CN1456296A - Tablets for improving vision acuity and nourishing kidney and preparation thereof - Google Patents
Tablets for improving vision acuity and nourishing kidney and preparation thereof Download PDFInfo
- Publication number
- CN1456296A CN1456296A CN 03118933 CN03118933A CN1456296A CN 1456296 A CN1456296 A CN 1456296A CN 03118933 CN03118933 CN 03118933 CN 03118933 A CN03118933 A CN 03118933A CN 1456296 A CN1456296 A CN 1456296A
- Authority
- CN
- China
- Prior art keywords
- time
- technology
- decocting
- dose
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A process for preparing Chinese medicine "Mingmu-Zishen particles" for treating deficiency of liver-Yin and Kidney-Yin, dizziness, tinnitus and sore lumbus and knee and clearing vision includes such steps as extracting raw Chinese-medicinal materials in alcohol, steaming, concentrating and preparing particles. Its advantage is high curative effect and safety.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medical granule, relates in particular to make eye bright nourishing kidney granule and preparation method.
Background technology
Granule according to the relevant drug act of China, changes dosage form as a kind of new drug research for dosage form commonly used, and the former dosage form nourishing kidney sheet that makes eye bright has been listed country of National Drug Administration standard for traditional Chinese medicines compilation terrestrial reference in and risen in the GB tentative standard.The technology features of this dosage form is that three flavors such as Radix Rehmanniae decoct with water in the prescription, is condensed into clear paste; The lixiviate of Flos Chrysanthemi hot water is condensed into clear paste; Fructus Lycii 60% ethanol percolate extraction gets clear paste, and Fructus Ligustri Lucidi is beaten powder and above-mentioned three kinds of clear paste and sucrose mixing, granulates, and tabletting, sugar coating are promptly.This medicine Fructus Lycii adopts 60% ethanol extraction, and effective ingredient such as polysaccharide are difficult to propose, and secondly, this medicine is a coated tablet, coating is loaded down with trivial details, prolonged disintegration, and this medicine dose is big, one time 6, dysphagia, aged debility person especially, simultaneously, its quality standard still can further improve.Based on this, we use the modern pharmaceutical technology this product technology are necessarily improved, and form new preparation, and the standard that comprehensively improves the quality, and guarantee the quality monitoring of product, to improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide make eye bright nourishing kidney granule and preparation method, improve the quality and the curative effect of product, enrich medicine variety, satisfy better and guarantee people medication demand.
The object of the present invention is achieved like this
1, the particulate prescription of nourishing kidney that makes eye bright is formed
Radix Rehmanniae 300～900g Fructus Ligustri Lucidi 450～1350g Fructus Lycii 600～1800g
Flos Chrysanthemi 300～900g Semen Cassiae 300～900g Radix Achyranthis Bidentatae 150～450g
Right amount of auxiliary materials is made 1000 bags altogether
The base optimum formula is:
Radix Rehmanniae 600g Fructus Ligustri Lucidi 900g Fructus Lycii 1200g
Flos Chrysanthemi 600g Semen Cassiae 600g Radix Achyranthis Bidentatae 300g
Right amount of auxiliary materials is made 1000 bags altogether
2, the nourishing kidney granule preparing process that makes eye bright
Technology one, will write out a prescription in the Six-element medicine be up to the standards standby respectively; Get Radix Rehmanniae, Radix Achyranthis Bidentatae, Semen Cassiae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.28 (60 ℃); Flos Chrysanthemi soaks secondary with hot water, and 1.5 hours for the first time, 1 hour for the second time, merge immersion, filter, filtrate is concentrated into the clear paste that relative density is 1.28 (60 ℃); Fructus Lycii carries out percolation with 60% ethanol as solvent, and percolate is decompressed to the clear paste that relative density is 1.28 (60 ℃); Other gets Fructus Ligustri Lucidi powder and is broken into fine powder, adds above-mentioned three kinds of clear paste mixings, and drying is pulverized, with appropriate amount of auxiliary materials, mixing, granulate, and drying, granulate, packing, promptly.
Technology two, will write out a prescription in the Six-element medicine inspection test qualified standby; Fructus Lycii, Fructus Ligustri Lucidi extract secondary with 75% alcohol heating reflux, and the 1.5th hour, extracting solution filtered, and reclaimed ethanol, are concentrated into an amount of; Medicinal residues are standby; Radix Rehmanniae, Radix Achyranthis Bidentatae, Semen Cassiae decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, above-mentioned medicinal residues add when frying in shallow oil for the second time with frying in shallow oil, and decocting liquid filters, and are concentrated to an amount of, merge with above-mentioned alcohol extract, concentrate drying is made dried cream powder, adds the appropriate amount of auxiliary materials mixing, granulates, dry, granulate, packing, promptly.
