CN102784292B - Constitution consolidating and life prolonging medicinal preparation and preparation method thereof - Google Patents
Constitution consolidating and life prolonging medicinal preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a constitution consolidating and life prolonging medicinal preparation and its preparation method. The preparation comprise medicine raw materials in the following ratio: 120-180g of ginseng, 120-180g of Radix Rehmanniae Preparata, 120-180g of radix rehmanniae, 120-180g of Polygonum multiflorum, 120-180g of fructus lycii, 120-180g of radix ophiopogonis, 120-180g of Dioscorea opposite, 120-180g of radix asparagi, 30-80g of schisandra chinensis, 120-180g of bighead atractylodes rhizomes, 30-80g of radix glycyrrhizae preparata, 120-180g of red dates, 30-80g of cinnamon, 220-280g of Salvia Miltiorrhiza, and 120-180g of Semen Nelumbinis. With a reasonable formula, the medicinal preparation provided in the invention has the efficacy of nourishing yin and supplementing the kidney, strengthening the spleen and harmonizing the stomach, consolidating the constitution and dispelling diseases, as well as prolonging longevity. And the preparation method is reasonable and feasible.
Description
Technical field
The invention belongs to Chinese medicine patent medicine preparing technical field.
Background technology
Along with improving constantly of people's material, the level of cultural life, people's average life all generally extends, but still exist now the serious threat human healths such as various senile disease, affluenza, therefore consolidate get rid of illness, basic demand and hope that life lengthening has become everyone.
The medicine of many life lengthening is found and has been applied in China's medical practice of several thousand.From recent studies, these medicine prescriptions with QI invigorating, invigorating the liver and kidney, blood circulation promoting and enriching have certain effect to improving immunity of organism level, endocrine regulation and internal metabolism.Especially the medicine of the kidney invigorating and defying age relation are more close.
As what record in " medical science main story ": " kidney unit contains the longevity and prolongs, the kidney unit longevity sky that declines." illustrating that kidney vital essence is vigorous, body constitution is strong, generation that can delay senility, and deficiency of kidney-QI will cause people's the presenility of crossing.Traditional Chinese medical science the kidney invigorating medicine generally comprises YIN nourishing, warming YANG, supports the aspects such as essence, QI invigorating.
Conventional antiaging agent has: Radix Ginseng, Ganoderma, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori, Fructus Lycii etc.This class medicine is mostly kidney-reinforcing drug, has reinforcement nervous function, improve physiological aging phenomenon (such as: promote memory, improve being quick on the draw property, improve sleep, make energetic etc.); Enhancing human body immunity function and reactivity, reduce old common disease as the generation of coronary heart disease, hypertension, arteriosclerosis apoplexy, tumor, chronic tracheitis etc.; And have the organism metabolism of promotion function, enliven the effect of vitality.For example, Radix Ginseng is the strengthening by means of tonics treasure that has won fame both at home and abroad, is world known.Its main component is ginsenoside, vitamin, inorganic salt, choline etc.Regarded as QI invigorating key medicine by motherland's medical science since ancient times, resist aging, effect that clothes are made light of one's life by commiting suicide and prolonged life for a long time.Although the domestic medicine that has more slow down aging, can not meet the requirement of society far away at present.
Summary of the invention
First object of the present invention is to provide a kind of pharmaceutical preparation of prolonging life that consolidates, and rationally, therapeutical effect is good for this kind of pharmaceutical preparation formula.
The present invention realizes the technical scheme that first goal of the invention adopts: a kind ofly consolidate the pharmaceutical preparation of prolonging life, the composition of its medicine material and proportioning are: Radix Ginseng 120-180g, Radix Rehmanniae Preparata 120-180g, Radix Rehmanniae 120-180g, Radix Polygoni Multiflori 120-180g, Fructus Lycii 120-180g, Radix Ophiopogonis 120-180g, Rhizoma Dioscoreae 120-180g, Radix Asparagi 120-180g, Fructus Schisandrae Chinensis 30-80g, Rhizoma Atractylodis Macrocephalae 120-180g, Radix Glycyrrhizae Preparata 30-80g, Fructus Jujubae 120-180g, Cortex Cinnamomi 30-80g, Radix Salviae Miltiorrhizae 220-280g, Semen Nelumbinis 120-180g.
