CN105250657A - Medicine composition for treating atherosclerosis and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of Chinese herb preparations, particularly relates to a medicine composition for treating atherosclerosis and discloses a preparation method of the medicine composition for treating atherosclerosis. The medicine composition for treating atherosclerosis is prepared from the raw materials of double coptis, angelica sinensis, white paeony roots, fructus aurantii, cassia seeds, gynostemma pentaphylla, radix rehmanniae, honeysuckles, poria cocos, polygonum multiflorum, radix ophiopogonis, cassia twigs, platycladi seeds, dried tangerine or orange peels, selfheal, pericarpium citri reticulatae viride, elecampane and rhizoma corydalis. The prepared medicine composition has a significant treatment effect on atherosclerosis, and the cure rate can reach 98%; besides, the medicine composition has the advantages of being short in treatment course and free of toxic and side effects, taking effect fast and preventing relapse from occurring easily.

Description

A kind of pharmaceutical composition for treating atherosclerosis and its preparation method

technical field

The invention belongs to the technical field of traditional Chinese medicine preparations, in particular relates to a pharmaceutical composition for treating atherosclerosis, and discloses a preparation method thereof.

Background technique

Atherosclerosis is also called atherosclerosis. In short, yellow substances containing cholesterol and fats appear in the intima of large and medium arteries, which leads to the deposition of a layer of lipids like millet porridge on the arterial wall, making the arteries Lesions with reduced elasticity and narrowed lumen are called atherosclerosis because of the appearance of yellow atheroma due to the accumulation of lipids in the arterial intima. Atherosclerosis is the most common and important type of vascular disease of arteriosclerosis, which is mostly caused by lipid metabolism disorder and neurovascular dysfunction; it is characterized by the involvement of arterial lesions starting from the intima, generally preceded by lipid and compound Sugar accumulation, hemorrhage and thrombosis, fibrous tissue hyperplasia and calcinosis, and gradual degeneration and calcification of the middle layer of the arteries. The lesions often involve elastic and medium-sized muscular arteries, often leading to thrombosis and blood supply disorders. If the artery lumen is blocked, the tissue or organ supplied by the artery will be ischemic or necrotic.

Hypertension is an important factor that promotes the occurrence and development of atherosclerosis, and the stenosis caused by atherosclerosis can cause secondary hypertension. The two influence and promote each other, and they are inseparable. Atherosclerosis promoted by high blood pressure mostly occurs in large and medium arteries, including the coronary arteries of the heart and the cerebral arteries of the head. High blood pressure causes blood to impact the intima of blood vessels, resulting in thickening of the vessel wall and thinning of the lumen. After the intima of the vessel wall is damaged, it is easy to deposit cholesterol and lipid, which aggravates the formation of atherosclerotic plaque. Therefore, hypertension is a risk factor for atherosclerosis.

The current treatment of atherosclerosis is mainly based on western medicine and western medicine, mainly taking blood lipid-lowering drugs, such as statins, fibrates, niacin, cholestyramine, clofibrate, and unsaturated fatty acids. , and sodium alginate, etc.; or antiplatelet drugs, such as aspirin, dipyridamole, clopidogrel, and cilostazol. However, the strong side effects of western medicine also have a certain negative impact on the treatment of atherosclerosis.

In addition to drug therapy, it is also recommended to supplement certain daily health care treatment in clinical practice. For example, pay attention to a reasonable diet, the total calories consumed should not be too high, prevent overweight, adhere to appropriate physical activities, and arrange work and life reasonably; Smoking, drinking less alcohol, controlling risk factors, etc. If you have diabetes, you should control your blood sugar in time, including diet control; if you have high blood pressure, you should take antihypertensive drugs to lower your blood pressure to an appropriate level; if you have elevated blood cholesterol, you should control high cholesterol and give appropriate lipid-lowering drugs.

Corresponding to western medicine, traditional Chinese medicine therapy has gradually attracted people's attention because of its advantages of less side effects, and it has also made clinical treatment of atherosclerosis, a disease for which western medicine is the main treatment, began to continuously seek traditional Chinese medicine. therapy, and some progress has been made. However, the existing traditional Chinese medicine preparations for treating atherosclerosis all have the problems of long treatment period and unsatisfactory treatment effect to a certain extent.

