CN104586903A - Method for extracting flavonoid glycosides from ginkgo leaf - Google Patents
Method for extracting flavonoid glycosides from ginkgo leaf Download PDFInfo
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- CN104586903A CN104586903A CN201410727875.1A CN201410727875A CN104586903A CN 104586903 A CN104586903 A CN 104586903A CN 201410727875 A CN201410727875 A CN 201410727875A CN 104586903 A CN104586903 A CN 104586903A
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Abstract
The invention relates to a method for extracting flavonoid glycosides from ginkgo leaf. The method is characterized in that flavonoid glycosides is extracted from the following traditional Chinese medicine raw materials according to the following weight proportions: 80-100 parts of ginkgo leaf, 5-10 parts of liquor, 80-100 parts of composite mother liquor, 2-5 parts of a medicinal starter and 5-10 parts of water. The method for extracting flavonoid glycosides utilizes technologies of cold dipping, hot dipping, boiling, fermentation and the like, and is capable of extracting flavonoid glycosides with the content being 200 times as much of that in ginkgo leaf. The method for extracting flavonoid glycosides is convenient to operate and possesses relatively good application prospect.
Description
Technical field
The present invention relates to extraction flavonoid glycoside, particularly relate to a kind of method that Folium Ginkgo extracts flavonoid glycoside.
Technical background
Containing two class active substances in Folium Ginkgo: flavonoid glycoside (flavonoid glycosides) and terpene lactones (ginkgolidesand bilobalide) compound.Wherein, Gingko yellow ketoside has been used for the treatment of the cardiovascular and cerebrovascular diseases such as arteriosclerosis, hypertension, apoplexy wind, also for making anti peroxidation of lipid, preventing skin aging and promoting sanguimotor health food, natural cosmetics etc.Ginkgetin glycoside material aglycon is Cortex querci dentatae rope, isorhamnetin and kaempferol 3 kinds of components mainly.Folium Ginkgo is the dried leaves of Ginkgoaceae plant Ginkgo biloba Ginkgo biloba L., and autumn gathers when leaf is still green.Nature and flavor: sweet, bitter, puckery, flat.There is blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringe the lung and relieving asthma, change effect of turbid blood fat reducing.Utilize the flavonoid glycoside that Folium Ginkgo extracts, it can increase cerebrovascular flow, improves Cerebrovascular disorders function, protection brain cell, and coronary artery dilator, prevents angina pectoris and myocardial infarction, prevent thrombosis, improves body immunity.Very useful per capita to coronary heart diseases and angina pectoris, cerebral arteriosclerosis, alzheimer disease, hypertension.
" Chinese Pharmacopoeia " of 2010 editions is recorded Folium Ginkgo quality standard and is specified: total flavonoids is that after measuring acid hydrolysis by HPLC-UV method, the content of Quercetin, nimbecetin and isorhamnetin controls, the method not only pre-treatment is loaded down with trivial details, length consuming time, and can not fully reflect flavonoid active component.The patent No. 200410069037.6, name is called, and " a kind of Folium Ginkgo extract and extracting method thereof, although reach 80% with the flavone of ethanol extraction, its flavone total amount extracted and active component, be far from reaching desirable requirement.
Summary of the invention
Based on above-mentioned technological deficiency, the present invention proposes a kind of method that Folium Ginkgo extracts flavone, utilizing Folium Ginkgo and herb fermenting to extract flavonoid glycoside, is 200 times of common flavonoid glycoside content.
A kind of Folium Ginkgo proposed to realize the present invention extracts the method for flavonoid glycoside, makes it reach the content of more than 100 times, it is characterized in that it is the flavonoid glycoside extracted by the raw material of Chinese medicine of following weight proportioning:
Folium Ginkgo 80-100;
Chinese liquor 10-20;
Compound mother solution 80-100;
Distiller’s yeast 2-5;
Water 5-10.
Described compound mother solution is the solution that various ingredients Chinese medicine extracts after fermentation, and its concrete composition weight (part) proportioning is as follows:
Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, dogwood meat processed 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and suitable quantity of water.
The preparation process that described Folium Ginkgo extracts flavone is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and
Add appropriate water to drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, stirring per week once, after the fermentation date has arrived, medicinal liquid is gone out cylinder and filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, obtain steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, and obtains yellowish-brown powder, i.e. Folium Ginkgo flavone after the medicinal liquid of step 7 being carried out concentrated spray drying.
The Advantageous Effects of patent of the present invention is: the multi-biological of Folium Ginkgo and plurality of Chinese ferments, and flavonoid glycoside extracted amount adds more than 100 times, and economic benefit is remarkable especially, is easy to suitability for industrialized production.