The optimum ratio of above-mentioned medicine material is: Radix Ginseng 150g, Radix Rehmanniae Preparata 150g, Radix Rehmanniae 150g, Radix Polygoni Multiflori 150g, Fructus Lycii 150g, Radix Ophiopogonis 150g, Rhizoma Dioscoreae 150g, Radix Asparagi 150g, Fructus Schisandrae Chinensis 50g, Rhizoma Atractylodis Macrocephalae 150g, Radix Glycyrrhizae Preparata 50g, Fructus Jujubae 150g, Cortex Cinnamomi 50g, Radix Salviae Miltiorrhizae 250g, Semen Nelumbinis 150g.
Compared with prior art, the invention has the beneficial effects as follows:
Medicine of the present invention is take Radix Ginseng, Radix Rehmanniae Preparata, Radix Polygoni Multiflori as monarch drug.The sweet temperature of Radix Ginseng, enters spleen, lung two warps, large spleen reinforcing lung vigour." book on Chinese herbal medicine is newly organized " said: Radix Ginseng, and sweet in the mouth, temperature, is slightly cold, and abnormal smells from the patient is all light, can rise and can fall, and has the moon in sun, nontoxic, is the panacea of QI invigorating." medical science main story " said: Radix Rehmanniae Preparata, fill out bone marrow, and swollen muscle, promoting generation of vital essence and blood, tonifying five ZANG-organs internal injury deficiency, promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, female woman damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments.Essentials of Matea Medica is said: Radix Polygoni Multiflori, flat invigorating the liver and kidney, arresting seminal emission.Bitter hard kidney, temperature compensation liver, sweet beneficial blood, puckery convergence vital essence.Sperm adding and marrow healthing, nourishing blood to expel wind, controls wind and first controls blood, and blood is lived, and wind is loose.Bone and muscle strengthening, black moustache is sent out, the therefore named Radix Polygoni Multiflori.Having made us son, is tonic medicine.QI and blood Taihe county, the thin wind void of labor, metrorrhagia and leukorrhagia skin ulcer hemorrhoid, all diseases of scrofula carbuncle oneself.Old friend joins benefit the foundation of acquired constitution taste, and Radix Rehmanniae Preparata, Radix Polygoni Multiflori are mended the congenital foundation kidney and be monarch drug.
Take Fructus Lycii, Radix Ophiopogonis, Radix Asparagi, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Semen Nelumbinis as ministerial drug." Records of Tradition Chinese and Western Medicine in Combination " meaning Fructus Lycii, the many liquid of sweet in the mouth, slightly cool in nature.For the best medicine of nourishing the liver and kidney, thus the kind improving eyesight of its property, reducing the asthenic fever, strengthening bone and muscle, except pain in the lumbar region, take for a long time useful, this all nourishing the liver and kidney merit also.Radix Ophiopogonis, Radix Asparagi are sweet cold clear and rich medicine, Compendium of Material Medica and " simple and easy side " cloud: Radix Rehmanniae energy promoting generation of vital essence and blood, Radix Asparagi is introduced the part of giving birth to.Radix Rehmanniae Preparata energy replenishing vital essence and blood, introduces the part of mending Radix Ophiopogonis.Essentials of Matea Medica is said: Fructus Schisandrae Chinensis, tonifying the lung kidney, arresting seminal emission gas.Warm in nature, the five tastes are had, and skin is sweet, carnic acid, and toil in core, has saline taste.Acid is salty is many.The kidney nourishing water therefore specially restrain lung qi, gas is Jellyfish.Through saying: lung wish is received, anxious food sour flavor having the property of astringing.Good Gu is said: the lunar blood system of hands, the few cloudy edema caused by disorder of QI of foot.The raw Feng of QI invigorating, lung governing qi, holds back therefore energy is beneficial, and QI invigorating is therefore can give birth to Feng.Tonify deficiency improving eyesight, reinforcing YIN-essence arresting seminal emission, Zhong Jing eight taste balls, the kidney invigorating in addition, lid kernel is like kidney, the justice of pictograph.So four medicines are worked in coordination with effect of Radix Rehmanniae Preparata, Radix Polygoni Multiflori reinforcement tonification the congenital foundation kidney." book on Chinese herbal medicine is high former " said: Rhizoma Dioscoreae abnormal smells from the patient is sweet flat, begins the Central Mountain, obtains the specially essence of middle soil, is the medicine of mending