Contents of the invention

Therefore, the technical problem to be solved by the present invention is to provide a pharmaceutical composition for treating atherosclerosis, which has the advantages of good curative effect and quick onset.

In order to solve the above-mentioned technical problems, the pharmaceutical composition for treating atherosclerosis according to the present invention, its raw material consists of:

50-70 parts by weight of Shuanghuanglian, 60-70 parts by weight of Angelica sinensis, 40-50 parts by weight of Radix Paeoniae Alba, 32-40 parts by weight of Citrus aurantii, 15-20 parts by weight of cassia seed, 10-25 parts by weight of Jiaogulan, 8-20 parts by weight of Shengdi 35-60 parts by weight of honeysuckle, 30-40 parts by weight of Poria cocos, 30-50 parts by weight of Polygonum multiflorum, 8-20 parts by weight of Radix Ophiopogon japonicus, 5-15 parts by weight of cassia twig, 10-30 parts by weight of Baiziren, 20-50 parts by weight of tangerine peel 40 parts by weight, 15-30 parts by weight of Prunella vulgaris, 6-10 parts by weight of Qingpi, 5-12 parts by weight of woody fragrance, 4-8 parts by weight of Corydalis Corydalis.

Preferably, the bulk drug of the pharmaceutical composition consists of:

60 parts by weight of Shuanghuanglian, 65 parts by weight of Angelica sinensis, 45 parts by weight of Radix Paeoniae Alba, 36 parts by weight of Citrus aurantii, 18 parts by weight of Semen Cassiae, 18 parts by weight of Jiaogulan, 14 parts by weight of Rehmannia, 48 parts by weight of honeysuckle, 35 parts by weight of Poria cocos, 40 parts by weight of Polygonum multiflorum Parts by weight, 15 parts by weight of Ophiopogon japonicus, 10 parts by weight of cassia twig, 20 parts by weight of Baiziren, 30 parts by weight of tangerine peel, 22 parts by weight of Prunella vulgaris, 8 parts by weight of green bark, 9 parts by weight of woody fragrance, 6 parts by weight of Corydalis Corydalis.

The pharmaceutical composition is optionally added with conventional adjuvants, and prepared into a clinically acceptable oral preparation according to a conventional process.

The invention also discloses a clinically acceptable preparation made from the pharmaceutical composition, optionally adding conventional auxiliary materials and following conventional techniques.

The preparation is an internal preparation, preferably including tablet, capsule, pill, powder or granule.

The present invention also discloses a method for preparing the pharmaceutical composition for treating atherosclerosis, the method comprising the following steps:

(1) Take the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Habitat, Honeysuckle, Poria, Polygonum multiflorum, Ophiopogon japonicus, Guizhi, Baiziren, Tangerine Peel, Prunella vulgaris, according to the selected parts by weight. Qingpi, Muxiang and Yanhusuo, crushed and mixed or mixed and crushed, set aside;

(2) Take the above-mentioned fine powder, add conventional excipients and make a clinically acceptable oral preparation according to the conventional process.

Preferably, the method comprises the steps of:

(1) Take the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria Cocos, Radix Polygoni Multiflori in selected parts by weight, add water to decoct to obtain the water extract, filter and combine the filtrates, Stand overnight, take the supernatant and concentrate to extract;

(2) Take the Ophiopogon japonicus, Guizhi, Baiziren, Chenpi, Prunella vulgaris, Qingpi, Woody and Corydalis according to the selected parts by weight, add ethanol to extract to obtain an alcohol extract, and concentrate to extract;

(3) Take the extract obtained in the above steps (1) and (2), add conventional auxiliary materials and make a clinically acceptable oral preparation according to a conventional process.

Optimally, the method includes the steps of:

(1) Take the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria, Polygonum multiflorum according to the selected parts by weight, add 3-5 times the weight of the total amount of medicine and decoct Get the water extract, filter and combine the filtrates, let stand overnight, take the supernatant and concentrate to the extract;

(2) Take the Ophiopogon japonicus, Guizhi, Baiziren, Chenpi, Prunella vulgaris, Qingpi, Woody and Corydalis according to the selected parts by weight, and add the mass concentration of 2-3 times the weight of the total amount of medicine to be 50-70 % ethanol to obtain alcoholic extract, and concentrated to extract;

(3) Take the extract obtained in the above steps (1) and (2), add conventional auxiliary materials and make a clinically acceptable oral preparation according to a conventional process.