Technology three, will write out a prescription in the Six-element medicine be up to the standards standby respectively; The prescription Chinese crude drug is ground into coarse powder, extracts 2 times with 75% alcohol heating reflux, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, be concentrated in right amount, medicinal residues decoct with water 2 times, each 1 hour, collecting decoction filtered, filtrate is concentrated in right amount, merges with above-mentioned alcohol extract, and concentrate drying is made dried cream powder, add the appropriate amount of auxiliary materials mixing, granulate drying, granulate, packing, promptly.
3, by technology one, two, three make for granule
Added adjuvant can be in the technology: 30 POVIDONE K 30 BP/USP
30, any or multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
The condition that decocting boils in the technology is: decoct 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, and second and third time doubly measured for the 4-10 of dose, and decocting time is 1-3 hour.Decocting the bests such as Radix Rehmanniae are: decoct 2 times, amount of water is 10 times of amounts of dose for the first time, is 8 times of amounts of dose for the second time, 2 hours for the first time, and 1.5 hours for the second time; Add during decocting such as Fructus Lycii boils and can fry in shallow oil the second time of Radix Rehmanniae etc. in the technology two and decoct together, it is best for decocting 2 times that the medicinal residues decocting after technology three alcohol extractions boils, and amount of water is 8 times of amounts, each 1 hour of time.
Adopt the ethanol extraction of 40-95% can adopt percolation or heating reflux method in the technology, the best is 60% ethanol percolate extraction in the technology one; The best is with 75% alcohol reflux in the technology three.
Technology ZHONGJUHUA hot water extracting condition is: extract 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, and second and third time doubly measured time 1-3 hour for the 4-10 of dose.Best amount of water is 10 times of amounts of dose for the first time in order to extract 2 times, is 8 times of amounts of dose for the second time, 1.5 hours for the first time, and 1 hour for the second time.
4, the particulate quality control standard of nourishing kidney that makes eye bright among the present invention further improves on the basis of original nourishing kidney sheet that makes eye bright, former dosage form has the thin layer of Semen Cassiae, Fructus Ligustri Lucidi, Fructus Lycii to differentiate on differentiating, now kept, and increased the thin layer of Flos Chrysanthemi has been differentiated, former dosage form does not have the limit examine of arsenic salt, heavy metal on checking, now increased heavy metal limit and must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths; Former dosage form has carried out quantitatively now being kept to Semen Cassiae on the assay, and increased to Fructus Ligustri Lucidi quantitatively.
This invention is dosage form technological innovation on the basis of existing tablet, produces easylier, and technology is more reasonable, and quality standard has new raising again, to improving the quality of products significant meaning is arranged, and has enriched medicine variety, and is satisfied and ensured people's medication demand.
The specific embodiment
The optimum implementation of this invention is that the Six-element medicine is up to the standards standby respectively in just writing out a prescription; The prescription Chinese crude drug is ground into coarse powder, extracts 2 times with 75% alcohol heating reflux, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, be concentrated in right amount, medicinal residues decoct with water 2 times, each 1 hour, collecting decoction filtered, filtrate is concentrated in right amount, merges with above-mentioned alcohol extract, and concentrate drying is made dried cream powder, add the appropriate amount of auxiliary materials mixing, granulate drying, granulate, packing, promptly.
Claims (2)
1, a kind of nourishing kidney granule and preparation method of making eye bright, its feature may further comprise the steps:
(1) Radix Rehmanniae, Radix Achyranthis Bidentatae, Semen Cassiae decocting boil in the prescription; The lixiviate of Flos Chrysanthemi hot water, Fructus Lycii 40～95% ethanol extractions; Fructus Ligustri Lucidi is beaten Radix Rehmanniae in powder/prescription, Radix Achyranthis Bidentatae, Semen Cassiae decocting and is boiled; The lixiviate of Flos Chrysanthemi hot water, Fructus Lycii, Fructus Ligustri Lucidi 40～95% ethanol extractions; Medical material is carried once/write out a prescription to medicinal residues water with 40～95% ethanol extractions, and medicinal residues decocting again extract, and add adjuvant through being prepared from the nourishing kidney granule that makes eye bright.
(2) added adjuvant can be in the technology: 30 POVIDONE K 30 BP/USP
30, any/multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
(3) condition that decocting boils in the technology is: decoct 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, second and third time doubly measured for the 4-10 of dose, decocting time is 1-3 hour, decocting the bests such as Radix Rehmanniae are: decoct 2 times, amount of water is 10 times of amounts of dose for the first time, is 8 times of amounts of dose for the second time, 2 hours for the first time, 1.5 hours for the second time; Add during decocting such as Fructus Lycii boils and can fry in shallow oil the second time of Radix Rehmanniae etc. in the technology two and decoct together, it is best for decocting 2 times that the medicinal residues decocting after technology three alcohol extractions boils, and amount of water is 8 times of amounts, each 1 hour of time.