lunar spleen soil, therefore the merit curing mainly is all at middle soil.Jing-Yue Complete Works is said: the Rhizoma Atractylodis Macrocephalae, and sweet in the mouth is pungent, temperature, abnormal smells from the patient is all thick, can rise and can fall, and has the moon in sun, has blood in gas.It is warm in nature dry, thus can QI invigorating and in, YANG invigorating hemopoietic, warming the stomach rapid digestion of food, beneficial Feng liquid, longue meat, helps spirit, tonifying the spleen stomach, preventing or arresting vomiting is contrary, mends overstrain, enters diet, Li little Shui, dehumidifying fortune expectorant, disappears and floatingly goes swollenly, controls trusted subordinate's cold type of pain, insufficiency of stomach dysentery, Xuan addiction mass in the abdomen." book on Chinese herbal medicine is looked for the truth " said: Fructus Jujubae, QI and blood in tonifying the spleen and stomach.Fructus Jujubae specially enters spleen, stomach.Sweet in the mouth temperature, red complexion meat profit, is tonifying the spleen and stomach key medicine.Through saying: inner not enough person, with sweet benefit it, weakened configuration person, warming with drugs of thick nature.The invigorating middle warmer of the sweet energy of Fructus Jujubae, temperature energy QI invigorating, taste were both mended, and the twelve regular channels is certainly logical, nine orifices profit, nine orifices: mouth, ear, nose, order, front and back two the moon.Extremity and also.Healthy energy foot is god's peace certainly." property of medicine solution " said: Semen Nelumbinis, and master clears away heart-fire and is amusing, and invigorating middle warmer is reposed, and enters diet, and antidiarrheal dysentery is prohibited and is let out essence, except lumbago, takes for a long time normal hearing and eyesight.Therefore the collaborative Radix Ginseng of four medicines is strengthened its effect of mending the foundation of acquired constitution taste greatly.
Take Radix Salviae Miltiorrhizae, Cortex Cinnamomi, Radix Rehmanniae as adjuvant drug.Radix Salviae Miltiorrhizae bitter in the mouth, cold nature.GUIXIN, pericardium, Liver Channel.Effect stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, nourishing blood to tranquillize the mind.According to modern pharmacological research: the water solublity in Radix Salviae Miltiorrhizae and liposoluble constituent contain multiple pharmacological component, clinical observation and zoopery all prove that it has extensively and complicated pharmacological action, and Radix Salviae Miltiorrhizae has the effects such as the anti-hepatocyte injury of the ischemical reperfusion injury of improvement, immunomodulating, infection and obvious antitumor.To be that first engaging of all medicines is logical make Shennong's Herbal meaning Cortex Cinnamomi, internal organs muscles and bones in the gas that lid is altered because of its perfume (or spice), outer and meridians space between skin and muscles, swiftly between there's no one who doesn't or isn't all round, therefore the not penetrating soothing the liver of all medicines place has Cortex Cinnamomi to draw it, there's no one who doesn't or isn't thoroughly reach also.Therefore Cortex Cinnamomi and Radix Salviae Miltiorrhizae compatibility add effect that the Radix Ginseng of strongly invigorating primordial QI in we can greatly be strengthened blood circulation promoting and blood stasis dispelling and dredge muscle arteries and veins, the strong blood supply that improves heart and periphery blood supply, make body obtain sufficient nutrition supply.Radix Rehmanniae clearing away heat and cooling blood, the raw Feng of yin nourishing eliminate the scorching of Radix Rehmanniae Preparata YIN nourishing generation and grow the greasy fraud that hinders stomach, make Radix Rehmanniae Preparata give full play to effect of the kidney invigorating essence.
" herbal lease making " meaning Radix Glycyrrhizae Preparata, sweet in the mouth.Current 12 warps, separate hundred poison of drug.Raw use gas is flat, tonifying the spleen and stomach, eliminating heart-fire and raw lung gold.Process with temperature, mend three warmers vigour, and loose exterior cold.Enter tonification of mediating recipe; Enter expelling pathogenic factors from muscles of diaphoretic; Entering cool dose purges heat; Enter high dose of emergency; Entering to moisten agent nourishes blood.Can make it out of question by all medicines of consonance.Therefore for making medicine.