Detailed description of the invention
Embodiment one
Folium Ginkgo of the present invention extracts the preparation method of flavonoid glycoside, and it is the flavonoid glycoside extracted by the raw material of Chinese medicine of following weight proportioning: Folium Ginkgo 80-100; Chinese liquor 15-30; Compound mother solution 80-100; Distiller’s yeast 2-5; Water 10-20;
Compound mother solution composition weight (part) proportioning is as follows: Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, Fructus Corni 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and appropriate water.
Distiller’s yeast is wherein Massa Medicata Fermentata, is ground into powder by medicines such as flour 10, Semen Armeniacae Amarum mud 4, Semen Phaseoli 4, Herba polygoni hydropiperis 7, Herba Artemisiae Annuae 7, fresh Herba Xanthiis 7, through the processed finished products made that ferments after mixing, is a kind of yeast preparation.
The preparation process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; Secondly, according to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards; By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The method preparation technology inventing a kind of Folium Ginkgo extraction flavonoid glycoside is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and
Add appropriate water to drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, stirring per week once, after the fermentation date has arrived, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, obtain steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, the medicinal liquid of step 7 is carried out concentrate, after spraying dry yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides.
The Advantageous Effects of patent of the present invention is: the multi-biological of Folium Ginkgo and plurality of Chinese ferments, and flavonoid glycoside extracted amount adds more than 100 times, and economic benefit is remarkable especially, is easy to suitability for industrialized production.
Embodiment two
Containing two class active substances in Folium Ginkgo: flavonoid glycoside (flavonoid glycosides) and terpene lactones (ginkgolidesand bilobalide) compound.Wherein, Gingko yellow ketoside has been used for the treatment of the cardiovascular and cerebrovascular diseases such as arteriosclerosis, hypertension, apoplexy wind, also for making anti peroxidation of lipid, preventing skin aging and promoting sanguimotor health food, natural cosmetics etc.Ginkgetin glycoside material aglycon is Cortex querci dentatae rope, isorhamnetin and kaempferol 3 kinds of components mainly.Utilize the flavonoid glycoside that Folium Ginkgo extracts, it can increase cerebrovascular flow, improves Cerebrovascular disorders function, protection brain cell, and coronary artery dilator, prevents angina pectoris and myocardial infarction, prevent thrombosis, improves body immunity.Very useful per capita to coronary heart diseases and angina pectoris, cerebral arteriosclerosis, alzheimer disease, hypertension.Therefore, utilizing Folium Ginkgo to act on oral liquid additive to extract flavonoid glycoside, is the health product of extraordinary prevention alzheimer disease.
The raw material of Chinese medicine component of getting weight proportion extracts flavonoid glycoside: Folium Ginkgo 80; Chinese liquor 15; Compound mother solution 80; Distiller’s yeast 2; Water 10;
Compound mother solution composition weight (part) proportioning is as follows: Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, Fructus Corni 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and appropriate water.
Distiller’s yeast is wherein Massa Medicata Fermentata, is ground into powder by medicines such as flour 10, Semen Armeniacae Amarum mud 4, Semen Phaseoli 4, Herba polygoni hydropiperis 7, Herba Artemisiae Annuae 7, fresh Herba Xanthiis 7, through the processed finished products made that ferments after mixing, is a kind of yeast preparation.
The preparation process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; Secondly, according to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards;
By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The method preparation technology inventing a kind of Folium Ginkgo extraction flavonoid glycoside is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and
Add appropriate water to drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, stirring per week once, after the fermentation date has arrived, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, obtain steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, the medicinal liquid of step 7 is carried out concentrate, after spraying dry yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides.
Embodiment three
The flavonoid glycoside that the raw material of Chinese medicine getting weight proportion extracts: Folium Ginkgo 100; Chinese liquor 30; Compound mother solution 100; Distiller’s yeast 5; Water 20;
Compound mother solution composition weight (part) proportioning is as follows: Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, Fructus Corni 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and appropriate water.
Distiller’s yeast is wherein Massa Medicata Fermentata, is ground into powder by medicines such as flour 10, Semen Armeniacae Amarum mud 4, Semen Phaseoli 4, Herba polygoni hydropiperis 7, Herba Artemisiae Annuae 7, fresh Herba Xanthiis 7, through the processed finished products made that ferments after mixing, is a kind of yeast preparation.
The making concrete technology flow process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; According to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards; By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The method preparation technology inventing a kind of Folium Ginkgo extraction flavone is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and add appropriate water and drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, once, fermentation is after the date arrived in stirring per week, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, both obtained merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, both obtained hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, both obtained steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, and obtains yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides after the medicinal liquid of step 7 being carried out concentrated spray drying.
