RU2769607C2 - N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность - Google Patents

N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность Download PDF

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RU2769607C2
RU2769607C2 RU2015143718A RU2015143718A RU2769607C2 RU 2769607 C2 RU2769607 C2 RU 2769607C2 RU 2015143718 A RU2015143718 A RU 2015143718A RU 2015143718 A RU2015143718 A RU 2015143718A RU 2769607 C2 RU2769607 C2 RU 2769607C2
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pyridin
methyl
oxy
carbamoyl
pyrazol
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RU2015143718A
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Russian (ru)
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RU2015143718A3 (enExample
RU2015143718A (ru
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Майкл Д. Кауфман
Тимоти Малкольм КОЛДУЭЛЛ
Дэниел Л. Флинн
Уильям С. ПАТТ
Тиванка САМАРАКООН
Лакшминараяна ВОГЕТИ
Карен М. ЙЕЙТС
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ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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RU2015143718A 2013-03-15 2014-03-14 N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность RU2769607C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
US61/789,971 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (3)

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RU2015143718A RU2015143718A (ru) 2017-04-21
RU2015143718A3 RU2015143718A3 (enExample) 2018-03-30
RU2769607C2 true RU2769607C2 (ru) 2022-04-04

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US (1) US9382228B2 (enExample)
EP (1) EP2968287B1 (enExample)
JP (3) JP6364472B2 (enExample)
KR (2) KR102333718B1 (enExample)
CN (3) CN105228620B (enExample)
AU (2) AU2014233414B2 (enExample)
BR (1) BR112015022263B1 (enExample)
CA (1) CA2903288C (enExample)
ES (1) ES2817902T3 (enExample)
IL (2) IL241523B (enExample)
MX (2) MX366429B (enExample)
PH (2) PH12020550201A1 (enExample)
RU (1) RU2769607C2 (enExample)
SG (1) SG11201508532VA (enExample)
WO (1) WO2014145028A2 (enExample)

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JP5335056B2 (ja) 2011-11-16 2013-11-06 住友電気工業株式会社 ボルト用アルミニウム合金線及びボルト並びにそれらの製造方法
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
BR112015022263B1 (pt) * 2013-03-15 2023-01-03 Deciphera Pharmaceuticals Llc N-acil-n-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica
TWI747873B (zh) * 2016-02-01 2021-12-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
KR102374012B1 (ko) 2017-05-24 2022-03-14 아비스코 테라퓨틱스 컴퍼니 리미티드 N-(아자릴)시클로락탐-1-카르복사미드 유도체 및 합성법과 그 용법
WO2018233526A1 (zh) * 2017-06-19 2018-12-27 上海和誉生物医药科技有限公司 一种csf1r抑制剂及其制备方法和应用
IL272806B2 (en) * 2017-08-24 2023-09-01 Merck Patent Gmbh The history of boronic acid, its preparation and pharmaceutical preparations containing it
CN109776401A (zh) * 2017-11-14 2019-05-21 成都博腾药业有限公司 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
CN110845476B (zh) * 2018-08-21 2022-11-18 上海和誉生物医药科技有限公司 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用
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