The invention also discloses a pharmaceutical composition for treating atherosclerosis prepared by the method.

The invention also discloses the application of the pharmaceutical composition in the preparation of drugs for treating atherosclerosis.

The pharmaceutical composition for treating atherosclerosis according to the present invention is selected from Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Habitat, Honeysuckle, Poria, Polygonum multiflorum, Ophiopogon japonicus, Guizhi, Baiziren, Chenpi , Prunella vulgaris, Green Bark, Woody Fragrance and Corydalis Corydalis as raw materials, the pharmaceutical composition made has a significant therapeutic effect in the treatment of atherosclerosis, and the cure rate can reach 98%; and it has a short course of treatment, quick results, and no toxic side effects , The advantage of not easy to relapse.

Experimental example The clinical observation of the pharmaceutical composition of the present invention in the treatment of atherosclerosis

1. Materials and methods

Clinical data: 400 patients with atherosclerosis were clinically observed.

The evaluation criteria of clinical treatment effect are:

(1) Clinical cure: the original symptoms disappear;

(2) Marked effect: the original symptoms partially disappear;

(3) Improvement: the original condition has been alleviated;

(4) Ineffective: no change in symptoms and signs.

Administration method: get respectively the tablet prepared in Example 1, the pill prepared in Example 2, the capsule prepared in Example 3 and the granule prepared in Example 4 and feed the patient, and each administration dose is 1 dose (pill) /capsule/bag), 2-3 times a day, every 30 days is a course of treatment. 100 patients were tested for each dosage form.

2. Treatment results

After using the pharmaceutical composition prepared in Example 1 of the present invention to treat 100 patients for 2-3 courses of treatment, observe the treatment results of the atherosclerosis of the 100 patients, wherein 97 cases were cured, 1 case was markedly effective, and 2 cases took a turn for the better. 0 cases were ineffective, and the cure rate was 97%;

After using the pharmaceutical composition prepared in Example 2 of the present invention to treat 100 patients for 2-3 courses of treatment, observe the treatment results of atherosclerosis in the 100 patients, wherein 98 cases were cured, 1 case was markedly effective, and 1 case took a turn for the better. 0 cases were ineffective, and the cure rate was 98%;

After using the pharmaceutical composition prepared in Example 3 of the present invention to treat 100 patients for 2-3 courses of treatment, observe the treatment results of atherosclerosis in the 100 patients, wherein 97 cases were cured, 1 case was markedly effective, and 2 cases were improved. 0 cases were ineffective, and the cure rate was 98%;

After using the pharmaceutical composition prepared in Example 4 of the present invention to treat another 100 patients for 2-3 courses of treatment, observe the treatment results of atherosclerosis in the 100 patients, wherein 98 cases were cured, 0 cases were markedly effective, and 2 cases were improved. , invalid 0 cases, the cure rate was 98%.

3. Toxic and side effects

The above-mentioned 400 patients, after the end of treatment, did not find any abnormal changes in hematuria routine, blood pressure, stool, heart, liver and kidney function; the above-mentioned cases were revisited after 3 months, and there was no recurrence.

4 Conclusion

The pharmaceutical composition of the invention has remarkable curative effect in treating atherosclerosis, and its cure rate can reach 98%, and has the advantages of short course of treatment, quick effect, no toxic and side effects, and not easy to relapse.

detailed description

Example 1 tablet

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 50g, Angelica 70g, Paeoniae Alba 40g, Citrus aurantium 40g, Cassia seed 15g, Gynostemma 25g, Rehmannia 8g, Honeysuckle 60g, Poria cocos 30g, Polygonum multiflorum 50g, Ophiopogon japonicus 8g, Guizhi 15g, Baiziren 10g, Tangerine peel 40g, Prunella vulgaris 15g, Qingpi 10g, Muxiang 5g, Corydalis 8g.

