CN105228620B - 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 - Google Patents

展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 Download PDF

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CN105228620B
CN105228620B CN201480026796.6A CN201480026796A CN105228620B CN 105228620 B CN105228620 B CN 105228620B CN 201480026796 A CN201480026796 A CN 201480026796A CN 105228620 B CN105228620 B CN 105228620B
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pyridin
methyl
oxy
carbamoyl
mmol
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CN105228620A (zh
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M·D·考夫曼
T·M·考德威尔
D·L·弗林
W·C·帕特
T·萨马拉孔
L·沃杰蒂
K·M·耶茨
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Deciphera Pharmaceuticals LLC
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Deciphera Pharmaceuticals LLC
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Priority to CN201910586017.2A priority Critical patent/CN110563700A/zh
Priority to CN202010826889.4A priority patent/CN112047927A/zh
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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CN201480026796.6A 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物 Active CN105228620B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201910586017.2A CN110563700A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
CN202010826889.4A CN112047927A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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US201361789971P 2013-03-15 2013-03-15
US61/789,971 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

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CN201910586017.2A Division CN110563700A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
CN202010826889.4A Division CN112047927A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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CN105228620B true CN105228620B (zh) 2020-09-04

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CN201910586017.2A Pending CN110563700A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
CN202010826889.4A Pending CN112047927A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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CN202010826889.4A Pending CN112047927A (zh) 2013-03-15 2014-03-14 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物

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JP5335056B2 (ja) 2011-11-16 2013-11-06 住友電気工業株式会社 ボルト用アルミニウム合金線及びボルト並びにそれらの製造方法
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
BR112015022263B1 (pt) * 2013-03-15 2023-01-03 Deciphera Pharmaceuticals Llc N-acil-n-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica
TWI747873B (zh) * 2016-02-01 2021-12-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
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