Embodiment four,
The component of optimum weight part of the present invention: Folium Ginkgo 90; Chinese liquor 20; Compound mother solution 90; Distiller’s yeast 4; Water 15;
Compound mother solution composition weight (part) proportioning is as follows: Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, Fructus Corni 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and appropriate water.
Distiller’s yeast is wherein Massa Medicata Fermentata, is ground into powder by medicines such as flour 10, Semen Armeniacae Amarum mud 4, Semen Phaseoli 4, Herba polygoni hydropiperis 7, Herba Artemisiae Annuae 7, fresh Herba Xanthiis 7, through the processed finished products made that ferments after mixing, is a kind of yeast preparation.
The making concrete technology flow process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; Secondly, according to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards; By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The method preparation technology inventing a kind of Folium Ginkgo extraction flavone is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and add appropriate water and drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, once, fermentation is after the date arrived in stirring per week, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, both obtained merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, both obtained hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, both obtained steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid;
8th step, medicinal liquid is fixed, and obtains yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides after the medicinal liquid of step 7 being carried out concentrated spray drying.
Embodiment five,
Folium Ginkgo extracts the preparation method of flavonoid glycoside, the capacity of its fermented extracted by 2000 grams, fresh Folium Ginkgo 1000 grams; Chinese liquor 100 grams; 700 grams, compound mother solution; Distiller’s yeast 100 grams; 100 grams, water;
Compound mother solution composition weight (part) proportioning is as follows: Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, Fructus Corni 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and appropriate water.
Distiller’s yeast is wherein Massa Medicata Fermentata, is ground into powder by medicines such as flour 10, Semen Armeniacae Amarum mud 4, Semen Phaseoli 4, Herba polygoni hydropiperis 7, Herba Artemisiae Annuae 7, fresh Herba Xanthiis 7, through the processed finished products made that ferments after mixing, is a kind of yeast preparation.
The making concrete technology flow process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; According to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards; By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The preparation process of above-mentioned compound mother solution is as follows: first carry out raw material disposal, and Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing; According to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards; By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
The method preparation technology inventing a kind of Folium Ginkgo extraction flavonoid glycoside is specific as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and
Add appropriate water to drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, stirring per week once, after the fermentation date has arrived, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, obtain steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, the medicinal liquid of step 7 is carried out concentrate, after spraying dry yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides.
The Folium Ginkgo flavone glycosides extracted is mainly used in oral liquid, and the fresh Folium Ginkgo of 1000g can extract 20mg flavonoid glycoside, more than 100 times of common content.
Non-ly therefore limit to protection scope of the present invention, therefore the equivalence techniques change of such as using description of the present invention and content to do, be all contained in protection scope of the present invention.
Claims (4)
1. Folium Ginkgo extracts a method for flavonoid glycoside, it is characterized in that it is the flavonoid glycoside extracted by the raw material of Chinese medicine of following weight proportioning:
Folium Ginkgo 80-100;
Chinese liquor 10-20;
Compound mother solution 80-100;
Distiller’s yeast 2-5;
Water 5-10.
2. a kind of Folium Ginkgo as claimed in claim 1 extracts the method for flavonoid glycoside, and it is characterized in that described compound mother solution is the solution that various ingredients Chinese medicine extracts after fermentation, its concrete composition weight (part) proportioning is as follows:
Radix Ginseng 20, the Rhizoma Atractylodis Macrocephalae 10, Poria 12, Radix Angelicae Sinensis 12, Radix Rehmanniae Preparata 12, the Radix Paeoniae Alba 10, Radix Glycyrrhizae Preparata 6, Rhizoma Chuanxiong 10, the Radix Astragali 50, Radix Paeoniae Rubra 10, Semen Persicae 10, Pheretima 8, Flos Carthami 10, Carapax et Plastrum Testudinis 3, Carapax Trionycis 3, dogwood meat processed 12, the Radix Rehmanniae 15, the Cortex Eucommiae 18, Cortex Phellodendri 10, Flos Lonicerae 20, Concha Ostreae 12, Rhizoma Imperatae 30, Fructus Rosae Laevigatae 10, Semen Euryales 10, Semen Cuscutae 15, Radix Glehniae 18, Radix Ophiopogonis 10, Radix Polygoni Multiflori 20, Fructus Ligustri Lucidi 12, Radix Dipsaci 12, Pericarpium Citri Reticulatae 18, Herba Ecliptae 20, Fructus Lycii 10, Fructus Tritici Levis 20, Radix Pseudostellariae 15-20, Rhizoma Acori Graminei 18, Radix Polygalae 10, Radix Salviae Miltiorrhizae 20, Ramulus Cinnamomi 10, Fructus Schisandrae Chinensis 8, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae 20, Fructus Gardeniae 10, Caulis Polygoni Multiflori 10, the Rhizoma Pinelliae 12, Rhizoma Alismatis 12, Herba Epimedii 20, Rhizoma Coptidis 8, Cortex Cinnamomi 18, Rhizoma Polygonati 10, Spica Prunellae 2, Herba Leonuri 20, Herba Plantaginis 20, Herba Siegesbeckiae 20, Radix Clematidis 25, Fructus Cannabis 6, Cortex Magnoliae Officinalis 9, Herba Cistanches 12, Radix et Rhizoma Rhei (stir-fried with wine) 6, Radix Aucklandiae (Radix Vladimiriae) 20, Radix Achyranthis Bidentatae 18, Herba Agrimoniae 20, Radix Platycodonis 12, Fructus Mume 8, white hibiscus flower 8, Semen Arecae 10, Fructus Crataegi 80, Radix Saposhnikoviae 2, Cordyceps 18, Radix Puerariae 30, Rhizoma Curcumae Longae 8, Herba Hedyotidis Diffusae 30, Semen Cassiae 5, Chinese liquor 3 and suitable quantity of water.
3. a kind of Folium Ginkgo as claimed in claim 2 extracts the method for flavonoid glycoside, it is characterized in that the preparation method of described compound mother solution is:
First carry out raw material disposal, Radix Angelicae Sinensis, Poria and Rhizoma Chuanxiong are cut into slices, and Carapax et Plastrum Testudinis, Carapax Trionycis are pulverized, and surplus stock is for subsequent use after pulverizing;
Secondly, according to proportioning, get the Radix Angelicae Sinensis in raw material, Poria, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Chuanxiong add appropriate water, slow fire endures one hour, collects solution for standby; Radix Ginseng, Cordyceps and grain wine are enclosed in container and carry out stewing system, within 15 days, filter solution for standby processed afterwards;
By above-mentioned two kinds of solution mixing, by mixed solution 1 part, the ratio that water is 4 parts adds water, then drops into jar fermenter with remaining ingredient, and after compressing, envelope cylinder ferments and plays cylinder in 6 months, filters, obtains compound mother solution.
4. the method preparation process of Folium Ginkgo extraction flavonoid glycoside as claimed in claim 1 is as follows:
The first step, has chosen the Folium Ginkgo of quality by proportioning, clean up for subsequent use; Compound mother solution is divided into three parts;
Second step, Folium Ginkgo being cleaned pulverizing, to be greater than 10 object granules for subsequent use;
3rd step, Folium Ginkgo granule adds soaking in Chinese liquor 3 days, and it is for subsequent use that the Folium Ginkgo granule after soaking is divided into the quartering;
4th step, utilizes low temperature cold-maceration, by the Folium Ginkgo in the compound mother solution in the first step and the 3rd step, and
Add appropriate water to drop into together in jar fermenter and be uniformly mixed rear sealed fermenting two months, during fermentation, stirring per week once, after the fermentation date has arrived, medicinal liquid is gone out cylinder to filter, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain merceration extracting solution;
5th step, utilize hot dipping, the Folium Ginkgo granule in the 3rd step is dropped in heating kettle together with compound mother solution and boils, from fire when there is foam with powder, sealed type storage in jar fermenter is dropped into after natural cooling, go out cylinder after fermentation first quarter moon, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain hot dipping extracting solution;
6th step, utilize brew cooking process: steaming and decocting 1.5 hours in the Folium Ginkgo granule mixing rear input pot of the compound mother solution in the first step and the 3rd step, until drop into jar fermenter compacting after cooling in pot, cylinder is gone out by medical filtration after fermenting one week, then squeeze medicinal residues, its pressed liquor and filtrate merge, and leave standstill after 24 hours, filter, obtain steaming and decocting extracting solution;
7th step, carry out comprehensive fermentation, by the Folium Ginkgo of above-mentioned steps (3) with step (4), (5), (6) extracting liq together with medicinal residues, and the distiller’s yeast mixed compaction after fermentation of will pulverize, monthly turn over a cylinder, ferment and go out cylinder after three months, by medical filtration, then squeeze medicinal residues, its pressed liquor and filtrate merge, leave standstill after 24 hours, filter, obtain medicinal liquid.
8th step, medicinal liquid is fixed, the medicinal liquid of step 7 is carried out concentrate, after spraying dry yellowish-brown powder, i.e. Folium Ginkgo flavone glycosides.
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