The pharmaceutical composition is prepared into tablets according to the following steps:

(1) Get the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria cocos, Polygonum multiflorum according to the selected parts by weight, add the water decoction of 3 times (1164g) of the total amount of the above drugs Boil the water extract, filter and combine the filtrate, let stand overnight, take the supernatant and concentrate to extract;

(2) Get described Ophiopogon japonicus, Guizhi, Boziren, Chenpi, Prunella vulgaris, Qingpi, Woody Fragrance, Corydalis Corydalis according to the selected parts by weight, add the mass concentration of 3 weight times (333g) of the above-mentioned drug total amount is Extract with 50% ethanol to obtain alcohol extract, and concentrate to extract;

(3) Take the extract obtained in the above steps (1) and (2), add dextrin as a conventional auxiliary material and make a clinically acceptable tablet according to a conventional process.

Embodiment 2 pills

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 70g, Angelica 60g, Paeoniae Alba 50g, Citrus aurantium 32g, Cassia seed 20g, Gynostemma 10g, Habitat 20g, Honeysuckle 35g, Poria cocos 40g, Polygonum multiflorum 30g, Ophiopogon japonicus 20g, Guizhi 5g, Baiziren 30g, Tangerine peel 20g, Prunella vulgaris 30g, Qingpi 6g, Muxiang 12g, Corydalis 4g.

Described pharmaceutical composition is prepared into pill according to the following steps:

(1) Get the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria, Polygonum multiflorum according to the selected parts by weight, add 5 weight times (1835g) of the total amount of the above-mentioned medicines to decoct Boil the water extract, filter and combine the filtrate, let stand overnight, take the supernatant and concentrate to extract;

(2) Get described Ophiopogon japonicus, Guizhi, Boziren, Chenpi, Prunella vulgaris, Qingpi, Woody Fragrance, Corydalis Corydalis according to the selected parts by weight, add the mass concentration of 2 weight times (254g) of the above-mentioned drug total amount: Extract with 70% ethanol to obtain alcohol extract, and concentrate to extract;

(3) Take the extract obtained in the above steps (1) and (2), add conventional auxiliary materials and make clinically acceptable pills according to conventional processes.

Embodiment 3 capsules

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 60g, Angelica 65g, Paeoniae Alba 45g, Citrus aurantium 36g, Cassia seed 18g, Gynostemma 18g, Habitat 14g, Honeysuckle 48g, Poria cocos 35g, Polygonum multiflorum 40g, Ophiopogon japonicus 15g, Guizhi 10g, Baiziren 20g, Tangerine peel 30g, Prunella vulgaris 22g, Qingpi 8g, Muxiang 9g, Yanhusuo 6g.

The pharmaceutical composition is prepared into capsules according to the following steps:

(1) Get the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria cocos, Polygonum multiflorum according to the selected parts by weight, add the water decoction of 4 weight times (1516g) of the total amount of the above drugs Boil the water extract, filter and combine the filtrate, let stand overnight, take the supernatant and concentrate to extract;

(2) Get described Ophiopogon japonicus, Guizhi, Baiziren, Chenpi, Prunella vulgaris, Qingpi, Woody Fragrance, Corydalis Corydalis according to the selected parts by weight, add the mass concentration of 2.5 times by weight (300g) of the above-mentioned drug total amount is Extract with 60% ethanol to obtain alcohol extract, and concentrate to extract;

(3) Take the extract obtained in the above steps (1) and (2), add conventional excipients and make clinically acceptable capsules according to conventional techniques.

Embodiment 4 Granules

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 60g, Angelica 65g, Paeoniae Alba 45g, Citrus aurantium 36g, Cassia seed 18g, Gynostemma 18g, Habitat 14g, Honeysuckle 48g, Poria cocos 35g, Polygonum multiflorum 40g, Ophiopogon japonicus 15g, Guizhi 10g, Baiziren 20g, Tangerine peel 30g, Prunella vulgaris 22g, Qingpi 8g, Muxiang 9g, Yanhusuo 6g.

The pharmaceutical composition is prepared into granules according to the following steps:

(1) Get the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Rehmannia Root, Honeysuckle, Poria cocos, Polygonum multiflorum according to the selected parts by weight, add the water decoction of 4 weight times (1516g) of the total amount of the above drugs Boil the water extract, filter and combine the filtrate, let stand overnight, take the supernatant and concentrate to extract;

(2) Get described Ophiopogon japonicus, Guizhi, Baiziren, Chenpi, Prunella vulgaris, Qingpi, Woody Fragrance, Corydalis Corydalis according to the selected parts by weight, add the mass concentration of 2.5 times by weight (300g) of the above-mentioned drug total amount is Extract with 60% ethanol to obtain alcohol extract, and concentrate to extract;

(3) Take the extract obtained in the above steps (1) and (2), add conventional excipients and make clinically acceptable granules according to conventional techniques.

Embodiment 5 tablet

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 55g, Angelica 68g, Paeoniae Alba 42g, Citrus aurantium 38g, Cassia seed 16g, Gynostemma 21g, Habitat 11g, Honeysuckle 54g, Poria cocos 32g, Polygonum multiflorum 45g, Ophiopogon japonicus 12g, Guizhi 13g, Baiziren 15g, Tangerine peel 35g, Prunella vulgaris 18g, Qingpi 9g, Muxiang 7g, Yanhusuo 7g.

The pharmaceutical composition is prepared into tablets according to the following steps:

(1) Take the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Habitat, Honeysuckle, Poria, Polygonum multiflorum, Ophiopogon japonicus, Guizhi, Baiziren, Tangerine Peel, Prunella vulgaris, according to the selected parts by weight. Qingpi, Muxiang, Yanhusuo, crushed and mixed or mixed and crushed, set aside;

(2) Take the above-mentioned fine powder, add conventional excipients, and make clinically acceptable tablets according to conventional processes.

Embodiment 6 capsules

The pharmaceutical composition for the treatment of atherosclerosis described in the present embodiment, its formula is as follows:

Shuanghuanglian 65g, Angelica 62g, Paeoniae Alba 48g, Citrus aurantium 34g, Cassia seed 19g, Gynostemma 14g, Habitat 17g, Honeysuckle 40g, Poria cocos 38g, Polygonum multiflorum 35g, Ophiopogon japonicus 17g, Guizhi 8g, Baiziren 25g, Tangerine peel 25g, Prunella vulgaris 26g, Qingpi 7g, Muxiang 10g, Corydalis 5g.

The pharmaceutical composition is prepared into capsules according to the following steps:

(1) Take the Shuanghuanglian, Angelica, Radix Paeoniae Alba, Fructus Citrifolia, Semen Cassiae, Gynostemma Gynostemma, Habitat, Honeysuckle, Poria, Polygonum multiflorum, Ophiopogon japonicus, Guizhi, Baiziren, Tangerine Peel, Prunella vulgaris, according to the selected parts by weight. Qingpi, Muxiang, Yanhusuo, crushed and mixed or mixed and crushed, set aside;

(2) Take the above-mentioned fine powder, add conventional excipients and make clinically acceptable capsules according to conventional techniques.

Apparently, the above-mentioned embodiments are only examples for clear description, rather than limiting the implementation. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. And the obvious changes or changes derived therefrom are still within the scope of protection of the present invention.

Claims (10)

1. be used for the treatment of an atherosclerotic pharmaceutical composition, it is characterized in that, the crude drug of described pharmaceutical composition consists of:

SHUANGHUANLIAN 50-70 weight portion, Radix Angelicae Sinensis 60-70 weight portion, Radix Paeoniae Alba 40-50 weight portion, Fructus Aurantii 32-40 weight portion, Semen Cassiae 15-20 weight portion, Herb Gynostemmae Pentaphylli 10-25 weight portion, Radix Rehmanniae 8-20 weight portion, Flos Lonicerae 35-60 weight portion, Poria 30-40 weight portion, Radix Polygoni Multiflori 30-50 weight portion, Radix Ophiopogonis 8-20 weight portion, Ramulus Cinnamomi 5-15 weight portion, Semen Platycladi 10-30 weight portion, Pericarpium Citri Reticulatae 20-40 weight portion, Spica Prunellae 15-30 weight portion, Pericarpium Citri Reticulatae Viride 6-10 weight portion, Radix Aucklandiae 5-12 weight portion, Rhizoma Corydalis 4-8 weight portion.

2. be according to claim 1ly used for the treatment of atherosclerotic pharmaceutical composition, it is characterized in that, the crude drug of described pharmaceutical composition consists of:

SHUANGHUANLIAN 60 weight portion, Radix Angelicae Sinensis 65 weight portion, the Radix Paeoniae Alba 45 weight portion, Fructus Aurantii 36 weight portion, Semen Cassiae 18 weight portion, Herb Gynostemmae Pentaphylli 18 weight portion, the Radix Rehmanniae 14 weight portion, Flos Lonicerae 48 weight portion, Poria 35 weight portion, Radix Polygoni Multiflori 40 weight portion, Radix Ophiopogonis 15 weight portion, Ramulus Cinnamomi 10 weight portion, Semen Platycladi 20 weight portion, Pericarpium Citri Reticulatae 30 weight portion, Spica Prunellae 22 weight portion, Pericarpium Citri Reticulatae Viride 8 weight portion, the Radix Aucklandiae 9 weight portion, Rhizoma Corydalis 6 weight portion.

3. be according to claim 1 and 2ly used for the treatment of atherosclerotic pharmaceutical composition, it is characterized in that, described pharmaceutical composition selectivity adds customary adjuvant, and conveniently technique makes acceptable oral preparations clinically.

4. by the arbitrary described pharmaceutical composition of claim 1-3, selectivity adds customary adjuvant, conveniently the acceptable clinically preparation made of technique.

5. preparation according to claim 4, is characterized in that, described preparation comprises tablet, capsule, pill, powder or granule.

6. prepare claim 1-3 arbitrary described in be used for the treatment of the method for atherosclerotic pharmaceutical composition, it is characterized in that, the method comprises the steps:

(1) described SHUANGHUANLIAN, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii, Semen Cassiae, Herb Gynostemmae Pentaphylli, the Radix Rehmanniae, Flos Lonicerae, Poria, Radix Polygoni Multiflori, Radix Ophiopogonis, Ramulus Cinnamomi, Semen Platycladi, Pericarpium Citri Reticulatae, Spica Prunellae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae and Rhizoma Corydalis is got according to selected parts by weight, pulverize after mixing or mixing after pulverizing, for subsequent use;

(2) get above-mentioned fine powder, add customary adjuvant conveniently technique make acceptable oral preparations clinically.

7. the method for the preparation of the atherosclerotic pharmaceutical composition for the treatment of according to claim 6, it is characterized in that, the method comprises the steps:

(1) described SHUANGHUANLIAN, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii, Semen Cassiae, Herb Gynostemmae Pentaphylli, the Radix Rehmanniae, Flos Lonicerae, Poria, Radix Polygoni Multiflori is got according to selected parts by weight, decoct with water to obtain Aqueous extracts, filter and merging filtrate, hold over night, gets supernatant concentration to extractum;

(2) get described Radix Ophiopogonis, Ramulus Cinnamomi, Semen Platycladi, Pericarpium Citri Reticulatae, Spica Prunellae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae and Rhizoma Corydalis according to selected parts by weight, add ethanol extraction and obtain alcohol extract, and be concentrated into extractum;

(3) get the extractum obtained in above-mentioned steps (1) and (2), add customary adjuvant conveniently technique make acceptable oral preparations clinically.

8. the method for the preparation of the atherosclerotic pharmaceutical composition for the treatment of according to claim 6 or 7, it is characterized in that, the method comprises the steps:

(1) described SHUANGHUANLIAN, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii, Semen Cassiae, Herb Gynostemmae Pentaphylli, the Radix Rehmanniae, Flos Lonicerae, Poria, Radix Polygoni Multiflori is got according to selected parts by weight, the water adding medicine total amount 3-5 times of weight carries out decocting to obtain Aqueous extracts, filter and merging filtrate, hold over night, gets supernatant concentration to extractum;

(2) get described Radix Ophiopogonis, Ramulus Cinnamomi, Semen Platycladi, Pericarpium Citri Reticulatae, Spica Prunellae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae and Rhizoma Corydalis according to selected parts by weight, the mass concentration adding medicine total amount 2-3 times of weight is that the ethanol extraction of 50-70% obtains alcohol extract, and is concentrated into extractum;

(3) get the extractum obtained in above-mentioned steps (1) and (2), add customary adjuvant conveniently technique make acceptable oral preparations clinically.

9. what prepared by the arbitrary described method of claim 6-8 is used for the treatment of atherosclerotic pharmaceutical composition.

10. the arbitrary or pharmaceutical composition described in 9 of claim 1-3 is for the preparation of the application for the treatment of atherosclerosis medicine.