MX2015013404A - N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anti-cancer y anti-proliferativas. - Google Patents

N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anti-cancer y anti-proliferativas.

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Publication number
MX2015013404A
MX2015013404A MX2015013404A MX2015013404A MX2015013404A MX 2015013404 A MX2015013404 A MX 2015013404A MX 2015013404 A MX2015013404 A MX 2015013404A MX 2015013404 A MX2015013404 A MX 2015013404A MX 2015013404 A MX2015013404 A MX 2015013404A
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MX
Mexico
Prior art keywords
cancer
ureas
pyridin
acyl
proliferative activities
Prior art date
Application number
MX2015013404A
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English (en)
Other versions
MX366429B (es
Inventor
Michael D Kaufman
Lakshminarayana Vogeti
Timothy Malcolm Caldwell
William C Patt
Thiwanka Samarakoon
Karen M Yates
Daniel L Flynn
Original Assignee
Deciphera Pharmaceuticals Llc
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Publication date
Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of MX2015013404A publication Critical patent/MX2015013404A/es
Publication of MX366429B publication Critical patent/MX366429B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de fórmula I (Ver Fórmula) los cuales encuentran utilidad en el tratamiento de cáncer, enfermedades autoinmunes y trastornos óseos metabólicos a través de la inhibición de c-FMS (CSF-IR), c-KIT, y/o PDGFR cinasas; estos compuestos también encuentran utilidad en el tratamiento de otras enfermedades de mamíferos mediadas por c-FMS, c-KIT,o PDGFR cinasas.
MX2015013404A 2013-03-15 2014-03-14 N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anticancerosas y antiproliferativas. MX366429B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (2)

Publication Number Publication Date
MX2015013404A true MX2015013404A (es) 2017-06-27
MX366429B MX366429B (es) 2019-07-04

Family

ID=51529946

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015013404A MX366429B (es) 2013-03-15 2014-03-14 N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anticancerosas y antiproliferativas.
MX2019008003A MX2019008003A (es) 2013-03-15 2015-09-17 N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anticancerosas y antiproliferativas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019008003A MX2019008003A (es) 2013-03-15 2015-09-17 N-acil-n'-(piridin-2-il) ureas y analogos que presentan actividades anticancerosas y antiproliferativas.

Country Status (16)

Country Link
US (1) US9382228B2 (es)
EP (1) EP2968287B1 (es)
JP (3) JP6364472B2 (es)
KR (2) KR102386952B1 (es)
CN (3) CN112047927A (es)
AU (2) AU2014233414B2 (es)
BR (1) BR112015022263B1 (es)
CA (1) CA2903288C (es)
ES (1) ES2817902T3 (es)
HK (1) HK1220400A1 (es)
IL (2) IL241523B (es)
MX (2) MX366429B (es)
PH (1) PH12015502336A1 (es)
RU (1) RU2769607C2 (es)
SG (1) SG11201508532VA (es)
WO (1) WO2014145028A2 (es)

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN112047927A (zh) * 2013-03-15 2020-12-08 德西费拉制药有限责任公司 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
TW202222786A (zh) 2016-02-01 2022-06-16 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
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CN110461849B (zh) * 2017-06-19 2020-09-01 上海和誉生物医药科技有限公司 一种csf1r抑制剂及其制备方法和应用
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CN113453684B (zh) 2018-12-28 2024-05-14 德西费拉制药有限责任公司 用于治疗癌症的csf1r抑制剂
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