CN101698026A - Traditional Chinese medicine formula for treating eye disease of amblyopia and method for producing preparation thereof - Google Patents
Traditional Chinese medicine formula for treating eye disease of amblyopia and method for producing preparation thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine formula for treating an eye disease of amblyopia and a method for producing a preparation thereof. The traditional Chinese medicine formula comprises the following components in parts by weight: 10-30 of medlar, 10-30 of cassia seed, 10-30 of chrysanthemum, 10-30 of caltrop, 10-30 of prepared rehmannia root, 10-30 of ginseng, 5-20 of glossy privet fruit, 5-20 of rhizoma ligustici wallichii and 10-30 of pearl. The method for producing the traditional Chinese medicine preparation for treating the eye disease of the amblyopia by the traditional Chinese medicine formula comprises the following steps: after mixing the eight previous components, extracting and concentrating by an ethanol water solution with the concentration of 55-90% into an extract, pulverizing into fine paste powder after drying, then pulverizing the pearl into superfine powder and mixing the fine paste powder and the superfine powder to prepare mixed fine powder; adding a right amount of auxiliary materials acceptable in medicine to prepare ointment, paste, medicinal granules, tablets or capsules. The preparation has the advantages of obvious curative effect, simple process, low cost and very convenient application, carrying and preservation.
Description
One, technology neck city
The present invention relates to a kind of Chinese medicine preparation for the treatment of eye disease of amblyopia, and according to the method for the Chinese medicine preparation of this prescription production for treating eye disease of amblyopia.
Two, background technology
Naked vision does not all reach 1.0 and is amblyopia with correcting defects of vision, and the amblyopia pilosity is born in the Childhood, nearly more than 1,000 ten thousand amblyopia patients among China 400,000,000 children, and 4～8 years old child be the optimal rehabilitation phase, can be more remote above 12 years old rehabilitation machines.Method of rehabilitation at present commonly used has covering method, strings, threads a needle, traces designs, wears glasses, magnetic therapy vibration etc., though certain rehabilitation efficacy is arranged, owing to be physiotherapy all, focus does not have direct administration, so fundamentally rehabilitation amblyopia.
The Chinese medicine preparation application of existing many in recent years treatment amblyopias patent of invention, for example application number is 200610018332.8, name is called the patent of " a kind of Chinese medicine for the treatment of amblyopia and myopia " and application number is 200410040983.8, name is called the patent of " a kind of Chinese medicine preparation for the treatment of weak ophthalmic and preparation method thereof ", comprise nearly 57 flavor Chinese crude drugs in these two patents in the former prescription, therefore consume many, the complex process of medical material, so cost is higher; The latter adopts water to carry out the extraction of effective ingredient, and its shortcoming is to extract effective ingredient soluble in water in the medical material, but can not extract the effective ingredient that is soluble in organic solvent in the medical material, causes the waste of medical material and the reduction of curative effect.
Three, summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation of new treatment eye disease of amblyopia and the production method of preparation thereof, this prescription and preparation good effect thereof, cost are low, and use, carry, keeping is all very convenient.
A kind of Chinese medicine preparation for the treatment of eye disease of amblyopia of the present invention mainly is made up of following compositions in weight portion: Fructus Lycii 10～30, Semen Cassiae 10～30, Flos Chrysanthemi 10～30, Fructus Tribuli 10～30, Radix Rehmanniae Preparata 10～30, Margarita 10～30, Radix Ginseng 10～30, Fructus Ligustri Lucidi 5～20, Rhizoma Chuanxiong 5～20.
The parts by weight of each component are preferably in the above-mentioned Chinese medicine preparation: Fructus Lycii 15～25, Semen Cassiae 15～25, Flos Chrysanthemi 15～25, Fructus Tribuli 15～25, Radix Rehmanniae Preparata 15～25, Margarita 15～25, Radix Ginseng 15～25, Fructus Ligustri Lucidi 8～15, Rhizoma Chuanxiong 8～15.
With the method for the Chinese medicine preparation of above-mentioned Chinese medicine preparation production for treating eye disease of amblyopia, it mainly may further comprise the steps:
(1) with Fructus Lycii, Semen Cassiae, Flos Chrysanthemi, Fructus Tribuli, Radix Rehmanniae Preparata, Radix Ginseng, Fructus Ligustri Lucidi, Rhizoma Chuanxiong, place the solvent reflux, extract, 2～4 times, each reflux, extract, 1～4 hour; Here said solvent is that concentration is 55%～90% ethanol water, and the weight that adds solvent is 5～10 times of medical material gross weight;
(2) with 2～4 times extracting solution merging, concentrating under reduced pressure, drying, be ground into the thin cream powder of 100 orders～300 purposes;
(3) under sub-zero low temperature, the Margarita processing powder is broken into 150 orders～350 purpose micropowders;
(4) thin cream powder and micropowders are mixed into mixing fine powders;
(5) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
Said reflux, extract, number of times is the best with 3 times in the said method, and each extraction time was the best with 1～2 hour.
The method for production of said unguentum is that medical ventolin is placed stainless steel ware in the said method, is heated to 70`～110 ℃, and it is melted fully, treats to add mixing fine powders after temperature is reduced to 20～60 ℃, stirs, and makes unguentum after the cooling.
Said medical ventolin is the best with medical ventolin 1000～2000 in the aforementioned production method.
The property of medicine of each component and drug effect are as follows in the above-mentioned Chinese medicine preparation:
Fructus Lycii (Lycium barbarum L) property is flat, sweet in the mouth, and energy nourishing the liver and kidney, replenishing vital essence to improve eyesight can be controlled dizzy, blurred vision not clear (seeing P204 of in 1990 version of the Pharmacopoeia of the People's Republic of China); Semen Cassiae (Cassia tora L is cold in nature, sweet in the mouth, hardship, and the energy clearing away heat to improve acuity of vision can be controlled the puckery pain of conjunctival congestion, the many tears of photophobia, dizzy, the poor vision (seeing P120 of in 1990 version of the Pharmacopoeia of the People's Republic of China) of headache; (Chrysanthemum morifolium Ramat) is cold in nature for Flos Chrysanthemi, and sweet in the mouth, hardship can make eye bright by suppressing the hyperactive liver, can control conjunctival congestion and swelling pain, eyes dim-sighted (seeing P272 of in 1990 version of the Pharmacopoeia of the People's Republic of China); Fructus Tribuli (Tribulus terrestris L) slightly warm in nature, acrid in the mouth, hardship can suppressing the hyperactive liver, make eye bright, and can control dizzy, conjunctival congestion (seeing P318 of in 1990 version of the Pharmacopoeia of the People's Republic of China); Radix Rehmanniae Preparata (Rehmannia glutinosaLibosch) slightly warm in nature, sweet in the mouth can nourishing YIN and supplementing blood, beneficial essence fills out marrow, but treating the liver deficiency of the kidney yin, dizzy (seeing P100 of in 1990 version of the Pharmacopoeia of the People's Republic of China); Radix Ginseng (Panax ginseng C.A.Mey) property is flat, and sweet in the mouth, little hardship can strongly invigorating primordial QI, promote the production of body fluid, calm the nerves, and can control (seeing P4 of in 1990 version of the Pharmacopoeia of the People's Republic of China) such as weak body and prostration, insufficiency of the spleen lack of appetite, palpitation with fear insomnias; (Ligustrum lucidum Ait) is cool in nature for Fructus Ligustri Lucidi, and sweet in the mouth, hardship can nourishing the liver and kidney, make eye bright, and can control vertigo and tinnitus, poor vision (seeing P33 of in 1990 version of the Pharmacopoeia of the People's Republic of China); (Ligusticum chuanxiong Hort) is warm in nature for Rhizoma Chuanxiong, and acrid in the mouth can blood-activating and qi-promoting, (seeing P28 of in 1990 version of the Pharmacopoeia of the People's Republic of China) dispels the wind etc.; (Cristaria plicata (Leach)) is cold in nature for Margarita, sweet in the mouth, salty, and the arresting convulsion of calming the nerves, (seeing P199 of in 1990 version of the Pharmacopoeia of the People's Republic of China) makes eye bright etc.This shows that each component in this Chinese medicine preparation has nourishing the liver and kidney, function such as make eye bright, add that the monarch and his subjects' compatibility of each component is reasonable, its comprehensive function variously has very significant curative effect with diseases to treating.The present invention treats the Chinese medicine preparation eye ointment of eye disease of amblyopia, once successfully cured many patients in Urumqi City dimension vision eyes rehabilitation center, wherein typical case has: (1) Wu Xiaoxia, the woman, 12 years old, attending school's senior class (3) class in the Urumqi City 78, is amblyopia after testing, and eyes naked vision in the left and right sides is 0.3.This unguentum 0.5～1 gram with invention spreads upon on 13 acupuncture points of circumference of eyes, makes it Transdermal absorption by acupoint massage, and every day 1～2 time, each 10-15 minute, 24 days was a course of treatment.Through six course of therapy, the naked vision of eyes all is increased to 1.5.(2) Zhao Zhuxing morning, the man, 8 years old, attend Urumqi City 79 primary school's second grades (2) class, be amblyopia after testing, eyes naked vision in the left and right sides is 0.5, treat four courses of treatment with unguentum of the present invention after, right vision is increased to 1.2, left vision is increased to 1.0.(3) Li Xiaoyan, the woman 7 years old, attends (1) class in 84 primary schools, Urumqi City, be amblyopia after testing, the naked vision of right eye is 0.6, and the naked vision of left eye is 0.8, with after unguentum of the present invention treatment three courses of treatment, right vision is increased to 1.2, and left side limit vision is increased to 1.5.(4) Bu Tianze, the man, 7 years old, attend in the Urumqi City 78 (1) class of school, be amblyopia after testing, eyes naked vision in the left and right sides is 0.6, treat six courses of treatment with unguentum of the present invention after, the naked vision of eyes all is increased to 1.2.
Technique scheme is because the extracting solution that adopted is alcoholic acid aqueous solution, it both solubilized extract can be water-soluble in the medicine active ingredient, also solubilized is extracted the active ingredient that can be dissolved in organic solvent in the medicine.Therefore, the content height of active ingredient in the preparation, it is few to consume medical material, add that used Chinese medicine has only 9 flavors, so technology is simple, with low cost.Again since it can be made into unguentum, patch, electuary, tablet and capsule, both brought into play the advantage of China's Chinese herbal medicine, saved the trouble of decocting medicinal herbs again, its medication, carry, preserve all very convenient.
Four, the specific embodiment
The present invention is further illustrated below in conjunction with embodiment
Embodiment 1:
(1), gets Fructus Lycii 1000g, Semen Cassiae 1000g, Flos Chrysanthemi 1000g, Fructus Tribuli 3000g, Radix Rehmanniae Preparata 3000g, Radix Ginseng 3000g, Fructus Ligustri Lucidi 1200g, Rhizoma Chuanxiong 1200g place in the rustless steel extraction vessel, add concentration and be 108 kilograms of 55% ethanol waters, reflux, extract, 2 times was extracted 4 hours at every turn.
(2), 2 times extracting solution are merged, under 70 ℃ temperature, be evaporated to extractum.
(3), extractum placed under 70 ℃ the temperature dryly, be ground into the thin cream powder of 100 purposes.
(4), under sub-zero low temperature, 1000g Margarita processing powder is broken into 350 purpose micropowders.
(5), thin cream powder and micropowders are mixed into mixing fine powders.
(6), medical ventolin 1000 is put the Stainless Steel vessel, be heated to 70 ℃, it is melted fully, treat to add after temperature is reduced to 20 ℃ and mix the system fine powder, stir, make unguentum after the cooling.
Embodiment 2:
(1), gets Fructus Lycii 3000g, Semen Cassiae 3000g, Flos Chrysanthemi 3000g, Fructus Tribuli 1000g, Radix Rehmanniae Preparata 1000g, Radix Ginseng 1000g,, Fructus Ligustri Lucidi 2000g, Rhizoma Chuanxiong 2000g, place in the rustless steel extraction vessel, add concentration and be 80 kilograms of 90% ethanol waters, reflux, extract, 3 times was extracted 1.5 hours at every turn.
(2), 3 times extracting solution are merged, under 70 ℃ temperature, be evaporated to extractum.
(3), extractum placed under 70 ℃ the temperature dryly, be ground into the thin cream powder of 300 purposes.
(4), under sub-zero low temperature, 2000g Margarita processing powder is broken into 150 purpose micropowders.
(5), thin cream powder and micropowders are mixed into mixing fine powders.
(6), medical ventolin 1000 is put the Stainless Steel vessel, be heated to 90 ℃, it is melted fully, treat to add after temperature is reduced to 40 ℃ and mix the system fine powder, stir, make unguentum after the cooling.
Embodiment 3:
(1), gets Fructus Lycii 2000g, Semen Cassiae 2000g, Flos Chrysanthemi 2000g, Fructus Tribuli 2000g, Radix Rehmanniae Preparata 2000g, Radix Ginseng 2000g, Fructus Ligustri Lucidi 500g, Rhizoma Chuanxiong 500g, place in the rustless steel extraction vessel, add concentration and be 130 kilograms of 70% ethanol waters, reflux, extract, 4 times was extracted 1 hour at every turn.
(2), 4 times ethanol extracts are merged, under 40 ℃ temperature, be evaporated to extractum.
(3), extractum placed under 50 ℃ the temperature dryly, be ground into the thin cream powder of 200 purposes.
(4), under sub-zero low temperature, 3000g Margarita processing powder is broken into 250 purpose micropowders.
(5), thin cream powder and micropowders are mixed into mixing fine powders.
(6), medical ventolin 1000 is put the Stainless Steel vessel, be heated to 110 ℃, it is melted fully, treat to add after temperature is reduced to 60 ℃ and mix the system fine powder, stir, make unguentum after the cooling.
Embodiment 4:
(1), gets Fructus Lycii 2000g, Semen Cassiae 2000g, Flos Chrysanthemi 2000g, Fructus Tribuli 2000g, Radix Rehmanniae Preparata 2000g, Radix Ginseng 2000g, Fructus Ligustri Lucidi 1200g, Rhizoma Chuanxiong 1200g place in the rustless steel extraction vessel, add concentration and be 108 kilograms of 75% ethanol waters, reflux, extract, 3 times was extracted 2.5 hours at every turn.
(2), 3 times extracting solution are merged, under 70 ℃ temperature, be evaporated to extractum.
(3), extractum placed under 70 ℃ the temperature dryly, be ground into the thin cream powder of 200 purposes.
(4), under sub-zero low temperature, 1000g Margarita processing powder is broken into 300 purpose micropowders.
(5), thin cream powder and micropowders are mixed into mixing fine powders.
(6), in mixing fine powders, add different auxiliary material medically commonly used routinely, make patch, electuary, tablet or capsule.
Claims (6)
1. Chinese medicine preparation for the treatment of eye disease of amblyopia, it is characterized in that: it mainly is made up of following compositions in weight portion: Fructus Lycii 10～30, Semen Cassiae 10～30, Flos Chrysanthemi 10～30, Fructus Tribuli 10～30, Radix Rehmanniae Preparata 10～30, Margarita 10～30, Radix Ginseng 10～30, Fructus Ligustri Lucidi 5～20, Rhizoma Chuanxiong 5～20.
2. as the said a kind of Chinese medicine preparation for the treatment of eye disease of amblyopia of claim 1, it is characterized in that: the parts by weight of each component are preferably: Fructus Lycii 15～25, Semen Cassiae 15～25, Flos Chrysanthemi 15～25, Fructus Tribuli 15～25, Radix Rehmanniae Preparata 15～25, Margarita 15～25, Radix Ginseng 15～25, Fructus Ligustri Lucidi 8～15, Rhizoma Chuanxiong 8～15.
3. method with the Chinese medicine preparation of the said Chinese medicine preparation production for treating of claim 1 eye disease of amblyopia, it may further comprise the steps:
(1) with Fructus Lycii, Semen Cassiae, Flos Chrysanthemi, Fructus Tribuli, Radix Rehmanniae Preparata, Radix Ginseng, Fructus Ligustri Lucidi, Rhizoma Chuanxiong, place the solvent reflux, extract, 2～4 times, each reflux, extract, 1～4 hour;
(2) with 2～4 times extracting solution merging, concentrating under reduced pressure, drying, be ground into the thin cream powder of 100 orders～300 purposes;
(3) under sub-zero low temperature, the Margarita processing powder is broken into 150 orders～350 purpose micropowders;
(4) thin cream powder and micropowders are mixed into mixing fine powders;
(5) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule;
It is characterized in that: said solvent is that concentration is 55%～90% ethanol water, and the weight that adds solvent is 5～10 times of medical material gross weight.
4. one kind as power require the method for Chinese medicine preparation of 3 said production for treating eye disease of amblyopia, and it is characterized in that: said reflux, extract, number of times is preferably 3 times, and each extraction time is preferably 1～2 hour.
5. one kind as power require the method for Chinese medicine preparation of 3 said production for treating eye disease of amblyopia, it is characterized in that: the method for production of said unguentum is that medical ventolin is placed stainless steel ware, be heated to 70～110 ℃, it is melted fully, treat to add mixing fine powders after temperature is reduced to 20～60 ℃, stir, make unguentum after the cooling.
6. one kind as power require the method for Chinese medicine preparation of 5 said production for treating eye disease of amblyopia, and it is characterized in that: said medical ventolin is a medical ventolin 1000～2000.
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| CN106728677A (en) * | 2016-12-26 | 2017-05-31 | 刘佳 | A kind of Chinese medicine ointment of prophylactic treatment amblyopia |
| CN107773633A (en) * | 2017-12-05 | 2018-03-09 | 张小华 | Chinese medicinal liquor and its compound method and the method using Chinese medicinal liquor treatment eyes amblyopia |
| CN110613767A (en) * | 2019-09-20 | 2019-12-27 | 王亚丽 | Traditional Chinese medicine formula for treating amblyopia and application thereof |
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| CN1456296A (en) * | 2003-04-10 | 2003-11-19 | 毛友昌 | Tablets for improving vision acuity and nourishing kidney and preparation thereof |
| CN1548090A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Eyesight improving and kidney-nourishing bolus and its prepn |
| CN101129609A (en) * | 2007-08-21 | 2008-02-27 | 王军 | Chrysanthemum powder forimproving acuity of vision |
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2009
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| CN103099976A (en) * | 2013-01-11 | 2013-05-15 | 管丽丽 | Medicament patch for treating monocular asthenopia |
| CN106074899A (en) * | 2016-07-12 | 2016-11-09 | 张明科 | A kind of Chinese medicine composition treating oculopathy and preparation method thereof |
| CN106728677A (en) * | 2016-12-26 | 2017-05-31 | 刘佳 | A kind of Chinese medicine ointment of prophylactic treatment amblyopia |
| CN107773633A (en) * | 2017-12-05 | 2018-03-09 | 张小华 | Chinese medicinal liquor and its compound method and the method using Chinese medicinal liquor treatment eyes amblyopia |
| CN110613767A (en) * | 2019-09-20 | 2019-12-27 | 王亚丽 | Traditional Chinese medicine formula for treating amblyopia and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101698026B (en) | 2013-07-17 |
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