PH12015502336B1 - N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities - Google Patents

N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

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Publication number
PH12015502336B1
PH12015502336B1 PH1/2015/502336A PH12015502336A PH12015502336B1 PH 12015502336 B1 PH12015502336 B1 PH 12015502336B1 PH 12015502336 A PH12015502336 A PH 12015502336A PH 12015502336 B1 PH12015502336 B1 PH 12015502336B1
Authority
PH
Philippines
Prior art keywords
cancer
ureas
pyridin
acyl
proliferative activities
Prior art date
Application number
PH1/2015/502336A
Other languages
English (en)
Other versions
PH12015502336A1 (en
Inventor
Timothy Malcolm Caldwell
Daniel L Flynn
Michael D Kaufman
William C Patt
Thiwanka Samarakoon
Lakshminarayana Vogeti
Karen M Yates
Original Assignee
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of PH12015502336A1 publication Critical patent/PH12015502336A1/en
Publication of PH12015502336B1 publication Critical patent/PH12015502336B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Gastroenterology & Hepatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH1/2015/502336A 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities PH12015502336B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (2)

Publication Number Publication Date
PH12015502336A1 PH12015502336A1 (en) 2016-02-22
PH12015502336B1 true PH12015502336B1 (en) 2022-07-15

Family

ID=51529946

Family Applications (2)

Application Number Title Priority Date Filing Date
PH1/2015/502336A PH12015502336B1 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
PH1/2020/550201A PH12020550201A1 (en) 2013-03-15 2014-03-14 N-acyl-n-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

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Application Number Title Priority Date Filing Date
PH1/2020/550201A PH12020550201A1 (en) 2013-03-15 2014-03-14 N-acyl-n-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Country Status (15)

Country Link
US (1) US9382228B2 (enExample)
EP (1) EP2968287B1 (enExample)
JP (3) JP6364472B2 (enExample)
KR (2) KR102386952B1 (enExample)
CN (3) CN112047927A (enExample)
AU (2) AU2014233414B2 (enExample)
BR (1) BR112015022263B1 (enExample)
CA (1) CA2903288C (enExample)
ES (1) ES2817902T3 (enExample)
IL (2) IL241523B (enExample)
MX (2) MX366429B (enExample)
PH (2) PH12015502336B1 (enExample)
RU (1) RU2769607C2 (enExample)
SG (1) SG11201508532VA (enExample)
WO (1) WO2014145028A2 (enExample)

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN112047927A (zh) * 2013-03-15 2020-12-08 德西费拉制药有限责任公司 展现抗癌和抗增殖活性的n-酰基-n′-(吡啶-2-基)脲及类似物
TWI854164B (zh) * 2016-02-01 2024-09-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
KR102374012B1 (ko) 2017-05-24 2022-03-14 아비스코 테라퓨틱스 컴퍼니 리미티드 N-(아자릴)시클로락탐-1-카르복사미드 유도체 및 합성법과 그 용법
CN110461849B (zh) * 2017-06-19 2020-09-01 上海和誉生物医药科技有限公司 一种csf1r抑制剂及其制备方法和应用
KR20200040295A (ko) * 2017-08-24 2020-04-17 메르크 파텐트 게엠베하 보론산 유도체
CN109776401A (zh) * 2017-11-14 2019-05-21 成都博腾药业有限公司 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法
EP3746059A1 (en) 2018-01-31 2020-12-09 Deciphera Pharmaceuticals, LLC Combination therapy for the treatment of gastrointestinal stromal tumors
WO2019152719A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
CN110845476B (zh) * 2018-08-21 2022-11-18 上海和誉生物医药科技有限公司 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用
EP4303583B1 (en) 2018-12-28 2025-07-23 Deciphera Pharmaceuticals, LLC Csf1r inhibitors for use in treating tenosynovial giant cell tumors
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CN118930524A (zh) 2019-05-10 2024-11-12 德西费拉制药有限责任公司 苯基氨基嘧啶酰胺自噬抑制剂及其使用方法
SG11202112171XA (en) 2019-05-10 2021-12-30 Deciphera Pharmaceuticals Llc Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
AU2020297422B2 (en) 2019-06-17 2024-03-21 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
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