CN1077433C - Method for preparing Bazhen sugarless powder - Google Patents
Method for preparing Bazhen sugarless powder Download PDFInfo
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- CN1077433C CN1077433C CN98112016A CN98112016A CN1077433C CN 1077433 C CN1077433 C CN 1077433C CN 98112016 A CN98112016 A CN 98112016A CN 98112016 A CN98112016 A CN 98112016A CN 1077433 C CN1077433 C CN 1077433C
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Abstract
The present invention provides a preparation method for eight-treasure sugarless medicinal granules. Firstly, certain proportion of white atractylodes rhizome, angelica and hemlock parsley are processed by refluxing extraction with ethanol. Then the materials are decocted with water, and a semifinished product is obtained. Then pilose asiabell roots, tuckahoe, prepared rehmannia roots, licorice roots and radix paeoniae alba are added in the materials according to proportion. The materials are decocted with water, and an excipient is added in after the materials are filtered and concentrated. The products of eight-treasure sugarless medicinal granules are obtain after the materials are made into granules and dried. The present invention adopts an advanced reduced dynamic warm immersion technique, which ensures the maximal content of the 8 natural effective active components. The present invention has high medicine effect, doesn't comprise sugar, is suitable for diabetic patients, obesity patients, old patients and tooth decay patients to take, enlarges the using range of the original eight-treasure pills, doesn, t comprise pigment and preservative, and has convenient taking, transport and storage.
Description
The present invention relates to the preparation method of Chinese patent medicine, particularly relate to a kind of preparation method of Bazhen sugar-free granule.
Method for making of putting down in writing Bazhen Pills of " Pharmacopoeia of People's Republic of China " in 1995 version, it is with above-mentioned eight flavor medicines, is ground into fine powder, sieves mixing.Per 100 gram powder add close 40～50 grams and an amount of water of refining, general ball, and drying is made the watertight ball; Or add close 110～140 grams of refining, make big close ball, promptly.This kind Bazhen Pills contains sugar part, and Unit Weight effective active component content is low, and dose is big, stores inconvenience.
The object of the present invention is to provide a kind ofly by extracting effective ingredient, make the natural constituent that contains that its product can maximum, drug effect is high and do not contain the preparation method of the Bazhen sugar-free granule of sugar part.
The preparation method of Bazhen sugar-free granule of the present invention is that material fiting ratio example (in weight %) is Radix Codonopsis 11～14, Poria 11～14, Radix Angelicae Sinensis 17～20., Rhizoma Chuanxiong 9～10, the Rhizoma Atractylodis Macrocephalae 11～14, Radix Glycyrrhizae 6～7, the Radix Paeoniae Alba 11～143, Radix Rehmanniae Preparata 17～20, above raw material is through removing impurity, clean, section, raw material after the pre-treatments such as drying extracts again.Its processing step is as follows: 1) with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Rhizoma Chuanxiong reflux, extract, of concentration 90～98% (weight) ethanol, the temperature of reflux, extract, is 79～85 ℃, return time 4～6 hours filters, get filtrate A and filtering residue A, filtering residue reuse concentration 45～55% (weight) ethanol secondary back extracts, the reflux, extract, temperature is 79～90 ℃, return time 3～5 hours filters, and gets liquor B and medicinal residues, liquor B and filtrate A merge, vacuum decompression concentrates, and gets pure cream, and water decocts for the first time, water consumption is 3～5 times, the temperature that water decocts is 90～100 ℃, 1～2 hour time, filters, get liquor C and filtering residue C, filtering residue C water decocts for the second time, and water consumption is 3～5 times, and the temperature that water decocts is 90～100 ℃, 1～2 hour time, filter, get filtrate D and medicinal residues, filtrate D is incorporated in the liquor C, through vacuum decompression concentrate concentrated solution, twice medicinal residues merged.2) in medicinal residues, add Radix Codonopsis, Poria, Radix Rehmanniae Preparata, the Radix Glycyrrhizae and the Radix Paeoniae Alba, water decocts for the first time, and water consumption is 3～5 times of material quantity, the temperature that water decocts is 90～100 ℃, 1～2 hour time, filters, get filtrate E and filtering residue E, filtering residue E water decocts for the second time, and water consumption is 3～5, and the temperature that water decocts is 90～100 ℃, 1～2 hour time, filter, get filtrate F and filtering residue F, filtrate F and filtrate E are merged, under 60～80 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get clear paste, filter, get clear paste filtrate and filtering residue G, merge clear paste filtrate and concentrated solution, under 50～55 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get thick paste, add excipient, be soluble starch, granulate, its cooperation ratio is a thick paste: excipient=1: 1.8～2.0, under 60～80 ℃ of temperature dry 0.30～1.00 hour again, sieve through 12 orders, 40 orders do not sieve and carry out granulate, and packing gets the product Bazhen sugar-free granule.Wherein, for well, for well, the machine grain degree of clear paste is 1.12～1.15 to Radix Glycyrrhizae to the Rhizoma Atractylodis Macrocephalae with close Radix Glycyrrhizae Preparata with Rhizoma Atractylodis Macrocephalae (parched), and the relative density of thick paste is 1.32～1.34.The product Bazhen sugar-free granule meets quality index.