(4) adopt the ethanol extraction of 40-95% can adopt percolation or heating reflux method in the technology, Fructus Lycii the best is 60% ethanol percolate extraction in the technology; The best such as Fructus Ligustri Lucidi is with 75% alcohol reflux in the technology.
(5) technology ZHONGJUHUA hot water extracting condition is: extract 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, second and third time doubly measured for the 4-10 of dose, time 1-3 hour, best amount of water is 10 times of amounts of dose for the first time in order to extract 2 times, is 8 times of amounts of dose for the second time, 1.5 hours for the first time, 1 hour for the second time.
2, nourishing kidney granule and the preparation method of making eye bright according to claim 1, it is characterized in that on quality control standard, having the thin layer of Flos Chrysanthemi to differentiate, have heavy metal limit must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit detection, and the detection by quantitative of Fructus Ligustri Lucidi is arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118933 CN1456296A (en) | 2003-04-10 | 2003-04-10 | Tablets for improving vision acuity and nourishing kidney and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118933 CN1456296A (en) | 2003-04-10 | 2003-04-10 | Tablets for improving vision acuity and nourishing kidney and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1456296A true CN1456296A (en) | 2003-11-19 |
Family
ID=29411431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03118933 Pending CN1456296A (en) | 2003-04-10 | 2003-04-10 | Tablets for improving vision acuity and nourishing kidney and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1456296A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698026B (en) * | 2009-06-01 | 2013-07-17 | 张红伟 | Method for producing traditional Chinese medicine formula for treating eye disease of amblyopia |
| CN105410910A (en) * | 2015-11-27 | 2016-03-23 | 黑龙江众生生物工程有限公司 | Frullania tamarisci heart clearing and eyesight improving granule and preparation method thereof |
| CN116920027A (en) * | 2023-08-31 | 2023-10-24 | 乐泰药业有限公司 | Traditional Chinese medicine composition for treating cataract caused by liver-kidney yin deficiency and qi and blood stasis, and preparation method and quality control method thereof |
-
2003
- 2003-04-10 CN CN 03118933 patent/CN1456296A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698026B (en) * | 2009-06-01 | 2013-07-17 | 张红伟 | Method for producing traditional Chinese medicine formula for treating eye disease of amblyopia |
| CN105410910A (en) * | 2015-11-27 | 2016-03-23 | 黑龙江众生生物工程有限公司 | Frullania tamarisci heart clearing and eyesight improving granule and preparation method thereof |
| CN116920027A (en) * | 2023-08-31 | 2023-10-24 | 乐泰药业有限公司 | Traditional Chinese medicine composition for treating cataract caused by liver-kidney yin deficiency and qi and blood stasis, and preparation method and quality control method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1456296A (en) | Tablets for improving vision acuity and nourishing kidney and preparation thereof | |
| CN1456268A (en) | Preparation of capsules against rhinitis | |
| CN1548090A (en) | Eyesight improving and kidney-nourishing bolus and its prepn | |
| CN1456284A (en) | Preparation of ginseng and schisandra fruit capsules | |
| CN1456289A (en) | Preparing method gynaecologic capsule for regulating menstruation | |
| CN1552364A (en) | Xuefu ecchymosis eliminating pills and their preparation | |
| CN1537575A (en) | Granule contg. Radix astragalic, donkey-hide gelatin, rattletop and others for increasing leucocyte and its prepn. method | |
| CN1456239A (en) | Preparation of nourishing yin tablets for chronic hepatitis | |
| CN1456301A (en) | Acadthopanax tablets for climacteric and preapration thereof | |
| CN1456237A (en) | Preparation of instant woman medicine | |
| CN1552365A (en) | Migraine treating pills and their preparation | |
| CN1456297A (en) | Tablet for regulating menstruation and removing spot, preparing method thereof | |
| CN1456238A (en) | Sedative tablet preparing method | |
| CN1537598A (en) | Traditional Chinese medicine Conghuang bushen granule for tonifying kidney, and its prepn. method | |
| CN1456260A (en) | Rheumatic strychnos nux-vomica preparing method | |
| CN1548091A (en) | Leukocyte-increasing Radix astragali and donkey-hide gelatin Qijiao shengbai bolus and its prepn | |
| CN1548102A (en) | Menstruation regulating and spot eliminating bolus and its prepn | |
| CN1548103A (en) | Fuyuekang bolus and its prepn | |
| CN1456298A (en) | Sugarless kidney composite medicines and preparation thereof | |
| CN1456249A (en) | Preparation of sweet dream tablets | |
| CN1552374A (en) | Maren bowel nourishing micro-pills and their preparation | |
| CN1552384A (en) | Yilingjing pills and their preparation | |
| CN1456267A (en) | Preparation of tablets against irregular manstruation | |
| CN1565496A (en) | Gynecological inflammation treating powder and its preparation | |
| CN1077433C (en) | Method for preparing Bazhen sugarless powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |