CN110613767A - Traditional Chinese medicine formula for treating amblyopia and application thereof - Google Patents

Traditional Chinese medicine formula for treating amblyopia and application thereof Download PDF

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CN110613767A
CN110613767A CN201910889704.1A CN201910889704A CN110613767A CN 110613767 A CN110613767 A CN 110613767A CN 201910889704 A CN201910889704 A CN 201910889704A CN 110613767 A CN110613767 A CN 110613767A
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王亚丽
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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Abstract

The invention provides a traditional Chinese medicine formula for treating amblyopia and application thereof, wherein the traditional Chinese medicine formula comprises the following raw materials in parts by weight: 45-50 parts of wild chrysanthemum flower, 30-35 parts of cassia seed, 20-25 parts of wolfberry fruit, 12-18 parts of mulberry, 12-18 parts of glossy privet fruit, 8-10 parts of butterflybush flower, 8-10 parts of amur corktree bark, 3-5 parts of ginseng and 3-5 parts of pearl. The Chinese medicinal composition is prepared by soaking, sterilizing, oven drying, pulverizing, adding appropriate amount of Chinese medicinal adjuvants, and making into powder, patch, tablet or capsule. The formula improves eye circulatory system, promotes vision restoration, and has remarkable effect in treating amblyopia.

Description

Traditional Chinese medicine formula for treating amblyopia and application thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating amblyopia and application thereof.
Background
Amblyopia is the condition that the best correction vision of single eye or double eyes in the visual development period is lower than that of normal children of corresponding age, and the eye examination has no organic lesion. Lower limit of normal value of vision for children of different ages: the lower limit of the normal vision of children aged 3-5 years is 0.5, and the lower limit of the normal vision of children aged 6 years and above is 0.7.
The reason of amblyopia is that the channels and collaterals around the eyes are obstructed, and the circulatory systems such as blood, lymph and the like can not supplement nutrition for a long time, so that the cooperative operation problem of the eyes and the brain is caused, and the induced vision disorder is caused, but the eyes do not have organic lesions, and the result of the amblyopia is hypopsia.
In recent years, as the age of people using intelligent devices is low and parents ignore the age, children are interfered and destroyed by various factors during the key development period of vision, and amblyopia occurs, but the existing products and methods for treating amblyopia in the market are many, but the comprehensive effect is not ideal.
Eye shade therapy: although the method is safe and economical, the effect is too slow, and the optimal period of vision maintenance is possibly delayed; and (3) amblyopia surgical treatment: although the effect can be shown quickly, the operation is accompanied by great operation risk and endless sequelae; amblyopia training instrument: common amblyopia training instruments include a plurality of amblyopia increasing instrument training instruments, optical brush training instruments, optical grating training instruments and the like, although risks and obvious sequelae do not exist, the amblyopia training instruments usually increase the visual burden, the effect is not obvious, and even the amblyopia problem is aggravated; traditional Chinese medicine eye ointment: the existing traditional Chinese medicine eye ointment is smeared on the skin around eyes, the skin absorption is slow, and the effective traditional Chinese medicine components are more difficult to be conveyed into the eyes, so the effect is not obvious generally.
Disclosure of Invention
The invention provides a traditional Chinese medicine formula for treating amblyopia and application thereof, wherein traditional Chinese medicine powder prepared by using the formula directly acts on eyes and peripheral acupuncture points by a traditional Chinese medicine atomization method, and the eye circulatory system can be improved by massaging the acupuncture points, so that the traditional Chinese medicine formula has an obvious effect on treating amblyopia, and has no risk and sequelae. Meanwhile, the traditional Chinese medicine formula can also be prepared into patches, tablets or capsules, and can achieve corresponding treatment effects on amblyopia patients.
The invention discloses a traditional Chinese medicine formula for treating amblyopia and application thereof, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 45-50 parts of wild chrysanthemum flower, 30-35 parts of cassia seed, 20-25 parts of wolfberry fruit, 12-18 parts of mulberry, 12-18 parts of glossy privet fruit, 8-10 parts of butterflybush flower, 8-10 parts of amur corktree bark, 3-5 parts of ginseng and 3-5 parts of pearl.
The powder prepared by the traditional Chinese medicine formula disclosed by the invention mainly comprises the following steps:
