CN101249175B - Chinese medicine prescription for curing myopic eye disease and production method of preparations - Google Patents
Chinese medicine prescription for curing myopic eye disease and production method of preparations Download PDFInfo
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- CN101249175B CN101249175B CN2008100860197A CN200810086019A CN101249175B CN 101249175 B CN101249175 B CN 101249175B CN 2008100860197 A CN2008100860197 A CN 2008100860197A CN 200810086019 A CN200810086019 A CN 200810086019A CN 101249175 B CN101249175 B CN 101249175B
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- 239000003814 drug Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 208000030533 eye disease Diseases 0.000 title 1
- 239000000843 powder Substances 0.000 claims abstract description 37
- 239000000284 extract Substances 0.000 claims abstract description 21
- 239000008589 Cortex Fraxini Substances 0.000 claims abstract description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 15
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 15
- 235000008434 ginseng Nutrition 0.000 claims abstract description 15
- 239000002775 capsule Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 7
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract 3
- 210000000582 semen Anatomy 0.000 claims description 31
- 241000628997 Flos Species 0.000 claims description 28
- 208000001491 myopia Diseases 0.000 claims description 22
- 230000004379 myopia Effects 0.000 claims description 19
- 238000010992 reflux Methods 0.000 claims description 16
- 241000208340 Araliaceae Species 0.000 claims description 14
- 244000293323 Cosmos caudatus Species 0.000 claims description 14
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 229910000831 Steel Inorganic materials 0.000 claims description 6
- 239000000469 ethanolic extract Substances 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000010959 steel Substances 0.000 claims description 6
- 241000123846 Buddleja officinalis Species 0.000 abstract 1
- 240000008365 Celosia argentea Species 0.000 abstract 1
- 235000000722 Celosia argentea Nutrition 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 210000001508 eye Anatomy 0.000 description 6
- -1 reflux Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 239000003643 water by type Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000001467 acupuncture Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003885 eye ointment Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002430 laser surgery Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000012913 prioritisation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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Abstract
The invention discloses a TCM prescription and a production method of a preparation thereof. The TCM prescription has the components and weight parts that: chrysanthemum is 15 to 30, cassia seed is 15 to 30, buddleia officinalis is 15 to 30, wolfberry fruit is 15 to 30, feather cockscomb seeds are 15 to 30, Cortex Fraxini is 15 to 30, pearl is 10 to 20, mint is 10 to 20, ginseng is 10 to 20, and schisandra chinensis is 10 to 20. The components are mixed and ethanol water solution is used as extractant to extract the mixture to obtain extracting solution; the extracting solution is decompressed and concentrated to obtain an extract; then the extract is dried and is crushed into fine extract powder, and then the pearl is crushed into ultra-fine powder; the fine extract powder and the ultra-fine powder are mixed to make mixed fine powder; proper auxiliary material which is acceptable in medicine is added in, so as to make pastes, pasters, infusions, tablets, or capsules.
Description
One, technical field
The present invention relates to a kind of Chinese medicine for the treatment of myopia, and with the method for the Chinese medicine preparation of this Chinese medicine production for treating myopia.
Two, background technology
Joint investigation according to Ministry of Public Health, the Ministry of Education shows that the teen-age near-sighted incidence rate of China occupies the second place of the world, is only second to Japan.China's myopia patient number has reached 2.8 hundred million people, and because of the number of myopia blinding reaches 300,000 people, and near-sighted number of the infected increasing progressively with annual 5% speed, to becoming younger, generalize development.
At present, doctor trained in Western medicine does not also have better method to treat myopia, and laser surgery not only requires child more than 18 years old, and except having increased a lot of unsafe factors, also holds eyeball and become pathological state from the normal physiological state; The head of a family does not wish that more child wears glasses in addition, joins mirror and be " only rectify and do not control ", has not only missed optimal treatment period, and the number of degrees wear higher and higher, has brought a lot of inconvenience for child's living and studying.
The existing development faster of the myopia of Chinese traditional treatment in recent years, Therapeutic Method is also more really, as patch, electuary, acupuncture, eye drop, pressure cave.But practicality shows that it is slow that these methods all exist onset, and the shortcoming that easily rebounds.Therefore need development a kind of easy to use, curative effect is fast, and is difficult for the new drug of the treatment myopia of bounce-back.