In a word, pharmaceutical preparation of the present invention has three large advantages: 1, tonification the foundation of acquired constitution " taste "; 2, tonification the congenital foundation " kidney "; 3, blood circulation promoting and blood stasis dispelling, improves blood supply.This three large effect meets the cause of disease (deficiency of kidney-QI, weakness of the spleen and stomach, stagnation of blood stasis) of the traditional Chinese medical science about human senility, therefore, has correct theoretical foundation.And our ingredients closes the symbol traditional Chinese medical science " water generating wood, wood generating fire, fire generating earth, earth generating metal, metal generating water " generation-inhibition in five elements inhibition and generation theory.We are by " spring wine to congradulate one's birthday " two side's addition or subtraction of changes of " Longevity and Life Preservation " " long-living tonic wine " and " health preserving four is wanted ", therefore there is ancient books and records foundation.We's effect: nourishing YIN to benefit the heart, strengthening the spleen stomach function regulating, the will of calming the nerves, black beard and hair, life lengthening.Be suitable for hepatic and renal YIN deficiency, deficiency of heart-blood, the lethargy that weakness of the spleen and stomach shows, Light-headedness or distending pain, blurring of vision, cardiopalmus severe palpitation, forgetful, insomnia and dreamful sleep, inappetence, tastelessness, hectic fever night sweat, the diseases such as constipation, early whitening of beard and hair of quenching one's thirst.
Second object of the present invention is to provide a kind of method that consolidates the pharmaceutical preparation of prolonging life of preparing, and the method craft science is reasonable, can better retain effective ingredient, the pharmaceutical preparation taking convenience making.
The present invention realizes the technical scheme that its second goal of the invention adopt: a kind of method that consolidates the pharmaceutical preparation of prolonging life of preparing, the steps include:
A, the Radix Ginseng of described proportioning, Rhizoma Dioscoreae powder are broken into fine powder, cross 80-120 mesh sieve, mix;
B, the Radix Rehmanniae of getting described proportioning, Fructus Lycii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae five kinds of Chinese medicine, make solvent with the alcoholic solution that 4-8 times of quality, mass percent are 40-80%, percolation, and decompression recycling ethanol, collects percolate, and is concentrated into clear paste;
C, the Radix Rehmanniae Preparata of getting described proportioning, Radix Polygoni Multiflori, Radix Ophiopogonis, Radix Asparagi, Fructus Jujubae, Cortex Cinnamomi, Radix Glycyrrhizae Preparata seven flavor medicine, the decocting that adds 6-8 times of quality boils 1-3 time, each 1-2 hour, collecting decoction, filters, and filtrate is concentrated into clear paste;
D, the clear paste that step B and step C are obtained merge, and are concentrated into thick paste;
E, the fine powder of steps A gained is added in the thick paste of step D gained, mix, carry out preparation, to obtain final product.
Above method fully takes into account the chemical property of each flavour of a drug, at utmost extracts and retains various middle the effective elements of the medicines, and making it well mutually warm, promotes mutually its good effect; And make modern medicines dosage form, taking convenience.
Following experiment showed, that Radix Ginseng of the present invention, Rhizoma Dioscoreae preparation method are stable, feasible, and be convenient to merge with other drug composition:
Radix Ginseng, Rhizoma Dioscoreae powder are broken into fine powder, cross 100 mesh sieves, mix, for subsequent use, pulverize flour extraction investigation and see the following form.
Medical material flour extraction is investigated
Conclusion: the average flour extraction of medical material is 95.3%, relative standard deviation (RSD) is 1.39%, shows that its technique is reasonable, stable.
Following zoopery proves, medicine of the present invention has that good consolidating gets rid of illness, effect of life lengthening:
(1) impact on D-galactose institute Aging mice serum superoxide dismutases (SOD), malonaldehyde (MDA) content
Get 60 of Kunming mouses, male and female half and half, body weight 18～22g, adaptability is raised three days, the full-valence pellet feed of freely ingesting, 18～25 ℃ of temperature.Be divided at random 6 groups, 10 every group, be respectively blank group, model group, positive drug (vitamin E) group, the high, medium and low dosage group of optimizing prescriptions concentrated pill aqueous solution.
1. the high, medium and low dosage group of this product concentrated pill aqueous solution: every group of back subcutaneous injection D-galactose 1mg/g, gavage concentrated pill aqueous solution simultaneously, dosage is respectively 2.4g/kg, 1.2g/kg and 0.6g/kg; 2. model group: every day back subcutaneous injection D-galactose 1mg/g, the simultaneously isodose normal saline of gavage; 3. blank group: every day back subcutaneous injection respective amount normal saline and the distilled water of gavage respective volume; 4. positive controls: every day back subcutaneous injection D-galactose 1mg/g, simultaneously gavage vitamin E 0.1g/kg.
