CN110563700A - 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 - Google Patents

展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 Download PDF

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Publication number
CN110563700A
CN110563700A CN201910586017.2A CN201910586017A CN110563700A CN 110563700 A CN110563700 A CN 110563700A CN 201910586017 A CN201910586017 A CN 201910586017A CN 110563700 A CN110563700 A CN 110563700A
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Prior art keywords
pyridin
methyl
oxy
carbamoyl
alkyl
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CN201910586017.2A
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Chinese (zh)
Inventor
M·D·考夫曼
T·M·考德威尔
D·L·弗林
W·C·帕特
T·萨马拉孔
L·沃杰蒂
K·M·耶茨
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Dexi Ferra Pharmaceutical Co Ltd
Deciphera Pharmaceuticals LLC
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Dexi Ferra Pharmaceutical Co Ltd
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Publication of CN110563700A publication Critical patent/CN110563700A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201910586017.2A 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 Pending CN110563700A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
US61/789,971 2013-03-15
CN201480026796.6A CN105228620B (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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CN201480026796.6A Division CN105228620B (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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CN201910586017.2A Pending CN110563700A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
CN202010826889.4A Pending CN112047927A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CA2903288C (en) * 2013-03-15 2021-09-21 Deciphera Pharmaceuticals, Llc N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
TWI854164B (zh) * 2016-02-01 2024-09-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
MX2019014021A (es) * 2017-05-24 2020-08-17 Abbisko Therapeutics Co Ltd Derivado de n-(azaarilo)ciclo lactam-1-carboxamida, metodo de preparacion del mismo y uso del mismo.
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IL272806B2 (en) * 2017-08-24 2023-09-01 Merck Patent Gmbh The history of boronic acid, its preparation and pharmaceutical preparations containing it
CN109776401A (zh) * 2017-11-14 2019-05-21 成都博腾药业有限公司 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法
BR112020015581A2 (pt) 2018-01-31 2021-02-02 Deciphera Pharmaceuticals, Llc terapia de combinação para o tratamento de tumores estromais gastrointestinais
EP3746060A1 (en) 2018-01-31 2020-12-09 Deciphera Pharmaceuticals, LLC Combination therapy for the treatment of mastocytosis
CN110845476B (zh) * 2018-08-21 2022-11-18 上海和誉生物医药科技有限公司 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用
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