The advantage of the preparation method of Bazhen sugar-free granule of the present invention is to have adopted the dynamic warm macerating technology of facilitation, can more fully extract the effective ingredient in the medicine, thereby guaranteed that maximum contains a day effective ingredient with limiting the quantity of in the finished medicines, volume is little, and the drug effect height does not contain pigment and antiseptic, take, transport, store very convenient, and do not contain sugar part, be suitable for that diabetes are gone into, adiposis patient, elderly patients and eurodonticus take, and enlarged the scope of application.
Describe the embodiment of the invention below in detail.
Embodiment 1; Proportioning raw materials (through above-mentioned pre-treatment and % meter by weight)
Radix Codonopsis 119.1Kg
Poria 119.1Kg
Radix Angelicae Sinensis 183.6Kg
Rhizoma Chuanxiong 91.3Kg
Rhizoma Atractylodis Macrocephalae 119.1Kg
Radix Glycyrrhizae 65.1Kg
Radix Paeoniae Alba 119.1Kg
Radix Rehmanniae Preparata 183.6Kg
1) with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Rhizoma Chuanxiong reflux, extract, of concentration 92% (weight) ethanol, the temperature of reflux, extract, is 81 ± 2 ℃, return time 5 hours, filter, get filtrate A and filtering residue A, filtering residue reuse concentration 47% (weight) ethanol secondary back extracts, and the reflux, extract, temperature is 85 ℃, return time 4 hours, filter, get liquor B and medicinal residues, liquor B and filtrate A merge, and vacuum decompression concentrates, get pure cream, water with 3 times decocts for the first time, and the temperature that water decocts is 90 ℃, 1.5 hours time, filter, get liquor C and filtering residue C, filtering residue C decocts for the second time with 3 times water, and the temperature that decocting boils is 90 ℃, 1.5 hours time, filter, get filtrate D and medicinal residues, filtrate D is incorporated in the liquor C, through vacuum decompression concentrate concentrated solution, twice medicinal residues merged.2) in medicinal residues, add Radix Codonopsis, Poria, thermally yellow, the Radix Glycyrrhizae and the Radix Paeoniae Alba decoct for the first time with 4 times water, and the temperature that water decocts is 90 ℃, 1.5 hours time, filter, get filtrate E and filtering residue E, filtering residue E decocts for the second time with 3 times water, and the temperature that decocting boils is 90 ℃, 1.5 hours time, filter, get filtrate F and filtering residue F, filtrate F and clear liquid E are merged, under 65 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get clear paste, filter, get clear paste filtrate and filtering residue G, merge clear paste filtrate and concentrated solution, under 50 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get thick paste, add soluble starch, granulate, its cooperation ratio is a thick paste: soluble starch=1: 1.8, under 60 ℃ of temperature dry 0.4 hour again, sieve through 12 orders, 40 orders do not sieve and carry out granulate, packing gets the product Bazhen sugar-free granule.Meet quality index.