(1) soaking the above raw materials in 3-5 deg.C purified water for 20 min, respectively, drying, controlling the temperature of drying oven at 52-58 deg.C for 45 min, and uniformly spreading in shade for two hours.
(2) Placing wild chrysanthemum, medlar, cassia seed and mulberry into a solvent for reflux extraction for 2-3 times, wherein the reflux interval of each time is 2-3 hours, the solvent is ethanol water solution with the concentration of 75-85%, and the total weight of the added solution is 6-8 times of the total volume of the medicinal materials.
(3) Processing and crushing the pearls into fine powder with 180-250 meshes at the low temperature of below zero ℃.
(4) Grinding flos Chrysanthemi Indici, fructus Lycii, semen Cassiae, and Mori fructus respectively into 180-mesh powder of 150 meshes.
(5) Finally, the traditional Chinese medicine raw materials are proportioned according to the weight proportion, and then a proper amount of traditional Chinese medicine processing auxiliary materials are added according to the conventional method to prepare powder, patch, tablet or capsule.
The raw materials of the traditional Chinese medicine formula have the following medicinal properties and medicinal effects:
wild chrysanthemum flower (CHRYSANTHEMINDICIFLOS), bitter, pungent and slightly cold. Enters liver and heart meridians and has the effects of clearing away heat and toxic materials, purging pathogenic fire and calming liver. Can be used for treating furuncle, carbuncle, swelling, conjunctival congestion, swelling and pain, headache, and vertigo (see pharmacopoeia 2015 edition, part P314).
Cassia seed (its scientific name is CASSIAESEMEN), sweet, bitter, salty and slightly cold, enters liver and large intestine meridians. Has the effects of clearing heat, improving eyesight, moistening intestines and relaxing bowels. Can be used for treating conjunctival congestion, dizziness, headache, vertigo, dim eyesight, and constipation (see pharmacopoeia 2015 edition, part P145).
Fructus Lycii (LYCIIFRUCTUS), sweet and neutral. It enters liver and kidney meridians. Has effects of nourishing liver and kidney, replenishing vital essence, and improving eyesight. Can be used for treating consumptive disease and essence deficiency, soreness of waist and knees, giddiness and tinnitus, sexual impotence and nocturnal emission, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision (see the P249 in 2015 th edition of Chinese pharmacopoeia).
Mulberry (famous Mullberry fruit), sweet and cold. Enter liver and kidney meridians. Has effects in nourishing liver, invigorating kidney, calming endogenous wind, and nourishing fluid. Can be used for treating yin deficiency of liver and kidney, insomnia, diabetes, constipation, dim eyesight, tinnitus, lymphoid tuberculosis, and joint disorder (seen in Wikipedia).
Fructus Ligustri Lucidi (LigustTRILUCIDIFRUCTUS), sweet, bitter, and cool. It enters liver and kidney meridians. Has effects of nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating yin deficiency of liver and kidney, vertigo, tinnitus, soreness of waist and knees, premature graying of hair, dim eyesight, internal heat, diabetes, and hectic fever due to bone steaming (see the pharmacopoeia 2015 edition, part P45).
Butterflybush flower (its academic name, Buddlejaeflos), sweet and slightly cold. It enters liver meridian. Has effects of clearing heat-fire, nourishing liver, improving eyesight, and removing nebula. Can be used for treating conjunctival congestion, swelling and pain, lacrimation, photophobia, nebula, liver deficiency, dim eyesight, and blurred vision (see pharmacopoeia 2015 edition, P329).
Phellodendron bark (phellodendron chinensissostrex), bitter and cold. It enters kidney and bladder meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substance, and treating sore. Can be used for treating damp-heat dysentery, jaundice, dark urine, stranguria with heat, pain, pyocutaneous disease, toxic swelling, and eczema (see the pharmacopoeia 2015 edition, part P305).
Ginseng (Panax ginseng C.A. Mey, GINSENGGRADIETRHIZOMA), sweet, slightly bitter and slightly warm. It enters spleen, lung, heart and kidney meridians. Has effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, and improving intelligence. Can be used for treating asthenia, anorexia due to spleen deficiency, thirst due to body fluid consumption, internal heat, diabetes, deficiency of qi and blood, palpitation, and insomnia (see pharmacopoeia 2015, P8).
Pearl (Margarita), sweet, salty and cold. It enters heart and liver meridians. Has effects of tranquilizing, arresting convulsion, improving eyesight, eliminating nebula, removing toxic substance, promoting granulation, caring skin, and removing speckle. Can be used for treating pavor, insomnia, infantile convulsion, epilepsy, conjunctival congestion, nebula, unhealing sore and ulcer, and skin mottle (see the pharmacopoeia 2015 edition, part P231).
The application method of the traditional Chinese medicine formula disclosed by the invention comprises the following steps:
