CN110678461A - Syk抑制剂及其使用方法 - Google Patents

Syk抑制剂及其使用方法 Download PDF

Info

Publication number
CN110678461A
CN110678461A CN201880036803.9A CN201880036803A CN110678461A CN 110678461 A CN110678461 A CN 110678461A CN 201880036803 A CN201880036803 A CN 201880036803A CN 110678461 A CN110678461 A CN 110678461A
Authority
CN
China
Prior art keywords
compound
methyl
amino
substitution
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880036803.9A
Other languages
English (en)
Other versions
CN110678461B (zh
Inventor
刘世岚
梁贵柏
王宏健
张明
陈曙辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of CN110678461A publication Critical patent/CN110678461A/zh
Application granted granted Critical
Publication of CN110678461B publication Critical patent/CN110678461B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

提供Syk抑制剂及其使用方法，具体公开了一种式(I)的喹啉酮或喹唑啉酮衍生物或其药学上可接受的盐，以及制备方法、药物组合物和在制备治疗Syk受体相关病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (36)

  1. PCT国内申请，权利要求书已公开。
CN201880036803.9A 2017-06-14 2018-06-14 Syk抑制剂及其使用方法 Active CN110678461B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710448438X 2017-06-14
CN201710448438 2017-06-14
PCT/CN2018/091269 WO2018228475A1 (zh) 2017-06-14 2018-06-14 Syk抑制剂及其使用方法

Publications (2)

Publication Number Publication Date
CN110678461A true CN110678461A (zh) 2020-01-10
CN110678461B CN110678461B (zh) 2021-08-10

Family

ID=64660192

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880036803.9A Active CN110678461B (zh) 2017-06-14 2018-06-14 Syk抑制剂及其使用方法

Country Status (8)

Country Link
US (1) US11091460B2 (zh)
EP (1) EP3640247B1 (zh)
JP (1) JP7299167B2 (zh)
CN (1) CN110678461B (zh)
AU (1) AU2018286247B2 (zh)
CA (1) CA3065114A1 (zh)
ES (1) ES2906205T3 (zh)
WO (1) WO2018228475A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112725413A (zh) * 2021-02-05 2021-04-30 厦门甄准生物技术有限公司 一种宫颈拭子核酸提取的裂解结合液、试剂盒及方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202106210QA (en) 2018-12-14 2021-07-29 Chia Tai Tianqing Pharmaceutical Group Co Ltd Salt of syk inhibitor and crystalline form thereof
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CA3236272A1 (en) * 2021-11-12 2023-05-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of quinolinone derivative in treatment of immune thrombocytopenia

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1784229A (zh) * 2003-03-10 2006-06-07 先灵公司 杂环激酶抑制剂:使用方法与合成
WO2010053757A1 (en) * 2008-10-29 2010-05-14 Gilead Palo Alto, Inc. 2 -oxoquinoxalin blockers of the late sodium channel
CN103168039A (zh) * 2010-03-11 2013-06-19 吉利德康涅狄格公司 咪唑并吡啶类syk抑制剂
WO2014060113A1 (en) * 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
WO2014093191A1 (en) * 2012-12-12 2014-06-19 Merck Sharp & Dohme Corp. AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
CN104203943A (zh) * 2012-01-20 2014-12-10 盖诺斯克公司 取代的嘧啶化合物及其作为syk抑制剂的用途
WO2015080707A1 (en) * 2013-11-26 2015-06-04 Gilead Sciences, Inc. Quinoline derivatives as bromodomain inhibitors
WO2016197987A1 (zh) * 2015-06-12 2016-12-15 杭州英创医药科技有限公司 作为Syk抑制剂和/或Syk-HDAC双重抑制剂的杂环化合物
WO2017001733A1 (en) * 2015-07-02 2017-01-05 Orion Corporation Bicyclic heterocycle derivatives as bromodomain inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519846A (ja) 2003-03-10 2006-08-31 シェーリング　コーポレイション 複素環式キナーゼインヒビター：使用および合成の方法
TW200942537A (en) 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
SI2516434T1 (sl) 2009-12-23 2015-10-30 Takeda Pharmaceutical Company Limited Zliti heteroaromatski pirolidinoni kot inhibitorji SYK
JP5473139B2 (ja) 2010-06-15 2014-04-16 富士通テレコムネットワークス株式会社 試験装置と試験方法
BR112012033770A2 (pt) * 2010-06-30 2016-11-22 Fujifilm Corp novo derivado de nicotinamida ou sal do mesmo
ES2450746B2 (es) 2012-03-14 2015-01-26 Universidad Complutense De Madrid Preparación y citotoxicidad de 2-quinolonas
CN105577525A (zh) 2015-12-25 2016-05-11 中兴通讯股份有限公司 融合通信交互方法，装置及系统

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1784229A (zh) * 2003-03-10 2006-06-07 先灵公司 杂环激酶抑制剂:使用方法与合成
WO2010053757A1 (en) * 2008-10-29 2010-05-14 Gilead Palo Alto, Inc. 2 -oxoquinoxalin blockers of the late sodium channel
CN103168039A (zh) * 2010-03-11 2013-06-19 吉利德康涅狄格公司 咪唑并吡啶类syk抑制剂
CN104203943A (zh) * 2012-01-20 2014-12-10 盖诺斯克公司 取代的嘧啶化合物及其作为syk抑制剂的用途
WO2014060113A1 (en) * 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
WO2014093191A1 (en) * 2012-12-12 2014-06-19 Merck Sharp & Dohme Corp. AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
WO2015080707A1 (en) * 2013-11-26 2015-06-04 Gilead Sciences, Inc. Quinoline derivatives as bromodomain inhibitors
WO2016197987A1 (zh) * 2015-06-12 2016-12-15 杭州英创医药科技有限公司 作为Syk抑制剂和/或Syk-HDAC双重抑制剂的杂环化合物
WO2017001733A1 (en) * 2015-07-02 2017-01-05 Orion Corporation Bicyclic heterocycle derivatives as bromodomain inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATHAN J.O’BRIEN ET AL.: ""Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors"", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112725413A (zh) * 2021-02-05 2021-04-30 厦门甄准生物技术有限公司 一种宫颈拭子核酸提取的裂解结合液、试剂盒及方法

Also Published As

Publication number Publication date
JP2020523328A (ja) 2020-08-06
AU2018286247A1 (en) 2020-01-02
US11091460B2 (en) 2021-08-17
CN110678461B (zh) 2021-08-10
AU2018286247B2 (en) 2021-12-23
CA3065114A1 (en) 2018-12-20
US20200199101A1 (en) 2020-06-25
EP3640247A4 (en) 2020-10-28
WO2018228475A1 (zh) 2018-12-20
ES2906205T3 (es) 2022-04-13
EP3640247B1 (en) 2022-01-12
JP7299167B2 (ja) 2023-06-27
EP3640247A1 (en) 2020-04-22

Similar Documents

Publication Publication Date Title
CN110678461B (zh) Syk抑制剂及其使用方法
JP6735330B2 (ja) Ｔｒｐａ１調節因子として有用な置換複素環式スルホンアミド化合物
KR101546167B1 (ko) 브루톤 티로신 키나아제의 억제제
CN107001377B (zh) 对呼吸道合胞病毒(rsv)的复制具有抑制活性的哌啶取代的吡唑并[1,5-a]嘧啶衍生物
CN112638373A (zh) 细胞周期蛋白依赖性激酶抑制剂
CN110494433B (zh) 布鲁顿酪氨酸激酶抑制剂
CN101305005A (zh) 新二氮杂螺烷以及它们用于治疗ccr8介导的疾病的用途
CN114867720A (zh) 杂芳基类衍生物及其制备方法和用途
US10239873B2 (en) 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same
AU2005213538A1 (en) Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists
TW201444821A (zh) 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
TW202039474A (zh) 吡唑基-氨基-嘧啶基衍生物的苯甲醯胺及其組合物和方法
CN115335376A (zh) 通过缀合btk抑制剂与e3连接酶配体降解布鲁顿氏酪氨酸激酶（btk）及其使用方法
TWI802604B (zh) 嘧啶ＴＢＫ/ＩＫＫε抑制劑化合物及其用途
WO2022134641A1 (zh) 芳香杂环类化合物、药物组合物及其应用
TWI639601B (zh) Ｓｙｋ抑制劑
WO2022194269A1 (zh) 新型egfr降解剂
KR20230005938A (ko) Ccr6 수용체 조절인자로서의 아제티딘-3-일메탄올 유도체
KR20230006560A (ko) 새로운 거대고리 lrrk2 키나제 억제제
CN114728932A (zh) 作为egfr激酶抑制剂的多芳基化合物
CN112778336A (zh) 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN113173924B (zh) 一种作为cdk抑制剂的吡啶乙酰胺类衍生物、其制备方法及用途
CN113149996B (zh) 一种作为cdk9抑制剂的多环酰胺类衍生物、其制备方法及用途
WO2023142641A1 (zh) 一种吡啶类衍生物、其制备方法及用途
CN117946093A (zh) 可用作hpk1抑制剂的化合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40015394

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant