CN110678172A - 用于治疗创伤性脑损伤的氨基酸组合物及其使用方法 - Google Patents

用于治疗创伤性脑损伤的氨基酸组合物及其使用方法 Download PDF

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Publication number
CN110678172A
CN110678172A CN201880035067.5A CN201880035067A CN110678172A CN 110678172 A CN110678172 A CN 110678172A CN 201880035067 A CN201880035067 A CN 201880035067A CN 110678172 A CN110678172 A CN 110678172A
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CN
China
Prior art keywords
amino acid
composition
leucine
isoleucine
valine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880035067.5A
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English (en)
Chinese (zh)
Inventor
肖恩·卡罗尔
瑞弗·亚非恩
瑞恩佐 吉安路卡·德
马修·拉塞尔
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Axcella Health Inc
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Axcella Health Inc
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Filing date
Publication date
Application filed by Axcella Health Inc filed Critical Axcella Health Inc
Publication of CN110678172A publication Critical patent/CN110678172A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880035067.5A 2017-04-28 2018-04-27 用于治疗创伤性脑损伤的氨基酸组合物及其使用方法 Pending CN110678172A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762491796P 2017-04-28 2017-04-28
US62/491,796 2017-04-28
PCT/US2018/029908 WO2018201024A1 (en) 2017-04-28 2018-04-27 Amino acid compositions and their use for the treatment of traumatic brain injury

Publications (1)

Publication Number Publication Date
CN110678172A true CN110678172A (zh) 2020-01-10

Family

ID=62165694

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880035067.5A Pending CN110678172A (zh) 2017-04-28 2018-04-27 用于治疗创伤性脑损伤的氨基酸组合物及其使用方法

Country Status (5)

Country Link
US (1) US11617731B2 (https=)
EP (1) EP3615018A1 (https=)
JP (1) JP2020517703A (https=)
CN (1) CN110678172A (https=)
WO (1) WO2018201024A1 (https=)

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JP2021529735A (ja) 2018-06-20 2021-11-04 アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． アミノ酸組成物の製造方法
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
CN112839643A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于治疗肌肉中脂肪浸润的组合物及方法
IT201800006725A1 (it) 2018-06-27 2019-12-27 Composizioni comprendenti aminoacidi per l'uso nella prevenzione e nel trattamento di malattie epatiche
IT201900002109A1 (it) * 2019-02-13 2020-08-13 Professional Dietetics Spa Composizioni comprendenti amminoacidi per l'uso nel trattamento di lesioni del sistema nervoso centrale
IT202000000442A1 (it) 2020-01-13 2021-07-13 Professional Dietetics Spa Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia
US20220218640A1 (en) * 2021-01-14 2022-07-14 Rob Dickerman Amino acid delivery system
WO2023009444A1 (en) 2021-07-26 2023-02-02 Axcella Health Inc. Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119235838A (zh) * 2024-11-04 2025-01-03 苏州市立医院 一种hmb在制备改善创伤性脑损伤药物中的应用

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US11617731B2 (en) 2023-04-04
EP3615018A1 (en) 2020-03-04
US20200163919A1 (en) 2020-05-28
JP2020517703A (ja) 2020-06-18
WO2018201024A1 (en) 2018-11-01

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