After administration 1h, extractd eyeball in the 40th day, get blood, blood sample adopts conventional centrifugal, gets wherein superoxide dismutase (SOD), malonaldehyde (MDA) of determination of serum, and assay method all operates by test kit description.The results are shown in following table.
Subacute aging SOD in Mice on D-galactose induction, the impact of MDA (x ± s)
As can be seen here, this product senior middle school low dose group all can improve SOD activity, reduces MDA content, shows that the party can enhancing body endogenous defying age material activity, thereby suppresses the infringement of radical pair cell and bring into play its antidotal effect.
(2) D-galactose is caused to the impact of aging rats serum levels of nitric oxide (NO), nitric oxide synthetase (NOS) content
Get 48 of Wistar rats, male and female half and half, are divided into Normal group, model control group, vitamin E group, the high, medium and low dosage group of optimizing prescriptions concentrated pill aqueous solution at random.Every group 8, adaptability is raised modeling after 1 week.
Adopt D-galactose to cause subacute aging method, D-galactose 5000mg is dissolved in 500mL normal saline, give rats by intraperitoneal injection by injected dose 100mg/kgd (being 0.01mL/g body weight), blank group injection equal-volume normal saline, the modeling time is 8 weeks, weigh weekly 1 time, the body weight of weighing according to last is adjusted dosage.
After modeling success, each treatment group is since gastric infusion respectively in the 9th week morning every day, and blank group and model group are given isopyknic normal saline, every day 1 time.Weigh weekly 1 time, adjust dosage according to rat last body weight.Administration time 10 weeks.After last administration, respectively organize rat and extract eyeball, blood sampling, blood sample, with the centrifugal 10min of 4000r/min, is got supernatant 0.1mL and 0.03mL, operates by test kit description.The results are shown in following table.
D-galactose is caused to the impact of aging rats serum NO level, NOS content
As can be seen here, this product senior middle school low dose group all can reduce in various degree D-galactose and cause aging rats Serum Nitric Oxide (NO), nitric oxide synthetase (NOS) content, points out this product to produce anti-aging effects by suppressing increasing of NO, NOS.
The fine powder of above-mentioned steps A is by the fine powder of 100 mesh sieves; The clear paste that when clear paste of described step B is 55 ℃, relative density is 1.20～1.25; The clear paste that when clear paste of described step C is 55 ℃, relative density is 1.20～1.25; The thick paste that when thick paste of described step D is 55 ℃, relative density is 1.35～1.40.
The dosage form that in above-mentioned steps E, preparation obtains is: pill, granule, soft extract preparation.
In above-mentioned step e, the fine powder of steps A gained is added in the thick paste of step D gained, mix, the specific practice of carrying out preparation is: fine powder, thick paste are mixed to pill, 25 ℃ of dry 36h, then 50 ℃ of dry 36h, then 60 ℃ of dry 12h, polishing, makes 1000g, obtains pill.
Pill is all or part of concentrated through extracting, and volume-diminished, is easy to take and absorb, performance good drug efficacy; Be beneficial to preservation simultaneously, be difficult for going mouldy.
Dissolve scattered time limit is the critical problem that concentrated pill (pill) will be noted, itself and drying means are closely related.Different drying meanss, leaches extremely importantly to product, now investigate with following drying means, the results are shown in following table.
Concentrated pill drying means is investigated
* remarks: " Chinese Pharmacopoeia " 2010 editions regulation concentrated pills should all leach in 2 hours.
As seen from the above table: although that method one leaches the time is qualified, drying time is longer, the easy microbiological contamination of pill, and waste energy, improper; Although the method two used time is shorter, temperature is higher, and in preparation, volatile ingredient easily loses, and it is defective to leach the time; Method three records product, and to leach the time be 60 minutes, and drying time is short, meets the regulation under pharmacopeia concentrated pill item, is therefore optimum selection.
The specific embodiment
Embodiment mono-:
A kind of specific embodiment of the present invention is, a kind ofly consolidates the pharmaceutical preparation of prolonging life, and the composition of its medicine material and proportioning are: Radix Ginseng 150g, Radix Rehmanniae Preparata 150g, Radix Rehmanniae 150g, Radix Polygoni Multiflori 150g, Fructus Lycii 150g, Radix Ophiopogonis 150g, Rhizoma Dioscoreae 150g, Radix Asparagi 150g, Fructus Schisandrae Chinensis 50g, Rhizoma Atractylodis Macrocephalae 150g, Radix Glycyrrhizae Preparata 50g, Fructus Jujubae 150g, Cortex Cinnamomi 50g, Radix Salviae Miltiorrhizae 250g, Semen Nelumbinis 150g.
The method that consolidates the pharmaceutical preparation of prolonging life that preparation is described, its concrete steps are:
A, the Radix Ginseng of described proportioning, Rhizoma Dioscoreae powder are broken into fine powder, cross 100 mesh sieves, mix;
B, the Radix Rehmanniae of getting described proportioning, Fructus Lycii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae five kinds of Chinese medicine, be that 60% alcoholic solution is made solvent by 6 times of quality, mass percent, percolation, decompression recycling ethanol, collect percolate, and the clear paste that relative density is 1.25 while being concentrated into 55 ℃;
C, the Radix Rehmanniae Preparata of getting described proportioning, Radix Polygoni Multiflori, Radix Ophiopogonis, Radix Asparagi, Fructus Jujubae, Cortex Cinnamomi, Radix Glycyrrhizae Preparata seven flavor medicine, the decocting that adds 7 times of quality boils 2 times, and each 1.5 hours, collecting decoction, filtered the clear paste that when filtrate is concentrated into 55 ℃, relative density is 1.25;
D, the clear paste that step B and step C are obtained merge, the thick paste that while being concentrated into 55 ℃, relative density is 1.40;
E, the fine powder of steps A gained is added in the thick paste of step D gained, mix, pill, 25 ℃ of dry 36h, then 50 ℃ of dry 36h, then 60 ℃ of dry 12h, polishing, obtains pill.
Instructions of taking is: oral.8 balls, 3 times on the one.
Embodiment bis-:
A kind of specific embodiment of the present invention is, a kind ofly consolidates the pharmaceutical preparation of prolonging life, and the composition of its medicine material and proportioning are: claim standby Radix Ginseng 120g, Radix Rehmanniae Preparata 120g, Radix Rehmanniae 120g, Radix Polygoni Multiflori 120g, Fructus Lycii 120g, Radix Ophiopogonis 120g, Rhizoma Dioscoreae 120g, Radix Asparagi 120g, Fructus Schisandrae Chinensis 30g, Rhizoma Atractylodis Macrocephalae 120g, Radix Glycyrrhizae Preparata 30g, Fructus Jujubae 120g, Cortex Cinnamomi 30g, Radix Salviae Miltiorrhizae 220g, Semen Nelumbinis 120g.
The method that consolidates the pharmaceutical preparation of prolonging life that preparation is described, its concrete steps are:
A, the Radix Ginseng of described proportioning, Rhizoma Dioscoreae powder are broken into fine powder, cross 80 mesh sieves, mix;
B, the Radix Rehmanniae of getting described proportioning, Fructus Lycii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae five kinds of Chinese medicine, be that 40% alcoholic solution is made solvent by 4 times of quality, mass percent, percolation, decompression recycling ethanol, collect percolate, and the clear paste that relative density is 1.24 while being concentrated into 55 ℃;
C, the Radix Rehmanniae Preparata of getting described proportioning, Radix Polygoni Multiflori, Radix Ophiopogonis, Radix Asparagi, Fructus Jujubae, Cortex Cinnamomi, Radix Glycyrrhizae Preparata seven flavor medicine, the decocting that adds 6 times of quality boils 1 time, and each 1 hour, collecting decoction, filtered the clear paste that when filtrate is concentrated into 55 ℃, relative density is 1.23;
D, the clear paste that step B and step C are obtained merge, the thick paste that while being concentrated into 55 ℃, relative density is 1.38;
E, the fine powder of steps A gained is added in the thick paste of step D gained, mix, obtain granule according to the preparation process preparation of granule.
Embodiment tri-:
A kind of specific embodiment of the present invention is, a kind ofly consolidates the pharmaceutical preparation of prolonging life, and the composition of its medicine material and proportioning are: claim standby Radix Ginseng 180g, Radix Rehmanniae Preparata 180g, Radix Rehmanniae 180g, Radix Polygoni Multiflori 180g, Fructus Lycii 180g, Radix Ophiopogonis 180g, Rhizoma Dioscoreae 180g, Radix Asparagi 180g, Fructus Schisandrae Chinensis 80g, Rhizoma Atractylodis Macrocephalae 180g, Radix Glycyrrhizae Preparata 80g, Fructus Jujubae 180g, Cortex Cinnamomi 80g, Radix Salviae Miltiorrhizae 280g, Semen Nelumbinis 180g.
The method that consolidates the pharmaceutical preparation of prolonging life that preparation is described, its concrete steps are:
A, the Radix Ginseng of described proportioning, Rhizoma Dioscoreae powder are broken into fine powder, cross 120 mesh sieves, mix;
B, the Radix Rehmanniae of getting described proportioning, Fructus Lycii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae five kinds of Chinese medicine, be that 80% alcoholic solution is made solvent by 8 times of quality, mass percent, percolation, decompression recycling ethanol, collect percolate, and the clear paste that relative density is 1.20 while being concentrated into 55 ℃;
C, the Radix Rehmanniae Preparata of getting described proportioning, Radix Polygoni Multiflori, Radix Ophiopogonis, Radix Asparagi, Fructus Jujubae, Cortex Cinnamomi, Radix Glycyrrhizae Preparata seven flavor medicine, the decocting that adds 8 times of quality boils 3 times, and each 2 hours, collecting decoction, filtered the clear paste that when filtrate is concentrated into 55 ℃, relative density is 1.20;
D, the clear paste that step B and step C are obtained merge, the thick paste that while being concentrated into 55 ℃, relative density is 1.35;
E, the fine powder of steps A gained is added in the thick paste of step D gained, mix, obtain soft extract according to the preparation process preparation of soft extract.
Claims (2)
1. one kind consolidates the pharmaceutical preparation of prolonging life, the composition of its medicine material and proportioning are: Radix Ginseng 120-180g, Radix Rehmanniae Preparata 120-180g, Radix Rehmanniae 120-180g, Radix Polygoni Multiflori 120-180g, Fructus Lycii 120-180g, Radix Ophiopogonis 120-180g, Rhizoma Dioscoreae 120-180g, Radix Asparagi 120-180g, Fructus Schisandrae Chinensis 30-80g, Rhizoma Atractylodis Macrocephalae 120-180g, Radix Glycyrrhizae Preparata 30-80g, Fructus Jujubae 120-180g, Cortex Cinnamomi 30-80g, Radix Salviae Miltiorrhizae 220-280g, Semen Nelumbinis 120-180g.
2. a kind of pharmaceutical preparation of prolonging life that consolidates according to claim 1, is characterized in that, the proportioning of described medicine material is: Radix Ginseng 150g, Radix Rehmanniae Preparata 150g, Radix Rehmanniae 150g, Radix Polygoni Multiflori 150g, Fructus Lycii 150g, Radix Ophiopogonis 150g, Rhizoma Dioscoreae 150g, Radix Asparagi 150g, Fructus Schisandrae Chinensis 50g, Rhizoma Atractylodis Macrocephalae 150g, Radix Glycyrrhizae Preparata 50g, Fructus Jujubae 150g, Cortex Cinnamomi 50g, Radix Salviae Miltiorrhizae 250g, Semen Nelumbinis 150g.
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| CN103599509B (en) * | 2013-11-19 | 2015-06-17 | 安徽宝芝堂药业有限公司 | Traditional Chinese medicine composition for treating typhoid floating Yang |
| CN107343902A (en) * | 2017-06-26 | 2017-11-14 | 无限极（中国）有限公司 | It is a kind of that there is herbal composite for alleviating hypothyroidism effect and preparation method and application |
| CN115887573B (en) * | 2022-12-07 | 2024-06-11 | 湖南中医药大学 | Traditional Chinese medicine composition for slowing down aging and improving brain function degradation and preparation method |
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| 刘汴生等.探寻从古到今的抗衰老之法.《家庭医药》.2006,(第9期),第6-9页. |
| 延缓衰老复方用药规律的研究;覃骊兰等;《吉林中医药》;20110831;第31卷(第8期);第803-805页 * |
| 探寻从古到今的抗衰老之法;刘汴生等;《家庭医药》;20061231(第9期);第6-9页 * |
| 覃骊兰等.延缓衰老复方用药规律的研究.《吉林中医药》.2011,第31卷(第8期),第803-805页. |
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