The Chinese patent file of the patent No. 200410040984.2 has announced that name is called " a kind of Chinese medicine preparation for the treatment of near-sighted ophthalmic and preparation method thereof ".This method is as follows:
Get Rhizoma Dioscoreae, Poria through cleaning, cure, be ground into fine powder, standby; Again medicinal clear water such as Semen Cassiae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Tropaeoli, Radix Adenophorae, golden bell core, Semen Sesami Nigrum, Fructus Rubi, Radix Ophiopogonis, Fructus Tribuli, Herba Lophatheri, Semen Plantaginis, Fructus Leonuri is decocted, extract decoction liquor, carry out altogether 3 times, the each decoction 1 hour, then the decoction liquor of extracting is filtered, get its filtrate steaming and decocting and concentrate and to make extractum, add standby medicated powder again, mixing; With the conventional method drying, pulverize, sieve, usually require below 1mm, after the assay was approved, the capsule of promptly packing into is made the capsule product.
But this medicine medicine position is 15 flavor Chinese crude drugs nearly, the cost height; And only water carries out the extraction of effective ingredient, is soluble in the effective ingredient of organic solvent, is difficult for extracting, and therefore the curative effect to the treatment myopia is still waiting to improve.
Three, summary of the invention
Purpose of the present invention just is to provide a kind of Chinese medicine and preparation thereof of new treatment myopia, and said preparation good effect, cost are low, and use, carry, keeping is all very convenient.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine for the treatment of myopia, it is made up of the component of following parts by weight (as follows): Flos Chrysanthemi 15～30, Semen Cassiae 15～30, Flos Buddlejae 15～30, Fructus Lycii 15～30, Semen Celosiae 15～30, Cortex Fraxini 15～30, Margarita 10～20, Herba Menthae 10～20, Radix Ginseng 10～20, Fructus Schisandrae Chinensis 10～20.
The prioritization scheme of above-mentioned component is: Flos Chrysanthemi 18～26, Semen Cassiae 16～28, Flos Buddlejae 18～26, Fructus Lycii 10～20, Semen Celosiae 18～26, Cortex Fraxini 18～26, Margarita 12～18, Herba Menthae 13～18, Radix Ginseng 13～17, Fructus Schisandrae Chinensis 15～18.
With the method for the Chinese medicine preparation of above-mentioned Chinese medicine production for treating myopia, it may further comprise the steps:
(1) with Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Cortex Fraxini, Herba Menthae, Radix Ginseng, Fructus Schisandrae Chinensis, place in the rustless steel extraction vessel, adding concentration is 50%～90% ethanol water, the amount of the ethanol water that adds is Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Cortex Fraxini, Herba Menthae, Radix Ginseng, Fructus Schisandrae Chinensis gross weight 5～9 times, reflux, extract, 1～4 hour, under these conditions, reflux, extract, is 2～4 times;
(2) with 2～4 times ethanol extract merging, under the temperature of 50～80 degree, be evaporated to extractum;
(3) extractum is placed under 30～70 the temperature dryly, be ground into the thin cream powder of 150 orders～300 purposes;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 200 orders～350 purpose micropowders;
(5) the thin cream powder of 150 orders～300 purposes and 200 orders～350 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
Said reflux, extract, number of times is the best with 3 times in the aforementioned production method.
Said reflux extracting time was the best with 1.5～2 hours in the aforementioned production method.
Adopted technique scheme because the extracting solution that adopted is alcoholic acid aqueous solution, it both solubilized extract can be water-soluble in the medicine active ingredient, also solubilized is extracted the active ingredient that can be dissolved in organic solvent in the medicine.Therefore, the content height of active ingredient in the preparation adds that the compatibility of each component is reasonable, so good effect, cost is low.Because it can be made into unguentum, patch, electuary, tablet and capsule, both brought into play the advantage of China's Chinese herbal medicine again, saved the trouble of decocting medicinal herbs again, its medication is carried, preserves all very convenient.
Tablet of the present invention, electuary, capsule can directly be taken, and unguentum and patch can be smeared or be attached on the acupuncture point of circumference of eyes.
The present invention treats the Chinese medicine preparation eye ointment of myopia, ties up vision eyes rehabilitation center in the Urumqi City and only do eye exercises to contrast.
Subjects is pupil and middle school student, and the age, observation group was the Chinese medicine preparation eye ointment of treatment myopia of the present invention at 7～16 years old, 180 people, 360 eyes, every day 2 times, each 10～15 minutes; Matched group 100 people, 200 eyes.Two groups of clinical test results are as follows:
| Title (eye number) | Rehabilitation % | Effective % | Invalid % | Total effective rate % |
| Observation group 360 | 53.2 | 46.8 | 0 | 100 |
| Matched group 200 | 0 | 15.8 | 84.2 | 15.8 |
Rehabilitation: treatment back binocular vision returns to 1.0～1.5.
Effectively: treatment back binocular vision returns to more than 0.1.
Invalid: after the treatment, vision does not have change.
Four, the specific embodiment
Embodiment 1:
Get Flos Chrysanthemi 960g, Semen Cassiae 880g, Flos Buddlejae 950g, Fructus Lycii 960g, Semen Celosiae 930g, Cortex Fraxini 900g, Margarita 280g, Herba Menthae 750g, Radix Ginseng 550g, Fructus Schisandrae Chinensis 820g place in the rustless steel extraction vessel, add concentration and be 7 kilograms of 50% ethanol waters, reflux, extract, 1 hour, under these conditions, reflux, extract, 4 times;
(2) with 4 times ethanol extract merging, under the temperature of 80 degree, be evaporated to extractum
(3) extractum is placed under 70 the temperature dryly, be ground into 300 thin cream powder;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 350 purpose micropowders;
(5) 300 thin cream powder and 350 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
Embodiment 2:
Get Flos Chrysanthemi 1280g, Semen Cassiae 960g, Flos Buddlejae 730g, Fructus Lycii 1100g, Semen Celosiae 800g, Cortex Fraxini 960g, Margarita 350g, Herba Menthae 920g, Radix Ginseng 700g, Fructus Schisandrae Chinensis 620g places in the rustless steel extraction vessel, adds concentration and be 4.5 kilograms of 90% ethanol waters, reflux, extract, 4 hours
Under these conditions, reflux, extract, is 2 times;
(2) with 2 times ethanol extract merging, under the temperature of 50 degree, be evaporated to extractum;
(3) extractum is placed under 30 the temperature dryly, be ground into 150 thin cream powder;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 200 purpose micropowders;
(5) 150 thin cream powder and 200 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch electuary, tablet or capsule.
Embodiment 3:
Get Flos Chrysanthemi 1050g, Semen Cassiae 1000g, Flos Buddlejae 1000g, Fructus Lycii 1050g, Semen Celosiae 900, Cortex Fraxini 820g, Margarita 460g, Herba Menthae 1060g, Radix Ginseng 680g, Fructus Schisandrae Chinensis 800g place in the rustless steel extraction vessel, add concentration and be 6 kilograms of 70% ethanol waters, reflux, extract, 2 under these conditions, reflux, extract, 3 times;
(2) with 3 times ethanol extract merging, under the temperature of 75 degree, be evaporated to extractum;
(3) extractum is placed under 50 the temperature dryly, be ground into 200 thin cream powder;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 250 purpose micropowders;
(5) 200 thin cream powder and 250 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
Embodiment 4:
Get Flos Chrysanthemi 890g, Semen Cassiae 900g, Flos Buddlejae 890g, Fructus Lycii 750g, Semen Celosiae 900g, Cortex Fraxini 720g, Margarita 450g, Herba Menthae 900g, Radix Ginseng 580g, Fructus Schisandrae Chinensis 850g place in the rustless steel extraction vessel, add concentration and be 6 kilograms of 80% ethanol waters, reflux, extract, 1.5 hours, under these conditions, reflux, extract, 3 times;
(2) with 3 times ethanol extract merging, under the temperature of 70 degree, be evaporated to extractum;
(3) extractum is placed under 60 the temperature dryly, be ground into 250 thin cream powder;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 300 purpose micropowders;
(5) 250 thin cream powder and 300 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
Claims (5)
1. Chinese medicine for the treatment of myopia, it is characterized in that: it is made up of following compositions in weight portion: Flos Chrysanthemi 15～30, Semen Cassiae 15～30, Flos Buddlejae 15～30, Fructus Lycii 15～30, Semen Celosiae 15～30, Cortex Fraxini 15～30, Margarita 10～20, Herba Menthae 10～20, Radix Ginseng 10～20, Fructus Schisandrae Chinensis 10～20.
