甲酰胺(B-1)和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺(B-2)中的1种以上，
(A)/(B)以质量比计为0.02～100。
2.根据权利要求1所述的口腔用组合物，其中，(A)植物提取物为选自迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶、黄檗、钓樟、胡椒木、百里香、白桦、芍药、柳栎、儿茶钩藤、姜黄、丁子香、甜叶菊、无患子、马郁兰、蜜蜂花、紫苏、月桂树、桉树、可乐树、罗汉果、山茶、丁香、众香树、苏木、紫草根、大黄、连翘、陈皮、桂皮、牛至、罗勒、香薷、牡丹皮和毗黎勒中的1种以上的植物的提取物。
3.根据权利要求2所述的口腔用组合物，其中，(A)植物提取物为选自迷迭香、黄芩、胡萝卜、鼠尾草、甘草、当归、柿子、刀豆、橄榄、茶叶和黄檗中的1种以上的植物的提取物。
4.根据权利要求1～3中任一项所述的口腔用组合物，其中，所述口腔用组合物还含有0.0001～0.01质量％的(C)选自单琥珀酸薄荷酯、N-{(乙氧基羰基)甲基}-对-薄荷烷-3-甲酰胺和乳酸薄荷酯中的1种以上。
5.根据权利要求1～4中任一项所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂或漱口剂。
6.根据权利要求5所述的口腔用组合物，其中，所述口腔用组合物为洁齿剂，其还含有8～70质量％的(D)研磨剂。
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