the traditional Chinese medicine formula is prepared into powder, the powder is filled into a non-woven fabric bag to form a traditional Chinese medicine powder bag, the traditional Chinese medicine powder bag is placed into a fumigation instrument, traditional Chinese medicine steam formed by atomization of traditional Chinese medicines directly acts on eyes, the circulatory system of the eyes is improved, the channels and collaterals around the eyes are dredged, blocked channels are unblocked, the eyesight is promoted, and the effect of treating amblyopia is remarkable.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1:
the traditional Chinese medicine composition comprises, by weight, 47 parts of wild chrysanthemum flower, 33 parts of cassia seed, 23 parts of wolfberry fruit, 15 parts of mulberry, 15 parts of glossy privet fruit, 9 parts of buddleja officinalis, 9 parts of golden cypress, 4 parts of ginseng and 4 parts of pearl.
The preparation method comprises the following steps:
(1) soaking the above raw materials in 3-5 deg.C purified water for 20 min, respectively, drying, controlling the temperature of drying oven at 52-58 deg.C for 45 min, and uniformly spreading in shade for two hours.
(2) Placing wild chrysanthemum, medlar, cassia seed and mulberry into a solvent for reflux extraction for 2-3 times, wherein the reflux interval of each time is 2-3 hours, the solvent is ethanol water solution with the concentration of 75-85%, and the total weight of the added solution is 6-8 times of the total volume of the medicinal materials.
(3) Processing and crushing the pearls into fine powder with 180-250 meshes at the low temperature of below zero ℃.
(4) Grinding flos Chrysanthemi Indici, fructus Lycii, semen Cassiae, and Mori fructus respectively into 180-mesh powder of 150 meshes.
(5) Finally, the traditional Chinese medicine raw materials are proportioned according to the weight proportion, and proper amount of traditional Chinese medicine processing auxiliary materials wheat bran are added to prepare powder.
The specific application method is as follows:
the traditional Chinese medicine formula is prepared into powder, the powder is filled into a non-woven fabric bag to form a traditional Chinese medicine powder bag, the traditional Chinese medicine powder bag is placed into a fumigation instrument, traditional Chinese medicine steam formed by atomization of traditional Chinese medicines directly acts on eyes, the circulatory system of the eyes is improved, the channels and collaterals around the eyes are dredged, blocked channels are unblocked, the eyesight is promoted, and the effect of treating amblyopia is remarkable.
And (3) observation of clinical curative effect:
(1) general data
520 patients were clinically selected, 270 men and 250 women, 278 patients aged 4-10, 157 patients aged 10-18 and 85 patients aged 15-25.
(2) Diagnostic criteria
The effect is shown: improving vision and observing for 2-3 months without rebound.
Improvement: the vision is slightly improved and can not be deteriorated on the existing vision level.
And (4) invalidation: and is ineffective after use.
(3) Method of treatment
The formula of the embodiment 1 is prepared into powder, the powder is filled into a non-woven fabric bag to form a traditional Chinese medicine powder bag, the traditional Chinese medicine powder bag is put into a fumigation instrument, a patient is fumigated once in the morning and at night every day, the traditional Chinese medicine powder is replaced before each fumigation, and 30 days is a treatment course.
(4) Therapeutic results
For 520 patient samples, the Chinese medicinal powder prepared in example 1 was used, and after fumigation treatment: 376 cases of obvious effect, the obvious effect rate is 72.3 percent; 129 cases of improvement are carried out, and the improvement rate is 24.8%; the efficiency is 2.9% in 15 cases.
Typical cases are as follows:
case 1: li mo zhi, male, 6.5 years old, left eye: 0.12, right eye: 1.0+1Once eye-mask covering therapy was used, the effect was not evident, and after one treatment period using the product of example 1, the left eye: 0.3, right eye: 1.0+3(ii) a At the end of three treatment sessions, left eye: 0.8, right eye: 1.2-1(ii) a Left eye after three further treatment sessions: 1.0-1And the right eye: 1.2, no vision rebound sign and no adverse reaction after the medicine is stopped for two years.
Case 2: whichever, female 16 years old, left eye: 1.2-2And the right eye: 0.1, after training eyesight with instruments such as increasing the visual acuity, grating for a period of time, right eye eyesight does not obviously promote, and left eye eyesight falls to 1.0 on the contrary, uses the product of embodiment 1 after three courses of treatment, the left eye: 1.2-1And the right eye: 0.3, after three further treatment periods, left eye: 1.2, right eye: 0.8, no vision rebound sign and no adverse reaction after the medicine is stopped for three years.
Case 3: some king, female 23 years old, left eye: 1.0-2And the right eye: 0.2, the amblyopia was treated with the traditional Chinese medicine eye ointment before, but the effect is not obvious, and after six courses of treatment by using the product of the example 1, the eye: 1.0, right eye: 0.4, after six treatment courses, left eye: 1.2, right eye: 0.6, currently still in active treatment.
The invention is capable of other embodiments and its several details are capable of modifications in various obvious respects, all without departing from the spirit and scope of the present invention.

Claims (2)

1. The traditional Chinese medicine formula for treating amblyopia and the application thereof are characterized by being prepared from the following traditional Chinese medicine raw materials in proportion: 45-50 parts of wild chrysanthemum flower, 30-35 parts of cassia seed, 20-25 parts of wolfberry fruit, 12-18 parts of mulberry, 12-18 parts of glossy privet fruit, 8-10 parts of butterflybush flower, 8-10 parts of amur corktree bark, 3-5 parts of ginseng and 3-5 parts of pearl.
2. The traditional Chinese medicine formula for treating amblyopia and the application thereof according to claim 1 are characterized by comprising the following application methods:
the traditional Chinese medicine formula is prepared into powder, the powder is filled into a non-woven fabric bag to form a traditional Chinese medicine powder bag, the traditional Chinese medicine powder bag is placed into a fumigation instrument, traditional Chinese medicine steam formed by atomization of traditional Chinese medicines directly acts on eyes, the circulatory system of the eyes is improved, the channels and collaterals around the eyes are dredged, blocked channels are unblocked, the eyesight is promoted, and the effect of treating amblyopia is remarkable.
CN201910889704.1A 2019-09-20 2019-09-20 Traditional Chinese medicine formula for treating amblyopia and application thereof Pending CN110613767A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698026A (en) * 2009-06-01 2010-04-28 张红伟 Traditional Chinese medicine formula for treating eye disease of amblyopia and method for producing preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698026A (en) * 2009-06-01 2010-04-28 张红伟 Traditional Chinese medicine formula for treating eye disease of amblyopia and method for producing preparation thereof

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