Embodiment 2: proportioning raw materials (through above-mentioned processing and weight % meter)
Radix Codonopsis 121.1Kg
Poria 121.1Kg
Radix Angelicae Sinensis 176.9Kg
Rhizoma Chuanxiong 95.3Kg
Rhizoma Atractylodis Macrocephalae 121.1Kg
Radix Glycyrrhizae 66.1Kg
Radix Paeoniae Alba 121.1Kg
Radix Rehmanniae Preparata 176.9Kg
1) with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Rhizoma Chuanxiong reflux, extract, of concentration 97% (weight) ethanol, the temperature of reflux, extract, is 81 ± 2 ℃, return time 6 hours, filter, get filtrate A and filtering residue A, filtering residue reuse concentration 50% (weight) ethanol secondary back extracts, and the reflux, extract, temperature is 80 ℃, return time 5 hours, filter, get liquor B and medicinal residues, liquor B and filtrate A merge, and vacuum decompression concentrates, get pure cream, water with 3.5 times decocts for the first time, and the temperature that decocting boils is 95 ℃, 1.8 hours time, filter, get liquor C and filtering residue C, filtering residue C decocts for the second time with 3.5 times water, and the temperature that decocting boils is 95 ℃, 1.8 hours time, filter, get filtrate D and medicinal residues, filtrate D is incorporated in the liquor C, through vacuum decompression concentrate concentrated solution, twice medicinal residues merged.2) in medicinal residues, add Radix Codonopsis, Poria, Radix Rehmanniae Preparata, the Radix Glycyrrhizae and the Radix Paeoniae Alba decoct for the first time with 4.5 times water, and the temperature that the water consumption decocting boils is 95 ℃, 1.8 hours time, filter, get filtrate E and filtering residue E, filtering residue E decocts for the second time with 3.5 times of water, and the temperature that decocting boils is 95 ℃, 1.8 hours time, filter, get filtrate F and filtering residue F, filtrate F and filtrate E are merged, under 70 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get clear paste, filter, get clear paste filtrate and filtering residue G, merge clear paste filtrate and concentrated solution, under 53 ℃ of temperature, carry out " triple effect " concentrating under reduced pressure, get thick paste, add soluble starch, granulate, its cooperation ratio is a thick paste: soluble starch=1: 2.0, under 70 ℃ of temperature dry 0.5 hour again, sieve through 12 orders, 40 orders do not sieve and carry out granulate, packing gets the product Bazhen sugar-free granule.Meet quality index.
Quality index is as follows:
1: character is light brown or brown granular, and it is sweet to distinguish the flavor of, little hardship.
2: moisture is no more than 9.0% (an appendix IX of Chinese Pharmacopoeia nineteen fifty-five version H).
3: other should meet the every regulation (appendix IC of Chinese Pharmacopoeia nineteen fifty-five version) under the granule item.
Claims (1)
1, a kind of preparation method of Bazhen sugar-free granule is characterized in that material fiting ratio example (in weight %) is a Radix Codonopsis 11～14, Poria 11～14, Radix Angelicae Sinensis 17～20., Rhizoma Chuanxiong 9～10, the Rhizoma Atractylodis Macrocephalae 11～14, Radix Glycyrrhizae 6～7, the Radix Paeoniae Alba 11～14, Radix Rehmanniae Preparata 17～20, its step of preparation process is as follows:
1) with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Rhizoma Chuanxiong reflux, extract, of ethanol, the temperature of reflux, extract, is 79～85 ℃, return time 4～6 hours, concentration of alcohol 90～98% (weight) filters, get filtrate A and filtering residue A, filtering residue A reuse ethanol secondary back extracts, the reflux, extract, temperature is 79～90 ℃, return time 3～5 hours, concentration of alcohol 45～55% (weight), filter, get liquor B and medicinal residues, liquor B and filtrate A merge, and vacuum decompression concentrates, get pure cream, water decocts for the first time, filters, and gets liquor C and filtering residue C, filtering residue C water decocts for the second time, filter, get filtrate D and medicinal residues, filtrate D is incorporated in the liquor C, through vacuum decompression concentrate concentrated solution, twice medicinal residues merged, and wherein, the temperature that decocting boils is 90～100 ℃, 1～2 hour time, water consumption is 3～5 times;
2) in medicinal residues, add Radix Codonopsis, Poria, Radix Rehmanniae Preparata, the Radix Glycyrrhizae and the Radix Paeoniae Alba, water decocts for the first time, and E and filtering residue E filter to get filtrate, filtering residue E water decocts for the second time, filters, and gets filtrate F and filtering residue F, filtrate F and filtrate E are merged, and " triple effect " concentrating under reduced pressure gets clear paste, filter, get clear paste filtrate and filtering residue G, merge clear paste filtrate and concentrated solution, through " triple effect " concentrating under reduced pressure, get thick paste, add excipient, granulate, dry, granulate, packing gets the product Bazhen sugar-free granule, wherein, the temperature that decocting boils is 90～100 ℃, and 1～2 hour time, water consumption is 3～5 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112016A CN1077433C (en) | 1998-05-20 | 1998-05-20 | Method for preparing Bazhen sugarless powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112016A CN1077433C (en) | 1998-05-20 | 1998-05-20 | Method for preparing Bazhen sugarless powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1235841A CN1235841A (en) | 1999-11-24 |
| CN1077433C true CN1077433C (en) | 2002-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98112016A Expired - Fee Related CN1077433C (en) | 1998-05-20 | 1998-05-20 | Method for preparing Bazhen sugarless powder |
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| Country | Link |
|---|---|
| CN (1) | CN1077433C (en) |
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1998
- 1998-05-20 CN CN98112016A patent/CN1077433C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 中药材 1990.3.1 闵贵春，"八珍合剂的配制" * |
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| Publication number | Publication date |
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| CN1235841A (en) | 1999-11-24 |
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