2. as the said a kind of Chinese medicine for the treatment of myopia of claim 1, it is characterized in that: it is made up of following compositions in weight portion: Flos Chrysanthemi 18～26, Semen Cassiae 16～28, Flos Buddlejae 18～26, Fructus Lycii 10～20, Semen Celosiae 18～26, Cortex Fraxini 18～26, Margarita 12～18, Herba Menthae 13～18, Radix Ginseng 13～17, Fructus Schisandrae Chinensis 15～18.
3. method with the Chinese medicine preparation of the said Chinese medicine production for treating of claim 1 myopia is characterized in that may further comprise the steps:
(1) with Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Cortex Fraxini, Herba Menthae, Radix Ginseng, Fructus Schisandrae Chinensis, place in the rustless steel extraction vessel, adding concentration is 50%～90% ethanol water, the amount of the ethanol water that adds is Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Cortex Fraxini, Herba Menthae, Radix Ginseng, Fructus Schisandrae Chinensis gross weight 5～9 times, reflux, extract, 1～4 hour, under these conditions, reflux, extract, is 2～4 times;
(2) with 2～4 times ethanol extract merging, under the temperature of 50～80 degree, be evaporated to extractum;
(3) extractum is placed under 30～70 the temperature dryly, be ground into the thin cream powder of 150 orders～300 purposes;
(4) under sub-zero low temperature, the Margarita processing powder is broken into 200 orders～350 purpose micropowders;
(5) the thin cream powder of 150 orders～300 purposes and 200 orders～350 purpose micropowders are mixed into mixing fine powders;
(6) in mixing fine powders, add different auxiliary material medically commonly used routinely, make unguentum, patch, electuary, tablet or capsule.
4. as the method for the Chinese medicine preparation of the said production for treating myopia of claim 3, it is characterized in that: Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Herba Menthae, Cortex Fraxini, Radix Ginseng, Fructus Schisandrae Chinensis reflux, extract, 3 times.
5. as the method for the Chinese medicine preparation of the said production for treating myopia of claim 3, it is characterized in that: Flos Chrysanthemi, Semen Cassiae, Flos Buddlejae, Fructus Lycii, Semen Celosiae, Herba Menthae, Cortex Fraxini, Radix Ginseng, Fructus Schisandrae Chinensis reflux, extract, 1.5～2 hours.
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| CN2008100860197A CN101249175B (en) | 2008-03-08 | 2008-03-08 | Chinese medicine prescription for curing myopic eye disease and production method of preparations |
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| CN102600356B (en) * | 2012-04-12 | 2014-01-29 | 北京阳光一佰生物技术开发有限公司 | Composition for improving vision and preparation method |
| CN104706852A (en) * | 2013-12-13 | 2015-06-17 | 吴小明 | External traditional Chinese medicine composition capable of improving eyesight, preparation method and applications thereof |
| CN104109617B (en) * | 2014-06-23 | 2015-12-02 | 汪从新 | One is clear liver and improved vision yellow rice wine and preparation method thereof |
| CN106177194A (en) * | 2016-08-30 | 2016-12-07 | 马利忠 | Three close oil nutritional oil |
| CN106309726A (en) * | 2016-09-18 | 2017-01-11 | 马利忠 | Eye beautifying and eyesight improving nutritional agent and preparation method thereof |
| CN111265609A (en) * | 2020-04-08 | 2020-06-12 | 四川御瞳府医院管理有限公司 | Traditional Chinese medicine composition for adjuvant treatment of true myopia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1883524A (en) * | 2006-05-30 | 2006-12-27 | 陕西九州生物科技股份有限公司 | Eyesight-improving capsule and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1883524A (en) * | 2006-05-30 | 2006-12-27 | 陕西九州生物科技股份有限公司 | Eyesight-improving capsule and preparation process thereof |
Non-Patent Citations (4)
| Title |
|---|
| 杨淑焕 |
| 霍润林 |
| 霍润林;杨淑焕;魏承朴.增视明目片治疗眼底病125例.陕西中医17 2.1996,17(2),59. * |
| 魏承朴.增视明目片治疗眼底病125例.陕西中医17 2.1996,17(2),59. |
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